Mutagenetix > Incidental Mutation

Incidental Mutation 'IGL02636:Igsf6'

301536

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Igsf6

Ensembl Gene

ENSMUSG00000035004

Gene Name

immunoglobulin superfamily, member 6

Synonyms

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.066) question?

Stock #

IGL02636

Quality Score

Status

Chromosome

Chromosomal Location

120663290-120673753 bp(-) (GRCm39)

Type of Mutation

intron

DNA Base Change (assembly)

C to A at 120666503 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Ref Sequence

ENSEMBL: ENSMUSP00000147071 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000033163] [ENSMUST00000047194] [ENSMUST00000207351]

AlphaFold

P0C6B7

Predicted Effect

probably benign
Transcript: ENSMUST00000033163

SMART Domains

Protein: ENSMUSP00000033163
Gene: ENSMUSG00000030876

Domain	Start	End	E-Value	Type
signal peptide	1	18	N/A	INTRINSIC
low complexity region	39	50	N/A	INTRINSIC
Pfam:DREV	56	317	1.4e-142	PFAM
Pfam:Methyltransf_23	123	289	2.7e-12	PFAM
Pfam:Methyltransf_12	150	236	9.1e-10	PFAM
Pfam:Methyltransf_11	150	238	9.4e-8	PFAM

Predicted Effect

probably benign
Transcript: ENSMUST00000047194

SMART Domains

Protein: ENSMUSP00000039059
Gene: ENSMUSG00000035004

Domain	Start	End	E-Value	Type
IG	35	142	2.79e-2	SMART
transmembrane domain	154	176	N/A	INTRINSIC

Predicted Effect

probably benign
Transcript: ENSMUST00000207351

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000207806

Coding Region Coverage

Validation Efficiency

Allele List at MGI

Other mutations in this stock

Total: 32 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Alms1	C	A	6: 85,605,636 (GRCm39)	Q1960K	probably benign	Het
Arhgef40	T	A	14: 52,234,865 (GRCm39)	V1056E	probably damaging	Het
Cdh26	T	A	2: 178,091,755 (GRCm39)	F105I	probably damaging	Het
Cep162	A	T	9: 87,130,432 (GRCm39)	D59E	possibly damaging	Het
Cngb3	A	T	4: 19,396,690 (GRCm39)	T348S	probably damaging	Het
Eci3	A	T	13: 35,130,963 (GRCm39)		probably null	Het
Gapvd1	A	G	2: 34,615,416 (GRCm39)	I409T	probably benign	Het
Golga2	T	C	2: 32,186,735 (GRCm39)		probably null	Het
Hoxd3	G	A	2: 74,577,298 (GRCm39)	A393T	probably benign	Het
Htr5a	T	C	5: 28,047,658 (GRCm39)	F71S	probably damaging	Het
Hyou1	T	C	9: 44,292,707 (GRCm39)		probably null	Het
Klrb1c	C	A	6: 128,765,515 (GRCm39)	C25F	probably benign	Het
Lrguk	C	A	6: 34,067,123 (GRCm39)	T483K	probably damaging	Het
Lrpprc	A	T	17: 85,060,532 (GRCm39)		probably benign	Het
Lrrk1	A	T	7: 65,958,407 (GRCm39)		probably null	Het
Megf8	G	A	7: 25,057,857 (GRCm39)	G2098D	probably damaging	Het
Nfkbia	T	C	12: 55,537,958 (GRCm39)	Q165R	possibly damaging	Het
Nipsnap2	A	G	5: 129,822,354 (GRCm39)		probably benign	Het
Phykpl	C	T	11: 51,489,540 (GRCm39)	T382I	probably damaging	Het
Prdm10	A	G	9: 31,240,977 (GRCm39)	D206G	possibly damaging	Het
Rab26	T	C	17: 24,752,533 (GRCm39)	S9G	probably benign	Het
Sema3e	C	A	5: 14,275,670 (GRCm39)	N258K	probably benign	Het
Slfn10-ps	T	A	11: 82,920,971 (GRCm39)		noncoding transcript	Het
Tgm5	A	T	2: 120,907,277 (GRCm39)	C149S	probably damaging	Het
Timp4	C	T	6: 115,226,785 (GRCm39)		probably null	Het
Traf7	T	C	17: 24,731,964 (GRCm39)	K251E	probably benign	Het
Ugcg	G	T	4: 59,207,763 (GRCm39)	R34L	possibly damaging	Het
Unc13d	T	C	11: 115,964,444 (GRCm39)	H300R	probably damaging	Het
Vmn1r20	G	T	6: 57,408,746 (GRCm39)	C24F	probably benign	Het
Vmn2r13	T	C	5: 109,339,883 (GRCm39)	R31G	probably damaging	Het
Vsig10l	A	G	7: 43,113,002 (GRCm39)	T87A	possibly damaging	Het
Zfp353-ps	T	A	8: 42,535,477 (GRCm39)		noncoding transcript	Het

Other mutations in Igsf6

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00155:Igsf6	APN	7	120,669,876 (GRCm39)	nonsense	probably null
IGL01592:Igsf6	APN	7	120,670,016 (GRCm39)	missense	probably damaging	1.00
IGL02519:Igsf6	APN	7	120,667,496 (GRCm39)	missense	possibly damaging	0.72
R0106:Igsf6	UTSW	7	120,673,677 (GRCm39)	missense	probably benign	0.28
R0106:Igsf6	UTSW	7	120,673,677 (GRCm39)	missense	probably benign	0.28
R1776:Igsf6	UTSW	7	120,667,522 (GRCm39)	missense	probably damaging	0.97
R1817:Igsf6	UTSW	7	120,670,031 (GRCm39)	missense	probably damaging	1.00
R7770:Igsf6	UTSW	7	120,667,548 (GRCm39)	missense	probably benign	0.01
R9435:Igsf6	UTSW	7	120,666,472 (GRCm39)	missense	probably damaging	1.00
R9500:Igsf6	UTSW	7	120,673,697 (GRCm39)	missense	probably benign	0.03

Posted On

2015-04-16