Incidental Mutation 'IGL02658:Or51g1'
ID 302435
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Or51g1
Ensembl Gene ENSMUSG00000045792
Gene Name olfactory receptor family 51 subfamily G member 1
Synonyms GA_x6K02T2PBJ9-5696486-5695545, MOR7-1, Olfr578
Accession Numbers
Essential gene? Probably non essential (E-score: 0.132) question?
Stock # IGL02658
Quality Score
Status
Chromosome 7
Chromosomal Location 102633428-102634369 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to G at 102633537 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Methionine to Threonine at position 278 (M278T)
Ref Sequence ENSEMBL: ENSMUSP00000149209 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000056235] [ENSMUST00000215606]
AlphaFold Q8VH17
Predicted Effect probably benign
Transcript: ENSMUST00000056235
AA Change: M278T

PolyPhen 2 Score 0.004 (Sensitivity: 0.98; Specificity: 0.59)
SMART Domains Protein: ENSMUSP00000058167
Gene: ENSMUSG00000045792
AA Change: M278T

DomainStartEndE-ValueType
Pfam:7tm_4 33 311 5e-130 PFAM
Pfam:7TM_GPCR_Srsx 37 309 1.6e-7 PFAM
Pfam:7tm_1 43 294 3.8e-21 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000215606
AA Change: M278T

PolyPhen 2 Score 0.004 (Sensitivity: 0.98; Specificity: 0.59)
Coding Region Coverage
Validation Efficiency
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 43 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Abca8b T A 11: 109,843,386 (GRCm39) Y946F probably benign Het
Abcb4 T G 5: 8,984,240 (GRCm39) W657G probably benign Het
Adcy1 T C 11: 7,088,279 (GRCm39) probably benign Het
Arap3 A G 18: 38,124,047 (GRCm39) V351A probably benign Het
Bpifb9b A C 2: 154,153,201 (GRCm39) Y89S probably benign Het
Carns1 C T 19: 4,223,083 (GRCm39) C47Y probably benign Het
Chd5 C T 4: 152,445,050 (GRCm39) H344Y probably damaging Het
Ctnna2 T C 6: 76,957,807 (GRCm39) T481A probably benign Het
Cyth1 T A 11: 118,073,072 (GRCm39) D264V probably damaging Het
Dph1 C A 11: 75,071,461 (GRCm39) L311F probably benign Het
Eif3l A G 15: 78,961,142 (GRCm39) D65G probably damaging Het
Gtf2a1l T A 17: 88,976,146 (GRCm39) F3Y probably benign Het
Hcn4 A T 9: 58,766,748 (GRCm39) T770S unknown Het
Hydin A T 8: 111,139,908 (GRCm39) I726F possibly damaging Het
Klf2 A G 8: 73,072,940 (GRCm39) I7V probably benign Het
Ltn1 A T 16: 87,212,662 (GRCm39) L633H probably damaging Het
Ncoa3 A G 2: 165,893,313 (GRCm39) D206G probably benign Het
Nlrp4a T G 7: 26,149,138 (GRCm39) D248E probably benign Het
Nyap1 A G 5: 137,733,746 (GRCm39) I429T probably damaging Het
Or1j10 T A 2: 36,267,072 (GRCm39) C95S probably damaging Het
Or2p2 G A 13: 21,256,982 (GRCm39) T163I probably damaging Het
Or2t6 T A 14: 14,175,732 (GRCm38) M117L possibly damaging Het
Or8s16 A G 15: 98,211,237 (GRCm39) S65P probably damaging Het
Pcf11 T C 7: 92,296,254 (GRCm39) E1322G probably damaging Het
Plcxd2 A T 16: 45,792,689 (GRCm39) F217I probably benign Het
Plxna4 A T 6: 32,162,346 (GRCm39) I1389N probably damaging Het
Ppp1r15a T C 7: 45,174,091 (GRCm39) Y239C probably benign Het
Psma6 A G 12: 55,458,996 (GRCm39) E126G probably benign Het
R3hcc1l T A 19: 42,551,141 (GRCm39) V46E probably damaging Het
Rap1gds1 G T 3: 138,663,240 (GRCm39) H320N probably damaging Het
Sdhaf3 A G 6: 7,038,992 (GRCm39) M105V probably damaging Het
Slc22a26 T A 19: 7,765,613 (GRCm39) N345I probably benign Het
Sncaip T C 18: 53,028,027 (GRCm39) I412T possibly damaging Het
Sorcs1 A T 19: 50,178,530 (GRCm39) I864N probably damaging Het
Spag5 C T 11: 78,212,157 (GRCm39) Q1062* probably null Het
Srrm1 G A 4: 135,052,415 (GRCm39) P658L unknown Het
Szrd1 A G 4: 140,867,057 (GRCm39) probably benign Het
Tns2 C A 15: 102,016,231 (GRCm39) probably benign Het
Trcg1 C A 9: 57,149,511 (GRCm39) S361* probably null Het
Tshz3 T C 7: 36,468,583 (GRCm39) F191L probably damaging Het
Ttc39a T C 4: 109,280,090 (GRCm39) V124A probably damaging Het
Ttf1 T C 2: 28,964,023 (GRCm39) I633T probably damaging Het
Zfp691 A G 4: 119,027,704 (GRCm39) F176S probably damaging Het
Other mutations in Or51g1
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL02580:Or51g1 APN 7 102,633,909 (GRCm39) missense probably damaging 0.97
R0833:Or51g1 UTSW 7 102,634,043 (GRCm39) missense possibly damaging 0.50
R1470:Or51g1 UTSW 7 102,633,530 (GRCm39) nonsense probably null
R1470:Or51g1 UTSW 7 102,633,530 (GRCm39) nonsense probably null
R2029:Or51g1 UTSW 7 102,633,478 (GRCm39) missense probably damaging 0.99
R2249:Or51g1 UTSW 7 102,633,647 (GRCm39) missense possibly damaging 0.74
R2413:Or51g1 UTSW 7 102,634,009 (GRCm39) missense probably damaging 1.00
R2898:Or51g1 UTSW 7 102,634,084 (GRCm39) missense probably benign 0.19
R4441:Or51g1 UTSW 7 102,633,516 (GRCm39) missense possibly damaging 0.65
R5696:Or51g1 UTSW 7 102,633,748 (GRCm39) missense probably benign 0.02
R6810:Or51g1 UTSW 7 102,634,042 (GRCm39) missense probably damaging 1.00
R7263:Or51g1 UTSW 7 102,633,524 (GRCm39) nonsense probably null
R7366:Or51g1 UTSW 7 102,633,723 (GRCm39) missense probably damaging 1.00
R7952:Or51g1 UTSW 7 102,633,721 (GRCm39) missense probably benign 0.00
R9095:Or51g1 UTSW 7 102,633,687 (GRCm39) missense probably damaging 1.00
R9554:Or51g1 UTSW 7 102,633,774 (GRCm39) missense probably damaging 0.98
R9571:Or51g1 UTSW 7 102,634,221 (GRCm39) missense probably benign 0.12
X0022:Or51g1 UTSW 7 102,634,233 (GRCm39) missense probably benign 0.02
X0028:Or51g1 UTSW 7 102,633,550 (GRCm39) missense probably benign 0.00
Posted On 2015-04-16