Incidental Mutation 'IGL02612:Cdc37l1'
ID 300505
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Cdc37l1
Ensembl Gene ENSMUSG00000024780
Gene Name cell division cycle 37-like 1
Synonyms 2700033A15Rik, Harc, Hsp90-associating relative of Cdc37
Accession Numbers
Essential gene? Non essential (E-score: 0.000) question?
Stock # IGL02612
Quality Score
Status
Chromosome 19
Chromosomal Location 28967752-29004081 bp(+) (GRCm39)
Type of Mutation makesense
DNA Base Change (assembly) T to A at 28993502 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Stop codon to Arginine at position 336 (*336R)
Ref Sequence ENSEMBL: ENSMUSP00000060421 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000025696] [ENSMUST00000050148] [ENSMUST00000223694] [ENSMUST00000224511] [ENSMUST00000225210] [ENSMUST00000225310]
AlphaFold Q9CZP7
Predicted Effect probably benign
Transcript: ENSMUST00000025696
SMART Domains Protein: ENSMUSP00000025696
Gene: ENSMUSG00000024782

DomainStartEndE-ValueType
Pfam:AAA_17 9 172 2.4e-7 PFAM
Pfam:ADK 12 192 2.6e-52 PFAM
Pfam:ADK_lid 128 163 4.3e-17 PFAM
Predicted Effect probably null
Transcript: ENSMUST00000050148
AA Change: *336R
SMART Domains Protein: ENSMUSP00000060421
Gene: ENSMUSG00000024780
AA Change: *336R

DomainStartEndE-ValueType
low complexity region 4 14 N/A INTRINSIC
low complexity region 21 40 N/A INTRINSIC
low complexity region 102 115 N/A INTRINSIC
CDC37_M 132 288 7.15e-80 SMART
Predicted Effect probably benign
Transcript: ENSMUST00000223694
Predicted Effect probably benign
Transcript: ENSMUST00000224092
Predicted Effect probably benign
Transcript: ENSMUST00000224511
Predicted Effect probably benign
Transcript: ENSMUST00000224830
Predicted Effect probably benign
Transcript: ENSMUST00000225210
Predicted Effect noncoding transcript
Transcript: ENSMUST00000225598
Predicted Effect probably benign
Transcript: ENSMUST00000225310
Coding Region Coverage
Validation Efficiency
MGI Phenotype FUNCTION: This gene encodes a protein related to the Hsp90 co-chaperone Cdc37. This protein may have a role in mediating interactions between the Hsp90 complex and other proteins. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Oct 2014]
Allele List at MGI
Other mutations in this stock
Total: 56 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
A2m A T 6: 121,654,971 (GRCm39) M1432L probably benign Het
Alg11 A G 8: 22,551,999 (GRCm39) R48G probably benign Het
Armc8 T C 9: 99,409,122 (GRCm39) probably benign Het
Bmp4 T A 14: 46,621,938 (GRCm39) D202V probably damaging Het
Car12 T G 9: 66,669,706 (GRCm39) L300R probably damaging Het
Cep89 A G 7: 35,124,080 (GRCm39) probably null Het
Ces3b T A 8: 105,811,901 (GRCm39) D103E possibly damaging Het
Chd5 A G 4: 152,445,033 (GRCm39) D338G probably damaging Het
Crot A G 5: 9,019,945 (GRCm39) C466R probably damaging Het
Dach2 T C X: 112,660,101 (GRCm39) M194T probably benign Het
Dmrtc1b A G X: 101,756,873 (GRCm39) D100G probably benign Het
Epm2a G A 10: 11,332,980 (GRCm39) R271H probably damaging Het
Fem1c G T 18: 46,638,781 (GRCm39) T407K probably benign Het
Fer1l4 T C 2: 155,889,848 (GRCm39) Y273C probably damaging Het
Foxc2 C A 8: 121,844,576 (GRCm39) A408E probably benign Het
Gbp10 A T 5: 105,366,368 (GRCm39) M512K possibly damaging Het
Gm5134 T C 10: 75,828,323 (GRCm39) L301P probably damaging Het
Grk3 A T 5: 113,117,100 (GRCm39) D100E probably benign Het
Gsdma3 T A 11: 98,526,707 (GRCm39) D322E probably damaging Het
Gucy1a2 C A 9: 3,894,556 (GRCm39) L680I possibly damaging Het
Ighv7-2 T C 12: 113,875,766 (GRCm39) Y79C probably damaging Het
Igkv4-50 T C 6: 69,678,024 (GRCm39) T27A probably benign Het
Ints2 T C 11: 86,106,404 (GRCm39) D1002G probably damaging Het
Map4k5 T A 12: 69,896,358 (GRCm39) I169F possibly damaging Het
Mink1 T C 11: 70,488,052 (GRCm39) V39A probably damaging Het
Mms22l T A 4: 24,508,482 (GRCm39) H301Q probably benign Het
Myh4 C T 11: 67,147,305 (GRCm39) T1650I probably benign Het
Or52n4 A T 7: 104,293,870 (GRCm39) D234E probably benign Het
Or8b37 T A 9: 37,958,662 (GRCm39) L48Q probably damaging Het
Or8b44 T C 9: 38,410,769 (GRCm39) M268T probably benign Het
Pate10 T C 9: 35,653,460 (GRCm39) I88T possibly damaging Het
Pbxip1 C T 3: 89,350,988 (GRCm39) T117M probably damaging Het
Pgghg C T 7: 140,526,251 (GRCm39) T572M probably damaging Het
Phactr2 G A 10: 13,121,167 (GRCm39) T511I probably damaging Het
Pip5k1a T C 3: 94,974,724 (GRCm39) I385V probably benign Het
Pwp2 A G 10: 78,018,828 (GRCm39) C60R probably damaging Het
Rgs11 G A 17: 26,426,605 (GRCm39) V279I probably benign Het
Rttn G T 18: 88,991,750 (GRCm39) D110Y probably damaging Het
Setbp1 G T 18: 78,798,925 (GRCm39) H1418Q probably damaging Het
Sf3b3 T C 8: 111,569,608 (GRCm39) I37V probably benign Het
Slc27a6 A T 18: 58,689,977 (GRCm39) I148F probably benign Het
Slmap A G 14: 26,180,621 (GRCm39) probably benign Het
Speer4a3 A C 5: 26,156,614 (GRCm39) Y122D probably benign Het
Stil A G 4: 114,880,893 (GRCm39) Q479R possibly damaging Het
Svop A G 5: 114,166,321 (GRCm39) *549Q probably null Het
Tnks C T 8: 35,316,453 (GRCm39) V889I possibly damaging Het
Tnrc6c T A 11: 117,633,826 (GRCm39) V1308E possibly damaging Het
Vmn1r208 C A 13: 22,956,993 (GRCm39) C168F probably damaging Het
Vmn2r117 A T 17: 23,678,758 (GRCm39) M822K possibly damaging Het
Vwa8 A G 14: 79,420,552 (GRCm39) N1751S probably benign Het
Vwde A T 6: 13,187,148 (GRCm39) F780I probably damaging Het
Washc2 T C 6: 116,197,577 (GRCm39) I184T possibly damaging Het
Wdr26 A T 1: 181,005,361 (GRCm39) probably benign Het
Zfp608 G A 18: 55,031,273 (GRCm39) T889M probably damaging Het
Zfp955a G T 17: 33,463,039 (GRCm39) Q31K probably damaging Het
Zpbp2 T C 11: 98,446,343 (GRCm39) L145S probably benign Het
Other mutations in Cdc37l1
AlleleSourceChrCoordTypePredicted EffectPPH Score
R2260:Cdc37l1 UTSW 19 28,984,448 (GRCm39) missense probably benign 0.05
R4043:Cdc37l1 UTSW 19 28,968,028 (GRCm39) missense possibly damaging 0.83
R4434:Cdc37l1 UTSW 19 28,985,021 (GRCm39) missense probably damaging 1.00
R4437:Cdc37l1 UTSW 19 28,985,021 (GRCm39) missense probably damaging 1.00
R4438:Cdc37l1 UTSW 19 28,985,021 (GRCm39) missense probably damaging 1.00
R4829:Cdc37l1 UTSW 19 28,967,983 (GRCm39) missense probably benign
R5385:Cdc37l1 UTSW 19 28,989,343 (GRCm39) missense possibly damaging 0.95
R5537:Cdc37l1 UTSW 19 28,972,518 (GRCm39) missense probably damaging 1.00
R5906:Cdc37l1 UTSW 19 28,989,386 (GRCm39) missense probably benign 0.42
R7385:Cdc37l1 UTSW 19 28,968,071 (GRCm39) critical splice donor site probably null
R7610:Cdc37l1 UTSW 19 28,985,132 (GRCm39) missense possibly damaging 0.90
R9142:Cdc37l1 UTSW 19 28,989,402 (GRCm39) missense possibly damaging 0.86
R9317:Cdc37l1 UTSW 19 28,972,518 (GRCm39) missense probably damaging 1.00
Posted On 2015-04-16