Mutagenetix > Incidental Mutation

Incidental Mutation 'IGL02628:Trav3-1'

301157

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Trav3-1

Ensembl Gene

ENSMUSG00000076760

Gene Name

T cell receptor alpha variable 3-1

Synonyms

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.069) question?

Stock #

IGL02628

Quality Score

Status

Chromosome

Chromosomal Location

52818219-52818670 bp(+) (GRCm39)

Type of Mutation

missense

DNA Base Change (assembly)

T to A at 52818551 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Valine to Glutamic Acid at position 75 (V75E)

Ref Sequence

ENSEMBL: ENSMUSP00000100346 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000103569]

AlphaFold

Q5R1I8

Predicted Effect

probably benign
Transcript: ENSMUST00000103569
AA Change: V75E

PolyPhen 2 Score 0.014 (Sensitivity: 0.96; Specificity: 0.79)

SMART Domains

Protein: ENSMUSP00000100346
Gene: ENSMUSG00000076760
AA Change: V75E

Domain	Start	End	E-Value	Type
IGv	39	113	6.02e-7	SMART

Coding Region Coverage

Validation Efficiency

Allele List at MGI

Other mutations in this stock

Total: 27 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Actr10	T	A	12: 71,001,430 (GRCm39)		probably null	Het
Ankhd1	T	C	18: 36,780,756 (GRCm39)	V1936A	probably benign	Het
Ap3m1	C	A	14: 21,095,588 (GRCm39)	E81*	probably null	Het
Camkk1	T	C	11: 72,919,995 (GRCm39)		probably benign	Het
Cdc45	C	T	16: 18,617,479 (GRCm39)	M200I	probably benign	Het
Cmc1	A	G	9: 117,894,376 (GRCm39)	Y33H	probably damaging	Het
Cntnap5b	A	T	1: 99,999,794 (GRCm39)	D184V	probably damaging	Het
F5	A	T	1: 164,021,644 (GRCm39)	D1373V	probably damaging	Het
Fam169a	T	C	13: 97,247,796 (GRCm39)		probably benign	Het
Fem1c	G	A	18: 46,639,019 (GRCm39)	R328W	probably damaging	Het
Gba2	T	C	4: 43,568,919 (GRCm39)	R579G	probably benign	Het
Gm42641	G	A	9: 108,887,698 (GRCm39)	Q98*	probably null	Het
Hsd17b7	A	G	1: 169,792,058 (GRCm39)	F117L	possibly damaging	Het
Itsn1	A	G	16: 91,696,511 (GRCm39)	D38G	possibly damaging	Het
Map1a	T	C	2: 121,130,585 (GRCm39)	I467T	probably damaging	Het
Map2k4	T	A	11: 65,581,567 (GRCm39)	I382F	possibly damaging	Het
Myh1	T	G	11: 67,097,088 (GRCm39)		probably benign	Het
Nr1h4	C	T	10: 89,309,701 (GRCm39)	A339T	probably damaging	Het
Opn4	T	A	14: 34,315,014 (GRCm39)	T420S	probably benign	Het
Or5h22	A	C	16: 58,895,155 (GRCm39)	M96R	probably benign	Het
Or6n1	A	G	1: 173,916,756 (GRCm39)	Y50C	probably benign	Het
Rnf123	G	A	9: 107,945,501 (GRCm39)	R390*	probably null	Het
Slc17a3	T	A	13: 24,026,434 (GRCm39)	M1K	probably null	Het
T	T	A	17: 8,654,190 (GRCm39)	I125N	probably damaging	Het
Tns2	T	A	15: 102,020,263 (GRCm39)	S710T	probably benign	Het
U2surp	A	G	9: 95,354,143 (GRCm39)	Y832H	possibly damaging	Het
Zng1	T	A	19: 24,935,269 (GRCm39)	E78D	probably damaging	Het

Other mutations in Trav3-1

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL01682:Trav3-1	APN	14	52,818,649 (GRCm39)	missense	probably benign	0.09
R2857:Trav3-1	UTSW	14	52,818,515 (GRCm39)	missense	probably benign	0.07
R4162:Trav3-1	UTSW	14	52,818,496 (GRCm39)	missense	probably damaging	1.00
R4674:Trav3-1	UTSW	14	52,818,460 (GRCm39)	missense	possibly damaging	0.66
R5475:Trav3-1	UTSW	14	52,818,494 (GRCm39)	missense	probably damaging	1.00
R5944:Trav3-1	UTSW	14	52,818,449 (GRCm39)	missense	probably benign	0.00
R6472:Trav3-1	UTSW	14	52,818,507 (GRCm39)	missense	possibly damaging	0.50
R6851:Trav3-1	UTSW	14	52,818,428 (GRCm39)	missense	probably damaging	1.00
R7788:Trav3-1	UTSW	14	52,818,581 (GRCm39)	missense	probably damaging	1.00
R7895:Trav3-1	UTSW	14	52,818,550 (GRCm39)	missense	probably benign	0.02
R8550:Trav3-1	UTSW	14	52,818,390 (GRCm39)	missense	probably benign	0.04
R8773:Trav3-1	UTSW	14	52,818,428 (GRCm39)	missense	probably damaging	1.00

Posted On

2015-04-16