Incidental Mutation 'IGL02649:Zfhx3'
ID 302061
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Zfhx3
Ensembl Gene ENSMUSG00000038872
Gene Name zinc finger homeobox 3
Synonyms Sci, A230102L03Rik, WBP9, Atbf1
Accession Numbers
Essential gene? Probably essential (E-score: 0.923) question?
Stock # IGL02649
Quality Score
Status
Chromosome 8
Chromosomal Location 109005975-109688268 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to C at 109520167 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Serine to Proline at position 430 (S430P)
Ref Sequence ENSEMBL: ENSMUSP00000152353 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000043896] [ENSMUST00000188994] [ENSMUST00000220518]
AlphaFold no structure available at present
Predicted Effect possibly damaging
Transcript: ENSMUST00000043896
AA Change: S430P

PolyPhen 2 Score 0.939 (Sensitivity: 0.80; Specificity: 0.94)
SMART Domains Protein: ENSMUSP00000044612
Gene: ENSMUSG00000038872
AA Change: S430P

DomainStartEndE-ValueType
ZnF_C2H2 79 103 7.89e0 SMART
low complexity region 110 127 N/A INTRINSIC
low complexity region 148 165 N/A INTRINSIC
ZnF_C2H2 282 305 1.36e1 SMART
low complexity region 393 411 N/A INTRINSIC
coiled coil region 453 496 N/A INTRINSIC
low complexity region 500 523 N/A INTRINSIC
ZnF_C2H2 641 664 3.47e0 SMART
ZnF_C2H2 672 695 6.78e-3 SMART
ZnF_U1 724 758 5.71e-1 SMART
ZnF_C2H2 727 751 4.87e-4 SMART
low complexity region 771 785 N/A INTRINSIC
low complexity region 796 804 N/A INTRINSIC
ZnF_C2H2 805 829 6.67e-2 SMART
ZnF_U1 982 1016 2.35e0 SMART
ZnF_C2H2 985 1009 4.57e0 SMART
ZnF_C2H2 1041 1065 3.99e0 SMART
ZnF_U1 1086 1120 1.36e0 SMART
ZnF_C2H2 1089 1113 1.33e-1 SMART
ZnF_C2H2 1233 1256 4.11e-2 SMART
ZnF_C2H2 1262 1285 4.34e-1 SMART
ZnF_C2H2 1370 1395 1.08e-1 SMART
ZnF_C2H2 1411 1433 3.34e-2 SMART
ZnF_C2H2 1439 1462 8.09e-1 SMART
low complexity region 1500 1512 N/A INTRINSIC
ZnF_U1 1552 1586 1.05e0 SMART
ZnF_C2H2 1555 1579 8.22e-2 SMART
ZnF_U1 1603 1637 4.19e0 SMART
ZnF_C2H2 1606 1630 1.16e-1 SMART
low complexity region 1643 1669 N/A INTRINSIC
low complexity region 1734 1776 N/A INTRINSIC
low complexity region 1792 1802 N/A INTRINSIC
low complexity region 1842 1878 N/A INTRINSIC
low complexity region 1881 1894 N/A INTRINSIC
low complexity region 1967 1985 N/A INTRINSIC
ZnF_C2H2 1990 2013 1.62e0 SMART
low complexity region 2041 2088 N/A INTRINSIC
low complexity region 2110 2125 N/A INTRINSIC
HOX 2152 2214 1.13e-16 SMART
HOX 2249 2311 2.41e-20 SMART
ZnF_C2H2 2335 2355 1.72e1 SMART
low complexity region 2383 2414 N/A INTRINSIC
low complexity region 2458 2473 N/A INTRINSIC
low complexity region 2476 2521 N/A INTRINSIC
ZnF_C2H2 2539 2561 1.79e-2 SMART
low complexity region 2606 2619 N/A INTRINSIC
HOX 2650 2712 2.97e-20 SMART
ZnF_C2H2 2720 2743 7.67e-2 SMART
low complexity region 2929 2950 N/A INTRINSIC
HOX 2954 3016 1.07e-17 SMART
ZnF_U1 3029 3063 1.8e-1 SMART
ZnF_C2H2 3032 3056 8.31e0 SMART
low complexity region 3130 3144 N/A INTRINSIC
low complexity region 3181 3235 N/A INTRINSIC
low complexity region 3237 3256 N/A INTRINSIC
low complexity region 3268 3282 N/A INTRINSIC
low complexity region 3290 3299 N/A INTRINSIC
coiled coil region 3362 3417 N/A INTRINSIC
low complexity region 3452 3476 N/A INTRINSIC
ZnF_C2H2 3489 3509 1.45e2 SMART
ZnF_U1 3546 3580 1.36e0 SMART
ZnF_C2H2 3549 3573 1.77e1 SMART
low complexity region 3602 3633 N/A INTRINSIC
low complexity region 3642 3674 N/A INTRINSIC
Predicted Effect probably benign
Transcript: ENSMUST00000188994
Predicted Effect possibly damaging
Transcript: ENSMUST00000220518
AA Change: S430P

PolyPhen 2 Score 0.939 (Sensitivity: 0.80; Specificity: 0.94)
Coding Region Coverage
Validation Efficiency
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a transcription factor with multiple homeodomains and zinc finger motifs, and regulates myogenic and neuronal differentiation. The encoded protein suppresses expression of the alpha-fetoprotein gene by binding to an AT-rich enhancer motif. The protein has also been shown to negatively regulate c-Myb, and transactivate the cell cycle inhibitor cyclin-dependent kinase inhibitor 1A (also known as p21CIP1). This gene is reported to function as a tumor suppressor in several cancers, and sequence variants of this gene are also associated with atrial fibrillation. Multiple transcript variants expressed from alternate promoters and encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2009]
PHENOTYPE: Mice homozygous for a gene trapped allele exhibit normal initial pituitary development but reduced GH and TSH-beta staining within the pituitary by E17.5. Mice homozygous for a knock-out allele exhibit prenatal lethality. Mice heterozygous for the same allele exhibit partial postnatal lethality, decreased body size and prolonged conception time. [provided by MGI curators]
Allele List at MGI

 All alleles(18) : Gene trapped(18)

Other mutations in this stock
Total: 47 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Aanat A T 11: 116,486,472 (GRCm39) I4F probably benign Het
Adamts17 T G 7: 66,499,626 (GRCm39) probably benign Het
Adcy1 A T 11: 7,117,156 (GRCm39) M1008L probably damaging Het
Atp2a3 C A 11: 72,866,165 (GRCm39) H262N probably benign Het
Atrnl1 T G 19: 57,638,873 (GRCm39) probably benign Het
Brd3 T A 2: 27,344,362 (GRCm39) E456V probably damaging Het
Cabin1 A T 10: 75,573,252 (GRCm39) L712H probably damaging Het
Ccna1 T A 3: 54,961,807 (GRCm39) T38S probably damaging Het
Chadl T A 15: 81,580,059 (GRCm39) I59F probably benign Het
Chmp3 T C 6: 71,529,417 (GRCm39) M27T possibly damaging Het
Clcn1 C T 6: 42,275,763 (GRCm39) T295I probably damaging Het
Col6a6 A G 9: 105,604,369 (GRCm39) probably null Het
Dennd2a T A 6: 39,447,290 (GRCm39) H776L probably benign Het
Dimt1 G A 13: 107,085,219 (GRCm39) R55K probably benign Het
Dlg5 T A 14: 24,196,319 (GRCm39) D1626V probably damaging Het
Dock10 T A 1: 80,551,840 (GRCm39) Y665F probably damaging Het
Hectd4 T C 5: 121,487,465 (GRCm39) S3487P possibly damaging Het
Hivep1 T C 13: 42,310,787 (GRCm39) V1009A possibly damaging Het
Ifna12 A T 4: 88,521,091 (GRCm39) V152E probably damaging Het
Igf2r A T 17: 12,930,974 (GRCm39) C903S possibly damaging Het
Ipo9 T C 1: 135,313,672 (GRCm39) D1002G possibly damaging Het
Isyna1 T C 8: 71,048,904 (GRCm39) S328P probably damaging Het
Itprid2 T C 2: 79,472,303 (GRCm39) probably benign Het
Lamc1 G A 1: 153,122,788 (GRCm39) T764I possibly damaging Het
Lta4h T C 10: 93,308,831 (GRCm39) V377A probably benign Het
Lyz2 C T 10: 117,118,090 (GRCm39) V20I probably benign Het
Myo3a A T 2: 22,328,418 (GRCm39) L329F probably benign Het
Nlgn2 T C 11: 69,716,628 (GRCm39) T638A probably benign Het
Oasl2 A G 5: 115,035,753 (GRCm39) T10A probably damaging Het
Or14j8 A T 17: 38,263,864 (GRCm39) F17Y probably damaging Het
Or5k1 T A 16: 58,617,713 (GRCm39) R165S probably damaging Het
Pde10a A T 17: 9,172,604 (GRCm39) N296I probably damaging Het
Plb1 A G 5: 32,519,912 (GRCm39) I1385M probably benign Het
Pld1 T C 3: 28,141,378 (GRCm39) V647A probably damaging Het
Pnp T C 14: 51,185,303 (GRCm39) probably benign Het
Ppl A T 16: 4,905,327 (GRCm39) I1656K probably damaging Het
Rimbp3 G T 16: 17,027,472 (GRCm39) E299* probably null Het
Sbsn C A 7: 30,452,683 (GRCm39) A566D probably damaging Het
Sh3rf1 T A 8: 61,816,225 (GRCm39) M494K probably damaging Het
Slc2a2 T A 3: 28,772,885 (GRCm39) V226E probably damaging Het
Smarca2 T A 19: 26,617,986 (GRCm39) I339N possibly damaging Het
Tenm2 G T 11: 36,097,912 (GRCm39) S445R possibly damaging Het
Tlcd5 C A 9: 43,022,783 (GRCm39) K190N probably benign Het
Tnip2 A T 5: 34,671,075 (GRCm39) L56Q probably damaging Het
Trpv1 C T 11: 73,141,612 (GRCm39) S485F probably damaging Het
Vmn2r23 T C 6: 123,681,437 (GRCm39) M115T probably benign Het
Zbtb38 G A 9: 96,568,672 (GRCm39) T804I probably damaging Het
Other mutations in Zfhx3
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01011:Zfhx3 APN 8 109,520,226 (GRCm39) missense probably benign 0.00
IGL01946:Zfhx3 APN 8 109,660,561 (GRCm39) missense probably damaging 0.98
IGL01973:Zfhx3 APN 8 109,673,825 (GRCm39) missense probably damaging 1.00
IGL01983:Zfhx3 APN 8 109,673,866 (GRCm39) missense probably damaging 1.00
IGL02151:Zfhx3 APN 8 109,520,515 (GRCm39) missense probably damaging 1.00
IGL02405:Zfhx3 APN 8 109,682,374 (GRCm39) missense unknown
IGL02406:Zfhx3 APN 8 109,682,374 (GRCm39) missense unknown
IGL02408:Zfhx3 APN 8 109,682,004 (GRCm39) splice site probably benign
IGL02549:Zfhx3 APN 8 109,527,141 (GRCm39) missense probably damaging 1.00
IGL02601:Zfhx3 APN 8 109,583,462 (GRCm39) missense probably damaging 1.00
IGL03027:Zfhx3 APN 8 109,519,820 (GRCm39) missense probably damaging 0.98
IGL03053:Zfhx3 APN 8 109,673,132 (GRCm39) missense probably damaging 0.99
IGL03168:Zfhx3 APN 8 109,673,132 (GRCm39) missense probably damaging 0.99
IGL03194:Zfhx3 APN 8 109,521,359 (GRCm39) missense probably damaging 0.97
IGL03248:Zfhx3 APN 8 109,673,182 (GRCm39) missense probably damaging 1.00
FR4449:Zfhx3 UTSW 8 109,682,726 (GRCm39) small insertion probably benign
FR4589:Zfhx3 UTSW 8 109,682,733 (GRCm39) small insertion probably benign
FR4737:Zfhx3 UTSW 8 109,682,735 (GRCm39) small insertion probably benign
FR4737:Zfhx3 UTSW 8 109,682,734 (GRCm39) small insertion probably benign
FR4737:Zfhx3 UTSW 8 109,682,720 (GRCm39) small insertion probably benign
G5030:Zfhx3 UTSW 8 109,678,091 (GRCm39) missense possibly damaging 0.86
R0016:Zfhx3 UTSW 8 109,676,810 (GRCm39) missense probably benign 0.02
R0090:Zfhx3 UTSW 8 109,676,689 (GRCm39) missense possibly damaging 0.85
R0330:Zfhx3 UTSW 8 109,675,589 (GRCm39) missense probably damaging 1.00
R0332:Zfhx3 UTSW 8 109,673,255 (GRCm39) missense probably damaging 1.00
R0398:Zfhx3 UTSW 8 109,677,878 (GRCm39) missense probably damaging 0.98
R0539:Zfhx3 UTSW 8 109,527,141 (GRCm39) missense probably damaging 1.00
R0546:Zfhx3 UTSW 8 109,520,819 (GRCm39) missense probably damaging 1.00
R0614:Zfhx3 UTSW 8 109,675,599 (GRCm39) nonsense probably null
R0614:Zfhx3 UTSW 8 109,675,171 (GRCm39) missense probably benign 0.03
R0653:Zfhx3 UTSW 8 109,673,440 (GRCm39) missense possibly damaging 0.95
R0718:Zfhx3 UTSW 8 109,682,282 (GRCm39) missense unknown
R0825:Zfhx3 UTSW 8 109,675,840 (GRCm39) missense probably damaging 0.99
R1143:Zfhx3 UTSW 8 109,521,043 (GRCm39) missense probably damaging 1.00
R1319:Zfhx3 UTSW 8 109,660,465 (GRCm39) missense probably damaging 0.99
R1347:Zfhx3 UTSW 8 109,527,330 (GRCm39) splice site probably benign
R1412:Zfhx3 UTSW 8 109,641,199 (GRCm39) missense possibly damaging 0.88
R1447:Zfhx3 UTSW 8 109,675,076 (GRCm39) missense probably benign 0.03
R1530:Zfhx3 UTSW 8 109,675,121 (GRCm39) missense probably damaging 1.00
R1745:Zfhx3 UTSW 8 109,682,494 (GRCm39) missense unknown
R1764:Zfhx3 UTSW 8 109,678,276 (GRCm39) missense probably benign 0.18
R1781:Zfhx3 UTSW 8 109,520,167 (GRCm39) missense probably benign 0.01
R1917:Zfhx3 UTSW 8 109,682,880 (GRCm39) missense unknown
R1956:Zfhx3 UTSW 8 109,520,774 (GRCm39) missense probably benign 0.02
R2049:Zfhx3 UTSW 8 109,671,809 (GRCm39) missense probably benign 0.01
R2196:Zfhx3 UTSW 8 109,526,885 (GRCm39) missense probably damaging 1.00
R3085:Zfhx3 UTSW 8 109,682,664 (GRCm39) missense unknown
R3765:Zfhx3 UTSW 8 109,519,394 (GRCm39) missense probably damaging 0.97
R4162:Zfhx3 UTSW 8 109,683,619 (GRCm39) missense unknown
R4243:Zfhx3 UTSW 8 109,518,952 (GRCm39) missense probably damaging 0.97
R4380:Zfhx3 UTSW 8 109,683,022 (GRCm39) missense unknown
R4433:Zfhx3 UTSW 8 109,682,269 (GRCm39) missense unknown
R4509:Zfhx3 UTSW 8 109,520,411 (GRCm39) missense probably benign 0.01
R4731:Zfhx3 UTSW 8 109,682,716 (GRCm39) missense unknown
R4788:Zfhx3 UTSW 8 109,520,842 (GRCm39) missense probably damaging 1.00
R4812:Zfhx3 UTSW 8 109,674,593 (GRCm39) missense possibly damaging 0.83
R4893:Zfhx3 UTSW 8 109,683,639 (GRCm39) missense unknown
R4907:Zfhx3 UTSW 8 109,519,986 (GRCm39) missense probably damaging 0.99
R4935:Zfhx3 UTSW 8 109,674,482 (GRCm39) missense possibly damaging 0.92
R4943:Zfhx3 UTSW 8 109,674,949 (GRCm39) missense probably damaging 0.98
R5154:Zfhx3 UTSW 8 109,527,207 (GRCm39) missense probably damaging 1.00
R5377:Zfhx3 UTSW 8 109,677,817 (GRCm39) missense possibly damaging 0.95
R5388:Zfhx3 UTSW 8 109,673,446 (GRCm39) missense possibly damaging 0.88
R5434:Zfhx3 UTSW 8 109,519,031 (GRCm39) missense probably damaging 0.99
R5445:Zfhx3 UTSW 8 109,682,842 (GRCm39) missense unknown
R5541:Zfhx3 UTSW 8 109,675,583 (GRCm39) missense probably damaging 0.99
R5571:Zfhx3 UTSW 8 109,682,623 (GRCm39) missense unknown
R5700:Zfhx3 UTSW 8 109,660,499 (GRCm39) missense probably damaging 1.00
R5754:Zfhx3 UTSW 8 109,526,964 (GRCm39) missense probably damaging 0.99
R5867:Zfhx3 UTSW 8 109,520,078 (GRCm39) missense probably damaging 1.00
R5905:Zfhx3 UTSW 8 109,520,135 (GRCm39) missense probably damaging 1.00
R5922:Zfhx3 UTSW 8 109,673,330 (GRCm39) missense probably damaging 1.00
R5972:Zfhx3 UTSW 8 109,677,483 (GRCm39) missense possibly damaging 0.91
R6020:Zfhx3 UTSW 8 109,519,159 (GRCm39) missense probably damaging 1.00
R6028:Zfhx3 UTSW 8 109,520,135 (GRCm39) missense probably damaging 1.00
R6113:Zfhx3 UTSW 8 109,674,053 (GRCm39) missense probably benign 0.04
R6253:Zfhx3 UTSW 8 109,682,020 (GRCm39) missense possibly damaging 0.96
R6356:Zfhx3 UTSW 8 109,673,251 (GRCm39) missense probably damaging 1.00
R6800:Zfhx3 UTSW 8 109,676,149 (GRCm39) missense probably benign 0.20
R6829:Zfhx3 UTSW 8 109,676,915 (GRCm39) missense probably damaging 0.98
R6872:Zfhx3 UTSW 8 109,527,273 (GRCm39) missense probably damaging 1.00
R6873:Zfhx3 UTSW 8 109,527,273 (GRCm39) missense probably damaging 1.00
R6919:Zfhx3 UTSW 8 109,527,160 (GRCm39) missense probably damaging 1.00
R6921:Zfhx3 UTSW 8 109,678,024 (GRCm39) missense possibly damaging 0.53
R6925:Zfhx3 UTSW 8 109,683,453 (GRCm39) missense unknown
R6927:Zfhx3 UTSW 8 109,683,453 (GRCm39) missense unknown
R7152:Zfhx3 UTSW 8 109,674,839 (GRCm39) missense possibly damaging 0.94
R7169:Zfhx3 UTSW 8 109,678,030 (GRCm39) missense possibly damaging 0.86
R7214:Zfhx3 UTSW 8 109,675,493 (GRCm39) missense probably damaging 0.98
R7378:Zfhx3 UTSW 8 109,519,880 (GRCm39) missense probably damaging 0.99
R7391:Zfhx3 UTSW 8 109,674,475 (GRCm39) missense probably damaging 0.96
R7442:Zfhx3 UTSW 8 109,519,468 (GRCm39) missense probably damaging 0.97
R7636:Zfhx3 UTSW 8 109,673,441 (GRCm39) missense probably benign 0.25
R7649:Zfhx3 UTSW 8 109,678,276 (GRCm39) missense probably benign 0.18
R7699:Zfhx3 UTSW 8 109,677,754 (GRCm39) missense probably benign 0.18
R7728:Zfhx3 UTSW 8 109,678,201 (GRCm39) missense probably benign 0.01
R7780:Zfhx3 UTSW 8 109,678,283 (GRCm39) missense possibly damaging 0.53
R7904:Zfhx3 UTSW 8 109,677,695 (GRCm39) missense probably damaging 0.98
R8032:Zfhx3 UTSW 8 109,677,854 (GRCm39) missense possibly damaging 0.51
R8158:Zfhx3 UTSW 8 109,675,353 (GRCm39) missense possibly damaging 0.82
R8163:Zfhx3 UTSW 8 109,675,925 (GRCm39) missense probably damaging 1.00
R8215:Zfhx3 UTSW 8 109,677,349 (GRCm39) missense probably benign
R8217:Zfhx3 UTSW 8 109,677,349 (GRCm39) missense probably benign
R8218:Zfhx3 UTSW 8 109,677,349 (GRCm39) missense probably benign
R8369:Zfhx3 UTSW 8 109,583,448 (GRCm39) missense possibly damaging 0.82
R8424:Zfhx3 UTSW 8 109,583,385 (GRCm39) missense probably damaging 0.98
R8482:Zfhx3 UTSW 8 109,674,511 (GRCm39) missense probably benign 0.02
R8504:Zfhx3 UTSW 8 109,583,549 (GRCm39) missense possibly damaging 0.95
R8871:Zfhx3 UTSW 8 109,676,867 (GRCm39) missense possibly damaging 0.85
R9144:Zfhx3 UTSW 8 109,676,794 (GRCm39) missense possibly damaging 0.53
R9202:Zfhx3 UTSW 8 109,677,920 (GRCm39) missense possibly damaging 0.92
R9213:Zfhx3 UTSW 8 109,676,756 (GRCm39) missense probably benign 0.18
R9218:Zfhx3 UTSW 8 109,520,501 (GRCm39) missense probably benign 0.17
R9370:Zfhx3 UTSW 8 109,521,340 (GRCm39) missense probably damaging 1.00
R9422:Zfhx3 UTSW 8 109,430,850 (GRCm39) start gained probably benign
R9530:Zfhx3 UTSW 8 109,527,010 (GRCm39) missense probably damaging 1.00
RF027:Zfhx3 UTSW 8 109,682,730 (GRCm39) small insertion probably benign
RF028:Zfhx3 UTSW 8 109,682,728 (GRCm39) small insertion probably benign
RF029:Zfhx3 UTSW 8 109,682,724 (GRCm39) small insertion probably benign
RF031:Zfhx3 UTSW 8 109,682,730 (GRCm39) small insertion probably benign
RF032:Zfhx3 UTSW 8 109,682,724 (GRCm39) small insertion probably benign
RF037:Zfhx3 UTSW 8 109,682,730 (GRCm39) nonsense probably null
RF038:Zfhx3 UTSW 8 109,682,733 (GRCm39) small insertion probably benign
RF040:Zfhx3 UTSW 8 109,682,733 (GRCm39) small insertion probably benign
RF042:Zfhx3 UTSW 8 109,682,730 (GRCm39) small insertion probably benign
RF042:Zfhx3 UTSW 8 109,682,720 (GRCm39) small insertion probably benign
RF054:Zfhx3 UTSW 8 109,682,728 (GRCm39) small insertion probably benign
RF060:Zfhx3 UTSW 8 109,682,720 (GRCm39) small insertion probably benign
X0019:Zfhx3 UTSW 8 109,678,285 (GRCm39) missense probably benign 0.00
X0026:Zfhx3 UTSW 8 109,675,777 (GRCm39) missense probably damaging 1.00
Z1088:Zfhx3 UTSW 8 109,677,989 (GRCm39) missense possibly damaging 0.72
Z1176:Zfhx3 UTSW 8 109,527,081 (GRCm39) missense probably damaging 1.00
Z1176:Zfhx3 UTSW 8 109,520,555 (GRCm39) missense probably benign 0.09
Posted On 2015-04-16