Mutagenetix > Incidental Mutation

Incidental Mutation 'IGL02647:Prl3d2'

301976

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Prl3d2

Ensembl Gene

ENSMUSG00000062737

Gene Name

prolactin family 3, subfamily d, member 1

Synonyms

Plib, PL-Ib

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.065) question?

Stock #

IGL02647

Quality Score

Status

Chromosome

Chromosomal Location

27305681-27311538 bp(+) (GRCm39)

Type of Mutation

missense

DNA Base Change (assembly)

A to C at 27309999 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Threonine to Proline at position 155 (T155P)

Ref Sequence

ENSEMBL: ENSMUSP00000130458 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000080755] [ENSMUST00000164964]

AlphaFold

F6R3P9

Predicted Effect

probably benign
Transcript: ENSMUST00000080755
AA Change: T154P

PolyPhen 2 Score 0.023 (Sensitivity: 0.95; Specificity: 0.81)

SMART Domains

Protein: ENSMUSP00000079579
Gene: ENSMUSG00000062737
AA Change: T154P

Domain	Start	End	E-Value	Type
Pfam:Hormone_1	17	224	4.5e-72	PFAM

Predicted Effect

probably benign
Transcript: ENSMUST00000164964
AA Change: T155P

PolyPhen 2 Score 0.057 (Sensitivity: 0.94; Specificity: 0.84)

SMART Domains

Protein: ENSMUSP00000130458
Gene: ENSMUSG00000062737
AA Change: T155P

Domain	Start	End	E-Value	Type
Pfam:Hormone_1	16	223	3e-69	PFAM

Coding Region Coverage

Validation Efficiency

Allele List at MGI

Other mutations in this stock

Total: 33 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Actr8	A	T	14: 29,712,847 (GRCm39)	R497W	probably damaging	Het
Atp2a3	C	A	11: 72,866,165 (GRCm39)	H262N	probably benign	Het
Bmx	T	C	X: 162,988,231 (GRCm39)	E495G	probably damaging	Het
Cbx5	T	C	15: 103,109,330 (GRCm39)		probably null	Het
Cenpj	C	T	14: 56,767,536 (GRCm39)	V1203M	probably damaging	Het
Ces1b	T	C	8: 93,783,672 (GRCm39)	H516R	probably benign	Het
D430041D05Rik	T	C	2: 104,078,611 (GRCm39)	N1235S	probably damaging	Het
Depdc1a	A	T	3: 159,228,503 (GRCm39)	K418N	probably damaging	Het
Dysf	G	A	6: 84,114,355 (GRCm39)	V1215M	probably damaging	Het
Flacc1	T	C	1: 58,709,613 (GRCm39)	T181A	probably benign	Het
Foxf2	A	T	13: 31,811,218 (GRCm39)	N386Y	probably damaging	Het
Frem1	A	T	4: 82,919,991 (GRCm39)	V455E	probably damaging	Het
Fzd7	C	A	1: 59,523,554 (GRCm39)	P479Q	probably damaging	Het
Hnmt	G	A	2: 23,904,319 (GRCm39)	S114F	possibly damaging	Het
Irf3	A	G	7: 44,649,800 (GRCm39)	N6S	probably benign	Het
Krt26	C	T	11: 99,224,471 (GRCm39)	R349Q	probably benign	Het
Lrba	A	G	3: 86,267,038 (GRCm39)	D1576G	probably benign	Het
Lsg1	A	T	16: 30,404,370 (GRCm39)		probably null	Het
Mal2	T	C	15: 54,451,833 (GRCm39)	F85L	probably damaging	Het
Me2	A	C	18: 73,930,974 (GRCm39)	S106R	probably benign	Het
Med21	T	C	6: 146,550,731 (GRCm39)	S81P	probably benign	Het
Mos	T	C	4: 3,870,961 (GRCm39)	Y285C	probably damaging	Het
Mtmr1	A	G	X: 70,436,939 (GRCm39)	N256S	probably damaging	Het
Or7e174	T	A	9: 20,012,505 (GRCm39)	M150K	probably benign	Het
R3hdm2	C	T	10: 127,295,353 (GRCm39)	S240L	probably damaging	Het
Semp2l2a	T	C	8: 13,886,979 (GRCm39)	T371A	probably damaging	Het
Skint6	A	T	4: 112,985,088 (GRCm39)		probably benign	Het
Ubr5	A	G	15: 37,992,326 (GRCm39)	S1933P	probably damaging	Het
Veph1	A	T	3: 66,066,869 (GRCm39)		probably benign	Het
Xpo7	A	G	14: 70,922,905 (GRCm39)	F557S	probably damaging	Het
Zfp647	T	C	15: 76,801,915 (GRCm39)	E30G	probably damaging	Het
Zfp655	A	T	5: 145,179,816 (GRCm39)	I75L	probably benign	Het
Zfp981	C	A	4: 146,621,709 (GRCm39)	Y211*	probably null	Het

Other mutations in Prl3d2

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00899:Prl3d2	APN	13	27,306,332 (GRCm39)	missense	probably damaging	1.00
IGL01362:Prl3d2	APN	13	27,306,438 (GRCm39)	nonsense	probably null
IGL02751:Prl3d2	APN	13	27,310,014 (GRCm39)	critical splice donor site	probably null
IGL02992:Prl3d2	APN	13	27,311,266 (GRCm39)	missense	probably benign	0.00
R1116:Prl3d2	UTSW	13	27,309,985 (GRCm39)	missense	probably damaging	1.00
R1500:Prl3d2	UTSW	13	27,305,689 (GRCm39)	unclassified	probably benign
R4713:Prl3d2	UTSW	13	27,306,379 (GRCm39)	missense	probably benign
R5193:Prl3d2	UTSW	13	27,306,312 (GRCm39)	missense	possibly damaging	0.87
R6386:Prl3d2	UTSW	13	27,311,286 (GRCm39)	missense	probably damaging	0.97
R7830:Prl3d2	UTSW	13	27,310,000 (GRCm39)	missense	probably benign	0.00
R7999:Prl3d2	UTSW	13	27,307,949 (GRCm39)	missense	probably benign	0.00
R8446:Prl3d2	UTSW	13	27,307,976 (GRCm39)	missense	probably benign	0.25
R8837:Prl3d2	UTSW	13	27,307,926 (GRCm39)	missense	probably benign	0.01

Posted On

2015-04-16