Incidental Mutation 'IGL02628:Actr10'
ID301180
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Actr10
Ensembl Gene ENSMUSG00000021076
Gene NameARP10 actin-related protein 10
SynonymsArp11
Accession Numbers
Is this an essential gene? Probably essential (E-score: 0.961) question?
Stock #IGL02628
Quality Score
Status
Chromosome12
Chromosomal Location70937857-70964718 bp(+) (GRCm38)
Type of Mutationcritical splice donor site (2 bp from exon)
DNA Base Change (assembly) T to A at 70954656 bp
ZygosityHeterozygous
Amino Acid Change
Ref Sequence ENSEMBL: ENSMUSP00000021479 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000021479] [ENSMUST00000220582] [ENSMUST00000223549]
Predicted Effect probably null
Transcript: ENSMUST00000021479
SMART Domains Protein: ENSMUSP00000021479
Gene: ENSMUSG00000021076

DomainStartEndE-ValueType
ACTIN 13 394 3e-26 SMART
Predicted Effect probably benign
Transcript: ENSMUST00000220582
Predicted Effect noncoding transcript
Transcript: ENSMUST00000220770
Predicted Effect noncoding transcript
Transcript: ENSMUST00000221583
Predicted Effect probably benign
Transcript: ENSMUST00000223549
Coding Region Coverage
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 27 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Ankhd1 T C 18: 36,647,703 V1936A probably benign Het
Ap3m1 C A 14: 21,045,520 E81* probably null Het
Camkk1 T C 11: 73,029,169 probably benign Het
Cbwd1 T A 19: 24,957,905 E78D probably damaging Het
Cdc45 C T 16: 18,798,729 M200I probably benign Het
Cmc1 A G 9: 118,065,308 Y33H probably damaging Het
Cntnap5b A T 1: 100,072,069 D184V probably damaging Het
F5 A T 1: 164,194,075 D1373V probably damaging Het
Fam169a T C 13: 97,111,288 probably benign Het
Fem1c G A 18: 46,505,952 R328W probably damaging Het
Gba2 T C 4: 43,568,919 R579G probably benign Het
Gm42641 G A 9: 109,058,630 Q98* probably null Het
Hsd17b7 A G 1: 169,964,489 F117L possibly damaging Het
Itsn1 A G 16: 91,899,623 D38G possibly damaging Het
Map1a T C 2: 121,300,104 I467T probably damaging Het
Map2k4 T A 11: 65,690,741 I382F possibly damaging Het
Myh1 T G 11: 67,206,262 probably benign Het
Nr1h4 C T 10: 89,473,839 A339T probably damaging Het
Olfr190 A C 16: 59,074,792 M96R probably benign Het
Olfr429 A G 1: 174,089,190 Y50C probably benign Het
Opn4 T A 14: 34,593,057 T420S probably benign Het
Rnf123 G A 9: 108,068,302 R390* probably null Het
Slc17a3 T A 13: 23,842,451 M1K probably null Het
T T A 17: 8,435,358 I125N probably damaging Het
Tns2 T A 15: 102,111,828 S710T probably benign Het
Trav3-1 T A 14: 52,581,094 V75E probably benign Het
U2surp A G 9: 95,472,090 Y832H possibly damaging Het
Other mutations in Actr10
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL02084:Actr10 APN 12 70954649 missense probably damaging 1.00
IGL02232:Actr10 APN 12 70943515 missense probably benign 0.05
IGL03202:Actr10 APN 12 70940831 missense probably damaging 0.99
IGL03266:Actr10 APN 12 70956666 missense probably benign 0.00
R0505:Actr10 UTSW 12 70959964 missense probably damaging 1.00
R1734:Actr10 UTSW 12 70961996 missense probably benign 0.23
R1919:Actr10 UTSW 12 70942330 missense probably benign 0.00
R2151:Actr10 UTSW 12 70940801 nonsense probably null
R2201:Actr10 UTSW 12 70960021 missense probably damaging 0.97
R4259:Actr10 UTSW 12 70952985 missense probably benign 0.02
R4261:Actr10 UTSW 12 70952985 missense probably benign 0.02
R5138:Actr10 UTSW 12 70961879 missense probably damaging 1.00
R5326:Actr10 UTSW 12 70954656 unclassified probably benign
R5542:Actr10 UTSW 12 70954656 unclassified probably benign
R6248:Actr10 UTSW 12 70952959 missense probably benign 0.00
R6882:Actr10 UTSW 12 70956351 missense probably benign 0.00
R7102:Actr10 UTSW 12 70953031 critical splice donor site probably null
X0012:Actr10 UTSW 12 70940865 missense probably benign 0.04
X0027:Actr10 UTSW 12 70959959 missense possibly damaging 0.94
Posted On2015-04-16