Mutagenetix > Incidental Mutation

Incidental Mutation 'IGL02619:Zfp111'

300788

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Zfp111

Ensembl Gene

ENSMUSG00000087598

Gene Name

zinc finger protein 111

Synonyms

Accession Numbers

Essential gene?

Non essential (E-score: 0.000) question?

Stock #

IGL02619

Quality Score

Status

Chromosome

Chromosomal Location

23890760-23907574 bp(-) (GRCm39)

Type of Mutation

missense

DNA Base Change (assembly)

A to T at 23899113 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Leucine to Glutamine at position 166 (L166Q)

Ref Sequence

ENSEMBL: ENSMUSP00000083169 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000056683] [ENSMUST00000073833] [ENSMUST00000086006]

AlphaFold

Q9R164

Predicted Effect

probably benign
Transcript: ENSMUST00000056683
AA Change: L167Q

PolyPhen 2 Score 0.069 (Sensitivity: 0.94; Specificity: 0.84)

SMART Domains

Protein: ENSMUSP00000129484
Gene: ENSMUSG00000087598
AA Change: L167Q

Domain	Start	End	E-Value	Type
KRAB	9	64	1.8e-21	SMART
low complexity region	114	128	N/A	INTRINSIC
ZnF_C2H2	210	232	2.3e-7	SMART
ZnF_C2H2	266	288	5.7e-4	SMART
ZnF_C2H2	294	316	3.3e-4	SMART
ZnF_C2H2	322	343	4.3e-1	SMART
ZnF_C2H2	349	371	4.5e-8	SMART
ZnF_C2H2	377	399	2.1e-6	SMART
ZnF_C2H2	405	427	8e-6	SMART
ZnF_C2H2	433	455	9.9e-5	SMART
ZnF_C2H2	461	481	4.3e-2	SMART
ZnF_C2H2	489	511	2.7e-5	SMART
ZnF_C2H2	517	539	1.1e-6	SMART
ZnF_C2H2	545	567	1.8e-5	SMART
ZnF_C2H2	573	595	3.5e-6	SMART
ZnF_C2H2	601	623	2.9e-6	SMART
ZnF_C2H2	629	651	1.3e-6	SMART
ZnF_C2H2	657	679	2.2e-5	SMART

Predicted Effect

possibly damaging
Transcript: ENSMUST00000073833
AA Change: L166Q

PolyPhen 2 Score 0.747 (Sensitivity: 0.85; Specificity: 0.92)

SMART Domains

Protein: ENSMUSP00000083174
Gene: ENSMUSG00000087598
AA Change: L166Q

Domain	Start	End	E-Value	Type
KRAB	8	63	4.03e-19	SMART
low complexity region	113	127	N/A	INTRINSIC
ZnF_C2H2	209	231	5.29e-5	SMART
ZnF_C2H2	265	287	1.33e-1	SMART
ZnF_C2H2	293	315	7.67e-2	SMART
ZnF_C2H2	321	342	1.01e2	SMART
ZnF_C2H2	348	370	1e-5	SMART
ZnF_C2H2	376	398	4.87e-4	SMART
ZnF_C2H2	404	426	1.82e-3	SMART
ZnF_C2H2	432	454	2.36e-2	SMART
ZnF_C2H2	460	480	9.96e0	SMART
ZnF_C2H2	488	510	6.32e-3	SMART
ZnF_C2H2	516	538	2.61e-4	SMART
ZnF_C2H2	544	566	4.17e-3	SMART
ZnF_C2H2	572	594	7.9e-4	SMART
ZnF_C2H2	600	622	6.88e-4	SMART
ZnF_C2H2	628	650	3.21e-4	SMART
ZnF_C2H2	656	678	5.14e-3	SMART

Predicted Effect

possibly damaging
Transcript: ENSMUST00000086006
AA Change: L166Q

PolyPhen 2 Score 0.747 (Sensitivity: 0.85; Specificity: 0.92)

SMART Domains

Protein: ENSMUSP00000083169
Gene: ENSMUSG00000087598
AA Change: L166Q

Domain	Start	End	E-Value	Type
KRAB	8	63	4.03e-19	SMART
low complexity region	113	127	N/A	INTRINSIC
ZnF_C2H2	209	231	5.29e-5	SMART
ZnF_C2H2	265	287	1.33e-1	SMART
ZnF_C2H2	293	315	7.67e-2	SMART
ZnF_C2H2	321	342	1.01e2	SMART
ZnF_C2H2	348	370	1e-5	SMART
ZnF_C2H2	376	398	4.87e-4	SMART
ZnF_C2H2	404	426	1.82e-3	SMART
ZnF_C2H2	432	454	2.36e-2	SMART
ZnF_C2H2	460	480	9.96e0	SMART
ZnF_C2H2	488	510	6.32e-3	SMART
ZnF_C2H2	516	538	2.61e-4	SMART
ZnF_C2H2	544	566	4.17e-3	SMART
ZnF_C2H2	572	594	7.9e-4	SMART
ZnF_C2H2	600	622	6.88e-4	SMART
ZnF_C2H2	628	650	3.21e-4	SMART
ZnF_C2H2	656	678	5.14e-3	SMART

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000148050

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000160563

Coding Region Coverage

Validation Efficiency

Allele List at MGI

Other mutations in this stock

Total: 52 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Ahctf1	C	T	1: 179,620,016 (GRCm39)	G220E	possibly damaging	Het
Arhgef10l	A	G	4: 140,321,504 (GRCm39)	I101T	probably benign	Het
Armc8	T	C	9: 99,409,122 (GRCm39)		probably benign	Het
Camkk2	A	T	5: 122,902,298 (GRCm39)	C4S	probably damaging	Het
Ccdc174	T	A	6: 91,876,538 (GRCm39)	D458E	possibly damaging	Het
Cercam	A	G	2: 29,770,686 (GRCm39)	N419S	probably benign	Het
Clca3a2	T	C	3: 144,512,083 (GRCm39)	N551S	probably damaging	Het
Cldn18	T	A	9: 99,580,988 (GRCm39)	I87F	probably damaging	Het
Ctso	T	A	3: 81,848,836 (GRCm39)		probably benign	Het
Ddhd2	C	A	8: 26,236,981 (GRCm39)		probably null	Het
Dscaml1	T	A	9: 45,359,094 (GRCm39)	Y118N	probably damaging	Het
Ece1	C	T	4: 137,666,044 (GRCm39)	A296V	probably benign	Het
Fbxo40	T	A	16: 36,790,766 (GRCm39)	I115F	possibly damaging	Het
Fkbp9	T	A	6: 56,827,609 (GRCm39)	N143K	probably damaging	Het
Foxk2	G	T	11: 121,190,402 (GRCm39)		probably benign	Het
Ggnbp1	A	G	17: 27,248,529 (GRCm39)	K33E	probably benign	Het
Hace1	A	T	10: 45,547,530 (GRCm39)		probably benign	Het
Hk3	A	T	13: 55,162,107 (GRCm39)	C133S	probably damaging	Het
Kbtbd3	C	T	9: 4,331,252 (GRCm39)	A542V	probably damaging	Het
Lrch2	A	C	X: 146,263,537 (GRCm39)	V363G	probably damaging	Het
Lrch2	C	T	X: 146,302,131 (GRCm39)	C264Y	probably damaging	Het
Lrrc56	C	A	7: 140,787,546 (GRCm39)		probably benign	Het
Lrtm2	C	T	6: 119,294,199 (GRCm39)	V311M	probably damaging	Het
N4bp1	G	T	8: 87,587,529 (GRCm39)	Q470K	probably benign	Het
Naa15	A	C	3: 51,367,552 (GRCm39)	D575A	probably benign	Het
Ncaph	A	T	2: 126,969,456 (GRCm39)	V69D	probably damaging	Het
Nlrp5	G	A	7: 23,123,489 (GRCm39)		probably null	Het
Nmbr	A	G	10: 14,636,331 (GRCm39)	D100G	probably damaging	Het
Ofcc1	C	T	13: 40,250,553 (GRCm39)	V588M	possibly damaging	Het
Or4b13	G	T	2: 90,082,849 (GRCm39)	T161N	probably damaging	Het
Or5p4	C	A	7: 107,680,949 (GRCm39)		probably benign	Het
Osmr	C	A	15: 6,871,475 (GRCm39)	R314M	probably damaging	Het
Pcdhb16	C	T	18: 37,611,270 (GRCm39)	Q77*	probably null	Het
Pglyrp4	G	A	3: 90,642,955 (GRCm39)		probably null	Het
Ptprh	A	G	7: 4,552,498 (GRCm39)	F922S	probably damaging	Het
Ror2	C	T	13: 53,264,764 (GRCm39)	S764N	probably damaging	Het
Rp1	T	A	1: 4,418,673 (GRCm39)	Q813L	possibly damaging	Het
Sgtb	A	G	13: 104,254,922 (GRCm39)	N64S	probably benign	Het
Slc5a12	T	C	2: 110,471,201 (GRCm39)	V481A	probably benign	Het
Slitrk1	A	G	14: 109,149,349 (GRCm39)	V454A	probably benign	Het
Sntg2	C	A	12: 30,317,025 (GRCm39)		probably null	Het
Synj1	C	T	16: 90,770,933 (GRCm39)	V499I	probably damaging	Het
Tmco1	T	C	1: 167,153,597 (GRCm39)		probably benign	Het
Tmem38b	T	C	4: 53,848,871 (GRCm39)	I92T	probably damaging	Het
Tmem9	T	C	1: 135,955,145 (GRCm39)	V93A	probably benign	Het
Ttn	T	A	2: 76,625,582 (GRCm39)	R15080S	possibly damaging	Het
Ube2e3	T	C	2: 78,749,065 (GRCm39)	I138T	probably damaging	Het
Urgcp	A	G	11: 5,665,752 (GRCm39)	I862T	possibly damaging	Het
Vmn1r68	A	T	7: 10,261,603 (GRCm39)	I165N	probably benign	Het
Washc4	G	A	10: 83,394,717 (GRCm39)	V316I	possibly damaging	Het
Zfyve1	A	T	12: 83,597,718 (GRCm39)		probably benign	Het
Zscan18	A	G	7: 12,508,793 (GRCm39)		probably benign	Het

Other mutations in Zfp111

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL02569:Zfp111	APN	7	23,906,494 (GRCm39)	missense	possibly damaging	0.91
FR4737:Zfp111	UTSW	7	23,899,230 (GRCm39)	small insertion	probably benign
FR4976:Zfp111	UTSW	7	23,899,232 (GRCm39)	small insertion	probably benign
FR4976:Zfp111	UTSW	7	23,898,462 (GRCm39)	missense	probably damaging	0.97
R0514:Zfp111	UTSW	7	23,898,568 (GRCm39)	missense	probably damaging	0.96
R3837:Zfp111	UTSW	7	23,898,891 (GRCm39)	missense	possibly damaging	0.53
R4682:Zfp111	UTSW	7	23,898,563 (GRCm39)	missense	probably damaging	0.98
R4844:Zfp111	UTSW	7	23,898,801 (GRCm39)	missense	probably damaging	0.99
R6105:Zfp111	UTSW	7	23,902,791 (GRCm39)	splice site	probably null
R6175:Zfp111	UTSW	7	23,897,554 (GRCm39)	missense	unknown
R7276:Zfp111	UTSW	7	23,898,978 (GRCm39)	missense	probably damaging	1.00
R7584:Zfp111	UTSW	7	23,898,025 (GRCm39)	missense	possibly damaging	0.89
R8682:Zfp111	UTSW	7	23,897,983 (GRCm39)	missense	probably damaging	0.99
R9655:Zfp111	UTSW	7	23,898,543 (GRCm39)	missense	probably damaging	0.99
R9746:Zfp111	UTSW	7	23,898,067 (GRCm39)	missense	possibly damaging	0.93
X0018:Zfp111	UTSW	7	23,899,416 (GRCm39)	missense	possibly damaging	0.96

Posted On

2015-04-16