Incidental Mutation 'IGL02646:Rnls'
ID 301971
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Rnls
Ensembl Gene ENSMUSG00000071573
Gene Name renalase, FAD-dependent amine oxidase
Synonyms 6530404N21Rik
Accession Numbers
Essential gene? Non essential (E-score: 0.000) question?
Stock # IGL02646
Quality Score
Status
Chromosome 19
Chromosomal Location 33115147-33369665 bp(-) (GRCm39)
Type of Mutation splice site
DNA Base Change (assembly) C to A at 33115684 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change
Ref Sequence ENSEMBL: ENSMUSP00000127592 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000096114] [ENSMUST00000163093]
AlphaFold no structure available at present
Predicted Effect probably benign
Transcript: ENSMUST00000096114
SMART Domains Protein: ENSMUSP00000093825
Gene: ENSMUSG00000071573

DomainStartEndE-ValueType
Pfam:Amino_oxidase 13 292 7.8e-16 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000163093
SMART Domains Protein: ENSMUSP00000127592
Gene: ENSMUSG00000071573

DomainStartEndE-ValueType
PDB:3QJ4|B 1 182 1e-92 PDB
Coding Region Coverage
Validation Efficiency
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] Renalase is a flavin adenine dinucleotide-dependent amine oxidase that is secreted into the blood from the kidney (Xu et al., 2005 [PubMed 15841207]).[supplied by OMIM, Mar 2008]
PHENOTYPE: Mice homozygous for a knock-out allele exhibit aggravated ischemic myocardial damage, increased heart rate, increased blood pressure and increased serum levels of dopamine, adrenaline and noradrenaline. [provided by MGI curators]
Allele List at MGI
Other mutations in this stock
Total: 36 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
1700013G24Rik T A 4: 137,182,101 (GRCm39) Y85* probably null Het
Abcg2 A G 6: 58,662,681 (GRCm39) I508V probably benign Het
Adgrb2 T C 4: 129,913,075 (GRCm39) probably null Het
Api5 T A 2: 94,260,184 (GRCm39) H24L possibly damaging Het
Apoh T C 11: 108,302,968 (GRCm39) V311A probably benign Het
Atp2a3 C A 11: 72,866,165 (GRCm39) H262N probably benign Het
Brca2 G T 5: 150,484,255 (GRCm39) V2994L possibly damaging Het
Brd1 A T 15: 88,585,080 (GRCm39) V918D probably damaging Het
Calr3 T G 8: 73,197,304 (GRCm39) D43A possibly damaging Het
Cdh16 T C 8: 105,348,737 (GRCm39) probably null Het
Cep192 T C 18: 67,995,548 (GRCm39) S2033P probably damaging Het
Dnah7a G A 1: 53,564,194 (GRCm39) T1955M probably damaging Het
Dock10 T A 1: 80,551,840 (GRCm39) Y665F probably damaging Het
Dync1i1 A G 6: 5,767,034 (GRCm39) D86G probably benign Het
Eri2 T C 7: 119,385,331 (GRCm39) D390G possibly damaging Het
Fank1 C T 7: 133,481,758 (GRCm39) probably benign Het
Hoxb7 A T 11: 96,177,570 (GRCm39) Y6F possibly damaging Het
Hspg2 A C 4: 137,279,159 (GRCm39) S3081R possibly damaging Het
Kcnt1 T A 2: 25,790,892 (GRCm39) probably benign Het
Med13 A G 11: 86,174,212 (GRCm39) I1762T probably benign Het
Mia2 A G 12: 59,155,622 (GRCm39) D445G probably damaging Het
Or8h9 T C 2: 86,789,697 (GRCm39) Y35C probably damaging Het
Plcg2 A T 8: 118,330,622 (GRCm39) I827F possibly damaging Het
Poglut3 A G 9: 53,295,551 (GRCm39) D51G probably benign Het
Scn1a A T 2: 66,129,962 (GRCm39) probably null Het
Sec22b T A 3: 97,828,561 (GRCm39) V208E possibly damaging Het
Slc8a3 A T 12: 81,361,868 (GRCm39) I317N probably damaging Het
Snx33 A G 9: 56,834,043 (GRCm39) Y9H probably damaging Het
Stard9 C A 2: 120,529,473 (GRCm39) T1910N probably damaging Het
Tas2r122 T A 6: 132,688,753 (GRCm39) I47F probably damaging Het
Tedc1 T G 12: 113,120,921 (GRCm39) L118V possibly damaging Het
Tln2 A T 9: 67,163,278 (GRCm39) S1090T probably benign Het
Tpcn2 T C 7: 144,812,311 (GRCm39) D511G probably benign Het
Usp21 T C 1: 171,110,669 (GRCm39) probably benign Het
Vmn2r17 T A 5: 109,600,946 (GRCm39) L748Q probably damaging Het
Zp2 T C 7: 119,734,564 (GRCm39) D495G possibly damaging Het
Other mutations in Rnls
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00569:Rnls APN 19 33,145,888 (GRCm39) missense probably benign 0.03
IGL01554:Rnls APN 19 33,368,499 (GRCm39) missense possibly damaging 0.47
IGL02312:Rnls APN 19 33,145,783 (GRCm39) missense probably benign 0.36
IGL02392:Rnls APN 19 33,180,012 (GRCm39) missense possibly damaging 0.86
IGL02525:Rnls APN 19 33,115,614 (GRCm39) missense possibly damaging 0.49
IGL03097:Rnls APN 19 33,115,679 (GRCm39) splice site probably benign
R1232:Rnls UTSW 19 33,180,046 (GRCm39) missense probably benign 0.00
R1832:Rnls UTSW 19 33,145,895 (GRCm39) missense possibly damaging 0.95
R1844:Rnls UTSW 19 33,179,931 (GRCm39) missense possibly damaging 0.94
R2063:Rnls UTSW 19 33,179,944 (GRCm39) missense probably benign 0.00
R5255:Rnls UTSW 19 33,359,823 (GRCm39) missense probably damaging 1.00
R6140:Rnls UTSW 19 33,115,600 (GRCm39) missense probably damaging 1.00
R6986:Rnls UTSW 19 33,359,781 (GRCm39) missense probably damaging 1.00
R8260:Rnls UTSW 19 33,180,048 (GRCm39) missense probably damaging 0.98
Posted On 2015-04-16