Mutagenetix > Incidental Mutation

Incidental Mutation 'IGL02620:Ccdc150'

300821

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Ccdc150

Ensembl Gene

ENSMUSG00000025983

Gene Name

coiled-coil domain containing 150

Synonyms

4930511H11Rik

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.073) question?

Stock #

IGL02620

Quality Score

Status

Chromosome

Chromosomal Location

54289842-54407886 bp(+) (GRCm39)

Type of Mutation

nonsense

DNA Base Change (assembly)

T to A at 54302704 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Leucine to Stop codon at position 108 (L108*)

Ref Sequence

ENSEMBL: ENSMUSP00000125195 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000027128] [ENSMUST00000160472]

AlphaFold

Q8CDI7

Predicted Effect

probably null
Transcript: ENSMUST00000027128
AA Change: L108*

SMART Domains

Protein: ENSMUSP00000027128
Gene: ENSMUSG00000025983
AA Change: L108*

Domain	Start	End	E-Value	Type
coiled coil region	160	250	N/A	INTRINSIC
coiled coil region	288	314	N/A	INTRINSIC
coiled coil region	418	676	N/A	INTRINSIC
coiled coil region	727	952	N/A	INTRINSIC
coiled coil region	985	1048	N/A	INTRINSIC

Predicted Effect

probably null
Transcript: ENSMUST00000160472
AA Change: L108*

SMART Domains

Protein: ENSMUSP00000125195
Gene: ENSMUSG00000025983
AA Change: L108*

Domain	Start	End	E-Value	Type
coiled coil region	160	250	N/A	INTRINSIC
coiled coil region	288	314	N/A	INTRINSIC
coiled coil region	418	551	N/A	INTRINSIC

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000161988

Coding Region Coverage

Validation Efficiency

Allele List at MGI

Other mutations in this stock

Total: 34 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Abcc12	A	T	8: 87,231,943 (GRCm39)		probably null	Het
Bltp1	T	C	3: 37,090,094 (GRCm39)	V4174A	possibly damaging	Het
Cdon	C	T	9: 35,364,095 (GRCm39)	T71I	probably benign	Het
Chdh	T	C	14: 29,753,096 (GRCm39)	W2R	probably damaging	Het
Ckap5	T	G	2: 91,436,714 (GRCm39)	L1605V	probably benign	Het
Cluh	C	T	11: 74,555,893 (GRCm39)	Q819*	probably null	Het
Csgalnact1	C	A	8: 68,854,144 (GRCm39)	G219V	probably damaging	Het
Cwc27	C	A	13: 104,938,714 (GRCm39)		probably benign	Het
Elk4	C	A	1: 131,946,109 (GRCm39)	A329D	probably benign	Het
Fbxo40	T	C	16: 36,786,442 (GRCm39)	H709R	probably benign	Het
Flna	A	G	X: 73,273,582 (GRCm39)		probably benign	Het
Grip2	G	T	6: 91,755,587 (GRCm39)	D592E	possibly damaging	Het
H2-T24	T	G	17: 36,328,183 (GRCm39)	N100T	probably damaging	Het
Hepacam2	C	A	6: 3,487,280 (GRCm39)		probably benign	Het
Ighv2-2	T	A	12: 113,551,912 (GRCm39)	T109S	possibly damaging	Het
Ipo11	T	C	13: 107,012,789 (GRCm39)		probably null	Het
Kcnh8	T	C	17: 53,205,525 (GRCm39)	M540T	probably damaging	Het
Kifc3	A	G	8: 95,836,582 (GRCm39)	S82P	probably damaging	Het
Map4k5	T	C	12: 69,939,476 (GRCm39)	Y20C	probably benign	Het
Milr1	C	A	11: 106,645,744 (GRCm39)	S95R	probably damaging	Het
Mtnr1b	A	C	9: 15,785,617 (GRCm39)	V47G	possibly damaging	Het
Nme1nme2	G	T	11: 93,843,682 (GRCm39)	R173S	possibly damaging	Het
Or6a2	T	A	7: 106,600,825 (GRCm39)	K81*	probably null	Het
Phactr2	T	C	10: 13,167,632 (GRCm39)	R100G	probably damaging	Het
Potefam1	C	T	2: 111,041,970 (GRCm39)	V322I	probably benign	Het
Ppargc1b	A	G	18: 61,431,810 (GRCm39)	Y997H	probably damaging	Het
Pramel3a	A	G	X: 134,211,158 (GRCm39)	M397V	probably benign	Het
Ptprz1	A	G	6: 22,959,739 (GRCm39)	K79E	probably damaging	Het
Rabgef1	T	C	5: 130,219,863 (GRCm39)	S109P	probably damaging	Het
Raf1	A	T	6: 115,609,848 (GRCm39)		probably benign	Het
Rptor	T	C	11: 119,671,413 (GRCm39)	L292P	probably benign	Het
Slc25a45	A	G	19: 5,934,554 (GRCm39)	D174G	probably damaging	Het
Tbcd	C	T	11: 121,352,081 (GRCm39)	T146M	probably damaging	Het
Zfp458	T	A	13: 67,406,058 (GRCm39)	H127L	probably damaging	Het

Other mutations in Ccdc150

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00712:Ccdc150	APN	1	54,311,709 (GRCm39)	splice site	probably benign
IGL00819:Ccdc150	APN	1	54,302,732 (GRCm39)	missense	probably damaging	1.00
IGL01973:Ccdc150	APN	1	54,339,647 (GRCm39)	splice site	probably null
IGL02352:Ccdc150	APN	1	54,311,680 (GRCm39)	missense	probably benign	0.25
IGL02359:Ccdc150	APN	1	54,311,680 (GRCm39)	missense	probably benign	0.25
IGL02673:Ccdc150	APN	1	54,368,149 (GRCm39)	missense	probably benign	0.09
IGL03148:Ccdc150	APN	1	54,317,874 (GRCm39)	missense	possibly damaging	0.68
IGL03185:Ccdc150	APN	1	54,339,482 (GRCm39)	missense	probably damaging	1.00
IGL03014:Ccdc150	UTSW	1	54,329,861 (GRCm39)	missense	probably damaging	0.99
R0066:Ccdc150	UTSW	1	54,395,850 (GRCm39)	missense	probably benign
R0066:Ccdc150	UTSW	1	54,395,850 (GRCm39)	missense	probably benign
R0217:Ccdc150	UTSW	1	54,339,589 (GRCm39)	missense	possibly damaging	0.87
R0582:Ccdc150	UTSW	1	54,368,670 (GRCm39)	missense	probably benign
R0687:Ccdc150	UTSW	1	54,324,790 (GRCm39)	splice site	probably null
R0790:Ccdc150	UTSW	1	54,316,935 (GRCm39)	splice site	probably benign
R1146:Ccdc150	UTSW	1	54,404,130 (GRCm39)	splice site	probably benign
R1288:Ccdc150	UTSW	1	54,403,617 (GRCm39)	missense	probably damaging	1.00
R1763:Ccdc150	UTSW	1	54,393,795 (GRCm39)	missense	probably benign	0.42
R1855:Ccdc150	UTSW	1	54,407,069 (GRCm39)	intron	probably benign
R1957:Ccdc150	UTSW	1	54,303,068 (GRCm39)	missense	probably benign	0.00
R2180:Ccdc150	UTSW	1	54,311,706 (GRCm39)	critical splice donor site	probably null
R2226:Ccdc150	UTSW	1	54,404,084 (GRCm39)	missense	probably null	0.11
R3054:Ccdc150	UTSW	1	54,328,001 (GRCm39)	missense	possibly damaging	0.51
R3055:Ccdc150	UTSW	1	54,328,001 (GRCm39)	missense	possibly damaging	0.51
R3056:Ccdc150	UTSW	1	54,328,001 (GRCm39)	missense	possibly damaging	0.51
R3409:Ccdc150	UTSW	1	54,395,932 (GRCm39)	missense	probably benign	0.02
R3411:Ccdc150	UTSW	1	54,395,932 (GRCm39)	missense	probably benign	0.02
R3812:Ccdc150	UTSW	1	54,407,469 (GRCm39)	missense	probably benign	0.00
R4031:Ccdc150	UTSW	1	54,317,970 (GRCm39)	missense	probably benign	0.31
R4356:Ccdc150	UTSW	1	54,392,213 (GRCm39)	missense	probably damaging	0.98
R4617:Ccdc150	UTSW	1	54,394,913 (GRCm39)	missense	probably benign	0.00
R4757:Ccdc150	UTSW	1	54,317,874 (GRCm39)	missense	possibly damaging	0.81
R4957:Ccdc150	UTSW	1	54,404,027 (GRCm39)	intron	probably benign
R5028:Ccdc150	UTSW	1	54,302,636 (GRCm39)	missense	probably benign	0.01
R5512:Ccdc150	UTSW	1	54,393,806 (GRCm39)	missense	probably damaging	0.96
R5757:Ccdc150	UTSW	1	54,302,779 (GRCm39)	missense	probably damaging	1.00
R5943:Ccdc150	UTSW	1	54,339,526 (GRCm39)	missense	probably benign	0.01
R5948:Ccdc150	UTSW	1	54,316,873 (GRCm39)	missense	possibly damaging	0.79
R6033:Ccdc150	UTSW	1	54,324,787 (GRCm39)	critical splice donor site	probably null
R6033:Ccdc150	UTSW	1	54,324,787 (GRCm39)	critical splice donor site	probably null
R6065:Ccdc150	UTSW	1	54,302,758 (GRCm39)	missense	possibly damaging	0.90
R6390:Ccdc150	UTSW	1	54,407,176 (GRCm39)	missense	probably benign	0.01
R6399:Ccdc150	UTSW	1	54,303,116 (GRCm39)	splice site	probably null
R6988:Ccdc150	UTSW	1	54,394,868 (GRCm39)	nonsense	probably null
R7248:Ccdc150	UTSW	1	54,344,057 (GRCm39)	missense	probably benign	0.00
R7319:Ccdc150	UTSW	1	54,302,496 (GRCm39)	splice site	probably null
R7322:Ccdc150	UTSW	1	54,299,125 (GRCm39)	missense	probably benign	0.01
R7366:Ccdc150	UTSW	1	54,339,541 (GRCm39)	nonsense	probably null
R7647:Ccdc150	UTSW	1	54,395,863 (GRCm39)	missense	probably damaging	1.00
R7981:Ccdc150	UTSW	1	54,407,551 (GRCm39)	missense	probably damaging	1.00
R8002:Ccdc150	UTSW	1	54,311,656 (GRCm39)	missense	probably damaging	0.99
R8201:Ccdc150	UTSW	1	54,368,646 (GRCm39)	missense	probably benign	0.10
R8688:Ccdc150	UTSW	1	54,407,132 (GRCm39)	missense	probably damaging	1.00
R8719:Ccdc150	UTSW	1	54,302,668 (GRCm39)	missense	probably benign	0.00
R8963:Ccdc150	UTSW	1	54,311,641 (GRCm39)	missense	probably benign	0.14
R9178:Ccdc150	UTSW	1	54,311,644 (GRCm39)	missense	probably damaging	0.99
R9200:Ccdc150	UTSW	1	54,299,197 (GRCm39)	missense	probably damaging	1.00
R9332:Ccdc150	UTSW	1	54,316,910 (GRCm39)	missense	probably damaging	0.99
R9367:Ccdc150	UTSW	1	54,324,760 (GRCm39)	missense	probably damaging	1.00
R9416:Ccdc150	UTSW	1	54,317,990 (GRCm39)	missense	probably damaging	0.97
R9430:Ccdc150	UTSW	1	54,320,930 (GRCm39)	missense	probably damaging	1.00
R9576:Ccdc150	UTSW	1	54,407,544 (GRCm39)	nonsense	probably null
R9747:Ccdc150	UTSW	1	54,299,107 (GRCm39)	nonsense	probably null

Posted On

2015-04-16