Incidental Mutation 'IGL02607:Gng8'
ID 300329
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Gng8
Ensembl Gene ENSMUSG00000063594
Gene Name guanine nucleotide binding protein (G protein), gamma 8
Synonyms G(y)8
Accession Numbers
Essential gene? Possibly non essential (E-score: 0.293) question?
Stock # IGL02607
Quality Score
Status
Chromosome 7
Chromosomal Location 16625711-16629361 bp(+) (GRCm39)
Type of Mutation splice site
DNA Base Change (assembly) T to C at 16628859 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change
Ref Sequence ENSEMBL: ENSMUSP00000145567 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000078182] [ENSMUST00000205459] [ENSMUST00000205716]
AlphaFold P63078
Predicted Effect probably benign
Transcript: ENSMUST00000078182
SMART Domains Protein: ENSMUSP00000077314
Gene: ENSMUSG00000063594

DomainStartEndE-ValueType
G_gamma 4 70 1.55e-22 SMART
GGL 8 70 8.6e-29 SMART
Predicted Effect noncoding transcript
Transcript: ENSMUST00000205314
Predicted Effect probably benign
Transcript: ENSMUST00000205459
Predicted Effect noncoding transcript
Transcript: ENSMUST00000205598
Predicted Effect probably benign
Transcript: ENSMUST00000205716
Predicted Effect noncoding transcript
Transcript: ENSMUST00000205838
Predicted Effect noncoding transcript
Transcript: ENSMUST00000206998
Coding Region Coverage
Validation Efficiency
MGI Phenotype PHENOTYPE: Homozygous inactivation of this gene results in a slow but progressive loss of vomeronasal neurons, impairment of specific vomeronasal-mediated behaviors such as maternal and intermale aggression, and reduced physiological responses to pheromonal stimulation. [provided by MGI curators]
Allele List at MGI
Other mutations in this stock
Total: 25 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Abca17 C T 17: 24,546,679 (GRCm39) W307* probably null Het
Cfap298 G A 16: 90,726,835 (GRCm39) T98M probably damaging Het
Cit A G 5: 115,997,268 (GRCm39) I84V probably benign Het
Cltc T C 11: 86,597,540 (GRCm39) D1132G probably benign Het
Cobll1 A T 2: 64,981,429 (GRCm39) S54T probably damaging Het
Dcstamp A G 15: 39,617,980 (GRCm39) R130G possibly damaging Het
Dennd4a A G 9: 64,769,609 (GRCm39) M439V probably damaging Het
Dnajc15 T A 14: 78,077,656 (GRCm39) I110F probably damaging Het
Dock1 T C 7: 134,453,242 (GRCm39) F824L probably benign Het
Eml2 A G 7: 18,940,036 (GRCm39) H617R probably damaging Het
Fgd6 A T 10: 93,880,310 (GRCm39) Q388L possibly damaging Het
Fkbp4 A T 6: 128,411,433 (GRCm39) probably benign Het
Fmnl3 A T 15: 99,222,653 (GRCm39) L431Q probably damaging Het
Hmcn1 T A 1: 150,620,746 (GRCm39) I1155F possibly damaging Het
Muc4 G T 16: 32,596,193 (GRCm39) C3135F possibly damaging Het
Mycbp2 C T 14: 103,522,709 (GRCm39) G685D probably damaging Het
Or2y1d T C 11: 49,321,339 (GRCm39) F12S probably damaging Het
Pcdhb8 A T 18: 37,490,634 (GRCm39) I771F probably benign Het
Pkn2 A G 3: 142,499,862 (GRCm39) probably null Het
Rrn3 G T 16: 13,624,427 (GRCm39) V420L possibly damaging Het
Samm50 A T 15: 84,092,039 (GRCm39) Y338F probably benign Het
Slc2a7 C T 4: 150,239,162 (GRCm39) T129I probably benign Het
Tbc1d8 T C 1: 39,418,592 (GRCm39) I806V probably benign Het
Tex2 T C 11: 106,437,573 (GRCm39) E699G unknown Het
Vmn2r85 T C 10: 130,262,290 (GRCm39) K150E possibly damaging Het
Other mutations in Gng8
AlleleSourceChrCoordTypePredicted EffectPPH Score
R0490:Gng8 UTSW 7 16,628,908 (GRCm39) missense probably benign
R0494:Gng8 UTSW 7 16,629,213 (GRCm39) missense probably benign
R1318:Gng8 UTSW 7 16,629,161 (GRCm39) missense probably damaging 0.99
Posted On 2015-04-16