Incidental Mutation 'IGL02661:Rnase10'
ID 302545
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Rnase10
Ensembl Gene ENSMUSG00000021872
Gene Name ribonuclease, RNase A family, 10 (non-active)
Synonyms 4930474F22Rik
Accession Numbers
Essential gene? Non essential (E-score: 0.000) question?
Stock # IGL02661
Quality Score
Status
Chromosome 14
Chromosomal Location 51245208-51248215 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to G at 51247273 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Valine to Glycine at position 180 (V180G)
Ref Sequence ENSEMBL: ENSMUSP00000131065 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000022424] [ENSMUST00000164632]
AlphaFold no structure available at present
Predicted Effect probably damaging
Transcript: ENSMUST00000022424
AA Change: V217G

PolyPhen 2 Score 0.999 (Sensitivity: 0.14; Specificity: 0.99)
SMART Domains Protein: ENSMUSP00000022424
Gene: ENSMUSG00000021872
AA Change: V217G

DomainStartEndE-ValueType
transmembrane domain 40 62 N/A INTRINSIC
low complexity region 87 98 N/A INTRINSIC
Pfam:RnaseA 132 244 2.2e-21 PFAM
Predicted Effect probably damaging
Transcript: ENSMUST00000164632
AA Change: V180G

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
SMART Domains Protein: ENSMUSP00000131065
Gene: ENSMUSG00000021872
AA Change: V180G

DomainStartEndE-ValueType
signal peptide 1 22 N/A INTRINSIC
low complexity region 50 61 N/A INTRINSIC
Pfam:RnaseA 91 208 1.4e-21 PFAM
Coding Region Coverage
Validation Efficiency
MGI Phenotype PHENOTYPE: Homozygous disruption of this gene leads to decreased bone mineral density, alterations in B cell, T cell and NK cell number, and abnormal circulating glucose, creatinine, chloride and serum albumin levels. [provided by MGI curators]
Allele List at MGI
Other mutations in this stock
Total: 41 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
1700034E13Rik G T 18: 52,793,566 (GRCm39) W33L probably damaging Het
Adam34 A T 8: 44,104,572 (GRCm39) C358S probably damaging Het
Ak5 C A 3: 152,169,593 (GRCm39) V561F probably benign Het
Ap1s1 T C 5: 137,066,327 (GRCm39) D158G probably benign Het
Bard1 A G 1: 71,114,469 (GRCm39) S171P probably damaging Het
Bsn A C 9: 107,984,135 (GRCm39) Y534* probably null Het
Clcn4 A T 7: 7,294,730 (GRCm39) probably null Het
Cyp2j7 T C 4: 96,124,887 (GRCm39) T4A probably benign Het
Dnajc10 T A 2: 80,157,084 (GRCm39) probably benign Het
Dtl G T 1: 191,273,483 (GRCm39) T475N probably benign Het
Eif3m T C 2: 104,835,314 (GRCm39) Y120C probably damaging Het
Gab1 A G 8: 81,515,566 (GRCm39) S251P probably damaging Het
Gba1 T A 3: 89,110,834 (GRCm39) V14E probably benign Het
Ggcx C T 6: 72,395,343 (GRCm39) P145S possibly damaging Het
Gm13889 G A 2: 93,787,024 (GRCm39) T150I probably benign Het
Gm4978 C A 9: 69,358,180 (GRCm39) probably benign Het
Herc2 A G 7: 55,762,821 (GRCm39) D850G probably damaging Het
Hspa1l A G 17: 35,196,251 (GRCm39) I97V probably benign Het
Ighv1-4 T G 12: 114,450,850 (GRCm39) K86T probably damaging Het
Ints4 C A 7: 97,144,912 (GRCm39) L175I probably benign Het
Kif13b T G 14: 65,005,140 (GRCm39) V1144G probably benign Het
Kpna3 T A 14: 61,610,398 (GRCm39) probably benign Het
Man2c1 A G 9: 57,044,766 (GRCm39) D371G probably damaging Het
Mtf1 T C 4: 124,718,902 (GRCm39) L305P probably damaging Het
Myo15b T G 11: 115,774,895 (GRCm39) V2139G probably benign Het
Nalcn T C 14: 123,830,321 (GRCm39) probably benign Het
Neurod2 T C 11: 98,218,405 (GRCm39) Q253R possibly damaging Het
Nfkbil1 C A 17: 35,439,647 (GRCm39) A289S probably benign Het
Or4k35 T A 2: 111,099,811 (GRCm39) R300S possibly damaging Het
Paxbp1 A T 16: 90,827,413 (GRCm39) I474K probably benign Het
Pde6c A T 19: 38,169,248 (GRCm39) I798F probably damaging Het
Pon3 T A 6: 5,256,205 (GRCm39) T8S probably benign Het
Prkdc A G 16: 15,587,689 (GRCm39) T2525A possibly damaging Het
Rreb1 T A 13: 38,114,778 (GRCm39) C712* probably null Het
Scamp2 T C 9: 57,494,697 (GRCm39) probably benign Het
Serpina3i A T 12: 104,231,515 (GRCm39) K51* probably null Het
Smyd4 C A 11: 75,281,767 (GRCm39) C413* probably null Het
Spata2 C T 2: 167,325,281 (GRCm39) V513M probably damaging Het
Sri T A 5: 8,113,252 (GRCm39) probably benign Het
Urah A T 7: 140,417,618 (GRCm39) K119M probably damaging Het
Wdr19 C T 5: 65,403,151 (GRCm39) T1005I probably benign Het
Other mutations in Rnase10
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00161:Rnase10 APN 14 51,247,238 (GRCm39) missense possibly damaging 0.91
IGL01534:Rnase10 APN 14 51,245,436 (GRCm39) missense probably benign 0.00
IGL02082:Rnase10 APN 14 51,246,856 (GRCm39) missense probably damaging 1.00
R1254:Rnase10 UTSW 14 51,247,083 (GRCm39) missense probably damaging 0.99
R1989:Rnase10 UTSW 14 51,247,095 (GRCm39) missense probably benign 0.03
R3878:Rnase10 UTSW 14 51,246,889 (GRCm39) missense probably damaging 0.97
R5405:Rnase10 UTSW 14 51,247,317 (GRCm39) missense probably damaging 1.00
R5942:Rnase10 UTSW 14 51,246,735 (GRCm39) missense probably benign 0.08
R6107:Rnase10 UTSW 14 51,246,751 (GRCm39) missense possibly damaging 0.89
R6994:Rnase10 UTSW 14 51,247,138 (GRCm39) missense probably damaging 1.00
R7138:Rnase10 UTSW 14 51,247,167 (GRCm39) missense probably damaging 1.00
R7186:Rnase10 UTSW 14 51,247,242 (GRCm39) missense probably damaging 1.00
R7848:Rnase10 UTSW 14 51,246,970 (GRCm39) missense possibly damaging 0.75
Posted On 2015-04-16