Incidental Mutation 'IGL02646:Tas2r122'
ID301957
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Tas2r122
Ensembl Gene ENSMUSG00000078280
Gene Nametaste receptor, type 2, member 122
SynonymsTas2r22, T2R22, mGR22
Accession Numbers
Is this an essential gene? Probably non essential (E-score: 0.019) question?
Stock #IGL02646
Quality Score
Status
Chromosome6
Chromosomal Location132710999-132711928 bp(-) (GRCm38)
Type of Mutationmissense
DNA Base Change (assembly) T to A at 132711790 bp
ZygosityHeterozygous
Amino Acid Change Isoleucine to Phenylalanine at position 47 (I47F)
Ref Sequence ENSEMBL: ENSMUSP00000100699 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000105077]
Predicted Effect probably damaging
Transcript: ENSMUST00000105077
AA Change: I47F

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
SMART Domains Protein: ENSMUSP00000100699
Gene: ENSMUSG00000078280
AA Change: I47F

DomainStartEndE-ValueType
Pfam:TAS2R 1 302 2.3e-73 PFAM
Coding Region Coverage
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 36 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
1700013G24Rik T A 4: 137,454,790 Y85* probably null Het
Abcg2 A G 6: 58,685,696 I508V probably benign Het
Adgrb2 T C 4: 130,019,282 probably null Het
Api5 T A 2: 94,429,839 H24L possibly damaging Het
Apoh T C 11: 108,412,142 V311A probably benign Het
Atp2a3 C A 11: 72,975,339 H262N probably benign Het
Brca2 G T 5: 150,560,790 V2994L possibly damaging Het
Brd1 A T 15: 88,700,877 V918D probably damaging Het
Calr3 T G 8: 72,443,460 D43A possibly damaging Het
Cdh16 T C 8: 104,622,105 probably null Het
Cep192 T C 18: 67,862,477 S2033P probably damaging Het
Dnah7a G A 1: 53,525,035 T1955M probably damaging Het
Dock10 T A 1: 80,574,123 Y665F probably damaging Het
Dync1i1 A G 6: 5,767,034 D86G probably benign Het
Eri2 T C 7: 119,786,108 D390G possibly damaging Het
Fank1 C T 7: 133,880,029 probably benign Het
Hoxb7 A T 11: 96,286,744 Y6F possibly damaging Het
Hspg2 A C 4: 137,551,848 S3081R possibly damaging Het
Kcnt1 T A 2: 25,900,880 probably benign Het
Kdelc2 A G 9: 53,384,251 D51G probably benign Het
Med13 A G 11: 86,283,386 I1762T probably benign Het
Mia2 A G 12: 59,108,836 D445G probably damaging Het
Olfr1099 T C 2: 86,959,353 Y35C probably damaging Het
Plcg2 A T 8: 117,603,883 I827F possibly damaging Het
Rnls C A 19: 33,138,284 probably benign Het
Scn1a A T 2: 66,299,618 probably null Het
Sec22b T A 3: 97,921,245 V208E possibly damaging Het
Slc8a3 A T 12: 81,315,094 I317N probably damaging Het
Snx33 A G 9: 56,926,759 Y9H probably damaging Het
Stard9 C A 2: 120,698,992 T1910N probably damaging Het
Tedc1 T G 12: 113,157,301 L118V possibly damaging Het
Tln2 A T 9: 67,255,996 S1090T probably benign Het
Tpcn2 T C 7: 145,258,574 D511G probably benign Het
Usp21 T C 1: 171,283,095 probably benign Het
Vmn2r17 T A 5: 109,453,080 L748Q probably damaging Het
Zp2 T C 7: 120,135,341 D495G possibly damaging Het
Other mutations in Tas2r122
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01712:Tas2r122 APN 6 132711762 missense possibly damaging 0.87
IGL02478:Tas2r122 APN 6 132711615 missense possibly damaging 0.81
IGL02605:Tas2r122 APN 6 132711609 missense probably damaging 0.99
IGL02716:Tas2r122 APN 6 132711264 missense probably damaging 1.00
R0318:Tas2r122 UTSW 6 132711832 missense possibly damaging 0.90
R0462:Tas2r122 UTSW 6 132711178 missense probably benign 0.06
R0532:Tas2r122 UTSW 6 132711828 missense possibly damaging 0.94
R0538:Tas2r122 UTSW 6 132711815 missense probably benign 0.06
R0570:Tas2r122 UTSW 6 132711811 missense probably damaging 1.00
R1863:Tas2r122 UTSW 6 132711102 nonsense probably null
R1966:Tas2r122 UTSW 6 132711194 nonsense probably null
R2001:Tas2r122 UTSW 6 132711622 missense possibly damaging 0.91
R3500:Tas2r122 UTSW 6 132711560 missense probably damaging 1.00
R3871:Tas2r122 UTSW 6 132711580 missense probably benign 0.00
R4174:Tas2r122 UTSW 6 132711876 missense probably damaging 0.96
R5533:Tas2r122 UTSW 6 132711430 missense probably damaging 1.00
R5567:Tas2r122 UTSW 6 132711372 missense probably benign 0.28
R6455:Tas2r122 UTSW 6 132711663 nonsense probably null
R6716:Tas2r122 UTSW 6 132711897 missense probably damaging 0.98
Posted On2015-04-16