Incidental Mutation 'IGL02645:Zfp94'
| ID |
301898 |
| Institutional Source |
Australian Phenomics Network
(link to record)
|
| Gene Symbol |
Zfp94
|
| Ensembl Gene |
ENSMUSG00000074282 |
| Gene Name |
zinc finger protein 94 |
| Synonyms |
|
| Accession Numbers |
|
| Essential gene? |
Probably non essential
(E-score: 0.085)
|
| Stock # |
IGL02645
|
| Quality Score |
|
|
Status
|
|
| Chromosome |
7 |
| Chromosomal Location |
24001129-24016091 bp(-) (GRCm39) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
C to T
at 24003179 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Glycine to Arginine
at position 88
(G88R)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000104075
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000032673]
[ENSMUST00000077780]
[ENSMUST00000108436]
[ENSMUST00000145131]
|
| AlphaFold |
E9Q6Y4 |
| Predicted Effect |
probably benign
Transcript: ENSMUST00000032673
AA Change: G82R
PolyPhen 2
Score 0.000 (Sensitivity: 1.00; Specificity: 0.00)
|
| SMART Domains |
Protein: ENSMUSP00000032673
Gene: ENSMUSG00000074282
AA Change: G82R
| Domain | Start | End | E-Value | Type |
|---|
|
KRAB
|
2 |
59 |
3.06e-19 |
SMART |
|
ZnF_C2H2
|
157 |
179 |
5.06e-2 |
SMART |
|
ZnF_C2H2
|
185 |
207 |
8.47e-4 |
SMART |
|
ZnF_C2H2
|
213 |
235 |
4.72e-2 |
SMART |
|
ZnF_C2H2
|
241 |
263 |
1.28e-3 |
SMART |
|
ZnF_C2H2
|
269 |
291 |
5.21e-4 |
SMART |
|
ZnF_C2H2
|
297 |
319 |
9.08e-4 |
SMART |
|
ZnF_C2H2
|
325 |
347 |
2.09e-3 |
SMART |
|
ZnF_C2H2
|
353 |
375 |
8.94e-3 |
SMART |
|
ZnF_C2H2
|
381 |
403 |
2.4e-3 |
SMART |
|
ZnF_C2H2
|
409 |
431 |
8.6e-5 |
SMART |
|
ZnF_C2H2
|
437 |
459 |
7.9e-4 |
SMART |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000077780
|
| SMART Domains |
Protein: ENSMUSP00000076954
Gene: ENSMUSG00000050605
| Domain | Start | End | E-Value | Type |
|---|
|
KRAB
|
4 |
63 |
2.28e-27 |
SMART |
|
ZnF_C2H2
|
311 |
333 |
1.4e-4 |
SMART |
|
ZnF_C2H2
|
339 |
361 |
5.5e-3 |
SMART |
|
ZnF_C2H2
|
367 |
389 |
2.99e-4 |
SMART |
|
ZnF_C2H2
|
395 |
417 |
1.18e-2 |
SMART |
|
ZnF_C2H2
|
423 |
445 |
2.4e-3 |
SMART |
|
ZnF_C2H2
|
451 |
473 |
2.95e-3 |
SMART |
|
ZnF_C2H2
|
479 |
501 |
9.88e-5 |
SMART |
|
ZnF_C2H2
|
507 |
529 |
1.5e-4 |
SMART |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000108436
AA Change: G88R
PolyPhen 2
Score 0.000 (Sensitivity: 1.00; Specificity: 0.00)
|
| SMART Domains |
Protein: ENSMUSP00000104075
Gene: ENSMUSG00000074282
AA Change: G88R
| Domain | Start | End | E-Value | Type |
|---|
|
KRAB
|
8 |
65 |
3.06e-19 |
SMART |
|
ZnF_C2H2
|
163 |
185 |
5.06e-2 |
SMART |
|
ZnF_C2H2
|
191 |
213 |
8.47e-4 |
SMART |
|
ZnF_C2H2
|
219 |
241 |
4.72e-2 |
SMART |
|
ZnF_C2H2
|
247 |
269 |
1.28e-3 |
SMART |
|
ZnF_C2H2
|
275 |
297 |
5.21e-4 |
SMART |
|
ZnF_C2H2
|
303 |
325 |
9.08e-4 |
SMART |
|
ZnF_C2H2
|
331 |
353 |
2.09e-3 |
SMART |
|
ZnF_C2H2
|
359 |
381 |
8.94e-3 |
SMART |
|
ZnF_C2H2
|
387 |
409 |
2.4e-3 |
SMART |
|
ZnF_C2H2
|
415 |
437 |
8.6e-5 |
SMART |
|
ZnF_C2H2
|
443 |
465 |
7.9e-4 |
SMART |
|
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000128421
|
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000137781
|
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000138619
|
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000139811
|
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000146817
|
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000206535
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000145131
|
| SMART Domains |
Protein: ENSMUSP00000117077
Gene: ENSMUSG00000050605
| Domain | Start | End | E-Value | Type |
|---|
|
KRAB
|
4 |
64 |
4.63e-19 |
SMART |
|
| Coding Region Coverage |
|
| Validation Efficiency |
|
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 39 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| Ang4 |
T |
C |
14: 52,001,804 (GRCm39) |
Y48C |
probably damaging |
Het |
| Aox1 |
T |
A |
1: 58,373,883 (GRCm39) |
M848K |
probably damaging |
Het |
| Apol7c |
A |
T |
15: 77,413,083 (GRCm39) |
S56T |
probably benign |
Het |
| Asic4 |
G |
A |
1: 75,449,998 (GRCm39) |
|
probably benign |
Het |
| Asxl1 |
A |
G |
2: 153,234,777 (GRCm39) |
K162R |
possibly damaging |
Het |
| Car12 |
T |
A |
9: 66,654,961 (GRCm39) |
H130Q |
probably benign |
Het |
| Cars1 |
T |
C |
7: 143,111,646 (GRCm39) |
E737G |
probably damaging |
Het |
| Ccdc141 |
G |
A |
2: 76,905,211 (GRCm39) |
R412* |
probably null |
Het |
| Cd36 |
T |
C |
5: 17,990,878 (GRCm39) |
T421A |
probably benign |
Het |
| Clasp2 |
T |
G |
9: 113,719,129 (GRCm39) |
M758R |
probably damaging |
Het |
| Dock10 |
T |
A |
1: 80,551,840 (GRCm39) |
Y665F |
probably damaging |
Het |
| Ebf4 |
A |
G |
2: 130,203,761 (GRCm39) |
K471E |
probably damaging |
Het |
| Fat2 |
T |
A |
11: 55,173,654 (GRCm39) |
D2353V |
probably damaging |
Het |
| Gm10136 |
A |
G |
19: 28,981,140 (GRCm39) |
|
probably benign |
Het |
| Intu |
A |
G |
3: 40,655,702 (GRCm39) |
I930V |
probably benign |
Het |
| Ndrg2 |
T |
A |
14: 52,143,979 (GRCm39) |
M300L |
possibly damaging |
Het |
| Nhs |
A |
G |
X: 160,942,054 (GRCm39) |
S111P |
probably benign |
Het |
| Nme8 |
T |
A |
13: 19,844,755 (GRCm39) |
L111F |
probably damaging |
Het |
| Nol8 |
T |
A |
13: 49,818,947 (GRCm39) |
|
probably null |
Het |
| Or10g1b |
T |
A |
14: 52,627,958 (GRCm39) |
T91S |
possibly damaging |
Het |
| Or12e13 |
C |
T |
2: 87,663,959 (GRCm39) |
T192M |
probably benign |
Het |
| Or4a76 |
T |
C |
2: 89,460,679 (GRCm39) |
T188A |
probably benign |
Het |
| Or4c116 |
T |
C |
2: 88,941,963 (GRCm39) |
R298G |
probably benign |
Het |
| Pcdhac2 |
G |
A |
18: 37,278,292 (GRCm39) |
G424D |
probably damaging |
Het |
| Pex3 |
T |
G |
10: 13,422,173 (GRCm39) |
E42D |
possibly damaging |
Het |
| Plxnb1 |
C |
T |
9: 108,943,311 (GRCm39) |
|
probably benign |
Het |
| Rpe65 |
T |
A |
3: 159,312,128 (GRCm39) |
I209N |
probably damaging |
Het |
| Rsl1 |
T |
A |
13: 67,330,273 (GRCm39) |
F240L |
probably benign |
Het |
| Rttn |
A |
T |
18: 89,128,810 (GRCm39) |
I1921F |
probably benign |
Het |
| Scn3a |
A |
T |
2: 65,344,871 (GRCm39) |
F539Y |
probably benign |
Het |
| Secisbp2 |
T |
A |
13: 51,836,496 (GRCm39) |
M767K |
probably damaging |
Het |
| Sipa1l3 |
C |
T |
7: 29,028,405 (GRCm39) |
|
probably null |
Het |
| Slfn8 |
T |
C |
11: 82,894,380 (GRCm39) |
N753S |
possibly damaging |
Het |
| Spmip6 |
A |
G |
4: 41,517,080 (GRCm39) |
V28A |
probably damaging |
Het |
| Sympk |
T |
G |
7: 18,786,349 (GRCm39) |
V984G |
probably damaging |
Het |
| Tacr3 |
A |
T |
3: 134,566,943 (GRCm39) |
D272V |
possibly damaging |
Het |
| Timd6 |
A |
G |
11: 46,477,047 (GRCm39) |
R167G |
probably benign |
Het |
| Tnpo3 |
G |
T |
6: 29,562,899 (GRCm39) |
S606* |
probably null |
Het |
| Zfp804a |
T |
C |
2: 81,884,220 (GRCm39) |
L29P |
possibly damaging |
Het |
|
| Other mutations in Zfp94 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL01755:Zfp94
|
APN |
7 |
24,010,906 (GRCm39) |
utr 5 prime |
probably benign |
|
|
R0684:Zfp94
|
UTSW |
7 |
24,002,495 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1177:Zfp94
|
UTSW |
7 |
24,002,953 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1644:Zfp94
|
UTSW |
7 |
24,010,927 (GRCm39) |
splice site |
probably benign |
|
|
R1675:Zfp94
|
UTSW |
7 |
24,002,259 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1826:Zfp94
|
UTSW |
7 |
24,008,540 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1861:Zfp94
|
UTSW |
7 |
24,008,541 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R3932:Zfp94
|
UTSW |
7 |
24,003,112 (GRCm39) |
missense |
probably benign |
0.06 |
|
R4912:Zfp94
|
UTSW |
7 |
24,003,166 (GRCm39) |
missense |
probably benign |
0.05 |
|
R5663:Zfp94
|
UTSW |
7 |
24,002,252 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6539:Zfp94
|
UTSW |
7 |
24,002,716 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7023:Zfp94
|
UTSW |
7 |
24,002,821 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7710:Zfp94
|
UTSW |
7 |
24,003,107 (GRCm39) |
missense |
probably benign |
|
|
R7810:Zfp94
|
UTSW |
7 |
24,002,498 (GRCm39) |
missense |
probably benign |
0.00 |
|
R8134:Zfp94
|
UTSW |
7 |
24,003,166 (GRCm39) |
missense |
probably benign |
0.40 |
|
R8291:Zfp94
|
UTSW |
7 |
24,002,155 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9421:Zfp94
|
UTSW |
7 |
24,002,978 (GRCm39) |
nonsense |
probably null |
|
|
Z1176:Zfp94
|
UTSW |
7 |
24,003,236 (GRCm39) |
missense |
probably benign |
0.00 |
|
| Posted On |
2015-04-16 |
Incidental Mutation