Incidental Mutation 'IGL02618:Soga1'
ID300745
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Soga1
Ensembl Gene ENSMUSG00000055485
Gene Namesuppressor of glucose, autophagy associated 1
SynonymsD430036N24Rik, 9830001H06Rik
Accession Numbers
Is this an essential gene? Possibly non essential (E-score: 0.323) question?
Stock #IGL02618
Quality Score
Status
Chromosome2
Chromosomal Location157015799-157079254 bp(-) (GRCm38)
Type of Mutationmissense
DNA Base Change (assembly) A to G at 157040566 bp
ZygosityHeterozygous
Amino Acid Change Leucine to Proline at position 522 (L522P)
Ref Sequence ENSEMBL: ENSMUSP00000066556 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000069098]
Predicted Effect probably damaging
Transcript: ENSMUST00000069098
AA Change: L522P

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
SMART Domains Protein: ENSMUSP00000066556
Gene: ENSMUSG00000055485
AA Change: L522P

DomainStartEndE-ValueType
low complexity region 15 23 N/A INTRINSIC
low complexity region 51 66 N/A INTRINSIC
low complexity region 97 112 N/A INTRINSIC
low complexity region 132 148 N/A INTRINSIC
low complexity region 155 174 N/A INTRINSIC
Blast:BRLZ 212 246 4e-8 BLAST
SCOP:d1fxkc_ 216 350 1e-3 SMART
Pfam:DUF3166 378 472 2.3e-31 PFAM
Pfam:DUF3166 504 593 5.3e-31 PFAM
low complexity region 637 649 N/A INTRINSIC
coiled coil region 807 867 N/A INTRINSIC
low complexity region 872 884 N/A INTRINSIC
low complexity region 938 950 N/A INTRINSIC
Pfam:DUF4482 1065 1205 3.9e-28 PFAM
low complexity region 1311 1321 N/A INTRINSIC
low complexity region 1363 1377 N/A INTRINSIC
low complexity region 1389 1418 N/A INTRINSIC
Predicted Effect noncoding transcript
Transcript: ENSMUST00000133571
Coding Region Coverage
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 34 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
2700097O09Rik G A 12: 55,057,301 Q178* probably null Het
Adgre1 T A 17: 57,444,021 V565E possibly damaging Het
Arfgef2 C A 2: 166,853,313 N535K probably damaging Het
Bbx A G 16: 50,247,798 L161S probably damaging Het
Bclaf1 T C 10: 20,323,528 S224P probably damaging Het
Car2 A G 3: 14,897,972 D189G probably benign Het
Catsperb A T 12: 101,480,724 probably benign Het
Ccdc88c C T 12: 100,913,553 V1770I probably benign Het
Cebpe T C 14: 54,710,777 D203G probably damaging Het
Chn2 A G 6: 54,220,437 N104S probably damaging Het
Clec2i G A 6: 128,896,501 C231Y probably damaging Het
Col4a5 C T X: 141,683,682 P1557S probably damaging Het
Creb3l1 T C 2: 91,983,198 N498S probably benign Het
Ctnnal1 A T 4: 56,817,060 D587E probably benign Het
Dnmt3l T C 10: 78,054,022 probably benign Het
Dock7 A G 4: 99,083,028 V100A probably benign Het
Frk C T 10: 34,583,964 T185I possibly damaging Het
Frmd4b G A 6: 97,308,105 Q340* probably null Het
Lima1 C A 15: 99,802,216 probably benign Het
Ndrg1 G A 15: 66,940,237 H202Y probably benign Het
Nxpe2 T G 9: 48,326,334 N207T probably damaging Het
Olfr201 A T 16: 59,268,927 S247T probably damaging Het
Pdzph1 T C 17: 58,879,073 probably benign Het
Pinx1 A G 14: 63,868,520 D75G probably damaging Het
Plxdc1 A T 11: 97,932,304 D370E probably benign Het
Polb A T 8: 22,637,093 L228Q probably damaging Het
Rab3gap2 T A 1: 185,251,741 I521N possibly damaging Het
Rapgef1 A G 2: 29,737,943 D1045G probably damaging Het
Rbks A T 5: 31,624,519 Y312* probably null Het
Ror2 C T 13: 53,110,728 S764N probably damaging Het
Src A T 2: 157,464,778 K234* probably null Het
Stk36 C A 1: 74,631,675 probably benign Het
Ttll6 G T 11: 96,147,562 C412F probably benign Het
Zfp58 A G 13: 67,491,356 F339L possibly damaging Het
Other mutations in Soga1
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00429:Soga1 APN 2 157030864 missense probably damaging 1.00
IGL00924:Soga1 APN 2 157040705 missense probably damaging 0.99
IGL01723:Soga1 APN 2 157030614 missense probably benign 0.00
IGL01749:Soga1 APN 2 157021541 splice site probably benign
IGL02199:Soga1 APN 2 157030945 missense probably damaging 1.00
IGL02262:Soga1 APN 2 157030906 missense probably damaging 1.00
IGL02643:Soga1 APN 2 157040743 missense probably damaging 1.00
deglutition UTSW 2 157039864 missense possibly damaging 0.63
gulp UTSW 2 157023817 nonsense probably null
IGL02835:Soga1 UTSW 2 157041934 missense possibly damaging 0.91
R0528:Soga1 UTSW 2 157020692 missense probably damaging 1.00
R0535:Soga1 UTSW 2 157033289 missense possibly damaging 0.89
R0726:Soga1 UTSW 2 157060262 missense probably damaging 1.00
R1473:Soga1 UTSW 2 157020448 nonsense probably null
R1589:Soga1 UTSW 2 157027637 missense probably benign 0.05
R1615:Soga1 UTSW 2 157020743 missense probably damaging 1.00
R1681:Soga1 UTSW 2 157030530 missense possibly damaging 0.70
R1701:Soga1 UTSW 2 157030619 missense probably damaging 1.00
R1872:Soga1 UTSW 2 157040261 missense possibly damaging 0.88
R2056:Soga1 UTSW 2 157022827 missense probably benign 0.00
R2118:Soga1 UTSW 2 157033325 missense probably damaging 1.00
R2120:Soga1 UTSW 2 157033325 missense probably damaging 1.00
R2121:Soga1 UTSW 2 157033325 missense probably damaging 1.00
R2124:Soga1 UTSW 2 157033325 missense probably damaging 1.00
R2249:Soga1 UTSW 2 157040093 missense probably benign 0.08
R3147:Soga1 UTSW 2 157020364 missense possibly damaging 0.91
R3758:Soga1 UTSW 2 157020638 missense possibly damaging 0.77
R4601:Soga1 UTSW 2 157039924 missense probably benign 0.41
R4646:Soga1 UTSW 2 157020506 missense probably damaging 1.00
R4653:Soga1 UTSW 2 157040591 missense probably damaging 1.00
R4736:Soga1 UTSW 2 157020554 missense probably damaging 1.00
R4773:Soga1 UTSW 2 157030569 missense probably benign 0.08
R4796:Soga1 UTSW 2 157020252 missense probably benign
R4999:Soga1 UTSW 2 157022856 missense probably benign 0.10
R5304:Soga1 UTSW 2 157023817 nonsense probably null
R5369:Soga1 UTSW 2 157040734 missense probably damaging 1.00
R5530:Soga1 UTSW 2 157020342 missense probably damaging 1.00
R5712:Soga1 UTSW 2 157030921 missense probably damaging 1.00
R5780:Soga1 UTSW 2 157018490 missense probably damaging 0.98
R6162:Soga1 UTSW 2 157039864 missense possibly damaging 0.63
R6253:Soga1 UTSW 2 157021419 missense probably benign 0.00
R6303:Soga1 UTSW 2 157040764 missense possibly damaging 0.91
R6304:Soga1 UTSW 2 157040764 missense possibly damaging 0.91
R6523:Soga1 UTSW 2 157060343 nonsense probably null
R7216:Soga1 UTSW 2 157018370 missense possibly damaging 0.76
R7335:Soga1 UTSW 2 157031005 missense possibly damaging 0.86
R7562:Soga1 UTSW 2 157053589 missense probably damaging 1.00
X0019:Soga1 UTSW 2 157020264 missense probably benign 0.04
Posted On2015-04-16