Incidental Mutation 'IGL02647:Zfp647'
ID 301975
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Zfp647
Ensembl Gene ENSMUSG00000054967
Gene Name zinc finger protein 647
Synonyms
Accession Numbers
Essential gene? Probably non essential (E-score: 0.097) question?
Stock # IGL02647
Quality Score
Status
Chromosome 15
Chromosomal Location 76794571-76809648 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to C at 76801915 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Glutamic Acid to Glycine at position 30 (E30G)
Ref Sequence ENSEMBL: ENSMUSP00000155272 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000048854] [ENSMUST00000229055] [ENSMUST00000229865] [ENSMUST00000230677]
AlphaFold Q7TNU6
Predicted Effect probably damaging
Transcript: ENSMUST00000048854
AA Change: E30G

PolyPhen 2 Score 0.993 (Sensitivity: 0.70; Specificity: 0.97)
SMART Domains Protein: ENSMUSP00000041575
Gene: ENSMUSG00000054967
AA Change: E30G

DomainStartEndE-ValueType
low complexity region 2 15 N/A INTRINSIC
KRAB 17 77 7.05e-33 SMART
ZnF_C2H2 174 196 3.39e-3 SMART
ZnF_C2H2 202 224 1.2e-3 SMART
ZnF_C2H2 230 252 2.95e-3 SMART
ZnF_C2H2 258 280 4.79e-3 SMART
ZnF_C2H2 286 308 1.84e-4 SMART
ZnF_C2H2 314 336 6.32e-3 SMART
ZnF_C2H2 342 364 7.37e-4 SMART
ZnF_C2H2 370 392 1.6e-4 SMART
ZnF_C2H2 398 420 2.2e-2 SMART
ZnF_C2H2 426 448 6.78e-3 SMART
ZnF_C2H2 454 476 4.87e-4 SMART
ZnF_C2H2 482 504 2.24e-3 SMART
ZnF_C2H2 510 532 9.08e-4 SMART
Predicted Effect probably damaging
Transcript: ENSMUST00000229055
AA Change: E30G

PolyPhen 2 Score 0.993 (Sensitivity: 0.70; Specificity: 0.97)
Predicted Effect probably damaging
Transcript: ENSMUST00000229865
AA Change: E30G

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
Predicted Effect unknown
Transcript: ENSMUST00000230677
AA Change: E30G
Coding Region Coverage
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 33 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Actr8 A T 14: 29,712,847 (GRCm39) R497W probably damaging Het
Atp2a3 C A 11: 72,866,165 (GRCm39) H262N probably benign Het
Bmx T C X: 162,988,231 (GRCm39) E495G probably damaging Het
Cbx5 T C 15: 103,109,330 (GRCm39) probably null Het
Cenpj C T 14: 56,767,536 (GRCm39) V1203M probably damaging Het
Ces1b T C 8: 93,783,672 (GRCm39) H516R probably benign Het
D430041D05Rik T C 2: 104,078,611 (GRCm39) N1235S probably damaging Het
Depdc1a A T 3: 159,228,503 (GRCm39) K418N probably damaging Het
Dysf G A 6: 84,114,355 (GRCm39) V1215M probably damaging Het
Flacc1 T C 1: 58,709,613 (GRCm39) T181A probably benign Het
Foxf2 A T 13: 31,811,218 (GRCm39) N386Y probably damaging Het
Frem1 A T 4: 82,919,991 (GRCm39) V455E probably damaging Het
Fzd7 C A 1: 59,523,554 (GRCm39) P479Q probably damaging Het
Hnmt G A 2: 23,904,319 (GRCm39) S114F possibly damaging Het
Irf3 A G 7: 44,649,800 (GRCm39) N6S probably benign Het
Krt26 C T 11: 99,224,471 (GRCm39) R349Q probably benign Het
Lrba A G 3: 86,267,038 (GRCm39) D1576G probably benign Het
Lsg1 A T 16: 30,404,370 (GRCm39) probably null Het
Mal2 T C 15: 54,451,833 (GRCm39) F85L probably damaging Het
Me2 A C 18: 73,930,974 (GRCm39) S106R probably benign Het
Med21 T C 6: 146,550,731 (GRCm39) S81P probably benign Het
Mos T C 4: 3,870,961 (GRCm39) Y285C probably damaging Het
Mtmr1 A G X: 70,436,939 (GRCm39) N256S probably damaging Het
Or7e174 T A 9: 20,012,505 (GRCm39) M150K probably benign Het
Prl3d2 A C 13: 27,309,999 (GRCm39) T155P probably benign Het
R3hdm2 C T 10: 127,295,353 (GRCm39) S240L probably damaging Het
Semp2l2a T C 8: 13,886,979 (GRCm39) T371A probably damaging Het
Skint6 A T 4: 112,985,088 (GRCm39) probably benign Het
Ubr5 A G 15: 37,992,326 (GRCm39) S1933P probably damaging Het
Veph1 A T 3: 66,066,869 (GRCm39) probably benign Het
Xpo7 A G 14: 70,922,905 (GRCm39) F557S probably damaging Het
Zfp655 A T 5: 145,179,816 (GRCm39) I75L probably benign Het
Zfp981 C A 4: 146,621,709 (GRCm39) Y211* probably null Het
Other mutations in Zfp647
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01565:Zfp647 APN 15 76,795,870 (GRCm39) nonsense probably null
IGL01680:Zfp647 APN 15 76,801,968 (GRCm39) splice site probably benign
IGL03213:Zfp647 APN 15 76,796,177 (GRCm39) missense possibly damaging 0.46
IGL03401:Zfp647 APN 15 76,795,568 (GRCm39) missense probably damaging 1.00
R0418:Zfp647 UTSW 15 76,795,586 (GRCm39) missense probably damaging 1.00
R1479:Zfp647 UTSW 15 76,795,403 (GRCm39) missense possibly damaging 0.94
R1913:Zfp647 UTSW 15 76,796,151 (GRCm39) missense probably benign 0.02
R1959:Zfp647 UTSW 15 76,795,314 (GRCm39) missense possibly damaging 0.57
R2176:Zfp647 UTSW 15 76,795,860 (GRCm39) missense probably damaging 1.00
R3076:Zfp647 UTSW 15 76,802,209 (GRCm39) start codon destroyed probably null
R3077:Zfp647 UTSW 15 76,802,209 (GRCm39) start codon destroyed probably null
R3701:Zfp647 UTSW 15 76,795,110 (GRCm39) missense probably damaging 1.00
R3702:Zfp647 UTSW 15 76,795,110 (GRCm39) missense probably damaging 1.00
R3960:Zfp647 UTSW 15 76,795,176 (GRCm39) splice site probably null
R4938:Zfp647 UTSW 15 76,795,244 (GRCm39) frame shift probably null
R4939:Zfp647 UTSW 15 76,795,244 (GRCm39) frame shift probably null
R5196:Zfp647 UTSW 15 76,796,285 (GRCm39) missense probably damaging 0.96
R5197:Zfp647 UTSW 15 76,796,285 (GRCm39) missense probably damaging 0.96
R5345:Zfp647 UTSW 15 76,795,695 (GRCm39) missense possibly damaging 0.48
R5415:Zfp647 UTSW 15 76,795,593 (GRCm39) missense possibly damaging 0.79
R5791:Zfp647 UTSW 15 76,802,206 (GRCm39) missense unknown
R5942:Zfp647 UTSW 15 76,796,285 (GRCm39) missense probably damaging 0.96
R5944:Zfp647 UTSW 15 76,796,285 (GRCm39) missense probably damaging 0.96
R5945:Zfp647 UTSW 15 76,796,285 (GRCm39) missense probably damaging 0.96
R5946:Zfp647 UTSW 15 76,796,285 (GRCm39) missense probably damaging 0.96
R5947:Zfp647 UTSW 15 76,796,285 (GRCm39) missense probably damaging 0.96
R6005:Zfp647 UTSW 15 76,796,285 (GRCm39) missense probably damaging 0.96
R6007:Zfp647 UTSW 15 76,796,285 (GRCm39) missense probably damaging 0.96
R6073:Zfp647 UTSW 15 76,796,285 (GRCm39) missense probably damaging 0.96
R6074:Zfp647 UTSW 15 76,796,285 (GRCm39) missense probably damaging 0.96
R6101:Zfp647 UTSW 15 76,796,285 (GRCm39) missense probably damaging 0.96
R6102:Zfp647 UTSW 15 76,796,285 (GRCm39) missense probably damaging 0.96
R6103:Zfp647 UTSW 15 76,796,285 (GRCm39) missense probably damaging 0.96
R6126:Zfp647 UTSW 15 76,796,285 (GRCm39) missense probably damaging 0.96
R6127:Zfp647 UTSW 15 76,796,285 (GRCm39) missense probably damaging 0.96
R6129:Zfp647 UTSW 15 76,796,285 (GRCm39) missense probably damaging 0.96
R6136:Zfp647 UTSW 15 76,796,285 (GRCm39) missense probably damaging 0.96
R6151:Zfp647 UTSW 15 76,796,285 (GRCm39) missense probably damaging 0.96
R6305:Zfp647 UTSW 15 76,796,285 (GRCm39) missense probably damaging 0.96
R6306:Zfp647 UTSW 15 76,796,285 (GRCm39) missense probably damaging 0.96
R6329:Zfp647 UTSW 15 76,796,285 (GRCm39) missense probably damaging 0.96
R6721:Zfp647 UTSW 15 76,796,076 (GRCm39) missense probably benign 0.00
R7158:Zfp647 UTSW 15 76,801,505 (GRCm39) missense probably benign 0.01
R7239:Zfp647 UTSW 15 76,795,956 (GRCm39) missense probably damaging 1.00
R7611:Zfp647 UTSW 15 76,795,988 (GRCm39) missense probably damaging 1.00
R8066:Zfp647 UTSW 15 76,796,095 (GRCm39) missense probably damaging 0.98
R8170:Zfp647 UTSW 15 76,795,571 (GRCm39) missense possibly damaging 0.87
R8346:Zfp647 UTSW 15 76,795,928 (GRCm39) missense probably damaging 1.00
Posted On 2015-04-16