Incidental Mutation 'IGL02662:Pla2g2d'
ID 302585
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Pla2g2d
Ensembl Gene ENSMUSG00000041202
Gene Name phospholipase A2, group IID
Synonyms Splash, mGIID
Accession Numbers
Essential gene? Non essential (E-score: 0.000) question?
Stock # IGL02662
Quality Score
Status
Chromosome 4
Chromosomal Location 138503046-138509357 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to G at 138506006 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Methionine to Arginine at position 5 (M5R)
Ref Sequence ENSEMBL: ENSMUSP00000101432 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000030528] [ENSMUST00000105806]
AlphaFold Q9WVF6
Predicted Effect possibly damaging
Transcript: ENSMUST00000030528
AA Change: M31R

PolyPhen 2 Score 0.927 (Sensitivity: 0.81; Specificity: 0.94)
SMART Domains Protein: ENSMUSP00000030528
Gene: ENSMUSG00000041202
AA Change: M31R

DomainStartEndE-ValueType
signal peptide 1 19 N/A INTRINSIC
PA2c 20 138 5.39e-48 SMART
Predicted Effect possibly damaging
Transcript: ENSMUST00000105806
AA Change: M5R

PolyPhen 2 Score 0.927 (Sensitivity: 0.81; Specificity: 0.94)
SMART Domains Protein: ENSMUSP00000101432
Gene: ENSMUSG00000041202
AA Change: M5R

DomainStartEndE-ValueType
PA2c 1 112 2.46e-42 SMART
Coding Region Coverage
Validation Efficiency
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a secreted member of the phospholipase A2 family, and is found in a cluster of related family members on chromosome 1. Phospholipase A2 family members hydrolyze the sn-2 fatty acid ester bond of glycerophospholipids to produce lysophospholipids and free fatty acid. This gene may be involved in inflammation and immune response, and in weight loss associated with chronic obstructive pulmonary disease. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Nov 2012]
PHENOTYPE: Mice homozygous for a knock-out allele exhibit impaired resolution of hapten-induced contact hypersensitivity. [provided by MGI curators]
Allele List at MGI
Other mutations in this stock
Total: 38 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Adcy8 A G 15: 64,618,744 (GRCm39) probably null Het
Ap5z1 G A 5: 142,462,644 (GRCm39) probably null Het
Cdhr5 T G 7: 140,854,416 (GRCm39) I120L possibly damaging Het
Chd5 C T 4: 152,456,588 (GRCm39) S975F probably damaging Het
Cts3 G T 13: 61,715,871 (GRCm39) Q132K probably damaging Het
Cylc2 T A 4: 51,216,698 (GRCm39) probably benign Het
Defb39 A G 8: 19,102,891 (GRCm39) V68A probably benign Het
Dgki A G 6: 36,839,421 (GRCm39) probably benign Het
Dhtkd1 G A 2: 5,904,783 (GRCm39) P867L probably damaging Het
Gata5 C T 2: 179,969,544 (GRCm39) probably benign Het
Glt28d2 T A 3: 85,779,423 (GRCm39) I17F probably damaging Het
Gstm2 T C 3: 107,892,378 (GRCm39) Y82C possibly damaging Het
Hs6st1 T A 1: 36,142,893 (GRCm39) L276* probably null Het
Iqgap1 T C 7: 80,392,827 (GRCm39) D712G probably benign Het
Kdm4c T C 4: 74,323,058 (GRCm39) S997P probably damaging Het
Ksr1 G A 11: 78,927,551 (GRCm39) T289I probably damaging Het
Lingo4 T C 3: 94,309,124 (GRCm39) probably benign Het
Ncapd2 A G 6: 125,153,694 (GRCm39) S674P probably damaging Het
Nek1 G A 8: 61,557,218 (GRCm39) V841I probably benign Het
Or10a48 T C 7: 108,424,952 (GRCm39) T85A probably benign Het
Or8i2 T C 2: 86,852,346 (GRCm39) T181A probably benign Het
Pigx A G 16: 31,906,201 (GRCm39) V40A probably damaging Het
Ppa2 G T 3: 133,073,644 (GRCm39) R234I probably damaging Het
Rbms1 A C 2: 60,592,650 (GRCm39) L221R probably damaging Het
Rnasel C A 1: 153,629,857 (GRCm39) N124K probably damaging Het
Serpinb9h A G 13: 33,588,513 (GRCm39) N366S possibly damaging Het
Sigirr T A 7: 140,674,707 (GRCm39) probably benign Het
Tas2r136 A T 6: 132,754,671 (GRCm39) V152E probably damaging Het
Tlnrd1 C T 7: 83,532,027 (GRCm39) V135M possibly damaging Het
Tlnrd1 A G 7: 83,531,744 (GRCm39) L229S probably damaging Het
Top1mt A G 15: 75,540,554 (GRCm39) V239A probably damaging Het
Tpd52 A T 3: 9,009,775 (GRCm39) probably null Het
Trim16 T A 11: 62,731,383 (GRCm39) L331Q possibly damaging Het
Ttll4 A G 1: 74,726,390 (GRCm39) probably null Het
Vmn1r27 T A 6: 58,192,272 (GRCm39) D244V probably damaging Het
Vmn2r72 A C 7: 85,387,391 (GRCm39) D724E probably benign Het
Zfp563 T C 17: 33,321,253 (GRCm39) W18R probably damaging Het
Zswim8 T C 14: 20,763,142 (GRCm39) V347A probably benign Het
Other mutations in Pla2g2d
AlleleSourceChrCoordTypePredicted EffectPPH Score
R0585:Pla2g2d UTSW 4 138,506,704 (GRCm39) missense probably benign 0.16
R1888:Pla2g2d UTSW 4 138,503,126 (GRCm39) start codon destroyed probably null
R1888:Pla2g2d UTSW 4 138,503,126 (GRCm39) start codon destroyed probably null
R5666:Pla2g2d UTSW 4 138,507,591 (GRCm39) missense probably damaging 1.00
R7842:Pla2g2d UTSW 4 138,506,089 (GRCm39) missense probably damaging 0.99
Z1177:Pla2g2d UTSW 4 138,503,144 (GRCm39) missense unknown
Posted On 2015-04-16