Incidental Mutation 'IGL02613:Zfp277'
| ID |
300543 |
| Institutional Source |
Australian Phenomics Network
(link to record)
|
| Gene Symbol |
Zfp277
|
| Ensembl Gene |
ENSMUSG00000055917 |
| Gene Name |
zinc finger protein 277 |
| Synonyms |
NIRF4, 2410017E24Rik |
| Accession Numbers |
|
| Essential gene? |
Probably non essential
(E-score: 0.061)
|
| Stock # |
IGL02613
|
| Quality Score |
|
|
Status
|
|
| Chromosome |
12 |
| Chromosomal Location |
40365045-40495789 bp(-) (GRCm39) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
A to G
at 40379514 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Phenylalanine to Serine
at position 340
(F340S)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000064226
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000069637]
[ENSMUST00000069692]
|
| AlphaFold |
E9Q6D6 |
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000069637
AA Change: F214S
PolyPhen 2
Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
|
| SMART Domains |
Protein: ENSMUSP00000068032
Gene: ENSMUSG00000055917
AA Change: F214S
| Domain | Start | End | E-Value | Type |
|---|
|
ZnF_C2H2
|
59 |
84 |
4.27e1 |
SMART |
|
coiled coil region
|
143 |
171 |
N/A |
INTRINSIC |
|
ZnF_C2H2
|
174 |
198 |
3.85e1 |
SMART |
|
ZnF_C2H2
|
225 |
249 |
2.24e-3 |
SMART |
|
low complexity region
|
280 |
292 |
N/A |
INTRINSIC |
|
ZnF_C2H2
|
303 |
326 |
1.91e1 |
SMART |
|
ZnF_C2H2
|
356 |
382 |
4.94e0 |
SMART |
|
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000069692
AA Change: F340S
PolyPhen 2
Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
|
| SMART Domains |
Protein: ENSMUSP00000064226
Gene: ENSMUSG00000055917
AA Change: F340S
| Domain | Start | End | E-Value | Type |
|---|
|
ZnF_C2H2
|
185 |
210 |
4.27e1 |
SMART |
|
coiled coil region
|
269 |
297 |
N/A |
INTRINSIC |
|
ZnF_C2H2
|
300 |
324 |
3.85e1 |
SMART |
|
ZnF_C2H2
|
351 |
375 |
2.24e-3 |
SMART |
|
low complexity region
|
406 |
418 |
N/A |
INTRINSIC |
|
ZnF_C2H2
|
429 |
452 |
1.91e1 |
SMART |
|
ZnF_C2H2
|
482 |
508 |
4.94e0 |
SMART |
|
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000222394
|
| Coding Region Coverage |
|
| Validation Efficiency |
|
| MGI Phenotype |
PHENOTYPE: Mice homozygous for a knock-out allele exhibit early cellular preplicative senescence in MEFs. [provided by MGI curators]
|
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 37 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| Adcy8 |
T |
G |
15: 64,655,833 (GRCm39) |
I549L |
possibly damaging |
Het |
| Arhgef17 |
A |
T |
7: 100,578,103 (GRCm39) |
H948Q |
probably damaging |
Het |
| Auh |
A |
G |
13: 53,073,035 (GRCm39) |
|
probably null |
Het |
| Btf3 |
A |
G |
13: 98,446,714 (GRCm39) |
|
probably benign |
Het |
| Capg |
A |
G |
6: 72,532,594 (GRCm39) |
N53S |
probably damaging |
Het |
| Cfap70 |
T |
C |
14: 20,459,132 (GRCm39) |
|
probably null |
Het |
| Chrna5 |
A |
T |
9: 54,913,705 (GRCm39) |
E417V |
probably damaging |
Het |
| Coch |
A |
G |
12: 51,642,132 (GRCm39) |
T35A |
possibly damaging |
Het |
| Dock4 |
T |
A |
12: 40,860,465 (GRCm39) |
L1284M |
probably damaging |
Het |
| Etv3 |
A |
G |
3: 87,443,702 (GRCm39) |
T429A |
possibly damaging |
Het |
| Fmnl2 |
T |
C |
2: 52,963,747 (GRCm39) |
|
probably null |
Het |
| Glb1 |
A |
G |
9: 114,293,130 (GRCm39) |
T502A |
possibly damaging |
Het |
| Greb1 |
C |
A |
12: 16,789,889 (GRCm39) |
|
probably null |
Het |
| Hspg2 |
A |
G |
4: 137,271,731 (GRCm39) |
Y2499C |
probably damaging |
Het |
| Kcnq1 |
A |
T |
7: 142,979,863 (GRCm39) |
|
probably benign |
Het |
| Lrriq1 |
A |
G |
10: 102,980,409 (GRCm39) |
S1497P |
probably damaging |
Het |
| Magel2 |
G |
A |
7: 62,029,946 (GRCm39) |
R950H |
unknown |
Het |
| Mcc |
A |
G |
18: 44,563,021 (GRCm39) |
L982P |
probably damaging |
Het |
| Naif1 |
T |
A |
2: 32,345,172 (GRCm39) |
M292K |
possibly damaging |
Het |
| Npb |
T |
A |
11: 120,499,716 (GRCm39) |
C99S |
probably damaging |
Het |
| Obscn |
G |
T |
11: 58,892,958 (GRCm39) |
R6763S |
probably benign |
Het |
| Or13a21 |
A |
G |
7: 139,999,383 (GRCm39) |
V101A |
probably benign |
Het |
| Or5p56 |
C |
T |
7: 107,590,381 (GRCm39) |
Q270* |
probably null |
Het |
| Pip5k1c |
C |
A |
10: 81,153,155 (GRCm39) |
|
probably null |
Het |
| Pitpnm3 |
A |
T |
11: 71,948,898 (GRCm39) |
S736T |
probably damaging |
Het |
| Polr1a |
A |
T |
6: 71,944,304 (GRCm39) |
E1257V |
probably damaging |
Het |
| Sec63 |
G |
A |
10: 42,677,703 (GRCm39) |
D270N |
probably damaging |
Het |
| Snrnp200 |
C |
T |
2: 127,060,346 (GRCm39) |
T530I |
probably damaging |
Het |
| Sorbs1 |
A |
T |
19: 40,315,991 (GRCm39) |
N383K |
probably damaging |
Het |
| Syk |
G |
A |
13: 52,797,076 (GRCm39) |
G546R |
probably damaging |
Het |
| Tfap2d |
T |
A |
1: 19,189,415 (GRCm39) |
L265Q |
probably damaging |
Het |
| Trav12-1 |
C |
T |
14: 53,775,742 (GRCm39) |
S9L |
possibly damaging |
Het |
| Trerf1 |
T |
C |
17: 47,659,766 (GRCm39) |
|
noncoding transcript |
Het |
| Ttn |
T |
A |
2: 76,558,704 (GRCm39) |
I29726L |
possibly damaging |
Het |
| Usp18 |
A |
G |
6: 121,238,049 (GRCm39) |
T143A |
probably benign |
Het |
| Usp32 |
A |
T |
11: 84,930,896 (GRCm39) |
N511K |
probably damaging |
Het |
| Wdr64 |
C |
T |
1: 175,594,613 (GRCm39) |
Q4* |
probably null |
Het |
|
| Other mutations in Zfp277 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL01466:Zfp277
|
APN |
12 |
40,428,825 (GRCm39) |
missense |
probably benign |
0.24 |
|
IGL01477:Zfp277
|
APN |
12 |
40,370,675 (GRCm39) |
missense |
probably benign |
0.00 |
|
IGL02081:Zfp277
|
APN |
12 |
40,378,795 (GRCm39) |
nonsense |
probably null |
|
|
IGL02165:Zfp277
|
APN |
12 |
40,365,802 (GRCm39) |
missense |
possibly damaging |
0.75 |
|
IGL02688:Zfp277
|
APN |
12 |
40,378,687 (GRCm39) |
missense |
possibly damaging |
0.95 |
|
IGL02825:Zfp277
|
APN |
12 |
40,367,175 (GRCm39) |
missense |
probably benign |
0.06 |
|
R0194:Zfp277
|
UTSW |
12 |
40,428,876 (GRCm39) |
splice site |
probably benign |
|
|
R0226:Zfp277
|
UTSW |
12 |
40,414,161 (GRCm39) |
missense |
possibly damaging |
0.67 |
|
R0843:Zfp277
|
UTSW |
12 |
40,370,599 (GRCm39) |
critical splice donor site |
probably null |
|
|
R1263:Zfp277
|
UTSW |
12 |
40,414,164 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R1584:Zfp277
|
UTSW |
12 |
40,428,825 (GRCm39) |
missense |
probably benign |
0.12 |
|
R1609:Zfp277
|
UTSW |
12 |
40,378,719 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R1644:Zfp277
|
UTSW |
12 |
40,379,609 (GRCm39) |
splice site |
probably null |
|
|
R1789:Zfp277
|
UTSW |
12 |
40,414,084 (GRCm39) |
missense |
probably benign |
0.00 |
|
R1882:Zfp277
|
UTSW |
12 |
40,495,745 (GRCm39) |
missense |
probably benign |
0.03 |
|
R2011:Zfp277
|
UTSW |
12 |
40,367,217 (GRCm39) |
nonsense |
probably null |
|
|
R4884:Zfp277
|
UTSW |
12 |
40,413,152 (GRCm39) |
missense |
probably damaging |
0.97 |
|
R4976:Zfp277
|
UTSW |
12 |
40,378,687 (GRCm39) |
missense |
possibly damaging |
0.95 |
|
R5119:Zfp277
|
UTSW |
12 |
40,378,687 (GRCm39) |
missense |
possibly damaging |
0.95 |
|
R5532:Zfp277
|
UTSW |
12 |
40,385,308 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6340:Zfp277
|
UTSW |
12 |
40,368,548 (GRCm39) |
missense |
possibly damaging |
0.57 |
|
R7191:Zfp277
|
UTSW |
12 |
40,379,561 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7378:Zfp277
|
UTSW |
12 |
40,365,852 (GRCm39) |
missense |
possibly damaging |
0.94 |
|
R7446:Zfp277
|
UTSW |
12 |
40,378,729 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7564:Zfp277
|
UTSW |
12 |
40,379,594 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R7861:Zfp277
|
UTSW |
12 |
40,365,880 (GRCm39) |
missense |
possibly damaging |
0.92 |
|
R8428:Zfp277
|
UTSW |
12 |
40,379,577 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9673:Zfp277
|
UTSW |
12 |
40,370,611 (GRCm39) |
missense |
probably benign |
0.15 |
|
| Posted On |
2015-04-16 |
Incidental Mutation