Mutagenetix > Incidental Mutation

Incidental Mutation 'IGL02626:Or10ak13'

301071

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Or10ak13

Ensembl Gene

ENSMUSG00000111159

Gene Name

olfactory receptor family 10 subfamily AK member 13

Synonyms

Olfr219-ps1, GA_x6K02SYWGW3-414-3, MOR259-10, GA_x6K02T2QD9B-18767132-18768073, Olfr1337

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.197) question?

Stock #

IGL02626

Quality Score

Status

Chromosome

Chromosomal Location

118638833-118639783 bp(-) (GRCm39)

Type of Mutation

missense

DNA Base Change (assembly)

T to C at 118639531 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Methionine to Valine at position 84 (M84V)

Ref Sequence

ENSEMBL: ENSMUSP00000076483 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000077247]

AlphaFold

A2ACY8

Predicted Effect

probably damaging
Transcript: ENSMUST00000077247
AA Change: M84V

PolyPhen 2 Score 0.978 (Sensitivity: 0.76; Specificity: 0.96)

SMART Domains

Protein: ENSMUSP00000076483
Gene: ENSMUSG00000111159
AA Change: M84V

Domain	Start	End	E-Value	Type
Pfam:7tm_4	34	310	7.8e-53	PFAM
Pfam:7TM_GPCR_Srsx	38	308	8.5e-7	PFAM
Pfam:7tm_1	44	293	8.3e-23	PFAM

Coding Region Coverage

Validation Efficiency

MGI Phenotype

FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]

Allele List at MGI

Other mutations in this stock

Total: 62 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
4930407I10Rik	A	G	15: 81,949,810 (GRCm39)	K1236E	probably damaging	Het
Actl7a	A	T	4: 56,744,353 (GRCm39)	E293D	possibly damaging	Het
Adamts2	T	C	11: 50,667,082 (GRCm39)	Y460H	probably damaging	Het
Aoc1	G	A	6: 48,883,044 (GRCm39)	V307I	probably benign	Het
Ar	C	T	X: 97,358,492 (GRCm39)	H756Y	probably damaging	Het
Atg3	C	T	16: 45,004,048 (GRCm39)	R224W	probably benign	Het
Atp5po	G	A	16: 91,483,201 (GRCm39)	P47S	probably damaging	Het
Bicd1	A	G	6: 149,311,054 (GRCm39)	E43G	probably damaging	Het
Ccdc88c	A	G	12: 100,934,059 (GRCm39)		probably benign	Het
Cd33	A	G	7: 43,179,736 (GRCm39)		probably benign	Het
Cd36	T	A	5: 18,002,126 (GRCm39)	R292*	probably null	Het
Cdc45	C	T	16: 18,617,479 (GRCm39)	M200I	probably benign	Het
Cdh23	T	C	10: 60,227,580 (GRCm39)	D1167G	probably damaging	Het
Cdk5rap1	A	G	2: 154,207,880 (GRCm39)		probably null	Het
Chd6	A	G	2: 160,881,270 (GRCm39)		probably benign	Het
Chd7	A	T	4: 8,826,519 (GRCm39)	Y961F	probably damaging	Het
Cpe	T	C	8: 65,145,829 (GRCm39)	E52G	probably benign	Het
Cpne5	C	T	17: 29,379,311 (GRCm39)	G491S	probably damaging	Het
Csmd3	A	T	15: 47,567,503 (GRCm39)		probably benign	Het
Ctbp2	T	A	7: 132,600,940 (GRCm39)	T608S	probably benign	Het
Cybb	A	G	X: 9,335,439 (GRCm39)		probably null	Het
Daam2	T	C	17: 49,797,282 (GRCm39)	T168A	possibly damaging	Het
Dnah5	G	T	15: 28,307,422 (GRCm39)	V1717F	possibly damaging	Het
Dse	G	A	10: 34,029,158 (GRCm39)	T644I	probably damaging	Het
Dtd2	A	C	12: 52,051,708 (GRCm39)	Y45*	probably null	Het
Fgfr1op2	T	A	6: 146,491,509 (GRCm39)	M124K	probably benign	Het
Flii	T	C	11: 60,610,685 (GRCm39)	D537G	probably benign	Het
Fntb	T	A	12: 76,944,145 (GRCm39)	I217N	probably benign	Het
Foxi1	A	G	11: 34,155,860 (GRCm39)	S257P	probably benign	Het
Fyn	G	A	10: 39,402,798 (GRCm39)	R190H	probably damaging	Het
Gm28557	T	A	13: 67,223,008 (GRCm39)	T8S	probably benign	Het
Gramd1b	T	C	9: 40,209,306 (GRCm39)	K873E	probably damaging	Het
Grb10	T	C	11: 11,895,503 (GRCm39)	T329A	probably benign	Het
Haus5	A	G	7: 30,356,675 (GRCm39)	L477P	probably damaging	Het
Hectd4	A	T	5: 121,491,944 (GRCm39)	E3761V	possibly damaging	Het
Ift172	T	C	5: 31,421,840 (GRCm39)	I930V	probably benign	Het
Itprid1	T	A	6: 55,945,631 (GRCm39)	V784D	probably benign	Het
Izumo2	A	G	7: 44,358,560 (GRCm39)		probably benign	Het
Map4k4	A	G	1: 40,053,257 (GRCm39)		probably benign	Het
Morc1	A	G	16: 48,436,123 (GRCm39)	S753G	probably damaging	Het
Mpzl2	C	T	9: 44,955,590 (GRCm39)	T167I	probably damaging	Het
Mta2	T	A	19: 8,926,532 (GRCm39)	I491N	probably damaging	Het
Myo18b	A	T	5: 113,025,951 (GRCm39)	I33N	unknown	Het
Nub1	C	T	5: 24,908,462 (GRCm39)	H404Y	possibly damaging	Het
Or4f58	A	T	2: 111,851,458 (GRCm39)	V247E	probably damaging	Het
Or5d47	T	C	2: 87,804,068 (GRCm39)	N314D	probably benign	Het
Or8d2b	T	C	9: 38,788,784 (GRCm39)	L104S	probably benign	Het
Ralyl	A	T	3: 13,842,094 (GRCm39)	M77L	probably benign	Het
Rap1gap	T	A	4: 137,454,364 (GRCm39)	V649E	probably benign	Het
Rnf40	C	A	7: 127,195,744 (GRCm39)	Q663K	probably damaging	Het
Slc22a18	T	C	7: 143,052,837 (GRCm39)	L354P	probably damaging	Het
Slc9a8	T	C	2: 167,309,597 (GRCm39)		probably benign	Het
Surf4	C	T	2: 26,815,619 (GRCm39)		probably null	Het
T	A	T	17: 8,654,069 (GRCm39)	N85Y	probably damaging	Het
Tanc1	A	G	2: 59,630,216 (GRCm39)	E732G	probably damaging	Het
Tas2r138	A	G	6: 40,589,649 (GRCm39)	V199A	possibly damaging	Het
Trim43b	T	C	9: 88,967,541 (GRCm39)	Y365C	possibly damaging	Het
Ubd	T	C	17: 37,506,573 (GRCm39)	L153P	probably damaging	Het
Xpnpep2	A	C	X: 47,215,786 (GRCm39)	M513L	probably benign	Het
Zar1l	C	T	5: 150,441,210 (GRCm39)	G139R	probably damaging	Het
Zc3hav1	T	G	6: 38,309,926 (GRCm39)	T299P	probably damaging	Het
Zfp236	C	A	18: 82,676,120 (GRCm39)		probably benign	Het

Other mutations in Or10ak13

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL02203:Or10ak13	APN	4	118,639,626 (GRCm39)	missense	possibly damaging	0.95
IGL02699:Or10ak13	APN	4	118,639,349 (GRCm39)	nonsense	probably null
IGL02754:Or10ak13	APN	4	118,639,117 (GRCm39)	missense	possibly damaging	0.90
IGL03287:Or10ak13	APN	4	118,639,551 (GRCm39)	missense	possibly damaging	0.64
R1341:Or10ak13	UTSW	4	118,639,579 (GRCm39)	missense	probably benign	0.01
R4894:Or10ak13	UTSW	4	118,639,483 (GRCm39)	missense	probably damaging	1.00
R6124:Or10ak13	UTSW	4	118,639,392 (GRCm39)	missense	probably damaging	1.00
R6515:Or10ak13	UTSW	4	118,639,467 (GRCm39)	missense	probably benign	0.13
R6529:Or10ak13	UTSW	4	118,638,907 (GRCm39)	missense	probably benign	0.15
R7040:Or10ak13	UTSW	4	118,639,183 (GRCm39)	missense	probably benign	0.00
R7398:Or10ak13	UTSW	4	118,638,896 (GRCm39)	missense	possibly damaging	0.80
R7684:Or10ak13	UTSW	4	118,639,471 (GRCm39)	missense	probably benign	0.40
R8377:Or10ak13	UTSW	4	118,639,203 (GRCm39)	missense	probably benign	0.22
R8717:Or10ak13	UTSW	4	118,638,996 (GRCm39)	missense	probably damaging	1.00
R9369:Or10ak13	UTSW	4	118,639,077 (GRCm39)	missense	probably benign	0.31
R9594:Or10ak13	UTSW	4	118,638,952 (GRCm39)	missense	probably benign
Z1189:Or10ak13	UTSW	4	118,639,284 (GRCm39)	missense	possibly damaging	0.85

Posted On

2015-04-16