Mutagenetix > Incidental Mutation

Incidental Mutation 'IGL02619:Pglyrp4'

300807

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Pglyrp4

Ensembl Gene

ENSMUSG00000042250

Gene Name

peptidoglycan recognition protein 4

Synonyms

LOC384997, LOC242097

Accession Numbers

Essential gene?

Non essential (E-score: 0.000) question?

Stock #

IGL02619

Quality Score

Status

Chromosome

Chromosomal Location

90634213-90648824 bp(+) (GRCm39)

Type of Mutation

splice site (5 bp from exon)

DNA Base Change (assembly)

G to A at 90642955 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Ref Sequence

ENSEMBL: ENSMUSP00000128113 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000047745] [ENSMUST00000169698]

AlphaFold

Q0VB07

Predicted Effect

probably null
Transcript: ENSMUST00000047745

SMART Domains

Protein: ENSMUSP00000040755
Gene: ENSMUSG00000042250

Domain	Start	End	E-Value	Type
signal peptide	1	20	N/A	INTRINSIC
PGRP	55	196	1.5e-58	SMART
Ami_2	66	213	1.14e-7	SMART
PGRP	212	353	2.13e-72	SMART
Ami_2	222	359	1.62e-21	SMART

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000156268

Predicted Effect

probably null
Transcript: ENSMUST00000169698

SMART Domains

Protein: ENSMUSP00000128113
Gene: ENSMUSG00000042250

Domain	Start	End	E-Value	Type
signal peptide	1	20	N/A	INTRINSIC
PGRP	55	196	1.5e-58	SMART
Ami_2	66	200	2.12e-7	SMART
PGRP	213	354	2.13e-72	SMART
Ami_2	223	360	1.62e-21	SMART

Coding Region Coverage

Validation Efficiency

MGI Phenotype

FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] Summary: This gene encodes a peptidoglycan recognition protein, which belongs to the N-acetylmuramoyl-L-alanine amidase 2 family. These proteins are part of the innate immune system and recognize peptidoglycan, a ubiquitous component of bacterial cell walls. This antimicrobial protein binds to murein peptidoglycans of Gram-positive bacteria. [provided by RefSeq, Oct 2014]
PHENOTYPE: Mice homozygous for a knock-out allele exhibit increased susceptibility to DSS-induced colitis. [provided by MGI curators]

Allele List at MGI

Other mutations in this stock

Total: 52 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Ahctf1	C	T	1: 179,620,016 (GRCm39)	G220E	possibly damaging	Het
Arhgef10l	A	G	4: 140,321,504 (GRCm39)	I101T	probably benign	Het
Armc8	T	C	9: 99,409,122 (GRCm39)		probably benign	Het
Camkk2	A	T	5: 122,902,298 (GRCm39)	C4S	probably damaging	Het
Ccdc174	T	A	6: 91,876,538 (GRCm39)	D458E	possibly damaging	Het
Cercam	A	G	2: 29,770,686 (GRCm39)	N419S	probably benign	Het
Clca3a2	T	C	3: 144,512,083 (GRCm39)	N551S	probably damaging	Het
Cldn18	T	A	9: 99,580,988 (GRCm39)	I87F	probably damaging	Het
Ctso	T	A	3: 81,848,836 (GRCm39)		probably benign	Het
Ddhd2	C	A	8: 26,236,981 (GRCm39)		probably null	Het
Dscaml1	T	A	9: 45,359,094 (GRCm39)	Y118N	probably damaging	Het
Ece1	C	T	4: 137,666,044 (GRCm39)	A296V	probably benign	Het
Fbxo40	T	A	16: 36,790,766 (GRCm39)	I115F	possibly damaging	Het
Fkbp9	T	A	6: 56,827,609 (GRCm39)	N143K	probably damaging	Het
Foxk2	G	T	11: 121,190,402 (GRCm39)		probably benign	Het
Ggnbp1	A	G	17: 27,248,529 (GRCm39)	K33E	probably benign	Het
Hace1	A	T	10: 45,547,530 (GRCm39)		probably benign	Het
Hk3	A	T	13: 55,162,107 (GRCm39)	C133S	probably damaging	Het
Kbtbd3	C	T	9: 4,331,252 (GRCm39)	A542V	probably damaging	Het
Lrch2	A	C	X: 146,263,537 (GRCm39)	V363G	probably damaging	Het
Lrch2	C	T	X: 146,302,131 (GRCm39)	C264Y	probably damaging	Het
Lrrc56	C	A	7: 140,787,546 (GRCm39)		probably benign	Het
Lrtm2	C	T	6: 119,294,199 (GRCm39)	V311M	probably damaging	Het
N4bp1	G	T	8: 87,587,529 (GRCm39)	Q470K	probably benign	Het
Naa15	A	C	3: 51,367,552 (GRCm39)	D575A	probably benign	Het
Ncaph	A	T	2: 126,969,456 (GRCm39)	V69D	probably damaging	Het
Nlrp5	G	A	7: 23,123,489 (GRCm39)		probably null	Het
Nmbr	A	G	10: 14,636,331 (GRCm39)	D100G	probably damaging	Het
Ofcc1	C	T	13: 40,250,553 (GRCm39)	V588M	possibly damaging	Het
Or4b13	G	T	2: 90,082,849 (GRCm39)	T161N	probably damaging	Het
Or5p4	C	A	7: 107,680,949 (GRCm39)		probably benign	Het
Osmr	C	A	15: 6,871,475 (GRCm39)	R314M	probably damaging	Het
Pcdhb16	C	T	18: 37,611,270 (GRCm39)	Q77*	probably null	Het
Ptprh	A	G	7: 4,552,498 (GRCm39)	F922S	probably damaging	Het
Ror2	C	T	13: 53,264,764 (GRCm39)	S764N	probably damaging	Het
Rp1	T	A	1: 4,418,673 (GRCm39)	Q813L	possibly damaging	Het
Sgtb	A	G	13: 104,254,922 (GRCm39)	N64S	probably benign	Het
Slc5a12	T	C	2: 110,471,201 (GRCm39)	V481A	probably benign	Het
Slitrk1	A	G	14: 109,149,349 (GRCm39)	V454A	probably benign	Het
Sntg2	C	A	12: 30,317,025 (GRCm39)		probably null	Het
Synj1	C	T	16: 90,770,933 (GRCm39)	V499I	probably damaging	Het
Tmco1	T	C	1: 167,153,597 (GRCm39)		probably benign	Het
Tmem38b	T	C	4: 53,848,871 (GRCm39)	I92T	probably damaging	Het
Tmem9	T	C	1: 135,955,145 (GRCm39)	V93A	probably benign	Het
Ttn	T	A	2: 76,625,582 (GRCm39)	R15080S	possibly damaging	Het
Ube2e3	T	C	2: 78,749,065 (GRCm39)	I138T	probably damaging	Het
Urgcp	A	G	11: 5,665,752 (GRCm39)	I862T	possibly damaging	Het
Vmn1r68	A	T	7: 10,261,603 (GRCm39)	I165N	probably benign	Het
Washc4	G	A	10: 83,394,717 (GRCm39)	V316I	possibly damaging	Het
Zfp111	A	T	7: 23,899,113 (GRCm39)	L166Q	possibly damaging	Het
Zfyve1	A	T	12: 83,597,718 (GRCm39)		probably benign	Het
Zscan18	A	G	7: 12,508,793 (GRCm39)		probably benign	Het

Other mutations in Pglyrp4

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00432:Pglyrp4	APN	3	90,646,335 (GRCm39)	missense	probably damaging	1.00
IGL00575:Pglyrp4	APN	3	90,638,098 (GRCm39)	missense	probably damaging	1.00
IGL01892:Pglyrp4	APN	3	90,646,348 (GRCm39)	missense	probably benign	0.00
IGL02097:Pglyrp4	APN	3	90,642,910 (GRCm39)	missense	probably benign	0.01
IGL02159:Pglyrp4	APN	3	90,638,160 (GRCm39)	missense	possibly damaging	0.87
IGL02398:Pglyrp4	APN	3	90,646,424 (GRCm39)	splice site	probably benign
IGL02565:Pglyrp4	APN	3	90,642,794 (GRCm39)	missense	probably benign
R1160:Pglyrp4	UTSW	3	90,636,138 (GRCm39)	splice site	probably null
R1420:Pglyrp4	UTSW	3	90,636,021 (GRCm39)	missense	probably damaging	0.96
R1828:Pglyrp4	UTSW	3	90,640,310 (GRCm39)	missense	probably damaging	1.00
R4974:Pglyrp4	UTSW	3	90,640,314 (GRCm39)	missense	probably benign	0.04
R5268:Pglyrp4	UTSW	3	90,634,271 (GRCm39)	missense	probably damaging	1.00
R5704:Pglyrp4	UTSW	3	90,647,581 (GRCm39)	splice site	probably null
R7286:Pglyrp4	UTSW	3	90,640,281 (GRCm39)	missense	probably damaging	1.00
R7787:Pglyrp4	UTSW	3	90,640,295 (GRCm39)	missense	probably damaging	1.00
R8772:Pglyrp4	UTSW	3	90,647,707 (GRCm39)	missense	possibly damaging	0.54
R9132:Pglyrp4	UTSW	3	90,635,238 (GRCm39)	nonsense	probably null
R9607:Pglyrp4	UTSW	3	90,638,151 (GRCm39)	missense	probably damaging	1.00
Z1176:Pglyrp4	UTSW	3	90,646,312 (GRCm39)	missense	probably damaging	1.00

Posted On

2015-04-16