Incidental Mutation 'IGL02622:Zscan25'
ID 300899
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Zscan25
Ensembl Gene ENSMUSG00000070420
Gene Name zinc finger and SCAN domain containing 25
Synonyms Zfp498, EG666311
Accession Numbers
Essential gene? Probably non essential (E-score: 0.151) question?
Stock # IGL02622
Quality Score
Status
Chromosome 5
Chromosomal Location 145217310-145228088 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to T at 145227512 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Histidine to Leucine at position 392 (H392L)
Ref Sequence ENSEMBL: ENSMUSP00000091664 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000094116] [ENSMUST00000199563] [ENSMUST00000200246]
AlphaFold B2RX31
Predicted Effect probably damaging
Transcript: ENSMUST00000094116
AA Change: H392L

PolyPhen 2 Score 0.997 (Sensitivity: 0.41; Specificity: 0.98)
SMART Domains Protein: ENSMUSP00000091664
Gene: ENSMUSG00000070420
AA Change: H392L

DomainStartEndE-ValueType
SCAN 38 150 5.94e-53 SMART
Blast:KRAB 231 288 4e-31 BLAST
ZnF_C2H2 346 368 2.15e-5 SMART
ZnF_C2H2 374 396 5.06e-2 SMART
ZnF_C2H2 402 424 8.34e-3 SMART
ZnF_C2H2 430 452 3.39e-3 SMART
ZnF_C2H2 458 479 1.08e1 SMART
ZnF_C2H2 485 507 4.47e-3 SMART
ZnF_C2H2 513 536 5.59e-4 SMART
Predicted Effect noncoding transcript
Transcript: ENSMUST00000197174
Predicted Effect probably benign
Transcript: ENSMUST00000199563
SMART Domains Protein: ENSMUSP00000143449
Gene: ENSMUSG00000070420

DomainStartEndE-ValueType
SCAN 38 150 2.1e-54 SMART
Predicted Effect probably benign
Transcript: ENSMUST00000200246
SMART Domains Protein: ENSMUSP00000142367
Gene: ENSMUSG00000070420

DomainStartEndE-ValueType
SCAN 38 150 1.9e-55 SMART
Coding Region Coverage
Validation Efficiency
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a protein that bears some similarity to zinc finger proteins, which are involved in DNA binding and protein-protein interactions. Multiple alternatively spliced transcript variants have been identified, but the full-length nature for most of them has not been determined. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 56 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
4930522L14Rik C T 5: 109,887,101 (GRCm39) V32M possibly damaging Het
Abca1 T C 4: 53,034,046 (GRCm39) D2228G probably damaging Het
Actr5 A G 2: 158,480,728 (GRCm39) K582R probably benign Het
Armc8 T C 9: 99,409,122 (GRCm39) probably benign Het
Atp7b T C 8: 22,518,454 (GRCm39) D128G possibly damaging Het
Cemip C A 7: 83,613,383 (GRCm39) G605V probably damaging Het
Cep112 A G 11: 108,409,509 (GRCm39) H133R probably benign Het
Cops3 C T 11: 59,723,864 (GRCm39) D98N probably benign Het
Crlf3 T C 11: 79,950,150 (GRCm39) D160G probably damaging Het
Csn1s1 T C 5: 87,825,501 (GRCm39) probably null Het
Ddx60 C A 8: 62,395,470 (GRCm39) probably null Het
Depdc1a T A 3: 159,221,147 (GRCm39) N159K probably benign Het
Dsg3 A T 18: 20,662,004 (GRCm39) probably benign Het
Eif4g3 A C 4: 137,824,677 (GRCm39) probably benign Het
Ercc6l2 T A 13: 64,001,437 (GRCm39) probably null Het
Fbxw19 T A 9: 109,322,602 (GRCm39) M123L probably benign Het
Fus T A 7: 127,584,794 (GRCm39) L100H probably damaging Het
Gm29247 A G 1: 44,146,269 (GRCm39) probably benign Het
Gucy2e T C 11: 69,115,857 (GRCm39) T842A probably damaging Het
Inpp4a A T 1: 37,418,115 (GRCm39) Q519L probably benign Het
Kcnip1 C A 11: 33,593,290 (GRCm39) probably benign Het
Lyst T A 13: 13,855,975 (GRCm39) L2432H probably damaging Het
Mastl A G 2: 23,022,857 (GRCm39) V622A probably benign Het
Myh15 A G 16: 48,997,317 (GRCm39) T1712A probably benign Het
Nlrp1a T C 11: 71,013,826 (GRCm39) T475A possibly damaging Het
Nr4a3 G A 4: 48,051,649 (GRCm39) M134I probably benign Het
Or2a56 T G 6: 42,932,663 (GRCm39) V77G probably damaging Het
Or52m1 T A 7: 102,290,290 (GRCm39) L279Q probably damaging Het
Or5p60 T A 7: 107,723,595 (GRCm39) I292F probably damaging Het
Paqr6 T G 3: 88,273,085 (GRCm39) I52S probably damaging Het
Pcdhb4 T A 18: 37,442,721 (GRCm39) L677Q probably benign Het
Phax C T 18: 56,717,372 (GRCm39) R250* probably null Het
Pkn3 A G 2: 29,973,158 (GRCm39) D356G probably benign Het
Pnpla2 T C 7: 141,035,285 (GRCm39) L29P probably damaging Het
Rad18 G A 6: 112,664,948 (GRCm39) T62I probably damaging Het
Riok3 C T 18: 12,276,017 (GRCm39) R238C probably benign Het
Ror2 C T 13: 53,264,764 (GRCm39) S764N probably damaging Het
Sccpdh G T 1: 179,504,025 (GRCm39) G125W probably damaging Het
Skint11 T A 4: 114,051,925 (GRCm39) L91H probably damaging Het
Slc25a45 A G 19: 5,928,725 (GRCm39) probably benign Het
Slco2a1 C T 9: 102,954,128 (GRCm39) Q370* probably null Het
Szt2 A G 4: 118,250,087 (GRCm39) S474P probably damaging Het
Tchh C A 3: 93,350,719 (GRCm39) T53K probably damaging Het
Tiam1 T C 16: 89,595,588 (GRCm39) T1298A possibly damaging Het
Tmem161a C T 8: 70,633,887 (GRCm39) Q183* probably null Het
Trim26 C A 17: 37,161,797 (GRCm39) A72E probably damaging Het
Trmt11 A T 10: 30,435,169 (GRCm39) I330K probably benign Het
Tspan1 A G 4: 116,021,052 (GRCm39) probably benign Het
Ubr4 C A 4: 139,194,561 (GRCm39) C4286* probably null Het
Unc13a T C 8: 72,105,158 (GRCm39) probably null Het
Vmn1r20 T A 6: 57,409,583 (GRCm39) F303Y probably damaging Het
Washc2 T C 6: 116,190,979 (GRCm39) probably benign Het
Xab2 C T 8: 3,661,699 (GRCm39) D585N probably benign Het
Ythdc2 C T 18: 44,993,001 (GRCm39) L791F probably damaging Het
Zfp319 C A 8: 96,055,589 (GRCm39) V205F probably damaging Het
Zswim6 A T 13: 107,884,786 (GRCm39) noncoding transcript Het
Other mutations in Zscan25
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00309:Zscan25 APN 5 145,220,559 (GRCm39) missense probably damaging 1.00
IGL02881:Zscan25 APN 5 145,227,296 (GRCm39) missense probably benign 0.25
PIT4445001:Zscan25 UTSW 5 145,227,422 (GRCm39) missense probably damaging 1.00
R1713:Zscan25 UTSW 5 145,220,501 (GRCm39) missense probably damaging 0.99
R1828:Zscan25 UTSW 5 145,227,858 (GRCm39) missense possibly damaging 0.95
R2233:Zscan25 UTSW 5 145,220,502 (GRCm39) missense probably damaging 1.00
R3882:Zscan25 UTSW 5 145,227,862 (GRCm39) missense probably damaging 1.00
R4330:Zscan25 UTSW 5 145,227,361 (GRCm39) missense probably damaging 0.99
R4527:Zscan25 UTSW 5 145,220,268 (GRCm39) missense probably damaging 1.00
R4539:Zscan25 UTSW 5 145,225,201 (GRCm39) missense probably benign 0.01
R4598:Zscan25 UTSW 5 145,227,815 (GRCm39) missense probably benign 0.30
R4611:Zscan25 UTSW 5 145,227,926 (GRCm39) missense probably damaging 1.00
R4662:Zscan25 UTSW 5 145,223,120 (GRCm39) missense unknown
R6733:Zscan25 UTSW 5 145,227,723 (GRCm39) splice site probably null
R6751:Zscan25 UTSW 5 145,227,373 (GRCm39) missense probably damaging 1.00
R7161:Zscan25 UTSW 5 145,223,251 (GRCm39) missense probably benign 0.00
R7912:Zscan25 UTSW 5 145,227,321 (GRCm39) missense probably benign 0.00
R8746:Zscan25 UTSW 5 145,224,157 (GRCm39) missense possibly damaging 0.81
R8936:Zscan25 UTSW 5 145,223,200 (GRCm39) missense probably damaging 1.00
Posted On 2015-04-16