Incidental Mutation 'IGL02653:Ncapg2'
ID 302254
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Ncapg2
Ensembl Gene ENSMUSG00000042029
Gene Name non-SMC condensin II complex, subunit G2
Synonyms 5830426I05Rik, Mtb, mCAP-G2, Luzp5
Accession Numbers
Essential gene? Essential (E-score: 1.000) question?
Stock # IGL02653
Quality Score
Status
Chromosome 12
Chromosomal Location 116368969-116427152 bp(+) (GRCm39)
Type of Mutation critical splice donor site (2 bp from exon)
DNA Base Change (assembly) T to A at 116389526 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change
Ref Sequence ENSEMBL: ENSMUSP00000081889 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000084828]
AlphaFold Q6DFV1
Predicted Effect probably null
Transcript: ENSMUST00000084828
SMART Domains Protein: ENSMUSP00000081889
Gene: ENSMUSG00000042029

DomainStartEndE-ValueType
low complexity region 14 25 N/A INTRINSIC
Pfam:Condensin2nSMC 212 361 7.2e-62 PFAM
Coding Region Coverage
Validation Efficiency
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a protein that belongs to the Condensin2nSMC family of proteins. The encoded protein is a regulatory subunit of the condensin II complex which, along with the condensin I complex, plays a role in chromosome assembly and segregation during mitosis. A similar protein in mouse is required for early development of the embryo. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Aug 2013]
PHENOTYPE: Homozygous null embryos exhibit impaired inner cell mass expansion and die shortly after implantation and prior to gastrulation and blood cell development. [provided by MGI curators]
Allele List at MGI
Other mutations in this stock
Total: 36 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Abcc8 T C 7: 45,765,191 (GRCm39) probably benign Het
Alox5 T A 6: 116,392,438 (GRCm39) H361L probably benign Het
Arid2 A G 15: 96,185,583 (GRCm39) N3S probably damaging Het
Atp1a4 T A 1: 172,078,973 (GRCm39) I182F possibly damaging Het
Cby2 T C 14: 75,820,597 (GRCm39) D385G probably damaging Het
Ctnna2 A T 6: 76,957,760 (GRCm39) D496E probably benign Het
Cyp3a25 G T 5: 145,939,920 (GRCm39) S29Y possibly damaging Het
Dglucy G A 12: 100,837,690 (GRCm39) G611D probably benign Het
Efcab5 T C 11: 77,022,848 (GRCm39) K622E probably damaging Het
Esyt1 T A 10: 128,346,877 (GRCm39) I1071L probably benign Het
Fbn2 T C 18: 58,209,777 (GRCm39) K1035E probably benign Het
Frem1 T G 4: 82,877,571 (GRCm39) E1335D probably benign Het
Gm5900 A G 7: 104,599,340 (GRCm39) noncoding transcript Het
Ikbke T A 1: 131,199,572 (GRCm39) Q283L possibly damaging Het
Lepr A T 4: 101,622,141 (GRCm39) I358F probably benign Het
Lnpk A G 2: 74,378,392 (GRCm39) V123A probably damaging Het
Mis12 A G 11: 70,916,357 (GRCm39) K130R probably damaging Het
Npy6r T C 18: 44,409,694 (GRCm39) *372Q probably null Het
Polr3d T C 14: 70,677,557 (GRCm39) D273G probably damaging Het
Ppp2r3d A G 9: 101,088,892 (GRCm39) V477A probably benign Het
Prpf19 T A 19: 10,880,328 (GRCm39) probably benign Het
Ptgr3 T C 18: 84,113,443 (GRCm39) V373A possibly damaging Het
Pwwp2a A G 11: 43,596,862 (GRCm39) T676A possibly damaging Het
Ralgapb T A 2: 158,285,229 (GRCm39) I242N probably damaging Het
Scn3a A T 2: 65,291,531 (GRCm39) S1738R probably damaging Het
Snapc1 C A 12: 74,029,261 (GRCm39) P348Q probably benign Het
Tbc1d7 T C 13: 43,318,874 (GRCm39) I88V probably benign Het
Tnks2 T C 19: 36,849,851 (GRCm39) S220P probably damaging Het
Trim56 A T 5: 137,141,760 (GRCm39) S585R probably damaging Het
Trpm2 T G 10: 77,748,503 (GRCm39) E1389A probably benign Het
Tspear T A 10: 77,542,799 (GRCm39) probably benign Het
Vmn1r180 T C 7: 23,652,500 (GRCm39) I221T probably damaging Het
Vmn1r204 A C 13: 22,740,800 (GRCm39) I144L probably benign Het
Vmn2r20 A T 6: 123,362,324 (GRCm39) I820N probably damaging Het
Vwa3b T A 1: 37,214,646 (GRCm39) probably benign Het
Wnt1 G A 15: 98,690,336 (GRCm39) G222R probably damaging Het
Other mutations in Ncapg2
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01410:Ncapg2 APN 12 116,388,270 (GRCm39) missense possibly damaging 0.54
IGL01694:Ncapg2 APN 12 116,370,850 (GRCm39) utr 5 prime probably benign
IGL01724:Ncapg2 APN 12 116,390,331 (GRCm39) missense probably damaging 1.00
IGL01792:Ncapg2 APN 12 116,389,438 (GRCm39) missense probably damaging 0.99
IGL02098:Ncapg2 APN 12 116,407,952 (GRCm39) missense possibly damaging 0.59
IGL02136:Ncapg2 APN 12 116,424,203 (GRCm39) missense probably benign
IGL02409:Ncapg2 APN 12 116,384,337 (GRCm39) missense probably damaging 1.00
IGL02580:Ncapg2 APN 12 116,384,309 (GRCm39) missense probably damaging 1.00
IGL03073:Ncapg2 APN 12 116,415,894 (GRCm39) missense probably benign 0.01
IGL03114:Ncapg2 APN 12 116,415,993 (GRCm39) splice site probably benign
IGL03199:Ncapg2 APN 12 116,382,856 (GRCm39) missense probably damaging 1.00
IGL03328:Ncapg2 APN 12 116,403,677 (GRCm39) missense possibly damaging 0.90
P0033:Ncapg2 UTSW 12 116,402,255 (GRCm39) missense probably benign 0.03
R0008:Ncapg2 UTSW 12 116,393,455 (GRCm39) missense probably damaging 1.00
R0194:Ncapg2 UTSW 12 116,384,303 (GRCm39) splice site probably null
R0379:Ncapg2 UTSW 12 116,406,695 (GRCm39) missense probably damaging 1.00
R0568:Ncapg2 UTSW 12 116,386,835 (GRCm39) missense probably damaging 1.00
R0771:Ncapg2 UTSW 12 116,376,779 (GRCm39) nonsense probably null
R1016:Ncapg2 UTSW 12 116,402,295 (GRCm39) missense probably damaging 1.00
R1507:Ncapg2 UTSW 12 116,424,186 (GRCm39) missense probably benign 0.00
R1524:Ncapg2 UTSW 12 116,398,198 (GRCm39) splice site probably benign
R1596:Ncapg2 UTSW 12 116,382,856 (GRCm39) missense probably damaging 1.00
R1635:Ncapg2 UTSW 12 116,398,305 (GRCm39) frame shift probably null
R1752:Ncapg2 UTSW 12 116,390,338 (GRCm39) missense probably damaging 1.00
R2164:Ncapg2 UTSW 12 116,414,095 (GRCm39) splice site probably null
R2266:Ncapg2 UTSW 12 116,393,296 (GRCm39) missense probably damaging 1.00
R2366:Ncapg2 UTSW 12 116,384,349 (GRCm39) nonsense probably null
R2924:Ncapg2 UTSW 12 116,402,349 (GRCm39) missense probably benign 0.03
R2925:Ncapg2 UTSW 12 116,402,349 (GRCm39) missense probably benign 0.03
R3828:Ncapg2 UTSW 12 116,370,938 (GRCm39) splice site probably benign
R3829:Ncapg2 UTSW 12 116,370,938 (GRCm39) splice site probably benign
R4384:Ncapg2 UTSW 12 116,403,497 (GRCm39) critical splice donor site probably null
R4651:Ncapg2 UTSW 12 116,389,407 (GRCm39) missense probably damaging 1.00
R4701:Ncapg2 UTSW 12 116,404,238 (GRCm39) missense probably benign
R4821:Ncapg2 UTSW 12 116,379,077 (GRCm39) missense probably damaging 0.99
R4845:Ncapg2 UTSW 12 116,404,208 (GRCm39) missense probably damaging 0.96
R5135:Ncapg2 UTSW 12 116,391,406 (GRCm39) missense possibly damaging 0.64
R5294:Ncapg2 UTSW 12 116,391,414 (GRCm39) missense possibly damaging 0.54
R5334:Ncapg2 UTSW 12 116,390,257 (GRCm39) missense probably damaging 1.00
R5588:Ncapg2 UTSW 12 116,376,697 (GRCm39) missense possibly damaging 0.95
R5888:Ncapg2 UTSW 12 116,389,420 (GRCm39) missense possibly damaging 0.84
R5938:Ncapg2 UTSW 12 116,393,277 (GRCm39) missense probably damaging 1.00
R5978:Ncapg2 UTSW 12 116,388,291 (GRCm39) missense possibly damaging 0.68
R6016:Ncapg2 UTSW 12 116,390,227 (GRCm39) missense probably damaging 1.00
R6026:Ncapg2 UTSW 12 116,406,641 (GRCm39) missense possibly damaging 0.73
R6155:Ncapg2 UTSW 12 116,401,631 (GRCm39) missense possibly damaging 0.83
R6509:Ncapg2 UTSW 12 116,391,376 (GRCm39) missense probably damaging 1.00
R6675:Ncapg2 UTSW 12 116,398,281 (GRCm39) missense possibly damaging 0.71
R6912:Ncapg2 UTSW 12 116,390,202 (GRCm39) missense probably benign
R7069:Ncapg2 UTSW 12 116,388,337 (GRCm39) splice site probably null
R7339:Ncapg2 UTSW 12 116,378,454 (GRCm39) missense probably damaging 0.96
R7440:Ncapg2 UTSW 12 116,414,033 (GRCm39) missense possibly damaging 0.89
R7445:Ncapg2 UTSW 12 116,382,888 (GRCm39) missense possibly damaging 0.50
R7704:Ncapg2 UTSW 12 116,382,897 (GRCm39) missense probably damaging 1.00
R8061:Ncapg2 UTSW 12 116,390,197 (GRCm39) missense probably benign
R8132:Ncapg2 UTSW 12 116,407,967 (GRCm39) missense possibly damaging 0.93
R8166:Ncapg2 UTSW 12 116,376,036 (GRCm39) missense probably benign 0.00
R8351:Ncapg2 UTSW 12 116,403,647 (GRCm39) missense possibly damaging 0.80
R8526:Ncapg2 UTSW 12 116,403,679 (GRCm39) missense probably benign 0.00
R8692:Ncapg2 UTSW 12 116,414,049 (GRCm39) missense probably damaging 1.00
R8739:Ncapg2 UTSW 12 116,379,098 (GRCm39) missense possibly damaging 0.75
R8766:Ncapg2 UTSW 12 116,390,356 (GRCm39) missense probably damaging 1.00
R8929:Ncapg2 UTSW 12 116,415,983 (GRCm39) missense probably damaging 1.00
R9046:Ncapg2 UTSW 12 116,376,145 (GRCm39) missense probably benign 0.01
R9187:Ncapg2 UTSW 12 116,402,287 (GRCm39) missense probably damaging 1.00
R9344:Ncapg2 UTSW 12 116,388,273 (GRCm39) missense probably damaging 1.00
R9444:Ncapg2 UTSW 12 116,370,863 (GRCm39) missense probably damaging 1.00
R9580:Ncapg2 UTSW 12 116,424,228 (GRCm39) missense probably damaging 1.00
R9634:Ncapg2 UTSW 12 116,379,077 (GRCm39) missense probably damaging 0.99
R9749:Ncapg2 UTSW 12 116,411,368 (GRCm39) nonsense probably null
X0020:Ncapg2 UTSW 12 116,388,327 (GRCm39) missense probably damaging 1.00
Z1177:Ncapg2 UTSW 12 116,402,225 (GRCm39) missense probably damaging 0.99
Posted On 2015-04-16