Mutagenetix > Incidental Mutation

Incidental Mutation 'IGL02630:Lgals12'

301281

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Lgals12

Ensembl Gene

ENSMUSG00000024972

Gene Name

lectin, galactose binding, soluble 12

Synonyms

galectin-12, galectin-related inhibitor of proliferation, GRIP1

Accession Numbers

Essential gene?

Non essential (E-score: 0.000) question?

Stock #

IGL02630

Quality Score

Status

Chromosome

Chromosomal Location

7574025-7584558 bp(-) (GRCm39)

Type of Mutation

splice site

DNA Base Change (assembly)

T to C at 7578607 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Ref Sequence

ENSEMBL: ENSMUSP00000124610 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000079902] [ENSMUST00000099729] [ENSMUST00000159983]

AlphaFold

Q91VD1

Predicted Effect

probably benign
Transcript: ENSMUST00000079902

SMART Domains

Protein: ENSMUSP00000078824
Gene: ENSMUSG00000024972

Domain	Start	End	E-Value	Type
GLECT	25	161	1.18e-33	SMART
Gal-bind_lectin	31	160	1.45e-48	SMART
Gal-bind_lectin	181	301	3.6e-12	SMART

Predicted Effect

probably benign
Transcript: ENSMUST00000099729

SMART Domains

Protein: ENSMUSP00000097318
Gene: ENSMUSG00000024972

Domain	Start	End	E-Value	Type
GLECT	25	161	1.18e-33	SMART
Gal-bind_lectin	31	160	1.45e-48	SMART
Gal-bind_lectin	194	314	3.6e-12	SMART

Predicted Effect

probably benign
Transcript: ENSMUST00000159983

SMART Domains

Protein: ENSMUSP00000124610
Gene: ENSMUSG00000024972

Domain	Start	End	E-Value	Type
GLECT	25	161	1.18e-33	SMART
Gal-bind_lectin	31	160	1.45e-48	SMART
Gal-bind_lectin	194	314	3.6e-12	SMART

Coding Region Coverage

Validation Efficiency

MGI Phenotype

FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a member of the galectin superfamily, a group of beta-galactoside-binding proteins with conserved carbohydrate recognition domains. The related mouse protein is a primary regulator of the early stages of adipose tissue development. Alternatively spliced transcript variants encoding different isoforms have been described. [provided by RefSeq, May 2010]
PHENOTYPE: Mice homozygous for a knock-out allele exhibit increased lipolysis, reduced adiposity, and enhanced insulin sensitivity. [provided by MGI curators]

Allele List at MGI

Other mutations in this stock

Total: 48 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Ahnak	T	A	19: 8,989,441 (GRCm39)	V3575E	probably damaging	Het
Arfgef3	G	A	10: 18,537,140 (GRCm39)		probably benign	Het
Arhgap23	A	G	11: 97,345,123 (GRCm39)	T631A	probably benign	Het
Chka	T	A	19: 3,942,112 (GRCm39)	H355Q	possibly damaging	Het
Ctsj	C	T	13: 61,149,214 (GRCm39)	A277T	probably damaging	Het
Ddx49	T	C	8: 70,753,668 (GRCm39)	D67G	probably damaging	Het
Dennd4b	T	C	3: 90,180,284 (GRCm39)	S716P	probably benign	Het
Enpp5	G	T	17: 44,393,766 (GRCm39)	D321Y	probably damaging	Het
Espl1	A	G	15: 102,205,253 (GRCm39)	E17G	probably benign	Het
Fam161b	G	A	12: 84,400,688 (GRCm39)	P428L	probably benign	Het
Fbxw7	T	C	3: 84,872,586 (GRCm39)	L256S	probably damaging	Het
Fgfr2	G	T	7: 129,830,525 (GRCm39)		probably null	Het
Foxred2	C	T	15: 77,831,362 (GRCm39)	V484I	probably benign	Het
Gm4744	T	A	6: 40,927,403 (GRCm39)		probably benign	Het
H3c1	C	T	13: 23,946,231 (GRCm39)	V36M	probably benign	Het
Hipk2	T	C	6: 38,795,456 (GRCm39)	N271S	possibly damaging	Het
Ifna1	A	G	4: 88,768,496 (GRCm39)	D58G	possibly damaging	Het
Igkv4-80	A	T	6: 68,993,680 (GRCm39)	Y70*	probably null	Het
Ivns1abp	G	A	1: 151,235,386 (GRCm39)	R218H	probably damaging	Het
Kng1	A	T	16: 22,898,595 (GRCm39)		probably benign	Het
Lars1	T	C	18: 42,390,234 (GRCm39)	D11G	probably damaging	Het
Lpar4	T	A	X: 105,974,817 (GRCm39)	F334I	probably benign	Het
Muc5b	G	A	7: 141,416,968 (GRCm39)	G3305S	probably benign	Het
Nalcn	T	C	14: 123,555,291 (GRCm39)	D864G	probably benign	Het
Ndor1	T	C	2: 25,145,299 (GRCm39)	E22G	probably damaging	Het
Nt5c2	T	A	19: 46,912,749 (GRCm39)	M69L	probably benign	Het
Or52ab4	A	C	7: 102,987,636 (GRCm39)	Y125S	probably damaging	Het
Or8k22	T	C	2: 86,163,212 (GRCm39)	I163V	probably benign	Het
Pde12	A	T	14: 26,387,552 (GRCm39)	H455Q	probably damaging	Het
Pdia6	A	G	12: 17,324,422 (GRCm39)	H91R	probably benign	Het
Pdk4	A	T	6: 5,491,671 (GRCm39)	I179K	possibly damaging	Het
Prl2c1	T	C	13: 28,041,480 (GRCm39)		probably benign	Het
Rasgrf2	C	T	13: 92,267,900 (GRCm39)	E35K	probably damaging	Het
Rnf123	G	A	9: 107,945,501 (GRCm39)	R390*	probably null	Het
Sash1	T	A	10: 8,620,299 (GRCm39)	M454L	probably benign	Het
Secisbp2	C	A	13: 51,832,942 (GRCm39)	T608K	possibly damaging	Het
Slco1a7	T	C	6: 141,668,836 (GRCm39)	Y532C	probably damaging	Het
Slmap	A	G	14: 26,143,586 (GRCm39)	V750A	possibly damaging	Het
Spaca6	T	A	17: 18,051,351 (GRCm39)	L9Q	probably damaging	Het
Sycp1	T	C	3: 102,786,080 (GRCm39)		probably benign	Het
Sycp2	A	T	2: 178,043,712 (GRCm39)	D131E	probably damaging	Het
Tc2n	A	T	12: 101,659,404 (GRCm39)	D176E	probably damaging	Het
Thoc7	T	C	14: 13,953,154 (GRCm38)	I83V	probably damaging	Het
Trank1	T	C	9: 111,202,143 (GRCm39)	V1590A	possibly damaging	Het
Tyrp1	T	C	4: 80,758,994 (GRCm39)	V289A	possibly damaging	Het
Ube2dnl1	T	A	X: 113,815,483 (GRCm39)	C119*	probably null	Het
Vmn1r191	T	A	13: 22,363,431 (GRCm39)	I108F	possibly damaging	Het
Zfp710	T	A	7: 79,731,789 (GRCm39)	I322N	probably damaging	Het

Other mutations in Lgals12

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL02442:Lgals12	APN	19	7,584,019 (GRCm39)	splice site	probably benign
IGL02700:Lgals12	APN	19	7,575,455 (GRCm39)	missense	probably benign	0.01
R0129:Lgals12	UTSW	19	7,580,403 (GRCm39)	missense	probably damaging	0.99
R1398:Lgals12	UTSW	19	7,581,322 (GRCm39)	splice site	probably benign
R1421:Lgals12	UTSW	19	7,584,079 (GRCm39)	missense	probably benign	0.08
R1548:Lgals12	UTSW	19	7,581,677 (GRCm39)	missense	probably benign	0.12
R1697:Lgals12	UTSW	19	7,581,530 (GRCm39)	missense	possibly damaging	0.91
R2075:Lgals12	UTSW	19	7,576,210 (GRCm39)	missense	possibly damaging	0.81
R2192:Lgals12	UTSW	19	7,578,606 (GRCm39)	splice site	probably null
R2253:Lgals12	UTSW	19	7,584,130 (GRCm39)	start gained	probably benign
R4256:Lgals12	UTSW	19	7,584,081 (GRCm39)	missense	possibly damaging	0.93
R4738:Lgals12	UTSW	19	7,581,464 (GRCm39)	missense	probably benign	0.01
R5495:Lgals12	UTSW	19	7,581,495 (GRCm39)	missense	probably damaging	1.00
R5810:Lgals12	UTSW	19	7,584,085 (GRCm39)	missense	probably benign	0.00
R6139:Lgals12	UTSW	19	7,581,742 (GRCm39)	missense	probably benign	0.07
R7414:Lgals12	UTSW	19	7,581,335 (GRCm39)	missense	probably damaging	1.00
R8755:Lgals12	UTSW	19	7,581,345 (GRCm39)	missense	possibly damaging	0.95
R8920:Lgals12	UTSW	19	7,576,166 (GRCm39)	missense	possibly damaging	0.55
R9334:Lgals12	UTSW	19	7,578,086 (GRCm39)	missense	probably benign	0.01
R9441:Lgals12	UTSW	19	7,581,356 (GRCm39)	missense	probably damaging	1.00
X0067:Lgals12	UTSW	19	7,581,329 (GRCm39)	splice site	probably null
Z1177:Lgals12	UTSW	19	7,575,445 (GRCm39)	missense	probably benign	0.03

Posted On

2015-04-16