Incidental Mutation 'IGL02643:Acad10'
ID 301843
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Acad10
Ensembl Gene ENSMUSG00000029456
Gene Name acyl-Coenzyme A dehydrogenase family, member 10
Synonyms 2410021P16Rik
Accession Numbers
Essential gene? Non essential (E-score: 0.000) question?
Stock # IGL02643
Quality Score
Status
Chromosome 5
Chromosomal Location 121759089-121798577 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to G at 121769633 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Methionine to Leucine at position 608 (M608L)
Ref Sequence ENSEMBL: ENSMUSP00000107400 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000031412] [ENSMUST00000111770]
AlphaFold Q8K370
Predicted Effect probably benign
Transcript: ENSMUST00000031412
AA Change: M608L

PolyPhen 2 Score 0.000 (Sensitivity: 1.00; Specificity: 0.00)
SMART Domains Protein: ENSMUSP00000031412
Gene: ENSMUSG00000029456
AA Change: M608L

DomainStartEndE-ValueType
Pfam:HAD_2 45 231 1.6e-14 PFAM
Pfam:Hydrolase 88 225 5e-8 PFAM
Pfam:APH 287 531 1.8e-52 PFAM
Pfam:Acyl-CoA_dh_N 660 787 1.7e-15 PFAM
Pfam:Acyl-CoA_dh_M 791 892 2.7e-20 PFAM
Pfam:Acyl-CoA_dh_1 904 1055 1.1e-35 PFAM
Pfam:Acyl-CoA_dh_2 919 1037 6.4e-13 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000111770
AA Change: M608L

PolyPhen 2 Score 0.000 (Sensitivity: 1.00; Specificity: 0.00)
SMART Domains Protein: ENSMUSP00000107400
Gene: ENSMUSG00000029456
AA Change: M608L

DomainStartEndE-ValueType
Pfam:HAD_2 45 231 2.3e-14 PFAM
Pfam:APH 287 523 3.2e-50 PFAM
Pfam:EcKinase 390 504 5.2e-8 PFAM
Pfam:Acyl-CoA_dh_N 660 787 3.4e-14 PFAM
Pfam:Acyl-CoA_dh_M 791 845 2.7e-13 PFAM
Pfam:Acyl-CoA_dh_1 904 1055 9.4e-36 PFAM
Pfam:Acyl-CoA_dh_2 919 1037 1.6e-14 PFAM
Predicted Effect noncoding transcript
Transcript: ENSMUST00000133775
Predicted Effect noncoding transcript
Transcript: ENSMUST00000137789
Predicted Effect noncoding transcript
Transcript: ENSMUST00000143187
Coding Region Coverage
Validation Efficiency
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a member of the acyl-CoA dehydrogenase family of enzymes (ACADs), which participate in the beta-oxidation of fatty acids in mitochondria. The encoded enzyme contains a hydrolase domain at the N-terminal portion, a serine/threonine protein kinase catlytic domain in the central region, and a conserved ACAD domain at the C-terminus. Several alternatively spliced transcript variants of this gene have been described, but the full-length nature of some of these variants has not been determined. [provided by RefSeq, Nov 2008]
Allele List at MGI
Other mutations in this stock
Total: 41 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Adamts2 A T 11: 50,679,527 (GRCm39) M836L probably benign Het
Ankrd11 A T 8: 123,619,061 (GRCm39) M1597K probably damaging Het
Arhgef17 A T 7: 100,533,089 (GRCm39) F1145L possibly damaging Het
Atp13a3 A T 16: 30,152,614 (GRCm39) W32R probably null Het
Atp2a3 C A 11: 72,866,165 (GRCm39) H262N probably benign Het
Bod1l T A 5: 41,976,148 (GRCm39) E1722V possibly damaging Het
Ceacam16 A G 7: 19,595,086 (GRCm39) probably benign Het
Col14a1 T A 15: 55,284,258 (GRCm39) Y840N unknown Het
Dlg5 A G 14: 24,241,250 (GRCm39) C132R probably damaging Het
Dock4 T A 12: 40,718,429 (GRCm39) N242K probably damaging Het
Dsg3 G A 18: 20,662,012 (GRCm39) V426I probably benign Het
Dync1h1 T C 12: 110,625,706 (GRCm39) probably benign Het
Flvcr2 T A 12: 85,842,997 (GRCm39) M357K possibly damaging Het
Gapvd1 A G 2: 34,594,192 (GRCm39) S932P probably damaging Het
Gata4 T A 14: 63,442,204 (GRCm39) D205V possibly damaging Het
Kcnk2 T A 1: 188,990,976 (GRCm39) I195L possibly damaging Het
Krt1 T C 15: 101,755,479 (GRCm39) I427V probably benign Het
Mapk1ip1l T A 14: 47,548,339 (GRCm39) H162Q possibly damaging Het
Micu1 A G 10: 59,675,558 (GRCm39) D380G probably damaging Het
Mknk2 A C 10: 80,504,435 (GRCm39) L289R probably damaging Het
Mtcl2 A G 2: 156,882,663 (GRCm39) V463A probably damaging Het
Myo18a A T 11: 77,668,998 (GRCm39) N286I possibly damaging Het
Or5ae2 A T 7: 84,506,239 (GRCm39) I221F probably damaging Het
Pdp1 C T 4: 11,962,062 (GRCm39) R83H probably benign Het
Ptafr A C 4: 132,307,437 (GRCm39) I276L probably benign Het
Rab3gap2 A T 1: 184,999,197 (GRCm39) D968V possibly damaging Het
Rplp1rt T C 19: 12,824,300 (GRCm39) noncoding transcript Het
Samd8 T A 14: 21,843,212 (GRCm39) M447K probably damaging Het
Six5 G T 7: 18,831,455 (GRCm39) V649L probably benign Het
Slc1a2 T A 2: 102,570,225 (GRCm39) F168I probably benign Het
Slc1a7 G A 4: 107,869,497 (GRCm39) V521M possibly damaging Het
Sorbs1 T C 19: 40,353,577 (GRCm39) D206G possibly damaging Het
Stim2 T C 5: 54,267,955 (GRCm39) V417A probably damaging Het
Tbx20 A G 9: 24,685,009 (GRCm39) probably benign Het
Tia1 A G 6: 86,393,372 (GRCm39) I71V probably benign Het
Ttc7 T C 17: 87,648,327 (GRCm39) S509P possibly damaging Het
Ttpal A G 2: 163,449,140 (GRCm39) probably benign Het
Tubgcp2 A T 7: 139,576,067 (GRCm39) N865K probably damaging Het
Wdr45 G T X: 7,593,288 (GRCm39) E62* probably null Het
Zfp507 A G 7: 35,494,656 (GRCm39) F129S probably damaging Het
Zfp518b T A 5: 38,831,498 (GRCm39) H169L probably damaging Het
Other mutations in Acad10
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL02379:Acad10 APN 5 121,760,106 (GRCm39) missense probably damaging 1.00
IGL02469:Acad10 APN 5 121,783,522 (GRCm39) missense probably damaging 1.00
IGL02526:Acad10 APN 5 121,784,923 (GRCm39) missense probably damaging 0.99
IGL02623:Acad10 APN 5 121,767,993 (GRCm39) missense possibly damaging 0.94
IGL02685:Acad10 APN 5 121,770,672 (GRCm39) missense probably benign
IGL03139:Acad10 APN 5 121,764,145 (GRCm39) missense probably benign
IGL03267:Acad10 APN 5 121,775,412 (GRCm39) missense probably benign 0.34
P0026:Acad10 UTSW 5 121,775,415 (GRCm39) missense probably damaging 1.00
R0099:Acad10 UTSW 5 121,759,353 (GRCm39) missense probably damaging 1.00
R0453:Acad10 UTSW 5 121,765,445 (GRCm39) nonsense probably null
R1051:Acad10 UTSW 5 121,764,143 (GRCm39) missense probably damaging 0.97
R1052:Acad10 UTSW 5 121,787,604 (GRCm39) missense possibly damaging 0.65
R1116:Acad10 UTSW 5 121,768,814 (GRCm39) missense probably damaging 1.00
R1548:Acad10 UTSW 5 121,764,104 (GRCm39) splice site probably benign
R1548:Acad10 UTSW 5 121,764,103 (GRCm39) splice site probably benign
R1571:Acad10 UTSW 5 121,759,411 (GRCm39) missense probably damaging 0.99
R1592:Acad10 UTSW 5 121,783,444 (GRCm39) missense probably damaging 0.99
R1741:Acad10 UTSW 5 121,785,899 (GRCm39) missense probably damaging 1.00
R1789:Acad10 UTSW 5 121,769,456 (GRCm39) missense possibly damaging 0.67
R1974:Acad10 UTSW 5 121,764,248 (GRCm39) missense possibly damaging 0.95
R2007:Acad10 UTSW 5 121,772,814 (GRCm39) missense probably damaging 1.00
R2085:Acad10 UTSW 5 121,787,523 (GRCm39) missense possibly damaging 0.79
R2351:Acad10 UTSW 5 121,767,990 (GRCm39) missense probably benign 0.23
R2511:Acad10 UTSW 5 121,769,630 (GRCm39) missense probably benign 0.02
R2570:Acad10 UTSW 5 121,768,267 (GRCm39) missense probably damaging 1.00
R3824:Acad10 UTSW 5 121,760,881 (GRCm39) missense probably benign
R3846:Acad10 UTSW 5 121,772,749 (GRCm39) missense probably benign 0.19
R4106:Acad10 UTSW 5 121,769,527 (GRCm39) missense probably damaging 0.98
R4107:Acad10 UTSW 5 121,769,527 (GRCm39) missense probably damaging 0.98
R4108:Acad10 UTSW 5 121,769,527 (GRCm39) missense probably damaging 0.98
R5569:Acad10 UTSW 5 121,764,143 (GRCm39) missense probably damaging 0.97
R5704:Acad10 UTSW 5 121,769,606 (GRCm39) missense probably benign 0.03
R5845:Acad10 UTSW 5 121,764,146 (GRCm39) missense probably benign
R5990:Acad10 UTSW 5 121,783,468 (GRCm39) missense probably damaging 1.00
R6019:Acad10 UTSW 5 121,772,864 (GRCm39) missense possibly damaging 0.88
R6145:Acad10 UTSW 5 121,760,096 (GRCm39) missense probably damaging 0.97
R6384:Acad10 UTSW 5 121,790,066 (GRCm39) missense probably benign 0.43
R6491:Acad10 UTSW 5 121,768,220 (GRCm39) missense probably damaging 1.00
R6608:Acad10 UTSW 5 121,770,555 (GRCm39) missense probably benign 0.02
R6941:Acad10 UTSW 5 121,787,420 (GRCm39) missense probably damaging 1.00
R7221:Acad10 UTSW 5 121,768,273 (GRCm39) missense probably damaging 1.00
R7283:Acad10 UTSW 5 121,787,538 (GRCm39) missense possibly damaging 0.79
R7355:Acad10 UTSW 5 121,768,780 (GRCm39) nonsense probably null
R7483:Acad10 UTSW 5 121,794,075 (GRCm39) critical splice donor site probably null
R7553:Acad10 UTSW 5 121,777,318 (GRCm39) missense probably damaging 1.00
R7721:Acad10 UTSW 5 121,784,929 (GRCm39) splice site probably null
R8075:Acad10 UTSW 5 121,790,148 (GRCm39) missense probably benign 0.00
R8400:Acad10 UTSW 5 121,764,268 (GRCm39) missense possibly damaging 0.82
R9171:Acad10 UTSW 5 121,767,981 (GRCm39) missense probably benign 0.14
X0061:Acad10 UTSW 5 121,760,876 (GRCm39) missense probably damaging 1.00
Posted On 2015-04-16