Mutagenetix > Incidental Mutation

Incidental Mutation 'IGL02652:Vmn2r6'

302199

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Vmn2r6

Ensembl Gene

ENSMUSG00000090581

Gene Name

vomeronasal 2, receptor 6

Synonyms

EG667069, EG620718

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.198) question?

Stock #

IGL02652

Quality Score

Status

Chromosome

Chromosomal Location

64444916-64472855 bp(-) (GRCm39)

Type of Mutation

missense

DNA Base Change (assembly)

T to C at 64463749 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Threonine to Alanine at position 362 (T362A)

Ref Sequence

ENSEMBL: ENSMUSP00000135148 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000165012] [ENSMUST00000176481]

AlphaFold

H3BK29

Predicted Effect

probably benign
Transcript: ENSMUST00000165012
AA Change: T273A

PolyPhen 2 Score 0.084 (Sensitivity: 0.93; Specificity: 0.85)

SMART Domains

Protein: ENSMUSP00000131831
Gene: ENSMUSG00000090581
AA Change: T273A

Domain	Start	End	E-Value	Type
Pfam:ANF_receptor	1	416	1.4e-72	PFAM
Pfam:Peripla_BP_6	58	244	1.2e-10	PFAM
Pfam:NCD3G	458	511	1.8e-17	PFAM
Pfam:7tm_3	542	779	3.9e-76	PFAM

Predicted Effect

probably benign
Transcript: ENSMUST00000176481
AA Change: T362A

PolyPhen 2 Score 0.243 (Sensitivity: 0.91; Specificity: 0.88)

SMART Domains

Protein: ENSMUSP00000135148
Gene: ENSMUSG00000090581
AA Change: T362A

Domain	Start	End	E-Value	Type
signal peptide	1	22	N/A	INTRINSIC
Pfam:ANF_receptor	88	505	9.8e-77	PFAM
Pfam:Peripla_BP_6	142	331	3.4e-10	PFAM
Pfam:NCD3G	547	600	5.4e-17	PFAM
Pfam:7tm_3	633	867	3.9e-47	PFAM

Coding Region Coverage

Validation Efficiency

Allele List at MGI

Other mutations in this stock

Total: 41 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Arhgap28	A	T	17: 68,191,795 (GRCm39)	D139E	probably benign	Het
Asph	C	T	4: 9,529,984 (GRCm39)	V347I	probably benign	Het
Ccdc138	A	T	10: 58,348,901 (GRCm39)	D149V	probably benign	Het
Cep192	A	G	18: 67,991,921 (GRCm39)		probably benign	Het
Cnnm2	G	A	19: 46,751,650 (GRCm39)	R480Q	probably damaging	Het
Col24a1	C	A	3: 145,198,056 (GRCm39)	S1321*	probably null	Het
Cops6	T	G	5: 138,159,700 (GRCm39)		probably null	Het
Crim1	G	A	17: 78,623,106 (GRCm39)	A435T	probably damaging	Het
Cttn	G	T	7: 143,995,468 (GRCm39)	Q382K	probably benign	Het
Dhx38	A	G	8: 110,282,761 (GRCm39)	L635P	probably damaging	Het
Dmtf1	T	A	5: 9,171,853 (GRCm39)	T458S	probably benign	Het
Dnah5	T	C	15: 28,366,333 (GRCm39)	F2682S	probably damaging	Het
Dnah6	T	A	6: 73,072,087 (GRCm39)	Q2413L	probably damaging	Het
Dock10	T	C	1: 80,570,561 (GRCm39)		probably null	Het
Engase	C	T	11: 118,369,776 (GRCm39)	P63S	probably damaging	Het
Grik4	A	G	9: 42,586,573 (GRCm39)	V94A	possibly damaging	Het
Heatr6	T	C	11: 83,660,558 (GRCm39)	V566A	probably damaging	Het
Hydin	A	C	8: 111,316,154 (GRCm39)	T4349P	possibly damaging	Het
Inpp4b	G	A	8: 82,497,429 (GRCm39)		probably benign	Het
Mertk	A	G	2: 128,643,190 (GRCm39)	E863G	probably benign	Het
Muc19	T	A	15: 91,762,009 (GRCm39)		noncoding transcript	Het
Myo9a	T	A	9: 59,771,211 (GRCm39)	F928I	probably damaging	Het
Nyap2	T	C	1: 81,219,435 (GRCm39)	Y486H	probably damaging	Het
Oas1e	T	C	5: 120,933,470 (GRCm39)	R32G	probably damaging	Het
Or14j2	A	T	17: 37,885,836 (GRCm39)	Y159*	probably null	Het
Or4k48	A	G	2: 111,475,839 (GRCm39)	F168L	probably benign	Het
Osbpl6	G	A	2: 76,423,798 (GRCm39)	R848Q	probably damaging	Het
Piezo2	G	A	18: 63,157,546 (GRCm39)	T2388I	probably damaging	Het
Prkdc	A	G	16: 15,600,951 (GRCm39)	T2871A	probably benign	Het
Ptpn12	T	C	5: 21,207,435 (GRCm39)	K308E	probably benign	Het
Rgsl1	A	G	1: 153,701,236 (GRCm39)	L441P	probably damaging	Het
Rictor	T	C	15: 6,805,668 (GRCm39)		probably null	Het
Scn2a	T	A	2: 65,532,382 (GRCm39)	S665T	possibly damaging	Het
Scn8a	A	G	15: 100,911,357 (GRCm39)	I926V	probably damaging	Het
Snrpg	T	C	6: 86,353,510 (GRCm39)	I30T	probably damaging	Het
Spryd3	A	T	15: 102,027,425 (GRCm39)		probably null	Het
Svil	A	G	18: 5,114,531 (GRCm39)	D2036G	probably damaging	Het
Synj2	A	T	17: 6,067,868 (GRCm39)	I551F	probably damaging	Het
Tiam2	A	T	17: 3,489,971 (GRCm39)		probably benign	Het
Tmem132b	T	C	5: 125,864,639 (GRCm39)	F915S	probably damaging	Het
Try5	C	A	6: 41,288,342 (GRCm39)	V204L	probably benign	Het

Other mutations in Vmn2r6

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL01547:Vmn2r6	APN	3	64,445,525 (GRCm39)	missense	probably damaging	1.00
IGL01968:Vmn2r6	APN	3	64,463,766 (GRCm39)	missense	possibly damaging	0.94
IGL02009:Vmn2r6	APN	3	64,445,323 (GRCm39)	missense	possibly damaging	0.61
IGL02039:Vmn2r6	APN	3	64,463,610 (GRCm39)	missense	probably damaging	1.00
IGL02737:Vmn2r6	APN	3	64,463,911 (GRCm39)	missense	possibly damaging	0.55
IGL02808:Vmn2r6	APN	3	64,463,917 (GRCm39)	missense	probably damaging	1.00
IGL03066:Vmn2r6	APN	3	64,472,574 (GRCm39)	missense	probably damaging	0.99
IGL03331:Vmn2r6	APN	3	64,445,428 (GRCm39)	missense	probably damaging	1.00
BB010:Vmn2r6	UTSW	3	64,467,224 (GRCm39)	missense	probably benign	0.02
BB020:Vmn2r6	UTSW	3	64,467,224 (GRCm39)	missense	probably benign	0.02
R0010:Vmn2r6	UTSW	3	64,466,966 (GRCm39)	nonsense	probably null
R0206:Vmn2r6	UTSW	3	64,447,333 (GRCm39)	missense	probably benign
R0206:Vmn2r6	UTSW	3	64,447,333 (GRCm39)	missense	probably benign
R0208:Vmn2r6	UTSW	3	64,447,333 (GRCm39)	missense	probably benign
R0427:Vmn2r6	UTSW	3	64,467,008 (GRCm39)	missense	probably damaging	1.00
R0466:Vmn2r6	UTSW	3	64,463,723 (GRCm39)	missense	probably damaging	1.00
R1018:Vmn2r6	UTSW	3	64,464,261 (GRCm39)	missense	probably benign	0.00
R1104:Vmn2r6	UTSW	3	64,445,487 (GRCm39)	missense	possibly damaging	0.93
R1186:Vmn2r6	UTSW	3	64,472,488 (GRCm39)	missense	probably benign	0.01
R1245:Vmn2r6	UTSW	3	64,464,211 (GRCm39)	missense	possibly damaging	0.53
R1295:Vmn2r6	UTSW	3	64,445,694 (GRCm39)	missense	probably damaging	1.00
R1473:Vmn2r6	UTSW	3	64,445,579 (GRCm39)	nonsense	probably null
R1498:Vmn2r6	UTSW	3	64,463,890 (GRCm39)	missense	probably damaging	1.00
R1925:Vmn2r6	UTSW	3	64,463,698 (GRCm39)	missense	possibly damaging	0.87
R2044:Vmn2r6	UTSW	3	64,445,262 (GRCm39)	missense	probably damaging	0.96
R2069:Vmn2r6	UTSW	3	64,463,519 (GRCm39)	missense	possibly damaging	0.89
R2253:Vmn2r6	UTSW	3	64,467,139 (GRCm39)	missense	probably damaging	1.00
R2261:Vmn2r6	UTSW	3	64,464,090 (GRCm39)	missense	probably benign	0.24
R2262:Vmn2r6	UTSW	3	64,464,090 (GRCm39)	missense	probably benign	0.24
R2350:Vmn2r6	UTSW	3	64,463,773 (GRCm39)	missense	probably benign	0.01
R2680:Vmn2r6	UTSW	3	64,445,707 (GRCm39)	missense	possibly damaging	0.91
R2846:Vmn2r6	UTSW	3	64,464,211 (GRCm39)	missense	possibly damaging	0.53
R2860:Vmn2r6	UTSW	3	64,454,760 (GRCm39)	missense	probably benign	0.00
R2861:Vmn2r6	UTSW	3	64,454,760 (GRCm39)	missense	probably benign	0.00
R3766:Vmn2r6	UTSW	3	64,463,929 (GRCm39)	missense	probably benign	0.19
R3870:Vmn2r6	UTSW	3	64,464,042 (GRCm39)	missense	probably damaging	0.96
R4018:Vmn2r6	UTSW	3	64,463,893 (GRCm39)	missense	probably benign	0.05
R4024:Vmn2r6	UTSW	3	64,445,671 (GRCm39)	missense	possibly damaging	0.73
R4026:Vmn2r6	UTSW	3	64,445,671 (GRCm39)	missense	possibly damaging	0.73
R4227:Vmn2r6	UTSW	3	64,445,369 (GRCm39)	missense	probably damaging	0.99
R4526:Vmn2r6	UTSW	3	64,445,145 (GRCm39)	missense	probably benign	0.32
R4570:Vmn2r6	UTSW	3	64,467,068 (GRCm39)	missense	probably benign	0.31
R4894:Vmn2r6	UTSW	3	64,454,829 (GRCm39)	missense	probably benign
R4934:Vmn2r6	UTSW	3	64,463,766 (GRCm39)	missense	probably damaging	0.99
R5057:Vmn2r6	UTSW	3	64,445,207 (GRCm39)	missense	probably damaging	1.00
R5059:Vmn2r6	UTSW	3	64,445,044 (GRCm39)	missense	possibly damaging	0.89
R5148:Vmn2r6	UTSW	3	64,464,015 (GRCm39)	missense	probably damaging	0.99
R5155:Vmn2r6	UTSW	3	64,445,935 (GRCm39)	missense	probably benign	0.44
R5179:Vmn2r6	UTSW	3	64,445,411 (GRCm39)	missense	probably benign	0.00
R5256:Vmn2r6	UTSW	3	64,464,263 (GRCm39)	missense	probably benign	0.33
R5861:Vmn2r6	UTSW	3	64,463,454 (GRCm39)	missense	probably benign	0.00
R5950:Vmn2r6	UTSW	3	64,472,652 (GRCm39)	missense	probably benign	0.05
R6081:Vmn2r6	UTSW	3	64,463,953 (GRCm39)	missense	probably benign	0.25
R6173:Vmn2r6	UTSW	3	64,467,176 (GRCm39)	missense	probably damaging	1.00
R6190:Vmn2r6	UTSW	3	64,445,424 (GRCm39)	missense	probably benign	0.04
R6240:Vmn2r6	UTSW	3	64,464,226 (GRCm39)	missense	probably damaging	1.00
R6433:Vmn2r6	UTSW	3	64,454,801 (GRCm39)	nonsense	probably null
R6645:Vmn2r6	UTSW	3	64,464,297 (GRCm39)	missense	probably damaging	1.00
R6791:Vmn2r6	UTSW	3	64,445,580 (GRCm39)	missense	probably damaging	1.00
R7265:Vmn2r6	UTSW	3	64,464,195 (GRCm39)	missense	probably benign	0.00
R7503:Vmn2r6	UTSW	3	64,447,372 (GRCm39)	nonsense	probably null
R7562:Vmn2r6	UTSW	3	64,463,941 (GRCm39)	missense	probably benign	0.00
R7584:Vmn2r6	UTSW	3	64,472,683 (GRCm39)	missense	probably benign	0.07
R7611:Vmn2r6	UTSW	3	64,472,563 (GRCm39)	missense	probably damaging	0.98
R7759:Vmn2r6	UTSW	3	64,463,991 (GRCm39)	missense	probably damaging	1.00
R7834:Vmn2r6	UTSW	3	64,445,443 (GRCm39)	missense	probably damaging	1.00
R7933:Vmn2r6	UTSW	3	64,467,224 (GRCm39)	missense	probably benign	0.02
R7982:Vmn2r6	UTSW	3	64,467,241 (GRCm39)	missense	probably damaging	1.00
R8024:Vmn2r6	UTSW	3	64,467,245 (GRCm39)	missense	probably benign	0.40
R8074:Vmn2r6	UTSW	3	64,455,064 (GRCm39)	intron	probably benign
R8169:Vmn2r6	UTSW	3	64,447,310 (GRCm39)	missense	probably benign	0.01
R8337:Vmn2r6	UTSW	3	64,463,526 (GRCm39)	nonsense	probably null
R8736:Vmn2r6	UTSW	3	64,467,221 (GRCm39)	missense	probably damaging	1.00
R8962:Vmn2r6	UTSW	3	64,463,576 (GRCm39)	missense	probably damaging	1.00
R9139:Vmn2r6	UTSW	3	64,464,277 (GRCm39)	missense	probably benign	0.12
R9206:Vmn2r6	UTSW	3	64,467,032 (GRCm39)	missense	probably damaging	0.97
R9295:Vmn2r6	UTSW	3	64,463,484 (GRCm39)	missense	probably benign	0.00
R9332:Vmn2r6	UTSW	3	64,454,671 (GRCm39)	missense	probably benign	0.01
R9616:Vmn2r6	UTSW	3	64,445,724 (GRCm39)	missense	probably damaging	1.00
R9663:Vmn2r6	UTSW	3	64,463,549 (GRCm39)	missense	possibly damaging	0.90
R9685:Vmn2r6	UTSW	3	64,464,081 (GRCm39)	missense	probably benign	0.19
X0020:Vmn2r6	UTSW	3	64,445,871 (GRCm39)	missense	probably benign
X0066:Vmn2r6	UTSW	3	64,454,799 (GRCm39)	missense	probably damaging	1.00
Z1176:Vmn2r6	UTSW	3	64,463,746 (GRCm39)	missense	probably damaging	0.98

Posted On

2015-04-16