Mutagenetix > Incidental Mutation

Incidental Mutation 'IGL02644:Or7e165'

301849

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Or7e165

Ensembl Gene

ENSMUSG00000058659

Gene Name

olfactory receptor family 7 subfamily E member 165

Synonyms

Olfr58, MOR146-7P, IG6, GA_x6K02T2PVTD-13523015-13523944, MOR146-3

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.059) question?

Stock #

IGL02644

Quality Score

Status

Chromosome

Chromosomal Location

19691579-19695360 bp(+) (GRCm39)

Type of Mutation

missense

DNA Base Change (assembly)

A to C at 19695010 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Isoleucine to Leucine at position 194 (I194L)

Ref Sequence

ENSEMBL: ENSMUSP00000150309 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000079660] [ENSMUST00000212363] [ENSMUST00000215112]

AlphaFold

Q7TRF6

Predicted Effect

probably benign
Transcript: ENSMUST00000079660
AA Change: I194L

PolyPhen 2 Score 0.297 (Sensitivity: 0.91; Specificity: 0.89)

SMART Domains

Protein: ENSMUSP00000078603
Gene: ENSMUSG00000063842
AA Change: I194L

Domain	Start	End	E-Value	Type
Pfam:7tm_4	31	308	1.3e-51	PFAM
Pfam:7TM_GPCR_Srsx	35	303	8.3e-8	PFAM
Pfam:7tm_1	41	290	4.5e-22	PFAM

Predicted Effect

probably benign
Transcript: ENSMUST00000212363

Predicted Effect

probably benign
Transcript: ENSMUST00000215112
AA Change: I194L

PolyPhen 2 Score 0.297 (Sensitivity: 0.91; Specificity: 0.89)

Coding Region Coverage

Validation Efficiency

MGI Phenotype

FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]

Allele List at MGI

Other mutations in this stock

Total: 46 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Adgrl4	A	T	3: 151,198,007 (GRCm39)	Y89F	probably benign	Het
Agl	A	G	3: 116,580,246 (GRCm39)	Y406H	probably damaging	Het
Ankhd1	G	A	18: 36,711,828 (GRCm39)		probably null	Het
Ankmy1	T	C	1: 92,812,776 (GRCm39)	D511G	probably benign	Het
Arid2	T	C	15: 96,266,589 (GRCm39)	Y546H	probably damaging	Het
Asap1	G	T	15: 63,982,911 (GRCm39)	P806T	probably damaging	Het
Aspa	T	A	11: 73,212,992 (GRCm39)	T117S	probably damaging	Het
Atp2a3	C	A	11: 72,866,165 (GRCm39)	H262N	probably benign	Het
Bspry	A	T	4: 62,414,565 (GRCm39)	H386L	probably damaging	Het
C1qc	T	C	4: 136,617,629 (GRCm39)	T156A	possibly damaging	Het
Cfhr4	A	G	1: 139,708,905 (GRCm39)	M1T	probably null	Het
Copz2	A	T	11: 96,744,257 (GRCm39)		probably benign	Het
Cybb	A	G	X: 9,333,395 (GRCm39)	V23A	probably benign	Het
D630003M21Rik	T	A	2: 158,058,730 (GRCm39)	D390V	possibly damaging	Het
Dennd10	T	A	19: 60,810,741 (GRCm39)	S43T	possibly damaging	Het
Dpy19l2	G	T	9: 24,569,888 (GRCm39)	P355Q	probably damaging	Het
Gcn1	A	T	5: 115,713,250 (GRCm39)	Q71L	probably benign	Het
Gpd1l	T	C	9: 114,732,725 (GRCm39)		probably null	Het
Hydin	A	G	8: 111,265,100 (GRCm39)	D2761G	probably damaging	Het
Ifi202b	T	A	1: 173,799,280 (GRCm39)	H256L	probably benign	Het
Igkv8-24	T	C	6: 70,193,872 (GRCm39)	Y112C	probably damaging	Het
Lama3	G	A	18: 12,658,910 (GRCm39)	R2022Q	probably benign	Het
Mroh4	T	A	15: 74,482,224 (GRCm39)	R675S	possibly damaging	Het
Mtf1	T	G	4: 124,714,028 (GRCm39)	C146G	probably damaging	Het
Nubpl	A	G	12: 52,317,841 (GRCm39)	D178G	probably damaging	Het
Pam16	A	G	16: 4,434,697 (GRCm39)	S91P	probably damaging	Het
Pcdhac2	A	G	18: 37,278,232 (GRCm39)	E404G	probably benign	Het
Pde7a	C	A	3: 19,311,031 (GRCm39)		probably benign	Het
Perm1	G	T	4: 156,303,043 (GRCm39)	G529V	probably damaging	Het
Pik3c2a	T	C	7: 115,972,049 (GRCm39)	T794A	probably benign	Het
Ppfibp1	A	G	6: 146,923,938 (GRCm39)	Y722C	probably damaging	Het
Ppm1m	A	T	9: 106,074,082 (GRCm39)	I241N	probably damaging	Het
Psd	T	C	19: 46,311,834 (GRCm39)	Y282C	probably damaging	Het
Rpl27	T	A	11: 101,336,317 (GRCm39)		probably benign	Het
Scaf1	A	G	7: 44,655,357 (GRCm39)		probably benign	Het
Sec14l2	A	T	11: 4,053,380 (GRCm39)		probably benign	Het
Smchd1	T	A	17: 71,667,016 (GRCm39)		probably benign	Het
Sptb	A	T	12: 76,652,391 (GRCm39)	D1615E	probably damaging	Het
Stt3a	A	C	9: 36,663,649 (GRCm39)	C198G	possibly damaging	Het
Tas2r144	T	C	6: 42,192,787 (GRCm39)	S176P	possibly damaging	Het
Tlr13	A	G	X: 105,200,503 (GRCm39)	D80G	probably benign	Het
Tmco4	A	G	4: 138,737,920 (GRCm39)		probably benign	Het
Tnpo2	T	A	8: 85,771,109 (GRCm39)	C132S	possibly damaging	Het
Tubgcp3	T	C	8: 12,698,733 (GRCm39)	D406G	probably damaging	Het
Vmn2r125	G	A	4: 156,703,294 (GRCm39)	R224Q	probably benign	Het
Zfp524	C	A	7: 5,020,479 (GRCm39)	D2E	probably damaging	Het

Other mutations in Or7e165

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL01461:Or7e165	APN	9	19,695,245 (GRCm39)	splice site	probably null
IGL01815:Or7e165	APN	9	19,695,311 (GRCm39)	missense	probably damaging	1.00
IGL02408:Or7e165	APN	9	19,694,711 (GRCm39)	missense	probably benign	0.31
IGL03243:Or7e165	APN	9	19,694,564 (GRCm39)	missense	probably damaging	0.99
R0603:Or7e165	UTSW	9	19,695,235 (GRCm39)	missense	probably damaging	1.00
R2363:Or7e165	UTSW	9	19,694,892 (GRCm39)	missense	probably benign	0.00
R2570:Or7e165	UTSW	9	19,695,305 (GRCm39)	missense	probably damaging	1.00
R3890:Or7e165	UTSW	9	19,695,011 (GRCm39)	missense	probably benign	0.03
R3892:Or7e165	UTSW	9	19,695,011 (GRCm39)	missense	probably benign	0.03
R4163:Or7e165	UTSW	9	19,695,086 (GRCm39)	missense	possibly damaging	0.69
R4610:Or7e165	UTSW	9	19,694,442 (GRCm39)	nonsense	probably null
R4691:Or7e165	UTSW	9	19,694,678 (GRCm39)	missense	probably benign	0.33
R4707:Or7e165	UTSW	9	19,694,596 (GRCm39)	missense	probably damaging	1.00
R4825:Or7e165	UTSW	9	19,694,872 (GRCm39)	missense	possibly damaging	0.74
R4950:Or7e165	UTSW	9	19,695,027 (GRCm39)	missense	probably benign
R5185:Or7e165	UTSW	9	19,694,672 (GRCm39)	missense	probably damaging	1.00
R5202:Or7e165	UTSW	9	19,694,514 (GRCm39)	missense	possibly damaging	0.46
R5439:Or7e165	UTSW	9	19,695,161 (GRCm39)	missense	probably damaging	1.00
R5669:Or7e165	UTSW	9	19,695,053 (GRCm39)	missense	probably benign	0.02
R5672:Or7e165	UTSW	9	19,694,507 (GRCm39)	missense	possibly damaging	0.92
R6038:Or7e165	UTSW	9	19,694,858 (GRCm39)	missense	probably benign
R6038:Or7e165	UTSW	9	19,694,858 (GRCm39)	missense	probably benign
R6212:Or7e165	UTSW	9	19,694,585 (GRCm39)	missense	probably damaging	1.00
R6415:Or7e165	UTSW	9	19,695,044 (GRCm39)	missense	probably damaging	1.00
R7385:Or7e165	UTSW	9	19,694,507 (GRCm39)	missense	possibly damaging	0.92
R7669:Or7e165	UTSW	9	19,694,839 (GRCm39)	missense	possibly damaging	0.79

Posted On

2015-04-16