Mutagenetix > Incidental Mutation

Incidental Mutation 'IGL02606:Or4n4'

300276

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Or4n4

Ensembl Gene

ENSMUSG00000091873

Gene Name

olfactory receptor family 4 subfamily N member 4

Synonyms

GA_x6K02T2PMLR-5975274-5974348, Olfr732, MOR241-1

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.107) question?

Stock #

IGL02606

Quality Score

Status

Chromosome

Chromosomal Location

50518685-50519728 bp(-) (GRCm39)

Type of Mutation

missense

DNA Base Change (assembly)

T to C at 50519530 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Tyrosine to Cysteine at position 60 (Y60C)

Ref Sequence

ENSEMBL: ENSMUSP00000148984 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000071208] [ENSMUST00000213701]

AlphaFold

Q8VFT5

Predicted Effect

probably damaging
Transcript: ENSMUST00000071208
AA Change: Y60C

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)

SMART Domains

Protein: ENSMUSP00000071195
Gene: ENSMUSG00000091873
AA Change: Y60C

Domain	Start	End	E-Value	Type
Pfam:7tm_4	30	305	7.4e-45	PFAM
Pfam:7tm_1	41	288	4.5e-21	PFAM

Predicted Effect

probably damaging
Transcript: ENSMUST00000213701
AA Change: Y60C

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)

Coding Region Coverage

Validation Efficiency

MGI Phenotype

FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]

Allele List at MGI

Other mutations in this stock

Total: 50 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
4921539E11Rik	T	A	4: 103,099,978 (GRCm39)	N74I	probably benign	Het
Abr	T	C	11: 76,369,990 (GRCm39)	K75R	probably damaging	Het
Adcy10	A	C	1: 165,347,087 (GRCm39)	D368A	possibly damaging	Het
Alas1	A	G	9: 106,118,309 (GRCm39)		probably benign	Het
Alms1	T	A	6: 85,576,949 (GRCm39)	D168E	probably benign	Het
Ankar	C	T	1: 72,729,444 (GRCm39)	A82T	possibly damaging	Het
Atp2c2	C	T	8: 120,457,013 (GRCm39)	T205I	probably benign	Het
Atp9a	A	T	2: 168,494,588 (GRCm39)	L639Q	probably damaging	Het
Btf3l4	T	C	4: 108,675,411 (GRCm39)	D134G	probably benign	Het
Cacna1s	T	C	1: 136,007,257 (GRCm39)	C425R	probably damaging	Het
Cct6b	G	T	11: 82,627,271 (GRCm39)	T322N	probably damaging	Het
Col19a1	G	A	1: 24,573,197 (GRCm39)	R192*	probably null	Het
Cyp8b1	A	T	9: 121,744,801 (GRCm39)	F177Y	probably damaging	Het
Dnajc11	T	A	4: 152,063,941 (GRCm39)	N474K	probably benign	Het
Dusp16	T	C	6: 134,737,999 (GRCm39)	E13G	probably damaging	Het
Ephx2	T	C	14: 66,323,741 (GRCm39)	N397S	probably damaging	Het
Fancm	T	C	12: 65,122,913 (GRCm39)	V145A	possibly damaging	Het
Fiz1	A	G	7: 5,012,158 (GRCm39)	L120P	possibly damaging	Het
Galnt6	C	T	15: 100,612,100 (GRCm39)	V181M	probably damaging	Het
Ginm1	A	G	10: 7,646,163 (GRCm39)	V279A	probably damaging	Het
Gja10	T	G	4: 32,601,509 (GRCm39)	I292L	probably benign	Het
Gnb3	T	C	6: 124,814,378 (GRCm39)	S136G	probably benign	Het
Gramd1a	A	T	7: 30,833,940 (GRCm39)	V495E	probably damaging	Het
Il1rn	G	T	2: 24,235,462 (GRCm39)		probably benign	Het
Itpr3	A	G	17: 27,333,486 (GRCm39)		probably benign	Het
Kctd1	A	G	18: 15,195,937 (GRCm39)	S229P	possibly damaging	Het
Kdm4a	T	C	4: 118,017,486 (GRCm39)	T527A	probably benign	Het
Kif14	C	T	1: 136,424,331 (GRCm39)	A982V	probably damaging	Het
Klf6	A	G	13: 5,916,734 (GRCm39)	K293R	probably damaging	Het
Letmd1	A	G	15: 100,372,972 (GRCm39)	D92G	probably damaging	Het
Lmod1	G	A	1: 135,292,218 (GRCm39)	V358M	probably benign	Het
Ndufs1	A	T	1: 63,199,011 (GRCm39)	D295E	probably damaging	Het
Nek4	A	G	14: 30,685,916 (GRCm39)	N283S	probably benign	Het
Nhsl1	A	G	10: 18,387,385 (GRCm39)	T220A	probably damaging	Het
Nucks1	T	A	1: 131,852,363 (GRCm39)	D71E	probably damaging	Het
Or8g18	C	A	9: 39,149,490 (GRCm39)	V77F	probably damaging	Het
Pkhd1l1	A	G	15: 44,452,852 (GRCm39)	T3926A	probably benign	Het
Pptc7	T	A	5: 122,451,651 (GRCm39)		probably benign	Het
Prdm11	A	G	2: 92,805,948 (GRCm39)	V334A	probably benign	Het
Ptdss2	C	A	7: 140,732,911 (GRCm39)	C231*	probably null	Het
R3hdm1	C	T	1: 128,118,456 (GRCm39)	P570S	probably benign	Het
Rlbp1	T	C	7: 79,027,037 (GRCm39)	T208A	possibly damaging	Het
Rnaseh2a	T	G	8: 85,686,723 (GRCm39)	D142A	probably damaging	Het
Rufy4	C	T	1: 74,172,509 (GRCm39)		probably benign	Het
Tektl1	A	G	10: 78,584,300 (GRCm39)	Y372H	probably benign	Het
Tlcd4	G	T	3: 121,022,013 (GRCm39)	D128E	possibly damaging	Het
Ttn	A	G	2: 76,646,565 (GRCm39)	I11081T	possibly damaging	Het
Ubap2l	A	T	3: 89,945,735 (GRCm39)	S173R	probably damaging	Het
Vmn1r80	A	G	7: 11,926,959 (GRCm39)	N23S	probably damaging	Het
Vwce	C	A	19: 10,632,712 (GRCm39)		probably benign	Het

Other mutations in Or4n4

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL01370:Or4n4	APN	14	50,519,689 (GRCm39)	missense	probably damaging	0.99
IGL01801:Or4n4	APN	14	50,519,665 (GRCm39)	missense	probably benign
IGL01992:Or4n4	APN	14	50,518,798 (GRCm39)	missense	probably benign	0.09
IGL02137:Or4n4	APN	14	50,519,135 (GRCm39)	missense	probably benign	0.16
IGL02494:Or4n4	APN	14	50,519,683 (GRCm39)	missense	probably damaging	1.00
IGL02799:Or4n4	UTSW	14	50,518,801 (GRCm39)	missense	probably benign
PIT4142001:Or4n4	UTSW	14	50,518,784 (GRCm39)	makesense	probably null
R0570:Or4n4	UTSW	14	50,519,370 (GRCm39)	missense	probably benign	0.00
R1570:Or4n4	UTSW	14	50,518,981 (GRCm39)	missense	probably damaging	1.00
R1860:Or4n4	UTSW	14	50,518,848 (GRCm39)	nonsense	probably null
R2313:Or4n4	UTSW	14	50,519,431 (GRCm39)	missense	probably damaging	1.00
R4594:Or4n4	UTSW	14	50,519,140 (GRCm39)	missense	probably benign	0.02
R6442:Or4n4	UTSW	14	50,518,826 (GRCm39)	missense	probably damaging	0.98
R6783:Or4n4	UTSW	14	50,519,644 (GRCm39)	missense	probably benign
R7334:Or4n4	UTSW	14	50,519,036 (GRCm39)	missense	probably benign	0.08
R7763:Or4n4	UTSW	14	50,518,945 (GRCm39)	missense	probably damaging	1.00
R8207:Or4n4	UTSW	14	50,519,036 (GRCm39)	missense	probably benign	0.02
R8228:Or4n4	UTSW	14	50,518,997 (GRCm39)	missense	probably damaging	1.00
R8806:Or4n4	UTSW	14	50,519,236 (GRCm39)	missense	probably benign	0.04
R8809:Or4n4	UTSW	14	50,519,236 (GRCm39)	missense	probably benign	0.04
R8898:Or4n4	UTSW	14	50,518,952 (GRCm39)	missense	probably damaging	1.00
R8962:Or4n4	UTSW	14	50,518,816 (GRCm39)	missense	possibly damaging	0.95
R9800:Or4n4	UTSW	14	50,519,701 (GRCm39)	missense	probably benign

Posted On

2015-04-16