Incidental Mutation 'IGL02626:Daam2'
ID 301086
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Daam2
Ensembl Gene ENSMUSG00000040260
Gene Name dishevelled associated activator of morphogenesis 2
Synonyms 2310016D11Rik
Accession Numbers
Essential gene? Non essential (E-score: 0.000) question?
Stock # IGL02626
Quality Score
Status
Chromosome 17
Chromosomal Location 49763050-49871371 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to C at 49797282 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Threonine to Alanine at position 168 (T168A)
Ref Sequence ENSEMBL: ENSMUSP00000153095 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000057610] [ENSMUST00000224595]
AlphaFold Q80U19
Predicted Effect possibly damaging
Transcript: ENSMUST00000057610
AA Change: T168A

PolyPhen 2 Score 0.460 (Sensitivity: 0.89; Specificity: 0.90)
SMART Domains Protein: ENSMUSP00000052085
Gene: ENSMUSG00000040260
AA Change: T168A

DomainStartEndE-ValueType
Drf_GBD 40 228 4.89e-61 SMART
Drf_FH3 231 429 1.19e-73 SMART
Blast:FH2 476 513 4e-10 BLAST
low complexity region 514 534 N/A INTRINSIC
low complexity region 539 576 N/A INTRINSIC
FH2 595 1085 7.36e-99 SMART
Predicted Effect possibly damaging
Transcript: ENSMUST00000224595
AA Change: T168A

PolyPhen 2 Score 0.460 (Sensitivity: 0.89; Specificity: 0.90)
Predicted Effect noncoding transcript
Transcript: ENSMUST00000224954
Coding Region Coverage
Validation Efficiency
MGI Phenotype PHENOTYPE: Homozygous KO in combination with homozygous Daam1 conditional KO increases the severity of the heart phenotype (abnormal ventricular morphology and pressure) of the Daam1 single KO. [provided by MGI curators]
Allele List at MGI
Other mutations in this stock
Total: 62 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
4930407I10Rik A G 15: 81,949,810 (GRCm39) K1236E probably damaging Het
Actl7a A T 4: 56,744,353 (GRCm39) E293D possibly damaging Het
Adamts2 T C 11: 50,667,082 (GRCm39) Y460H probably damaging Het
Aoc1 G A 6: 48,883,044 (GRCm39) V307I probably benign Het
Ar C T X: 97,358,492 (GRCm39) H756Y probably damaging Het
Atg3 C T 16: 45,004,048 (GRCm39) R224W probably benign Het
Atp5po G A 16: 91,483,201 (GRCm39) P47S probably damaging Het
Bicd1 A G 6: 149,311,054 (GRCm39) E43G probably damaging Het
Ccdc88c A G 12: 100,934,059 (GRCm39) probably benign Het
Cd33 A G 7: 43,179,736 (GRCm39) probably benign Het
Cd36 T A 5: 18,002,126 (GRCm39) R292* probably null Het
Cdc45 C T 16: 18,617,479 (GRCm39) M200I probably benign Het
Cdh23 T C 10: 60,227,580 (GRCm39) D1167G probably damaging Het
Cdk5rap1 A G 2: 154,207,880 (GRCm39) probably null Het
Chd6 A G 2: 160,881,270 (GRCm39) probably benign Het
Chd7 A T 4: 8,826,519 (GRCm39) Y961F probably damaging Het
Cpe T C 8: 65,145,829 (GRCm39) E52G probably benign Het
Cpne5 C T 17: 29,379,311 (GRCm39) G491S probably damaging Het
Csmd3 A T 15: 47,567,503 (GRCm39) probably benign Het
Ctbp2 T A 7: 132,600,940 (GRCm39) T608S probably benign Het
Cybb A G X: 9,335,439 (GRCm39) probably null Het
Dnah5 G T 15: 28,307,422 (GRCm39) V1717F possibly damaging Het
Dse G A 10: 34,029,158 (GRCm39) T644I probably damaging Het
Dtd2 A C 12: 52,051,708 (GRCm39) Y45* probably null Het
Fgfr1op2 T A 6: 146,491,509 (GRCm39) M124K probably benign Het
Flii T C 11: 60,610,685 (GRCm39) D537G probably benign Het
Fntb T A 12: 76,944,145 (GRCm39) I217N probably benign Het
Foxi1 A G 11: 34,155,860 (GRCm39) S257P probably benign Het
Fyn G A 10: 39,402,798 (GRCm39) R190H probably damaging Het
Gm28557 T A 13: 67,223,008 (GRCm39) T8S probably benign Het
Gramd1b T C 9: 40,209,306 (GRCm39) K873E probably damaging Het
Grb10 T C 11: 11,895,503 (GRCm39) T329A probably benign Het
Haus5 A G 7: 30,356,675 (GRCm39) L477P probably damaging Het
Hectd4 A T 5: 121,491,944 (GRCm39) E3761V possibly damaging Het
Ift172 T C 5: 31,421,840 (GRCm39) I930V probably benign Het
Itprid1 T A 6: 55,945,631 (GRCm39) V784D probably benign Het
Izumo2 A G 7: 44,358,560 (GRCm39) probably benign Het
Map4k4 A G 1: 40,053,257 (GRCm39) probably benign Het
Morc1 A G 16: 48,436,123 (GRCm39) S753G probably damaging Het
Mpzl2 C T 9: 44,955,590 (GRCm39) T167I probably damaging Het
Mta2 T A 19: 8,926,532 (GRCm39) I491N probably damaging Het
Myo18b A T 5: 113,025,951 (GRCm39) I33N unknown Het
Nub1 C T 5: 24,908,462 (GRCm39) H404Y possibly damaging Het
Or10ak13 T C 4: 118,639,531 (GRCm39) M84V probably damaging Het
Or4f58 A T 2: 111,851,458 (GRCm39) V247E probably damaging Het
Or5d47 T C 2: 87,804,068 (GRCm39) N314D probably benign Het
Or8d2b T C 9: 38,788,784 (GRCm39) L104S probably benign Het
Ralyl A T 3: 13,842,094 (GRCm39) M77L probably benign Het
Rap1gap T A 4: 137,454,364 (GRCm39) V649E probably benign Het
Rnf40 C A 7: 127,195,744 (GRCm39) Q663K probably damaging Het
Slc22a18 T C 7: 143,052,837 (GRCm39) L354P probably damaging Het
Slc9a8 T C 2: 167,309,597 (GRCm39) probably benign Het
Surf4 C T 2: 26,815,619 (GRCm39) probably null Het
T A T 17: 8,654,069 (GRCm39) N85Y probably damaging Het
Tanc1 A G 2: 59,630,216 (GRCm39) E732G probably damaging Het
Tas2r138 A G 6: 40,589,649 (GRCm39) V199A possibly damaging Het
Trim43b T C 9: 88,967,541 (GRCm39) Y365C possibly damaging Het
Ubd T C 17: 37,506,573 (GRCm39) L153P probably damaging Het
Xpnpep2 A C X: 47,215,786 (GRCm39) M513L probably benign Het
Zar1l C T 5: 150,441,210 (GRCm39) G139R probably damaging Het
Zc3hav1 T G 6: 38,309,926 (GRCm39) T299P probably damaging Het
Zfp236 C A 18: 82,676,120 (GRCm39) probably benign Het
Other mutations in Daam2
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL02150:Daam2 APN 17 49,797,332 (GRCm39) missense possibly damaging 0.82
IGL02373:Daam2 APN 17 49,780,408 (GRCm39) missense probably damaging 1.00
IGL02793:Daam2 APN 17 49,771,056 (GRCm39) missense probably damaging 1.00
IGL02861:Daam2 APN 17 49,776,455 (GRCm39) missense probably damaging 1.00
IGL02875:Daam2 APN 17 49,771,056 (GRCm39) missense probably damaging 1.00
IGL03370:Daam2 APN 17 49,793,529 (GRCm39) missense probably benign 0.19
R0145:Daam2 UTSW 17 49,787,806 (GRCm39) missense probably benign
R0310:Daam2 UTSW 17 49,770,952 (GRCm39) critical splice donor site probably null
R0362:Daam2 UTSW 17 49,787,813 (GRCm39) splice site probably null
R0423:Daam2 UTSW 17 49,776,449 (GRCm39) nonsense probably null
R0883:Daam2 UTSW 17 49,805,911 (GRCm39) utr 5 prime probably benign
R0928:Daam2 UTSW 17 49,795,255 (GRCm39) missense probably benign 0.30
R1444:Daam2 UTSW 17 49,787,779 (GRCm39) missense possibly damaging 0.89
R1559:Daam2 UTSW 17 49,803,148 (GRCm39) splice site probably benign
R1733:Daam2 UTSW 17 49,797,231 (GRCm39) missense possibly damaging 0.60
R1919:Daam2 UTSW 17 49,792,485 (GRCm39) missense probably benign 0.00
R1930:Daam2 UTSW 17 49,769,241 (GRCm39) splice site probably null
R1968:Daam2 UTSW 17 49,790,088 (GRCm39) missense probably damaging 1.00
R2520:Daam2 UTSW 17 49,787,785 (GRCm39) nonsense probably null
R3004:Daam2 UTSW 17 49,767,682 (GRCm39) missense probably damaging 0.98
R3726:Daam2 UTSW 17 49,776,766 (GRCm39) missense probably damaging 1.00
R3854:Daam2 UTSW 17 49,765,624 (GRCm39) missense probably benign
R4833:Daam2 UTSW 17 49,797,173 (GRCm39) missense possibly damaging 0.91
R4878:Daam2 UTSW 17 49,767,738 (GRCm39) missense probably damaging 1.00
R5015:Daam2 UTSW 17 49,783,550 (GRCm39) missense probably damaging 1.00
R5106:Daam2 UTSW 17 49,783,489 (GRCm39) missense probably damaging 1.00
R5184:Daam2 UTSW 17 49,801,419 (GRCm39) missense possibly damaging 0.50
R5419:Daam2 UTSW 17 49,787,782 (GRCm39) missense possibly damaging 0.95
R5529:Daam2 UTSW 17 49,766,085 (GRCm39) missense probably benign
R5974:Daam2 UTSW 17 49,771,501 (GRCm39) missense probably damaging 1.00
R5979:Daam2 UTSW 17 49,766,232 (GRCm39) missense possibly damaging 0.47
R6032:Daam2 UTSW 17 49,793,525 (GRCm39) missense probably damaging 1.00
R6032:Daam2 UTSW 17 49,793,525 (GRCm39) missense probably damaging 1.00
R6050:Daam2 UTSW 17 49,793,530 (GRCm39) missense possibly damaging 0.78
R6180:Daam2 UTSW 17 49,776,694 (GRCm39) missense probably damaging 0.99
R6225:Daam2 UTSW 17 49,801,467 (GRCm39) missense probably damaging 0.98
R6385:Daam2 UTSW 17 49,770,964 (GRCm39) missense probably damaging 1.00
R6426:Daam2 UTSW 17 49,776,404 (GRCm39) missense probably damaging 1.00
R6427:Daam2 UTSW 17 49,776,404 (GRCm39) missense probably damaging 1.00
R6428:Daam2 UTSW 17 49,776,404 (GRCm39) missense probably damaging 1.00
R6539:Daam2 UTSW 17 49,776,739 (GRCm39) missense probably damaging 1.00
R7090:Daam2 UTSW 17 49,789,973 (GRCm39) missense probably damaging 0.99
R7108:Daam2 UTSW 17 49,767,702 (GRCm39) missense probably damaging 1.00
R7487:Daam2 UTSW 17 49,793,510 (GRCm39) missense probably benign 0.03
R7599:Daam2 UTSW 17 49,787,755 (GRCm39) nonsense probably null
R7763:Daam2 UTSW 17 49,797,050 (GRCm39) missense probably benign 0.04
R8039:Daam2 UTSW 17 49,771,566 (GRCm39) missense probably damaging 1.00
R8700:Daam2 UTSW 17 49,803,180 (GRCm39) missense probably damaging 1.00
R9000:Daam2 UTSW 17 49,769,197 (GRCm39) missense probably damaging 1.00
R9286:Daam2 UTSW 17 49,786,922 (GRCm39) missense possibly damaging 0.63
R9508:Daam2 UTSW 17 49,765,618 (GRCm39) missense probably damaging 1.00
R9621:Daam2 UTSW 17 49,780,332 (GRCm39) missense probably damaging 1.00
V1662:Daam2 UTSW 17 49,771,629 (GRCm39) missense possibly damaging 0.85
Z1177:Daam2 UTSW 17 49,796,044 (GRCm39) missense probably damaging 1.00
Z1177:Daam2 UTSW 17 49,771,648 (GRCm39) missense probably damaging 1.00
Posted On 2015-04-16