Mutagenetix > Incidental Mutation

Incidental Mutation 'IGL02645:Ang4'

301909

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Ang4

Ensembl Gene

ENSMUSG00000060615

Gene Name

angiogenin, ribonuclease A family, member 4

Synonyms

Rnase5d

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.052) question?

Stock #

IGL02645

Quality Score

Status

Chromosome

Chromosomal Location

52001349-52011047 bp(-) (GRCm39)

Type of Mutation

missense

DNA Base Change (assembly)

T to C at 52001804 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Tyrosine to Cysteine at position 48 (Y48C)

Ref Sequence

ENSEMBL: ENSMUSP00000073525 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000073860]

AlphaFold

Q3TMQ6

PDB Structure

Biological and Structural Features of Murine Angiogenin-4, an Angiogenic Protein [X-RAY DIFFRACTION]

Predicted Effect

probably damaging
Transcript: ENSMUST00000073860
AA Change: Y48C

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)

SMART Domains

Protein: ENSMUSP00000073525
Gene: ENSMUSG00000060615
AA Change: Y48C

Domain	Start	End	E-Value	Type
low complexity region	5	21	N/A	INTRINSIC
RNAse_Pc	25	141	5.34e-61	SMART

Coding Region Coverage

Validation Efficiency

Allele List at MGI

Other mutations in this stock

Total: 39 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Aox1	T	A	1: 58,373,883 (GRCm39)	M848K	probably damaging	Het
Apol7c	A	T	15: 77,413,083 (GRCm39)	S56T	probably benign	Het
Asic4	G	A	1: 75,449,998 (GRCm39)		probably benign	Het
Asxl1	A	G	2: 153,234,777 (GRCm39)	K162R	possibly damaging	Het
Car12	T	A	9: 66,654,961 (GRCm39)	H130Q	probably benign	Het
Cars1	T	C	7: 143,111,646 (GRCm39)	E737G	probably damaging	Het
Ccdc141	G	A	2: 76,905,211 (GRCm39)	R412*	probably null	Het
Cd36	T	C	5: 17,990,878 (GRCm39)	T421A	probably benign	Het
Clasp2	T	G	9: 113,719,129 (GRCm39)	M758R	probably damaging	Het
Dock10	T	A	1: 80,551,840 (GRCm39)	Y665F	probably damaging	Het
Ebf4	A	G	2: 130,203,761 (GRCm39)	K471E	probably damaging	Het
Fat2	T	A	11: 55,173,654 (GRCm39)	D2353V	probably damaging	Het
Gm10136	A	G	19: 28,981,140 (GRCm39)		probably benign	Het
Intu	A	G	3: 40,655,702 (GRCm39)	I930V	probably benign	Het
Ndrg2	T	A	14: 52,143,979 (GRCm39)	M300L	possibly damaging	Het
Nhs	A	G	X: 160,942,054 (GRCm39)	S111P	probably benign	Het
Nme8	T	A	13: 19,844,755 (GRCm39)	L111F	probably damaging	Het
Nol8	T	A	13: 49,818,947 (GRCm39)		probably null	Het
Or10g1b	T	A	14: 52,627,958 (GRCm39)	T91S	possibly damaging	Het
Or12e13	C	T	2: 87,663,959 (GRCm39)	T192M	probably benign	Het
Or4a76	T	C	2: 89,460,679 (GRCm39)	T188A	probably benign	Het
Or4c116	T	C	2: 88,941,963 (GRCm39)	R298G	probably benign	Het
Pcdhac2	G	A	18: 37,278,292 (GRCm39)	G424D	probably damaging	Het
Pex3	T	G	10: 13,422,173 (GRCm39)	E42D	possibly damaging	Het
Plxnb1	C	T	9: 108,943,311 (GRCm39)		probably benign	Het
Rpe65	T	A	3: 159,312,128 (GRCm39)	I209N	probably damaging	Het
Rsl1	T	A	13: 67,330,273 (GRCm39)	F240L	probably benign	Het
Rttn	A	T	18: 89,128,810 (GRCm39)	I1921F	probably benign	Het
Scn3a	A	T	2: 65,344,871 (GRCm39)	F539Y	probably benign	Het
Secisbp2	T	A	13: 51,836,496 (GRCm39)	M767K	probably damaging	Het
Sipa1l3	C	T	7: 29,028,405 (GRCm39)		probably null	Het
Slfn8	T	C	11: 82,894,380 (GRCm39)	N753S	possibly damaging	Het
Spmip6	A	G	4: 41,517,080 (GRCm39)	V28A	probably damaging	Het
Sympk	T	G	7: 18,786,349 (GRCm39)	V984G	probably damaging	Het
Tacr3	A	T	3: 134,566,943 (GRCm39)	D272V	possibly damaging	Het
Timd6	A	G	11: 46,477,047 (GRCm39)	R167G	probably benign	Het
Tnpo3	G	T	6: 29,562,899 (GRCm39)	S606*	probably null	Het
Zfp804a	T	C	2: 81,884,220 (GRCm39)	L29P	possibly damaging	Het
Zfp94	C	T	7: 24,003,179 (GRCm39)	G88R	probably benign	Het

Other mutations in Ang4

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL01363:Ang4	APN	14	52,001,636 (GRCm39)	missense	probably benign	0.11
IGL01393:Ang4	APN	14	52,001,670 (GRCm39)	missense	probably benign	0.00
IGL02023:Ang4	APN	14	52,001,511 (GRCm39)	utr 3 prime	probably benign
R0023:Ang4	UTSW	14	52,001,860 (GRCm39)	nonsense	probably null
R0834:Ang4	UTSW	14	52,001,725 (GRCm39)	missense	probably benign
R1076:Ang4	UTSW	14	52,001,759 (GRCm39)	missense	probably damaging	1.00
R2258:Ang4	UTSW	14	52,001,955 (GRCm39)	start gained	probably benign
R4524:Ang4	UTSW	14	52,001,605 (GRCm39)	nonsense	probably null
R4981:Ang4	UTSW	14	52,001,829 (GRCm39)	missense	probably benign	0.11
R5929:Ang4	UTSW	14	52,001,708 (GRCm39)	missense	probably damaging	1.00
R7840:Ang4	UTSW	14	52,001,529 (GRCm39)	missense	probably damaging	1.00
R8879:Ang4	UTSW	14	52,001,943 (GRCm39)	missense	probably benign	0.03
Z1176:Ang4	UTSW	14	52,001,605 (GRCm39)	nonsense	probably null

Posted On

2015-04-16