Incidental Mutation 'IGL02656:Rps26'
ID 302335
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Rps26
Ensembl Gene ENSMUSG00000025362
Gene Name ribosomal protein S26
Synonyms
Accession Numbers
Essential gene? Not available question?
Stock # IGL02656
Quality Score
Status
Chromosome 10
Chromosomal Location 128460398-128462375 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to G at 128461126 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Serine to Proline at position 88 (S88P)
Ref Sequence ENSEMBL: ENSMUSP00000026420 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000026420]
AlphaFold P62855
Predicted Effect possibly damaging
Transcript: ENSMUST00000026420
AA Change: S88P

PolyPhen 2 Score 0.810 (Sensitivity: 0.84; Specificity: 0.93)
SMART Domains Protein: ENSMUSP00000026420
Gene: ENSMUSG00000025362
AA Change: S88P

DomainStartEndE-ValueType
Pfam:Ribosomal_S26e 1 114 7.9e-57 PFAM
Predicted Effect noncoding transcript
Transcript: ENSMUST00000219591
Predicted Effect noncoding transcript
Transcript: ENSMUST00000219773
Coding Region Coverage
Validation Efficiency
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a ribosomal protein that is a component of the 40S subunit. The protein belongs to the S26E family of ribosomal proteins. It is located in the cytoplasm. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 31 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Ankrd28 G T 14: 31,424,197 (GRCm39) A981D possibly damaging Het
Ccdc69 G T 11: 54,943,263 (GRCm39) Q114K possibly damaging Het
Cct5 A T 15: 31,597,576 (GRCm39) D66E probably damaging Het
Ces2e G T 8: 105,653,688 (GRCm39) R42I possibly damaging Het
Cib2 T G 9: 54,453,182 (GRCm39) D178A probably damaging Het
Cldn7 G A 11: 69,857,834 (GRCm39) V97I probably benign Het
Dok3 A T 13: 55,676,293 (GRCm39) I12N probably damaging Het
Fndc5 T A 4: 129,033,239 (GRCm39) V102E probably damaging Het
Gas2 T C 7: 51,593,492 (GRCm39) S191P probably benign Het
Herc6 T A 6: 57,588,821 (GRCm39) probably null Het
Krt18 A G 15: 101,939,357 (GRCm39) T277A probably benign Het
Mpp3 A G 11: 101,899,427 (GRCm39) S365P probably benign Het
Msmo1 T C 8: 65,180,906 (GRCm39) T3A probably benign Het
Or1e34 A G 11: 73,778,865 (GRCm39) F111S probably damaging Het
Or4e2 G T 14: 52,688,166 (GRCm39) A99S possibly damaging Het
Or8g18 T A 9: 39,149,456 (GRCm39) E88V probably benign Het
Pex19 C A 1: 171,958,252 (GRCm39) A77E probably benign Het
Phf20l1 A G 15: 66,501,676 (GRCm39) D620G probably damaging Het
Prr5 A G 15: 84,583,337 (GRCm39) D105G probably damaging Het
Rab12 T A 17: 66,813,049 (GRCm39) K88M probably damaging Het
Rictor T C 15: 6,806,401 (GRCm39) V673A probably damaging Het
Sema5a T A 15: 32,631,431 (GRCm39) S605T possibly damaging Het
Slc35a4 T C 18: 36,815,500 (GRCm39) M110T probably damaging Het
Sowahb T C 5: 93,191,106 (GRCm39) S538G probably benign Het
Srrt T A 5: 137,297,938 (GRCm39) probably benign Het
Ssbp2 G A 13: 91,817,871 (GRCm39) probably benign Het
Supt20 C T 3: 54,615,816 (GRCm39) R236W probably damaging Het
Tenm4 A G 7: 96,534,640 (GRCm39) D1791G probably damaging Het
Tgm6 G A 2: 129,987,023 (GRCm39) G497D probably damaging Het
Trim12c C T 7: 103,990,410 (GRCm39) V356I probably damaging Het
Vwce T A 19: 10,641,716 (GRCm39) I814K probably benign Het
Other mutations in Rps26
AlleleSourceChrCoordTypePredicted EffectPPH Score
R7226:Rps26 UTSW 10 128,461,087 (GRCm39) missense unknown
R7835:Rps26 UTSW 10 128,461,995 (GRCm39) missense probably benign 0.02
Posted On 2015-04-16