Incidental Mutation 'IGL02614:Or10g1b'
ID 300605
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Or10g1b
Ensembl Gene ENSMUSG00000063867
Gene Name olfactory receptor family 10 subfamily G member 1B
Synonyms Olfr1511, GA_x6K02T2RJGY-608749-609705, MOR223-9
Accession Numbers
Essential gene? Probably non essential (E-score: 0.074) question?
Stock # IGL02614
Quality Score
Status
Chromosome 14
Chromosomal Location 52627272-52628228 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to C at 52627627 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Glutamic Acid to Glycine at position 201 (E201G)
Ref Sequence ENSEMBL: ENSMUSP00000149479 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000078171] [ENSMUST00000214168]
AlphaFold E9PWU0
Predicted Effect probably damaging
Transcript: ENSMUST00000078171
AA Change: E201G

PolyPhen 2 Score 0.990 (Sensitivity: 0.72; Specificity: 0.97)
SMART Domains Protein: ENSMUSP00000077302
Gene: ENSMUSG00000063867
AA Change: E201G

DomainStartEndE-ValueType
Pfam:7tm_4 35 310 1.3e-50 PFAM
Pfam:7tm_1 45 293 2.5e-20 PFAM
Predicted Effect probably damaging
Transcript: ENSMUST00000214168
AA Change: E201G

PolyPhen 2 Score 0.990 (Sensitivity: 0.72; Specificity: 0.97)
Coding Region Coverage
Validation Efficiency
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 35 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Aasdh A T 5: 77,044,215 (GRCm39) probably benign Het
Acadsb A G 7: 131,026,357 (GRCm39) T67A probably benign Het
Aff2 A G X: 68,907,693 (GRCm39) D1225G possibly damaging Het
Atp2a2 T C 5: 122,627,366 (GRCm39) D133G probably benign Het
Cacul1 A T 19: 60,551,661 (GRCm39) M187K possibly damaging Het
Celf4 A G 18: 25,637,207 (GRCm39) Y263H probably damaging Het
Cmbl G T 15: 31,589,830 (GRCm39) V187F probably damaging Het
Epha1 T C 6: 42,337,491 (GRCm39) N896S probably benign Het
Fbxo27 G A 7: 28,396,201 (GRCm39) probably null Het
Galnt16 T C 12: 80,623,337 (GRCm39) S166P probably damaging Het
Gm1110 A G 9: 26,832,010 (GRCm39) V47A probably benign Het
Gmnn A G 13: 24,944,137 (GRCm39) probably benign Het
Gpbp1 T C 13: 111,573,007 (GRCm39) I382V probably benign Het
Gpr87 C A 3: 59,086,738 (GRCm39) V256L probably damaging Het
Il4ra C A 7: 125,174,962 (GRCm39) S390* probably null Het
Itprid1 A T 6: 55,945,262 (GRCm39) D661V probably damaging Het
Lrrc47 T C 4: 154,103,392 (GRCm39) probably null Het
Lrriq4 A T 3: 30,709,788 (GRCm39) L362F probably damaging Het
Lrrtm4 A T 6: 79,998,827 (GRCm39) N79Y probably benign Het
Nr1i2 T A 16: 38,074,118 (GRCm39) H165L probably damaging Het
Phf11a T A 14: 59,516,817 (GRCm39) T214S possibly damaging Het
Prr14l A T 5: 32,987,887 (GRCm39) I536K possibly damaging Het
Rpn1 T A 6: 88,079,087 (GRCm39) I510N probably benign Het
Sall4 A T 2: 168,597,805 (GRCm39) L20Q probably null Het
Sema3f T C 9: 107,559,710 (GRCm39) E759G probably benign Het
Slc5a1 T C 5: 33,311,945 (GRCm39) S446P probably benign Het
Srrm1 G A 4: 135,052,415 (GRCm39) P658L unknown Het
Tcn2 C A 11: 3,876,158 (GRCm39) S90I possibly damaging Het
Ttn T C 2: 76,542,331 (GRCm39) T31806A possibly damaging Het
Ubr1 T C 2: 120,701,460 (GRCm39) probably benign Het
Vac14 T G 8: 111,361,750 (GRCm39) L214R probably damaging Het
Vmn2r58 T C 7: 41,486,553 (GRCm39) K781E probably damaging Het
Vmn2r92 T C 17: 18,387,503 (GRCm39) probably benign Het
Zfp518a G A 19: 40,903,061 (GRCm39) G997R probably damaging Het
Zfp609 G A 9: 65,610,072 (GRCm39) P964S probably damaging Het
Other mutations in Or10g1b
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL02645:Or10g1b APN 14 52,627,958 (GRCm39) missense possibly damaging 0.50
R0277:Or10g1b UTSW 14 52,627,846 (GRCm39) missense probably damaging 1.00
R0601:Or10g1b UTSW 14 52,627,283 (GRCm39) nonsense probably null
R1956:Or10g1b UTSW 14 52,628,037 (GRCm39) missense probably benign 0.06
R2342:Or10g1b UTSW 14 52,627,322 (GRCm39) missense possibly damaging 0.89
R5193:Or10g1b UTSW 14 52,628,069 (GRCm39) missense probably benign 0.00
R5439:Or10g1b UTSW 14 52,627,582 (GRCm39) missense probably damaging 1.00
R5506:Or10g1b UTSW 14 52,628,084 (GRCm39) missense probably damaging 1.00
R6948:Or10g1b UTSW 14 52,627,614 (GRCm39) missense probably benign 0.22
R8191:Or10g1b UTSW 14 52,627,987 (GRCm39) missense probably benign 0.00
R8267:Or10g1b UTSW 14 52,627,903 (GRCm39) missense probably damaging 1.00
R8503:Or10g1b UTSW 14 52,627,354 (GRCm39) missense probably damaging 0.97
X0035:Or10g1b UTSW 14 52,627,823 (GRCm39) missense probably benign 0.18
Posted On 2015-04-16