Incidental Mutation 'IGL02628:Trav3-1'
ID301157
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Trav3-1
Ensembl Gene ENSMUSG00000076760
Gene NameT cell receptor alpha variable 3-1
Synonyms
Accession Numbers
Is this an essential gene? Probably non essential (E-score: 0.055) question?
Stock #IGL02628
Quality Score
Status
Chromosome14
Chromosomal Location52580762-52581213 bp(+) (GRCm38)
Type of Mutationmissense
DNA Base Change (assembly) T to A at 52581094 bp
ZygosityHeterozygous
Amino Acid Change Valine to Glutamic Acid at position 75 (V75E)
Ref Sequence ENSEMBL: ENSMUSP00000100346 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000103569]
Predicted Effect probably benign
Transcript: ENSMUST00000103569
AA Change: V75E

PolyPhen 2 Score 0.014 (Sensitivity: 0.96; Specificity: 0.79)
SMART Domains Protein: ENSMUSP00000100346
Gene: ENSMUSG00000076760
AA Change: V75E

DomainStartEndE-ValueType
IGv 39 113 6.02e-7 SMART
Coding Region Coverage
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 27 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Actr10 T A 12: 70,954,656 probably null Het
Ankhd1 T C 18: 36,647,703 V1936A probably benign Het
Ap3m1 C A 14: 21,045,520 E81* probably null Het
Camkk1 T C 11: 73,029,169 probably benign Het
Cbwd1 T A 19: 24,957,905 E78D probably damaging Het
Cdc45 C T 16: 18,798,729 M200I probably benign Het
Cmc1 A G 9: 118,065,308 Y33H probably damaging Het
Cntnap5b A T 1: 100,072,069 D184V probably damaging Het
F5 A T 1: 164,194,075 D1373V probably damaging Het
Fam169a T C 13: 97,111,288 probably benign Het
Fem1c G A 18: 46,505,952 R328W probably damaging Het
Gba2 T C 4: 43,568,919 R579G probably benign Het
Gm42641 G A 9: 109,058,630 Q98* probably null Het
Hsd17b7 A G 1: 169,964,489 F117L possibly damaging Het
Itsn1 A G 16: 91,899,623 D38G possibly damaging Het
Map1a T C 2: 121,300,104 I467T probably damaging Het
Map2k4 T A 11: 65,690,741 I382F possibly damaging Het
Myh1 T G 11: 67,206,262 probably benign Het
Nr1h4 C T 10: 89,473,839 A339T probably damaging Het
Olfr190 A C 16: 59,074,792 M96R probably benign Het
Olfr429 A G 1: 174,089,190 Y50C probably benign Het
Opn4 T A 14: 34,593,057 T420S probably benign Het
Rnf123 G A 9: 108,068,302 R390* probably null Het
Slc17a3 T A 13: 23,842,451 M1K probably null Het
T T A 17: 8,435,358 I125N probably damaging Het
Tns2 T A 15: 102,111,828 S710T probably benign Het
U2surp A G 9: 95,472,090 Y832H possibly damaging Het
Other mutations in Trav3-1
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01682:Trav3-1 APN 14 52581192 missense probably benign 0.09
R2857:Trav3-1 UTSW 14 52581058 missense probably benign 0.07
R4162:Trav3-1 UTSW 14 52581039 missense probably damaging 1.00
R4674:Trav3-1 UTSW 14 52581003 missense possibly damaging 0.66
R5475:Trav3-1 UTSW 14 52581037 missense probably damaging 1.00
R5944:Trav3-1 UTSW 14 52580992 missense probably benign 0.00
R6472:Trav3-1 UTSW 14 52581050 missense possibly damaging 0.50
R6851:Trav3-1 UTSW 14 52580971 missense probably damaging 1.00
Posted On2015-04-16