Incidental Mutation 'R0363:Olfr498'
ID30182
Institutional Source Beutler Lab
Gene Symbol Olfr498
Ensembl Gene ENSMUSG00000096679
Gene Nameolfactory receptor 498
SynonymsMOR204-36, GA_x6K02T2PBJ9-10795522-10796514
MMRRC Submission 038569-MU
Accession Numbers
Is this an essential gene? Probably non essential (E-score: 0.074) question?
Stock #R0363 (G1)
Quality Score225
Status Validated
Chromosome7
Chromosomal Location108465326-108467585 bp(+) (GRCm38)
Type of Mutationmissense
DNA Base Change (assembly) A to T at 108465734 bp
ZygosityHeterozygous
Amino Acid Change Threonine to Serine at position 137 (T137S)
Ref Sequence ENSEMBL: ENSMUSP00000150971 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000217616]
Predicted Effect possibly damaging
Transcript: ENSMUST00000074787
AA Change: T137S

PolyPhen 2 Score 0.770 (Sensitivity: 0.85; Specificity: 0.92)
SMART Domains Protein: ENSMUSP00000074343
Gene: ENSMUSG00000096679
AA Change: T137S

DomainStartEndE-ValueType
Pfam:7tm_4 34 311 1.7e-51 PFAM
Pfam:7tm_1 44 293 5.2e-19 PFAM
Predicted Effect possibly damaging
Transcript: ENSMUST00000217616
AA Change: T137S

PolyPhen 2 Score 0.807 (Sensitivity: 0.84; Specificity: 0.93)
Meta Mutation Damage Score 0.092 question?
Coding Region Coverage
  • 1x: 98.9%
  • 3x: 97.8%
  • 10x: 94.7%
  • 20x: 86.5%
Validation Efficiency 98% (78/80)
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 75 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
4930522H14Rik T A 4: 109,524,323 Q86L probably null Het
5430403G16Rik T C 5: 109,676,888 E232G probably benign Het
Abhd2 A G 7: 79,350,813 D262G possibly damaging Het
Abhd5 T C 9: 122,368,146 F133L possibly damaging Het
Agap2 T A 10: 127,090,965 V957E probably damaging Het
Ankrd12 T C 17: 65,985,681 K919R probably damaging Het
Ap1m1 T C 8: 72,252,894 S245P probably benign Het
Ap1m1 T C 8: 72,256,724 probably benign Het
Apcdd1 A G 18: 62,937,097 Y145C possibly damaging Het
Apob A T 12: 8,010,136 N2840Y probably damaging Het
Arel1 A G 12: 84,934,253 S327P probably damaging Het
Arhgap21 C A 2: 20,881,133 R421L probably damaging Het
Ccdc85a A T 11: 28,583,400 I48N probably damaging Het
Chd6 A G 2: 161,014,324 S672P probably damaging Het
Ciz1 G C 2: 32,377,363 probably null Het
Cmbl G A 15: 31,585,442 probably null Het
Cmya5 A G 13: 93,094,869 V1237A possibly damaging Het
Cntnap4 A T 8: 112,856,511 K1074* probably null Het
Cntnap5b A G 1: 100,274,468 M347V probably benign Het
Col1a2 G A 6: 4,518,822 probably benign Het
Cuzd1 A T 7: 131,316,262 M203K probably benign Het
Cyp3a16 T C 5: 145,455,879 probably benign Het
Dlgap3 A G 4: 127,235,521 E892G probably damaging Het
Dnah7b T C 1: 46,236,788 S2612P probably damaging Het
Epas1 T G 17: 86,805,848 probably benign Het
Etv5 G A 16: 22,411,708 A192V probably benign Het
Fa2h T A 8: 111,349,289 H234L probably damaging Het
Fcho1 T C 8: 71,717,490 Y47C probably damaging Het
Flvcr1 T A 1: 191,012,254 probably benign Het
Il1rl1 CTTGTTGTTGTTGTTGTTG CTTGTTGTTGTTGTTGTTGTTG 1: 40,442,574 probably benign Het
Ino80 G A 2: 119,382,960 R1249C probably damaging Het
Inpp4b T C 8: 81,884,257 probably benign Het
Isy1 G A 6: 87,819,185 R257W probably damaging Het
Kmt2a A G 9: 44,809,713 probably null Het
Krt4 G A 15: 101,924,646 R9C possibly damaging Het
Map1a T C 2: 121,302,044 S876P probably damaging Het
Mettl21e A G 1: 44,211,030 probably null Het
Msh2 C T 17: 87,717,476 T594M probably benign Het
Mtmr3 A G 11: 4,487,536 S973P probably damaging Het
Muc5ac A T 7: 141,800,960 M889L probably benign Het
Ntn1 A G 11: 68,385,543 I193T probably benign Het
Nudt13 A T 14: 20,309,783 I193F probably damaging Het
Olfr1272 A T 2: 90,281,856 S240T probably damaging Het
Olfr134 A G 17: 38,175,447 D121G probably damaging Het
Olfr410 C T 11: 74,335,099 G44D probably damaging Het
Otulin A G 15: 27,606,295 V344A probably damaging Het
P2rx7 C T 5: 122,657,030 Q128* probably null Het
Pcdhb22 G A 18: 37,519,160 R227H probably benign Het
Plekha5 G A 6: 140,591,747 R646K possibly damaging Het
Pltp C T 2: 164,840,136 R394H probably benign Het
Ppip5k1 C G 2: 121,347,355 A324P probably damaging Het
Pramef17 C T 4: 143,991,651 M407I probably benign Het
Prdm13 A C 4: 21,679,737 V251G unknown Het
Prkg1 T C 19: 31,664,196 E29G probably damaging Het
Prrc2c A G 1: 162,697,811 S409P unknown Het
Rp1 T A 1: 4,347,718 D1057V probably damaging Het
Rttn G A 18: 89,010,955 C599Y probably damaging Het
Shisa6 C T 11: 66,525,327 R213Q probably benign Het
Slc3a1 T C 17: 85,032,845 Y232H probably damaging Het
Slx4 G A 16: 3,980,089 A1477V probably damaging Het
Ssrp1 T G 2: 85,040,674 I218S probably damaging Het
St6galnac1 A C 11: 116,768,930 S186A probably benign Het
Stab1 A G 14: 31,159,008 probably benign Het
Sycp2 T C 2: 178,346,411 probably benign Het
Syne2 T A 12: 76,072,207 I5867N probably damaging Het
Taar7f T A 10: 24,049,941 D144E probably damaging Het
Tmem136 A T 9: 43,111,753 M84K probably damaging Het
Tmem87b T A 2: 128,831,233 S196T probably damaging Het
Tnfrsf21 A G 17: 43,037,877 T127A probably benign Het
Trp73 A G 4: 154,063,949 I336T probably benign Het
Ttl A G 2: 129,076,061 I148V probably damaging Het
Ttll7 T C 3: 146,944,215 Y667H probably benign Het
Ubr4 A G 4: 139,391,860 T152A probably damaging Het
Vmn1r58 A T 7: 5,410,637 V198E probably damaging Het
Vps52 T A 17: 33,962,117 F376L probably benign Het
Other mutations in Olfr498
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL03232:Olfr498 APN 7 108465605 missense probably benign 0.06
IGL03348:Olfr498 APN 7 108465408 missense probably benign
IGL03408:Olfr498 APN 7 108465347 missense probably damaging 1.00
IGL03047:Olfr498 UTSW 7 108465776 missense probably damaging 0.97
R0208:Olfr498 UTSW 7 108465543 missense probably damaging 1.00
R1481:Olfr498 UTSW 7 108465960 missense probably benign 0.00
R1886:Olfr498 UTSW 7 108465740 missense probably benign 0.39
R2065:Olfr498 UTSW 7 108465668 missense possibly damaging 0.69
R2103:Olfr498 UTSW 7 108465603 missense probably benign 0.03
R3731:Olfr498 UTSW 7 108465426 missense possibly damaging 0.88
R4763:Olfr498 UTSW 7 108466186 missense probably benign 0.34
R4839:Olfr498 UTSW 7 108465731 missense probably benign 0.03
R4997:Olfr498 UTSW 7 108465494 missense probably benign 0.01
R5533:Olfr498 UTSW 7 108466262 missense probably benign 0.00
R7286:Olfr498 UTSW 7 108465435 missense possibly damaging 0.52
Z1088:Olfr498 UTSW 7 108465371 missense probably benign
Predicted Primers PCR Primer
(F):5'- GAACCTCAGCACCATCCTTCTTATCAG -3'
(R):5'- GTGACATCAGAACAGGAGAGTTCCAAC -3'

Sequencing Primer
(F):5'- GTTGACATAGGCATTTCATCTTCTG -3'
(R):5'- GAGTTCCAACAAAGGAGCAAAATC -3'
Posted On2013-04-24