Incidental Mutation 'R0363:Fcho1'
ID 30185
Institutional Source Beutler Lab
Gene Symbol Fcho1
Ensembl Gene ENSMUSG00000070000
Gene Name FCH domain only 1
Synonyms 3322402E17Rik
MMRRC Submission 038569-MU
Accession Numbers
Essential gene? Possibly non essential (E-score: 0.259) question?
Stock # R0363 (G1)
Quality Score 225
Status Validated
Chromosome 8
Chromosomal Location 72161031-72178360 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to C at 72170134 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Tyrosine to Cysteine at position 47 (Y47C)
Ref Sequence ENSEMBL: ENSMUSP00000116135 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000093444] [ENSMUST00000125092] [ENSMUST00000136640] [ENSMUST00000146100] [ENSMUST00000153800]
AlphaFold Q8K285
Predicted Effect probably damaging
Transcript: ENSMUST00000093444
AA Change: Y47C

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
SMART Domains Protein: ENSMUSP00000091151
Gene: ENSMUSG00000070000
AA Change: Y47C

DomainStartEndE-ValueType
FCH 6 92 2.05e-21 SMART
low complexity region 334 351 N/A INTRINSIC
low complexity region 364 382 N/A INTRINSIC
low complexity region 446 466 N/A INTRINSIC
low complexity region 567 576 N/A INTRINSIC
Pfam:muHD 610 872 4.9e-59 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000123425
SMART Domains Protein: ENSMUSP00000123631
Gene: ENSMUSG00000070000

DomainStartEndE-ValueType
low complexity region 52 70 N/A INTRINSIC
Predicted Effect probably damaging
Transcript: ENSMUST00000125092
AA Change: Y47C

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
SMART Domains Protein: ENSMUSP00000123554
Gene: ENSMUSG00000070000
AA Change: Y47C

DomainStartEndE-ValueType
FCH 6 88 7.62e-16 SMART
Predicted Effect noncoding transcript
Transcript: ENSMUST00000126455
Predicted Effect probably damaging
Transcript: ENSMUST00000136640
AA Change: Y47C

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
SMART Domains Protein: ENSMUSP00000119273
Gene: ENSMUSG00000070000
AA Change: Y47C

DomainStartEndE-ValueType
FCH 6 92 2.05e-21 SMART
Predicted Effect noncoding transcript
Transcript: ENSMUST00000141323
Predicted Effect probably damaging
Transcript: ENSMUST00000146100
AA Change: Y47C

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
SMART Domains Protein: ENSMUSP00000117606
Gene: ENSMUSG00000070000
AA Change: Y47C

DomainStartEndE-ValueType
FCH 6 92 2.05e-21 SMART
low complexity region 334 351 N/A INTRINSIC
low complexity region 364 382 N/A INTRINSIC
low complexity region 446 466 N/A INTRINSIC
low complexity region 567 576 N/A INTRINSIC
Pfam:muHD 610 872 1.4e-62 PFAM
Predicted Effect probably damaging
Transcript: ENSMUST00000153800
AA Change: Y47C

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
SMART Domains Protein: ENSMUSP00000116135
Gene: ENSMUSG00000070000
AA Change: Y47C

DomainStartEndE-ValueType
FCH 6 92 2.05e-21 SMART
Predicted Effect noncoding transcript
Transcript: ENSMUST00000143699
Predicted Effect noncoding transcript
Transcript: ENSMUST00000152742
Meta Mutation Damage Score 0.9593 question?
Coding Region Coverage
  • 1x: 98.9%
  • 3x: 97.8%
  • 10x: 94.7%
  • 20x: 86.5%
Validation Efficiency 98% (78/80)
Allele List at MGI
Other mutations in this stock
Total: 75 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
4930522H14Rik T A 4: 109,381,520 (GRCm39) Q86L probably null Het
Abhd2 A G 7: 79,000,561 (GRCm39) D262G possibly damaging Het
Abhd5 T C 9: 122,197,211 (GRCm39) F133L possibly damaging Het
Agap2 T A 10: 126,926,834 (GRCm39) V957E probably damaging Het
Ankrd12 T C 17: 66,292,676 (GRCm39) K919R probably damaging Het
Ap1m1 T C 8: 73,006,738 (GRCm39) S245P probably benign Het
Ap1m1 T C 8: 73,010,568 (GRCm39) probably benign Het
Apcdd1 A G 18: 63,070,168 (GRCm39) Y145C possibly damaging Het
Apob A T 12: 8,060,136 (GRCm39) N2840Y probably damaging Het
Arel1 A G 12: 84,981,027 (GRCm39) S327P probably damaging Het
Arhgap21 C A 2: 20,885,944 (GRCm39) R421L probably damaging Het
Ccdc85a A T 11: 28,533,400 (GRCm39) I48N probably damaging Het
Chd6 A G 2: 160,856,244 (GRCm39) S672P probably damaging Het
Ciz1 G C 2: 32,267,375 (GRCm39) probably null Het
Cmbl G A 15: 31,585,588 (GRCm39) probably null Het
Cmya5 A G 13: 93,231,377 (GRCm39) V1237A possibly damaging Het
Cntnap4 A T 8: 113,583,143 (GRCm39) K1074* probably null Het
Cntnap5b A G 1: 100,202,193 (GRCm39) M347V probably benign Het
Col1a2 G A 6: 4,518,822 (GRCm39) probably benign Het
Cuzd1 A T 7: 130,917,991 (GRCm39) M203K probably benign Het
Cyp3a16 T C 5: 145,392,689 (GRCm39) probably benign Het
Dlgap3 A G 4: 127,129,314 (GRCm39) E892G probably damaging Het
Dnah7b T C 1: 46,275,948 (GRCm39) S2612P probably damaging Het
Epas1 T G 17: 87,113,276 (GRCm39) probably benign Het
Etv5 G A 16: 22,230,458 (GRCm39) A192V probably benign Het
Fa2h T A 8: 112,075,921 (GRCm39) H234L probably damaging Het
Flvcr1 T A 1: 190,744,451 (GRCm39) probably benign Het
Il1rl1 CTTGTTGTTGTTGTTGTTG CTTGTTGTTGTTGTTGTTGTTG 1: 40,481,734 (GRCm39) probably benign Het
Ino80 G A 2: 119,213,441 (GRCm39) R1249C probably damaging Het
Inpp4b T C 8: 82,610,886 (GRCm39) probably benign Het
Isy1 G A 6: 87,796,167 (GRCm39) R257W probably damaging Het
Kmt2a A G 9: 44,721,010 (GRCm39) probably null Het
Krt4 G A 15: 101,833,081 (GRCm39) R9C possibly damaging Het
Map1a T C 2: 121,132,525 (GRCm39) S876P probably damaging Het
Mettl21e A G 1: 44,250,190 (GRCm39) probably null Het
Msh2 C T 17: 88,024,904 (GRCm39) T594M probably benign Het
Mtmr3 A G 11: 4,437,536 (GRCm39) S973P probably damaging Het
Muc5ac A T 7: 141,354,697 (GRCm39) M889L probably benign Het
Ntn1 A G 11: 68,276,369 (GRCm39) I193T probably benign Het
Nudt13 A T 14: 20,359,851 (GRCm39) I193F probably damaging Het
Or2n1 A G 17: 38,486,338 (GRCm39) D121G probably damaging Het
Or3a1 C T 11: 74,225,925 (GRCm39) G44D probably damaging Het
Or4b1b A T 2: 90,112,200 (GRCm39) S240T probably damaging Het
Or5p73 A T 7: 108,064,941 (GRCm39) T137S possibly damaging Het
Otulin A G 15: 27,606,381 (GRCm39) V344A probably damaging Het
P2rx7 C T 5: 122,795,093 (GRCm39) Q128* probably null Het
Pcdhb22 G A 18: 37,652,213 (GRCm39) R227H probably benign Het
Plekha5 G A 6: 140,537,473 (GRCm39) R646K possibly damaging Het
Pltp C T 2: 164,682,056 (GRCm39) R394H probably benign Het
Ppip5k1 C G 2: 121,177,836 (GRCm39) A324P probably damaging Het
Pramel14 C T 4: 143,718,221 (GRCm39) M407I probably benign Het
Prdm13 A C 4: 21,679,737 (GRCm39) V251G unknown Het
Prkg1 T C 19: 31,641,596 (GRCm39) E29G probably damaging Het
Prrc2c A G 1: 162,525,380 (GRCm39) S409P unknown Het
Rp1 T A 1: 4,417,941 (GRCm39) D1057V probably damaging Het
Rttn G A 18: 89,029,079 (GRCm39) C599Y probably damaging Het
Shisa6 C T 11: 66,416,153 (GRCm39) R213Q probably benign Het
Slc3a1 T C 17: 85,340,273 (GRCm39) Y232H probably damaging Het
Slx4 G A 16: 3,797,953 (GRCm39) A1477V probably damaging Het
Ssrp1 T G 2: 84,871,018 (GRCm39) I218S probably damaging Het
St6galnac1 A C 11: 116,659,756 (GRCm39) S186A probably benign Het
Stab1 A G 14: 30,880,965 (GRCm39) probably benign Het
Sycp2 T C 2: 177,988,204 (GRCm39) probably benign Het
Syne2 T A 12: 76,118,981 (GRCm39) I5867N probably damaging Het
Taar7f T A 10: 23,925,839 (GRCm39) D144E probably damaging Het
Tlcd5 A T 9: 43,023,048 (GRCm39) M84K probably damaging Het
Tmem87b T A 2: 128,673,153 (GRCm39) S196T probably damaging Het
Tnfrsf21 A G 17: 43,348,768 (GRCm39) T127A probably benign Het
Trp73 A G 4: 154,148,406 (GRCm39) I336T probably benign Het
Ttl A G 2: 128,917,981 (GRCm39) I148V probably damaging Het
Ttll7 T C 3: 146,649,970 (GRCm39) Y667H probably benign Het
Ubr4 A G 4: 139,119,171 (GRCm39) T152A probably damaging Het
Vmn1r58 A T 7: 5,413,636 (GRCm39) V198E probably damaging Het
Vps52 T A 17: 34,181,091 (GRCm39) F376L probably benign Het
Zfp1007 T C 5: 109,824,754 (GRCm39) E232G probably benign Het
Other mutations in Fcho1
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01021:Fcho1 APN 8 72,166,167 (GRCm39) nonsense probably null
IGL01291:Fcho1 APN 8 72,165,191 (GRCm39) missense probably benign 0.08
IGL01473:Fcho1 APN 8 72,164,782 (GRCm39) missense probably benign 0.03
IGL02021:Fcho1 APN 8 72,173,919 (GRCm39) missense probably benign 0.06
IGL02086:Fcho1 APN 8 72,169,444 (GRCm39) missense probably damaging 1.00
IGL02808:Fcho1 APN 8 72,165,185 (GRCm39) missense possibly damaging 0.89
IGL03146:Fcho1 APN 8 72,170,074 (GRCm39) splice site probably benign
IGL03267:Fcho1 APN 8 72,164,943 (GRCm39) unclassified probably benign
cameo UTSW 8 72,169,507 (GRCm39) missense possibly damaging 0.92
Lesser UTSW 8 72,165,204 (GRCm39) missense probably benign 0.00
Sidekick UTSW 8 72,168,369 (GRCm39) missense probably damaging 1.00
ANU05:Fcho1 UTSW 8 72,165,191 (GRCm39) missense probably benign 0.08
R0003:Fcho1 UTSW 8 72,161,597 (GRCm39) missense probably damaging 1.00
R0010:Fcho1 UTSW 8 72,162,643 (GRCm39) missense probably damaging 1.00
R0020:Fcho1 UTSW 8 72,169,514 (GRCm39) missense probably benign 0.11
R0457:Fcho1 UTSW 8 72,165,204 (GRCm39) missense probably benign 0.00
R0485:Fcho1 UTSW 8 72,165,204 (GRCm39) missense probably benign 0.00
R0501:Fcho1 UTSW 8 72,165,204 (GRCm39) missense probably benign 0.00
R0502:Fcho1 UTSW 8 72,165,204 (GRCm39) missense probably benign 0.00
R0551:Fcho1 UTSW 8 72,164,818 (GRCm39) missense probably benign 0.06
R0583:Fcho1 UTSW 8 72,168,369 (GRCm39) missense probably damaging 1.00
R0584:Fcho1 UTSW 8 72,168,369 (GRCm39) missense probably damaging 1.00
R0585:Fcho1 UTSW 8 72,168,369 (GRCm39) missense probably damaging 1.00
R0612:Fcho1 UTSW 8 72,168,168 (GRCm39) missense probably damaging 1.00
R0614:Fcho1 UTSW 8 72,165,204 (GRCm39) missense probably benign 0.00
R0647:Fcho1 UTSW 8 72,165,204 (GRCm39) missense probably benign 0.00
R0841:Fcho1 UTSW 8 72,165,204 (GRCm39) missense probably benign 0.00
R0842:Fcho1 UTSW 8 72,165,204 (GRCm39) missense probably benign 0.00
R1034:Fcho1 UTSW 8 72,165,204 (GRCm39) missense probably benign 0.00
R1036:Fcho1 UTSW 8 72,165,204 (GRCm39) missense probably benign 0.00
R1399:Fcho1 UTSW 8 72,165,204 (GRCm39) missense probably benign 0.00
R1466:Fcho1 UTSW 8 72,165,204 (GRCm39) missense probably benign 0.00
R1466:Fcho1 UTSW 8 72,165,204 (GRCm39) missense probably benign 0.00
R1618:Fcho1 UTSW 8 72,163,047 (GRCm39) missense probably damaging 0.98
R1754:Fcho1 UTSW 8 72,163,890 (GRCm39) missense probably benign
R1793:Fcho1 UTSW 8 72,161,666 (GRCm39) nonsense probably null
R2073:Fcho1 UTSW 8 72,163,133 (GRCm39) missense probably damaging 0.98
R2177:Fcho1 UTSW 8 72,164,905 (GRCm39) missense probably damaging 1.00
R4072:Fcho1 UTSW 8 72,163,013 (GRCm39) missense probably damaging 0.99
R4074:Fcho1 UTSW 8 72,163,013 (GRCm39) missense probably damaging 0.99
R4076:Fcho1 UTSW 8 72,163,013 (GRCm39) missense probably damaging 0.99
R4606:Fcho1 UTSW 8 72,165,124 (GRCm39) missense probably benign
R4732:Fcho1 UTSW 8 72,169,439 (GRCm39) missense probably benign 0.00
R4733:Fcho1 UTSW 8 72,169,439 (GRCm39) missense probably benign 0.00
R4860:Fcho1 UTSW 8 72,163,125 (GRCm39) missense probably benign 0.04
R4860:Fcho1 UTSW 8 72,163,125 (GRCm39) missense probably benign 0.04
R5082:Fcho1 UTSW 8 72,169,829 (GRCm39) missense possibly damaging 0.69
R5083:Fcho1 UTSW 8 72,169,820 (GRCm39) missense probably benign 0.00
R5185:Fcho1 UTSW 8 72,167,600 (GRCm39) unclassified probably benign
R6025:Fcho1 UTSW 8 72,165,217 (GRCm39) splice site probably null
R6624:Fcho1 UTSW 8 72,162,015 (GRCm39) missense probably damaging 0.99
R6875:Fcho1 UTSW 8 72,167,069 (GRCm39) splice site probably null
R7069:Fcho1 UTSW 8 72,163,141 (GRCm39) splice site probably null
R7476:Fcho1 UTSW 8 72,166,190 (GRCm39) missense probably damaging 1.00
R7512:Fcho1 UTSW 8 72,169,507 (GRCm39) missense possibly damaging 0.92
R7951:Fcho1 UTSW 8 72,164,920 (GRCm39) missense probably benign 0.00
R8699:Fcho1 UTSW 8 72,162,277 (GRCm39) missense possibly damaging 0.63
R8938:Fcho1 UTSW 8 72,169,790 (GRCm39) missense possibly damaging 0.96
R9090:Fcho1 UTSW 8 72,163,068 (GRCm39) missense possibly damaging 0.80
R9117:Fcho1 UTSW 8 72,164,712 (GRCm39) missense possibly damaging 0.87
R9119:Fcho1 UTSW 8 72,164,712 (GRCm39) missense possibly damaging 0.87
R9271:Fcho1 UTSW 8 72,163,068 (GRCm39) missense possibly damaging 0.80
R9433:Fcho1 UTSW 8 72,169,468 (GRCm39) missense probably benign 0.03
R9447:Fcho1 UTSW 8 72,169,913 (GRCm39) missense probably damaging 1.00
Predicted Primers PCR Primer
(F):5'- CACAACACTGCCGTCATTGCTG -3'
(R):5'- CCTTTTAAATCATGCCCCAGGGGTC -3'

Sequencing Primer
(F):5'- ACTGCCGTCATTGCTGATATG -3'
(R):5'- GGCCAGTTCCTGTGTCaaag -3'
Posted On 2013-04-24