Incidental Mutation 'IGL02655:Vmn2r4'
ID 302298
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Vmn2r4
Ensembl Gene ENSMUSG00000092049
Gene Name vomeronasal 2, receptor 4
Synonyms EG637053
Accession Numbers
Essential gene? Probably non essential (E-score: 0.066) question?
Stock # IGL02655
Quality Score
Status
Chromosome 3
Chromosomal Location 64295982-64322741 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to G at 64305886 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Isoleucine to Threonine at position 512 (I512T)
Ref Sequence ENSEMBL: ENSMUSP00000135228 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000170280] [ENSMUST00000175724]
AlphaFold K7N784
Predicted Effect possibly damaging
Transcript: ENSMUST00000170280
AA Change: I423T

PolyPhen 2 Score 0.897 (Sensitivity: 0.82; Specificity: 0.94)
SMART Domains Protein: ENSMUSP00000127513
Gene: ENSMUSG00000092049
AA Change: I423T

DomainStartEndE-ValueType
Pfam:ANF_receptor 1 416 2.7e-72 PFAM
Pfam:Peripla_BP_6 61 240 1.9e-9 PFAM
Pfam:NCD3G 458 511 1.1e-17 PFAM
Pfam:7tm_3 542 779 1.8e-75 PFAM
Predicted Effect probably damaging
Transcript: ENSMUST00000175724
AA Change: I512T

PolyPhen 2 Score 0.967 (Sensitivity: 0.77; Specificity: 0.95)
SMART Domains Protein: ENSMUSP00000135228
Gene: ENSMUSG00000092049
AA Change: I512T

DomainStartEndE-ValueType
signal peptide 1 22 N/A INTRINSIC
Pfam:ANF_receptor 88 505 2.3e-75 PFAM
Pfam:NCD3G 547 600 4.7e-17 PFAM
Pfam:7tm_3 633 867 8.2e-47 PFAM
Coding Region Coverage
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 34 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
4930402F06Rik A T 2: 35,270,498 (GRCm39) S68T possibly damaging Het
4930544G11Rik T G 6: 65,930,074 (GRCm39) V103G probably damaging Het
Adam7 A T 14: 68,754,060 (GRCm39) D346E probably damaging Het
Adamts1 A G 16: 85,599,505 (GRCm39) S32P probably benign Het
Adamtsl2 T C 2: 26,972,542 (GRCm39) probably benign Het
Adgrb2 C A 4: 129,885,972 (GRCm39) Y37* probably null Het
Apba3 A G 10: 81,108,788 (GRCm39) R547G probably benign Het
Ccnd2 C T 6: 127,125,733 (GRCm39) G101D probably damaging Het
Cpm A G 10: 117,519,186 (GRCm39) T365A probably benign Het
Cpt2 A G 4: 107,764,624 (GRCm39) V380A probably damaging Het
Dnah7b A T 1: 46,155,461 (GRCm39) probably benign Het
Enpp1 A C 10: 24,553,872 (GRCm39) D105E probably damaging Het
Ermp1 C A 19: 29,623,610 (GRCm39) E127* probably null Het
Evi5 T C 5: 107,961,446 (GRCm39) K375R probably benign Het
Gm11564 A T 11: 99,705,982 (GRCm39) C149* probably null Het
Golgb1 A T 16: 36,738,442 (GRCm39) E2260D probably damaging Het
Gpc2 T C 5: 138,277,187 (GRCm39) D80G possibly damaging Het
Hsd11b2 A G 8: 106,248,960 (GRCm39) I151V probably benign Het
Knl1 T C 2: 118,901,473 (GRCm39) I1058T possibly damaging Het
Krtap4-8 A T 11: 99,671,454 (GRCm39) probably benign Het
Me1 A G 9: 86,536,780 (GRCm39) probably benign Het
Mki67 C T 7: 135,315,748 (GRCm39) R38H probably damaging Het
Nsmaf A G 4: 6,424,933 (GRCm39) F272L possibly damaging Het
Pcyox1 A T 6: 86,366,326 (GRCm39) V78E probably damaging Het
Pkp1 G T 1: 135,817,511 (GRCm39) T208N probably benign Het
Plagl2 T C 2: 153,074,337 (GRCm39) E188G probably damaging Het
Pramel15 A G 4: 144,099,416 (GRCm39) F450L probably benign Het
Relch G A 1: 105,605,971 (GRCm39) V204M probably damaging Het
Ric1 T A 19: 29,572,851 (GRCm39) S764T probably damaging Het
Sec24a G A 11: 51,625,482 (GRCm39) T247M probably benign Het
Slc25a17 C T 15: 81,207,844 (GRCm39) R248Q probably benign Het
Stk36 C T 1: 74,673,694 (GRCm39) P1068S probably damaging Het
Tcn2 C A 11: 3,876,158 (GRCm39) S90I possibly damaging Het
Tfec C T 6: 16,834,308 (GRCm39) A200T possibly damaging Het
Other mutations in Vmn2r4
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01310:Vmn2r4 APN 3 64,317,200 (GRCm39) splice site probably null
IGL01448:Vmn2r4 APN 3 64,313,816 (GRCm39) missense probably damaging 0.99
IGL01452:Vmn2r4 APN 3 64,313,816 (GRCm39) missense probably damaging 0.99
IGL01454:Vmn2r4 APN 3 64,313,816 (GRCm39) missense probably damaging 0.99
IGL01456:Vmn2r4 APN 3 64,313,816 (GRCm39) missense probably damaging 0.99
IGL01463:Vmn2r4 APN 3 64,313,816 (GRCm39) missense probably damaging 0.99
IGL01467:Vmn2r4 APN 3 64,313,816 (GRCm39) missense probably damaging 0.99
IGL01468:Vmn2r4 APN 3 64,313,816 (GRCm39) missense probably damaging 0.99
IGL01470:Vmn2r4 APN 3 64,313,816 (GRCm39) missense probably damaging 0.99
IGL01476:Vmn2r4 APN 3 64,313,816 (GRCm39) missense probably damaging 0.99
IGL01481:Vmn2r4 APN 3 64,313,816 (GRCm39) missense probably damaging 0.99
IGL01534:Vmn2r4 APN 3 64,313,844 (GRCm39) missense probably damaging 1.00
IGL01636:Vmn2r4 APN 3 64,313,657 (GRCm39) missense probably benign 0.21
IGL01879:Vmn2r4 APN 3 64,298,431 (GRCm39) missense probably damaging 1.00
IGL02147:Vmn2r4 APN 3 64,305,782 (GRCm39) splice site probably benign
IGL02276:Vmn2r4 APN 3 64,313,877 (GRCm39) missense possibly damaging 0.95
IGL02432:Vmn2r4 APN 3 64,313,821 (GRCm39) missense probably benign 0.38
IGL02533:Vmn2r4 APN 3 64,305,840 (GRCm39) nonsense probably null
IGL02666:Vmn2r4 APN 3 64,296,433 (GRCm39) missense probably benign 0.10
IGL02902:Vmn2r4 APN 3 64,314,337 (GRCm39) missense probably benign 0.22
IGL03189:Vmn2r4 APN 3 64,296,589 (GRCm39) missense possibly damaging 0.89
IGL03250:Vmn2r4 APN 3 64,314,063 (GRCm39) missense probably damaging 1.00
IGL03271:Vmn2r4 APN 3 64,305,850 (GRCm39) missense probably benign 0.01
R0310:Vmn2r4 UTSW 3 64,296,855 (GRCm39) nonsense probably null
R0504:Vmn2r4 UTSW 3 64,296,784 (GRCm39) missense probably damaging 1.00
R1546:Vmn2r4 UTSW 3 64,314,309 (GRCm39) missense probably damaging 1.00
R1562:Vmn2r4 UTSW 3 64,296,865 (GRCm39) missense probably damaging 0.98
R1863:Vmn2r4 UTSW 3 64,314,410 (GRCm39) missense probably benign 0.33
R1873:Vmn2r4 UTSW 3 64,298,479 (GRCm39) missense possibly damaging 0.93
R1939:Vmn2r4 UTSW 3 64,305,976 (GRCm39) missense probably benign 0.00
R2103:Vmn2r4 UTSW 3 64,322,704 (GRCm39) missense possibly damaging 0.48
R3083:Vmn2r4 UTSW 3 64,296,788 (GRCm39) missense probably damaging 1.00
R3687:Vmn2r4 UTSW 3 64,296,896 (GRCm39) missense possibly damaging 0.93
R3707:Vmn2r4 UTSW 3 64,296,895 (GRCm39) missense probably damaging 0.99
R3963:Vmn2r4 UTSW 3 64,322,572 (GRCm39) missense probably damaging 0.99
R4428:Vmn2r4 UTSW 3 64,322,590 (GRCm39) missense probably damaging 1.00
R4710:Vmn2r4 UTSW 3 64,317,201 (GRCm39) critical splice donor site probably null
R4737:Vmn2r4 UTSW 3 64,317,384 (GRCm39) missense probably damaging 1.00
R4767:Vmn2r4 UTSW 3 64,298,397 (GRCm39) missense probably damaging 0.99
R4776:Vmn2r4 UTSW 3 64,296,082 (GRCm39) missense probably damaging 0.96
R4834:Vmn2r4 UTSW 3 64,317,484 (GRCm39) missense probably benign 0.40
R4893:Vmn2r4 UTSW 3 64,313,676 (GRCm39) missense probably damaging 0.96
R4908:Vmn2r4 UTSW 3 64,296,476 (GRCm39) missense possibly damaging 0.59
R5049:Vmn2r4 UTSW 3 64,306,019 (GRCm39) splice site probably null
R5092:Vmn2r4 UTSW 3 64,298,373 (GRCm39) missense probably benign 0.01
R5234:Vmn2r4 UTSW 3 64,305,878 (GRCm39) missense possibly damaging 0.88
R5240:Vmn2r4 UTSW 3 64,314,358 (GRCm39) missense possibly damaging 0.53
R5704:Vmn2r4 UTSW 3 64,317,370 (GRCm39) missense probably benign 0.03
R5897:Vmn2r4 UTSW 3 64,322,687 (GRCm39) nonsense probably null
R5907:Vmn2r4 UTSW 3 64,298,487 (GRCm39) missense probably damaging 0.99
R5924:Vmn2r4 UTSW 3 64,296,685 (GRCm39) missense probably damaging 1.00
R6145:Vmn2r4 UTSW 3 64,314,364 (GRCm39) missense probably benign 0.00
R6191:Vmn2r4 UTSW 3 64,322,702 (GRCm39) missense probably benign 0.34
R6192:Vmn2r4 UTSW 3 64,322,699 (GRCm39) missense probably benign 0.00
R6207:Vmn2r4 UTSW 3 64,313,926 (GRCm39) missense probably damaging 1.00
R6457:Vmn2r4 UTSW 3 64,317,378 (GRCm39) missense probably damaging 1.00
R6533:Vmn2r4 UTSW 3 64,322,519 (GRCm39) missense probably benign
R6545:Vmn2r4 UTSW 3 64,313,777 (GRCm39) missense possibly damaging 0.50
R6594:Vmn2r4 UTSW 3 64,296,731 (GRCm39) missense probably damaging 1.00
R7049:Vmn2r4 UTSW 3 64,296,550 (GRCm39) missense probably benign 0.14
R7150:Vmn2r4 UTSW 3 64,305,898 (GRCm39) missense probably benign 0.01
R7187:Vmn2r4 UTSW 3 64,322,681 (GRCm39) missense probably benign 0.00
R7363:Vmn2r4 UTSW 3 64,314,432 (GRCm39) missense probably damaging 1.00
R7477:Vmn2r4 UTSW 3 64,305,850 (GRCm39) missense probably benign 0.01
R7675:Vmn2r4 UTSW 3 64,322,657 (GRCm39) missense probably benign 0.01
R7858:Vmn2r4 UTSW 3 64,317,226 (GRCm39) missense probably benign 0.00
R7888:Vmn2r4 UTSW 3 64,313,943 (GRCm39) missense probably damaging 0.99
R8678:Vmn2r4 UTSW 3 64,314,391 (GRCm39) missense probably benign
R8743:Vmn2r4 UTSW 3 64,317,247 (GRCm39) missense possibly damaging 0.95
R8841:Vmn2r4 UTSW 3 64,314,058 (GRCm39) missense probably damaging 0.97
R9671:Vmn2r4 UTSW 3 64,317,271 (GRCm39) missense probably benign 0.00
R9778:Vmn2r4 UTSW 3 64,322,497 (GRCm39) missense probably benign 0.15
X0019:Vmn2r4 UTSW 3 64,314,057 (GRCm39) missense probably damaging 0.99
Posted On 2015-04-16