Incidental Mutation 'IGL02658:Olfr338'
ID302414
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Olfr338
Ensembl Gene ENSMUSG00000068950
Gene Nameolfactory receptor 338
SynonymsMOR136-5, GA_x6K02T2NLDC-33070879-33071799
Accession Numbers
Is this an essential gene? Probably non essential (E-score: 0.038) question?
Stock #IGL02658
Quality Score
Status
Chromosome2
Chromosomal Location36373519-36382433 bp(+) (GRCm38)
Type of Mutationmissense
DNA Base Change (assembly) T to A at 36377060 bp
ZygosityHeterozygous
Amino Acid Change Cysteine to Serine at position 95 (C95S)
Ref Sequence ENSEMBL: ENSMUSP00000149146 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000072114] [ENSMUST00000091006] [ENSMUST00000217511]
Predicted Effect probably damaging
Transcript: ENSMUST00000072114
AA Change: C95S

PolyPhen 2 Score 0.969 (Sensitivity: 0.77; Specificity: 0.95)
SMART Domains Protein: ENSMUSP00000071985
Gene: ENSMUSG00000068950
AA Change: C95S

DomainStartEndE-ValueType
Pfam:7tm_4 31 308 3.3e-57 PFAM
Pfam:7TM_GPCR_Srsx 35 305 3.8e-8 PFAM
Pfam:7tm_1 41 290 1.1e-24 PFAM
Predicted Effect probably damaging
Transcript: ENSMUST00000091006
AA Change: C95S

PolyPhen 2 Score 0.969 (Sensitivity: 0.77; Specificity: 0.95)
SMART Domains Protein: ENSMUSP00000088528
Gene: ENSMUSG00000068950
AA Change: C95S

DomainStartEndE-ValueType
Pfam:7tm_4 29 306 3.9e-56 PFAM
Pfam:7tm_1 39 288 4.5e-22 PFAM
Predicted Effect probably damaging
Transcript: ENSMUST00000217511
AA Change: C95S

PolyPhen 2 Score 0.969 (Sensitivity: 0.77; Specificity: 0.95)
Coding Region Coverage
Validation Efficiency
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 43 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Abca8b T A 11: 109,952,560 Y946F probably benign Het
Abcb4 T G 5: 8,934,240 W657G probably benign Het
Adcy1 T C 11: 7,138,279 probably benign Het
Arap3 A G 18: 37,990,994 V351A probably benign Het
Bpifb9b A C 2: 154,311,281 Y89S probably benign Het
Carns1 C T 19: 4,173,084 C47Y probably benign Het
Chd5 C T 4: 152,360,593 H344Y probably damaging Het
Ctnna2 T C 6: 76,980,824 T481A probably benign Het
Cyth1 T A 11: 118,182,246 D264V probably damaging Het
Dph1 C A 11: 75,180,635 L311F probably benign Het
Eif3l A G 15: 79,076,942 D65G probably damaging Het
Gtf2a1l T A 17: 88,668,718 F3Y probably benign Het
Hcn4 A T 9: 58,859,465 T770S unknown Het
Hydin A T 8: 110,413,276 I726F possibly damaging Het
Klf2 A G 8: 72,319,096 I7V probably benign Het
Ltn1 A T 16: 87,415,774 L633H probably damaging Het
Ncoa3 A G 2: 166,051,393 D206G probably benign Het
Nlrp4a T G 7: 26,449,713 D248E probably benign Het
Nyap1 A G 5: 137,735,484 I429T probably damaging Het
Olfr1370 G A 13: 21,072,812 T163I probably damaging Het
Olfr285 A G 15: 98,313,356 S65P probably damaging Het
Olfr578 A G 7: 102,984,330 M278T probably benign Het
Olfr720 T A 14: 14,175,732 M117L possibly damaging Het
Pcf11 T C 7: 92,647,046 E1322G probably damaging Het
Plcxd2 A T 16: 45,972,326 F217I probably benign Het
Plxna4 A T 6: 32,185,411 I1389N probably damaging Het
Ppp1r15a T C 7: 45,524,667 Y239C probably benign Het
Psma6 A G 12: 55,412,211 E126G probably benign Het
R3hcc1l T A 19: 42,562,702 V46E probably damaging Het
Rap1gds1 G T 3: 138,957,479 H320N probably damaging Het
Sdhaf3 A G 6: 7,038,992 M105V probably damaging Het
Slc22a26 T A 19: 7,788,248 N345I probably benign Het
Sncaip T C 18: 52,894,955 I412T possibly damaging Het
Sorcs1 A T 19: 50,190,092 I864N probably damaging Het
Spag5 C T 11: 78,321,331 Q1062* probably null Het
Srrm1 G A 4: 135,325,104 P658L unknown Het
Szrd1 A G 4: 141,139,746 probably benign Het
Tns2 C A 15: 102,107,796 probably benign Het
Trcg1 C A 9: 57,242,228 S361* probably null Het
Tshz3 T C 7: 36,769,158 F191L probably damaging Het
Ttc39a T C 4: 109,422,893 V124A probably damaging Het
Ttf1 T C 2: 29,074,011 I633T probably damaging Het
Zfp691 A G 4: 119,170,507 F176S probably damaging Het
Other mutations in Olfr338
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00958:Olfr338 APN 2 36376916 missense probably damaging 0.99
IGL01089:Olfr338 APN 2 36377166 missense probably damaging 1.00
IGL01298:Olfr338 APN 2 36377448 missense probably benign 0.01
IGL01300:Olfr338 APN 2 36377042 missense probably benign 0.13
IGL01632:Olfr338 APN 2 36377564 missense probably benign 0.02
IGL02480:Olfr338 APN 2 36377492 missense probably damaging 0.98
IGL02519:Olfr338 APN 2 36377313 missense possibly damaging 0.84
IGL02716:Olfr338 APN 2 36377343 missense possibly damaging 0.88
IGL02983:Olfr338 APN 2 36377637 missense probably damaging 1.00
IGL03334:Olfr338 APN 2 36377051 missense possibly damaging 0.66
IGL03054:Olfr338 UTSW 2 36376932 missense possibly damaging 0.65
R0469:Olfr338 UTSW 2 36377462 missense probably benign 0.02
R1263:Olfr338 UTSW 2 36376994 missense probably damaging 0.99
R1500:Olfr338 UTSW 2 36377621 missense probably benign 0.04
R2444:Olfr338 UTSW 2 36377613 missense possibly damaging 0.59
R5571:Olfr338 UTSW 2 36377117 missense probably benign 0.01
R5999:Olfr338 UTSW 2 36377310 missense probably damaging 1.00
R6030:Olfr338 UTSW 2 36377544 missense probably damaging 0.97
R6030:Olfr338 UTSW 2 36377544 missense probably damaging 0.97
R6351:Olfr338 UTSW 2 36377196 missense possibly damaging 0.78
R6695:Olfr338 UTSW 2 36377105 missense probably benign 0.28
R6785:Olfr338 UTSW 2 36376842 missense probably benign 0.12
R6785:Olfr338 UTSW 2 36376951 nonsense probably null
Posted On2015-04-16