Mutagenetix > Incidental Mutation

Incidental Mutation 'IGL02650:Suco'

302124

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Suco

Ensembl Gene

ENSMUSG00000040297

Gene Name

SUN domain containing ossification factor

Synonyms

AI848100, osteopotentia, Opt

Accession Numbers

Essential gene?

Possibly essential (E-score: 0.557) question?

Stock #

IGL02650

Quality Score

Status

Chromosome

Chromosomal Location

161643683-161704251 bp(-) (GRCm39)

Type of Mutation

splice site

DNA Base Change (assembly)

C to A at 161676322 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Gene Model

predicted gene model for transcript(s): [ENSMUST00000048377]

AlphaFold

no structure available at present

Predicted Effect

probably benign
Transcript: ENSMUST00000048377

SMART Domains

Protein: ENSMUSP00000044815
Gene: ENSMUSG00000040297

Domain	Start	End	E-Value	Type
signal peptide	1	29	N/A	INTRINSIC
low complexity region	32	41	N/A	INTRINSIC
low complexity region	117	145	N/A	INTRINSIC
low complexity region	208	224	N/A	INTRINSIC
low complexity region	272	284	N/A	INTRINSIC
Pfam:Sad1_UNC	325	455	9e-43	PFAM
low complexity region	665	683	N/A	INTRINSIC
low complexity region	745	758	N/A	INTRINSIC
coiled coil region	933	1009	N/A	INTRINSIC
low complexity region	1014	1030	N/A	INTRINSIC
low complexity region	1105	1119	N/A	INTRINSIC
low complexity region	1163	1176	N/A	INTRINSIC

Predicted Effect

probably benign
Transcript: ENSMUST00000191975

Predicted Effect

probably benign
Transcript: ENSMUST00000192570

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000194106

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000194388

Coding Region Coverage

Validation Efficiency

MGI Phenotype

PHENOTYPE: Mice homozygous for a mutation in this gene display background strain-dependent neonatal and postnatal lethality, and impaired osteoblast differentiation resulting in impaired bone formation, brittle bones, and impaired fracture repair. [provided by MGI curators]

Allele List at MGI

Other mutations in this stock

Total: 36 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
4932414N04Rik	A	G	2: 68,571,881 (GRCm39)	T586A	probably benign	Het
Acads	G	T	5: 115,250,874 (GRCm39)	T141N	probably benign	Het
Ankmy1	C	T	1: 92,808,745 (GRCm39)	R721H	probably damaging	Het
Appl1	A	G	14: 26,672,665 (GRCm39)	V236A	possibly damaging	Het
Arhgef5	C	T	6: 43,249,869 (GRCm39)	Q207*	probably null	Het
Atp2a3	C	A	11: 72,866,165 (GRCm39)	H262N	probably benign	Het
Atp6v0a2	G	T	5: 124,789,426 (GRCm39)		probably benign	Het
Cenpf	T	C	1: 189,384,670 (GRCm39)	K2537E	possibly damaging	Het
Cox7a1	A	T	7: 29,884,562 (GRCm39)	E32V	possibly damaging	Het
Dis3	A	T	14: 99,336,221 (GRCm39)	M95K	probably benign	Het
Dnah5	A	T	15: 28,289,193 (GRCm39)		probably benign	Het
Dock10	T	A	1: 80,551,840 (GRCm39)	Y665F	probably damaging	Het
Dynlt5	C	A	4: 102,845,803 (GRCm39)	Q12K	probably benign	Het
Ghsr	A	T	3: 27,429,004 (GRCm39)	Q343L	probably benign	Het
Gm3252	T	A	14: 4,746,353 (GRCm38)	V215E	probably damaging	Het
Gm9979	A	G	13: 40,859,225 (GRCm39)		noncoding transcript	Het
Grik2	A	T	10: 48,977,331 (GRCm39)	M867K	probably benign	Het
Grm7	A	G	6: 111,335,919 (GRCm39)	T777A	probably damaging	Het
Hc	T	A	2: 34,890,886 (GRCm39)	Q1310L	possibly damaging	Het
Ifi44	A	G	3: 151,451,492 (GRCm39)	F205L	probably damaging	Het
Igkv4-86	T	C	6: 68,887,617 (GRCm39)	I40V	probably benign	Het
Jag1	T	C	2: 136,957,505 (GRCm39)	D69G	possibly damaging	Het
Lrch1	T	C	14: 75,051,138 (GRCm39)	D333G	probably damaging	Het
Mapre3	T	A	5: 31,022,053 (GRCm39)	I187N	probably damaging	Het
Myo15b	T	C	11: 115,777,337 (GRCm39)		probably null	Het
Nanos2	C	T	7: 18,721,794 (GRCm39)	P89S	probably damaging	Het
Or4c109	T	A	2: 88,818,424 (GRCm39)	M41L	probably benign	Het
Parp16	G	A	9: 65,141,098 (GRCm39)	V223I	probably damaging	Het
Rnf123	A	G	9: 107,946,947 (GRCm39)	M231T	probably benign	Het
Synj1	G	T	16: 90,773,584 (GRCm39)	T459N	probably benign	Het
Taf4b	C	T	18: 14,975,040 (GRCm39)	Q732*	probably null	Het
Tas2r102	A	G	6: 132,739,173 (GRCm39)	N27S	probably null	Het
Tll1	C	T	8: 64,500,031 (GRCm39)		probably benign	Het
Vmn1r168	A	G	7: 23,240,916 (GRCm39)	I258V	probably benign	Het
Vmn2r71	T	A	7: 85,273,535 (GRCm39)	M783K	probably damaging	Het
Vmn2r98	G	A	17: 19,301,223 (GRCm39)	V742I	probably benign	Het

Other mutations in Suco

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL01432:Suco	APN	1	161,661,689 (GRCm39)	missense	probably damaging	1.00
IGL01688:Suco	APN	1	161,691,480 (GRCm39)	splice site	probably null
IGL01794:Suco	APN	1	161,655,294 (GRCm39)	missense	probably benign	0.01
IGL01891:Suco	APN	1	161,666,371 (GRCm39)	missense	probably damaging	1.00
IGL02028:Suco	APN	1	161,684,428 (GRCm39)	missense	possibly damaging	0.95
IGL02102:Suco	APN	1	161,655,274 (GRCm39)	missense	probably damaging	1.00
IGL02351:Suco	APN	1	161,646,195 (GRCm39)	missense	probably benign	0.35
IGL02358:Suco	APN	1	161,646,195 (GRCm39)	missense	probably benign	0.35
IGL02392:Suco	APN	1	161,662,136 (GRCm39)	missense	probably benign	0.11
IGL02638:Suco	APN	1	161,655,256 (GRCm39)	missense	probably damaging	1.00
IGL03106:Suco	APN	1	161,662,049 (GRCm39)	missense	possibly damaging	0.91
IGL03189:Suco	APN	1	161,684,906 (GRCm39)	unclassified	probably benign
IGL03328:Suco	APN	1	161,647,990 (GRCm39)	missense	probably damaging	0.99
girth	UTSW	1	161,655,809 (GRCm39)	missense	possibly damaging	0.86
pleasingly	UTSW	1	161,661,977 (GRCm39)	missense	possibly damaging	0.65
3-1:Suco	UTSW	1	161,649,600 (GRCm39)	intron	probably benign
H8562:Suco	UTSW	1	161,680,420 (GRCm39)	missense	probably damaging	1.00
H8786:Suco	UTSW	1	161,680,420 (GRCm39)	missense	probably damaging	1.00
R0023:Suco	UTSW	1	161,673,154 (GRCm39)	splice site	probably null
R0023:Suco	UTSW	1	161,673,154 (GRCm39)	splice site	probably null
R0179:Suco	UTSW	1	161,703,874 (GRCm39)	splice site	probably benign
R0299:Suco	UTSW	1	161,681,379 (GRCm39)	missense	probably benign
R0418:Suco	UTSW	1	161,662,419 (GRCm39)	missense	probably benign	0.11
R0481:Suco	UTSW	1	161,689,882 (GRCm39)	unclassified	probably benign
R0610:Suco	UTSW	1	161,691,601 (GRCm39)	splice site	probably benign
R0610:Suco	UTSW	1	161,687,072 (GRCm39)	missense	probably benign
R0634:Suco	UTSW	1	161,666,373 (GRCm39)	missense	possibly damaging	0.77
R0645:Suco	UTSW	1	161,661,683 (GRCm39)	missense	probably damaging	1.00
R1276:Suco	UTSW	1	161,685,025 (GRCm39)	missense	probably benign	0.10
R1720:Suco	UTSW	1	161,661,623 (GRCm39)	missense	probably damaging	1.00
R1739:Suco	UTSW	1	161,655,224 (GRCm39)	critical splice donor site	probably null
R1763:Suco	UTSW	1	161,662,518 (GRCm39)	missense	possibly damaging	0.80
R1835:Suco	UTSW	1	161,687,069 (GRCm39)	nonsense	probably null
R1988:Suco	UTSW	1	161,646,380 (GRCm39)	critical splice acceptor site	probably null
R2939:Suco	UTSW	1	161,676,220 (GRCm39)	missense	probably damaging	1.00
R3773:Suco	UTSW	1	161,671,565 (GRCm39)	splice site	probably null
R3882:Suco	UTSW	1	161,662,313 (GRCm39)	missense	probably benign	0.33
R4193:Suco	UTSW	1	161,691,528 (GRCm39)	missense	probably benign	0.32
R4367:Suco	UTSW	1	161,674,799 (GRCm39)	missense	probably damaging	1.00
R4397:Suco	UTSW	1	161,672,421 (GRCm39)	missense	probably damaging	1.00
R4846:Suco	UTSW	1	161,661,977 (GRCm39)	missense	possibly damaging	0.65
R4851:Suco	UTSW	1	161,661,761 (GRCm39)	missense	probably damaging	1.00
R5224:Suco	UTSW	1	161,662,274 (GRCm39)	missense	probably benign	0.06
R5329:Suco	UTSW	1	161,660,999 (GRCm39)	missense	probably damaging	0.99
R6133:Suco	UTSW	1	161,662,752 (GRCm39)	nonsense	probably null
R6632:Suco	UTSW	1	161,655,809 (GRCm39)	missense	possibly damaging	0.86
R6643:Suco	UTSW	1	161,687,001 (GRCm39)	missense	possibly damaging	0.71
R7378:Suco	UTSW	1	161,689,780 (GRCm39)	missense	possibly damaging	0.76
R7405:Suco	UTSW	1	161,655,783 (GRCm39)	missense	possibly damaging	0.65
R7509:Suco	UTSW	1	161,672,903 (GRCm39)	missense	probably damaging	1.00
R7838:Suco	UTSW	1	161,656,890 (GRCm39)	missense	probably benign	0.07
R7867:Suco	UTSW	1	161,665,365 (GRCm39)	missense	possibly damaging	0.77
R7895:Suco	UTSW	1	161,672,937 (GRCm39)	splice site	probably null
R8440:Suco	UTSW	1	161,679,907 (GRCm39)	missense	probably damaging	1.00
R8453:Suco	UTSW	1	161,650,586 (GRCm39)	intron	probably benign
R8781:Suco	UTSW	1	161,645,951 (GRCm39)	missense	probably damaging	1.00
R8798:Suco	UTSW	1	161,648,004 (GRCm39)	missense	probably damaging	1.00
R9292:Suco	UTSW	1	161,671,574 (GRCm39)	missense	probably damaging	1.00
R9310:Suco	UTSW	1	161,684,427 (GRCm39)	missense	probably damaging	1.00
R9380:Suco	UTSW	1	161,646,074 (GRCm39)	missense	possibly damaging	0.61
R9411:Suco	UTSW	1	161,666,356 (GRCm39)	missense	probably damaging	0.99
R9542:Suco	UTSW	1	161,661,668 (GRCm39)	missense	probably damaging	1.00

Posted On

2015-04-16