Mutagenetix > Incidental Mutation

Incidental Mutation 'IGL02622:Or5p60'

300883

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Or5p60

Ensembl Gene

ENSMUSG00000110171

Gene Name

olfactory receptor family 5 subfamily P member 60

Synonyms

GA_x6K02T2PBJ9-10454128-10453163, MOR204-16, Olfr484

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.135) question?

Stock #

IGL02622

Quality Score

Status

Chromosome

Chromosomal Location

107723503-107724468 bp(-) (GRCm39)

Type of Mutation

missense

DNA Base Change (assembly)

T to A at 107723595 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Isoleucine to Phenylalanine at position 292 (I292F)

Ref Sequence

ENSEMBL: ENSMUSP00000150774 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000210881] [ENSMUST00000214722]

AlphaFold

Q8VFD3

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000157612

Predicted Effect

probably damaging
Transcript: ENSMUST00000210881
AA Change: I292F

PolyPhen 2 Score 0.999 (Sensitivity: 0.14; Specificity: 0.99)

Predicted Effect

probably damaging
Transcript: ENSMUST00000214722
AA Change: I292F

PolyPhen 2 Score 0.999 (Sensitivity: 0.14; Specificity: 0.99)

Coding Region Coverage

Validation Efficiency

MGI Phenotype

FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]

Allele List at MGI

Other mutations in this stock

Total: 56 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
4930522L14Rik	C	T	5: 109,887,101 (GRCm39)	V32M	possibly damaging	Het
Abca1	T	C	4: 53,034,046 (GRCm39)	D2228G	probably damaging	Het
Actr5	A	G	2: 158,480,728 (GRCm39)	K582R	probably benign	Het
Armc8	T	C	9: 99,409,122 (GRCm39)		probably benign	Het
Atp7b	T	C	8: 22,518,454 (GRCm39)	D128G	possibly damaging	Het
Cemip	C	A	7: 83,613,383 (GRCm39)	G605V	probably damaging	Het
Cep112	A	G	11: 108,409,509 (GRCm39)	H133R	probably benign	Het
Cops3	C	T	11: 59,723,864 (GRCm39)	D98N	probably benign	Het
Crlf3	T	C	11: 79,950,150 (GRCm39)	D160G	probably damaging	Het
Csn1s1	T	C	5: 87,825,501 (GRCm39)		probably null	Het
Ddx60	C	A	8: 62,395,470 (GRCm39)		probably null	Het
Depdc1a	T	A	3: 159,221,147 (GRCm39)	N159K	probably benign	Het
Dsg3	A	T	18: 20,662,004 (GRCm39)		probably benign	Het
Eif4g3	A	C	4: 137,824,677 (GRCm39)		probably benign	Het
Ercc6l2	T	A	13: 64,001,437 (GRCm39)		probably null	Het
Fbxw19	T	A	9: 109,322,602 (GRCm39)	M123L	probably benign	Het
Fus	T	A	7: 127,584,794 (GRCm39)	L100H	probably damaging	Het
Gm29247	A	G	1: 44,146,269 (GRCm39)		probably benign	Het
Gucy2e	T	C	11: 69,115,857 (GRCm39)	T842A	probably damaging	Het
Inpp4a	A	T	1: 37,418,115 (GRCm39)	Q519L	probably benign	Het
Kcnip1	C	A	11: 33,593,290 (GRCm39)		probably benign	Het
Lyst	T	A	13: 13,855,975 (GRCm39)	L2432H	probably damaging	Het
Mastl	A	G	2: 23,022,857 (GRCm39)	V622A	probably benign	Het
Myh15	A	G	16: 48,997,317 (GRCm39)	T1712A	probably benign	Het
Nlrp1a	T	C	11: 71,013,826 (GRCm39)	T475A	possibly damaging	Het
Nr4a3	G	A	4: 48,051,649 (GRCm39)	M134I	probably benign	Het
Or2a56	T	G	6: 42,932,663 (GRCm39)	V77G	probably damaging	Het
Or52m1	T	A	7: 102,290,290 (GRCm39)	L279Q	probably damaging	Het
Paqr6	T	G	3: 88,273,085 (GRCm39)	I52S	probably damaging	Het
Pcdhb4	T	A	18: 37,442,721 (GRCm39)	L677Q	probably benign	Het
Phax	C	T	18: 56,717,372 (GRCm39)	R250*	probably null	Het
Pkn3	A	G	2: 29,973,158 (GRCm39)	D356G	probably benign	Het
Pnpla2	T	C	7: 141,035,285 (GRCm39)	L29P	probably damaging	Het
Rad18	G	A	6: 112,664,948 (GRCm39)	T62I	probably damaging	Het
Riok3	C	T	18: 12,276,017 (GRCm39)	R238C	probably benign	Het
Ror2	C	T	13: 53,264,764 (GRCm39)	S764N	probably damaging	Het
Sccpdh	G	T	1: 179,504,025 (GRCm39)	G125W	probably damaging	Het
Skint11	T	A	4: 114,051,925 (GRCm39)	L91H	probably damaging	Het
Slc25a45	A	G	19: 5,928,725 (GRCm39)		probably benign	Het
Slco2a1	C	T	9: 102,954,128 (GRCm39)	Q370*	probably null	Het
Szt2	A	G	4: 118,250,087 (GRCm39)	S474P	probably damaging	Het
Tchh	C	A	3: 93,350,719 (GRCm39)	T53K	probably damaging	Het
Tiam1	T	C	16: 89,595,588 (GRCm39)	T1298A	possibly damaging	Het
Tmem161a	C	T	8: 70,633,887 (GRCm39)	Q183*	probably null	Het
Trim26	C	A	17: 37,161,797 (GRCm39)	A72E	probably damaging	Het
Trmt11	A	T	10: 30,435,169 (GRCm39)	I330K	probably benign	Het
Tspan1	A	G	4: 116,021,052 (GRCm39)		probably benign	Het
Ubr4	C	A	4: 139,194,561 (GRCm39)	C4286*	probably null	Het
Unc13a	T	C	8: 72,105,158 (GRCm39)		probably null	Het
Vmn1r20	T	A	6: 57,409,583 (GRCm39)	F303Y	probably damaging	Het
Washc2	T	C	6: 116,190,979 (GRCm39)		probably benign	Het
Xab2	C	T	8: 3,661,699 (GRCm39)	D585N	probably benign	Het
Ythdc2	C	T	18: 44,993,001 (GRCm39)	L791F	probably damaging	Het
Zfp319	C	A	8: 96,055,589 (GRCm39)	V205F	probably damaging	Het
Zscan25	A	T	5: 145,227,512 (GRCm39)	H392L	probably damaging	Het
Zswim6	A	T	13: 107,884,786 (GRCm39)		noncoding transcript	Het

Other mutations in Or5p60

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL01879:Or5p60	APN	7	107,724,371 (GRCm39)	missense	possibly damaging	0.88
IGL01899:Or5p60	APN	7	107,724,048 (GRCm39)	missense	probably benign	0.01
IGL02124:Or5p60	APN	7	107,724,249 (GRCm39)	missense	probably benign	0.01
IGL03188:Or5p60	APN	7	107,723,841 (GRCm39)	missense	probably benign	0.00
R0389:Or5p60	UTSW	7	107,724,023 (GRCm39)	missense	probably benign	0.00
R0443:Or5p60	UTSW	7	107,724,023 (GRCm39)	missense	probably benign	0.00
R0731:Or5p60	UTSW	7	107,723,941 (GRCm39)	missense	probably benign	0.12
R1061:Or5p60	UTSW	7	107,723,663 (GRCm39)	missense	probably damaging	1.00
R1505:Or5p60	UTSW	7	107,724,200 (GRCm39)	missense	probably benign	0.00
R1591:Or5p60	UTSW	7	107,723,571 (GRCm39)	missense	possibly damaging	0.56
R1789:Or5p60	UTSW	7	107,724,122 (GRCm39)	missense	probably benign	0.44
R2988:Or5p60	UTSW	7	107,724,045 (GRCm39)	nonsense	probably null
R4778:Or5p60	UTSW	7	107,723,687 (GRCm39)	missense	possibly damaging	0.95
R5288:Or5p60	UTSW	7	107,724,375 (GRCm39)	missense	probably benign	0.00
R5644:Or5p60	UTSW	7	107,723,858 (GRCm39)	missense	probably benign	0.04
R6112:Or5p60	UTSW	7	107,724,369 (GRCm39)	missense	probably benign	0.01
R6351:Or5p60	UTSW	7	107,723,637 (GRCm39)	missense	probably damaging	1.00
R6934:Or5p60	UTSW	7	107,724,026 (GRCm39)	missense	probably benign	0.14
R7094:Or5p60	UTSW	7	107,723,840 (GRCm39)	missense	probably benign	0.35
R7135:Or5p60	UTSW	7	107,723,781 (GRCm39)	missense	probably damaging	0.99
R7422:Or5p60	UTSW	7	107,724,068 (GRCm39)	missense	probably damaging	1.00
R7660:Or5p60	UTSW	7	107,724,041 (GRCm39)	missense	probably benign	0.04
R7916:Or5p60	UTSW	7	107,724,329 (GRCm39)	missense	possibly damaging	0.59
R8489:Or5p60	UTSW	7	107,724,372 (GRCm39)	missense	probably benign	0.03
R9204:Or5p60	UTSW	7	107,723,935 (GRCm39)	missense	possibly damaging	0.75
R9526:Or5p60	UTSW	7	107,723,801 (GRCm39)	missense	probably benign	0.06
X0021:Or5p60	UTSW	7	107,724,314 (GRCm39)	missense	probably damaging	1.00
X0025:Or5p60	UTSW	7	107,723,606 (GRCm39)	nonsense	probably null
Z1176:Or5p60	UTSW	7	107,724,086 (GRCm39)	missense	probably damaging	1.00

Posted On

2015-04-16