Incidental Mutation 'IGL02663:Vmn2r22'
| ID |
302611 |
| Institutional Source |
Australian Phenomics Network
(link to record)
|
| Gene Symbol |
Vmn2r22
|
| Ensembl Gene |
ENSMUSG00000095486 |
| Gene Name |
vomeronasal 2, receptor 22 |
| Synonyms |
EG546913 |
| Accession Numbers |
|
| Essential gene? |
Probably non essential
(E-score: 0.058)
|
| Stock # |
IGL02663
|
| Quality Score |
|
|
Status
|
|
| Chromosome |
6 |
| Chromosomal Location |
123586717-123627594 bp(-) (GRCm39) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
A to T
at 123626117 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Histidine to Glutamine
at position 106
(H106Q)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000132043
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000170808]
|
| AlphaFold |
E9Q7S8 |
| Predicted Effect |
probably benign
Transcript: ENSMUST00000170808
AA Change: H106Q
PolyPhen 2
Score 0.107 (Sensitivity: 0.93; Specificity: 0.86)
|
| SMART Domains |
Protein: ENSMUSP00000132043
Gene: ENSMUSG00000095486
AA Change: H106Q
| Domain | Start | End | E-Value | Type |
|---|
|
signal peptide
|
1 |
17 |
N/A |
INTRINSIC |
|
Pfam:ANF_receptor
|
81 |
473 |
1.4e-32 |
PFAM |
|
Pfam:NCD3G
|
517 |
570 |
2.2e-23 |
PFAM |
|
Pfam:7tm_3
|
601 |
838 |
1.2e-54 |
PFAM |
|
| Coding Region Coverage |
|
| Validation Efficiency |
|
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 32 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| Bcl9 |
A |
C |
3: 97,112,648 (GRCm39) |
F1269C |
probably damaging |
Het |
| Cdc20b |
T |
A |
13: 113,192,665 (GRCm39) |
|
probably null |
Het |
| Chrna1 |
A |
G |
2: 73,404,660 (GRCm39) |
|
probably benign |
Het |
| Creb5 |
A |
G |
6: 53,657,946 (GRCm39) |
H236R |
probably damaging |
Het |
| Cyp17a1 |
A |
G |
19: 46,661,005 (GRCm39) |
F93S |
probably damaging |
Het |
| Cyp4a32 |
T |
A |
4: 115,467,787 (GRCm39) |
L257H |
probably damaging |
Het |
| Dnai3 |
A |
T |
3: 145,760,312 (GRCm39) |
M692K |
possibly damaging |
Het |
| Fahd1 |
C |
T |
17: 25,068,478 (GRCm39) |
G200R |
probably damaging |
Het |
| Ifit1 |
A |
G |
19: 34,618,380 (GRCm39) |
|
probably benign |
Het |
| Mfhas1 |
G |
T |
8: 36,057,060 (GRCm39) |
V512L |
probably damaging |
Het |
| Myh13 |
C |
T |
11: 67,245,753 (GRCm39) |
Q1095* |
probably null |
Het |
| Nfia |
A |
G |
4: 97,929,856 (GRCm39) |
T339A |
probably benign |
Het |
| Npas3 |
T |
C |
12: 54,115,691 (GRCm39) |
L840P |
probably damaging |
Het |
| Nsf |
T |
C |
11: 103,821,641 (GRCm39) |
T2A |
probably benign |
Het |
| Or11g7 |
A |
G |
14: 50,691,309 (GRCm39) |
T267A |
probably benign |
Het |
| Or14j10 |
A |
T |
17: 37,934,935 (GRCm39) |
I197K |
probably benign |
Het |
| Or5b111 |
A |
G |
19: 13,290,743 (GRCm39) |
V302A |
probably benign |
Het |
| P2rx2 |
C |
T |
5: 110,488,115 (GRCm39) |
E480K |
possibly damaging |
Het |
| P2rx2 |
G |
T |
5: 110,488,052 (GRCm39) |
|
probably null |
Het |
| Ppp1r8 |
G |
A |
4: 132,560,419 (GRCm39) |
T94I |
probably damaging |
Het |
| S100a11 |
A |
T |
3: 93,431,464 (GRCm39) |
E33D |
probably damaging |
Het |
| Sec31b |
C |
A |
19: 44,522,717 (GRCm39) |
A92S |
probably damaging |
Het |
| Serpina3g |
C |
T |
12: 104,205,399 (GRCm39) |
T46I |
possibly damaging |
Het |
| Sgo2b |
A |
T |
8: 64,396,148 (GRCm39) |
I36N |
probably damaging |
Het |
| Slc35e1 |
A |
G |
8: 73,242,053 (GRCm39) |
L223P |
probably damaging |
Het |
| St14 |
T |
C |
9: 31,011,678 (GRCm39) |
|
probably null |
Het |
| Sult2a8 |
A |
G |
7: 14,159,368 (GRCm39) |
Y84H |
possibly damaging |
Het |
| Tas1r2 |
T |
C |
4: 139,387,593 (GRCm39) |
Y322H |
probably benign |
Het |
| Tmem59 |
T |
C |
4: 107,054,738 (GRCm39) |
L181P |
probably damaging |
Het |
| Trp73 |
A |
G |
4: 154,146,963 (GRCm39) |
|
probably null |
Het |
| Ube2h |
A |
G |
6: 30,241,412 (GRCm39) |
V86A |
probably damaging |
Het |
| Xirp2 |
T |
C |
2: 67,339,802 (GRCm39) |
V681A |
possibly damaging |
Het |
|
| Other mutations in Vmn2r22 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL01024:Vmn2r22
|
APN |
6 |
123,615,012 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL01764:Vmn2r22
|
APN |
6 |
123,627,379 (GRCm39) |
critical splice donor site |
probably null |
|
|
IGL02037:Vmn2r22
|
APN |
6 |
123,626,026 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02183:Vmn2r22
|
APN |
6 |
123,614,963 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02335:Vmn2r22
|
APN |
6 |
123,615,051 (GRCm39) |
missense |
probably damaging |
0.99 |
|
IGL02440:Vmn2r22
|
APN |
6 |
123,614,364 (GRCm39) |
missense |
probably benign |
0.00 |
|
IGL03101:Vmn2r22
|
APN |
6 |
123,614,295 (GRCm39) |
missense |
probably benign |
0.09 |
|
R0266:Vmn2r22
|
UTSW |
6 |
123,614,363 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R0348:Vmn2r22
|
UTSW |
6 |
123,614,684 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0780:Vmn2r22
|
UTSW |
6 |
123,614,933 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0849:Vmn2r22
|
UTSW |
6 |
123,614,363 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R1074:Vmn2r22
|
UTSW |
6 |
123,626,217 (GRCm39) |
missense |
probably benign |
0.02 |
|
R1456:Vmn2r22
|
UTSW |
6 |
123,614,624 (GRCm39) |
missense |
possibly damaging |
0.86 |
|
R1719:Vmn2r22
|
UTSW |
6 |
123,614,802 (GRCm39) |
missense |
possibly damaging |
0.68 |
|
R1989:Vmn2r22
|
UTSW |
6 |
123,614,500 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2928:Vmn2r22
|
UTSW |
6 |
123,614,402 (GRCm39) |
missense |
probably damaging |
0.96 |
|
R2939:Vmn2r22
|
UTSW |
6 |
123,614,594 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R3727:Vmn2r22
|
UTSW |
6 |
123,627,584 (GRCm39) |
missense |
possibly damaging |
0.70 |
|
R3782:Vmn2r22
|
UTSW |
6 |
123,627,591 (GRCm39) |
nonsense |
probably null |
|
|
R3873:Vmn2r22
|
UTSW |
6 |
123,614,339 (GRCm39) |
missense |
possibly damaging |
0.68 |
|
R4344:Vmn2r22
|
UTSW |
6 |
123,614,756 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4407:Vmn2r22
|
UTSW |
6 |
123,614,913 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4428:Vmn2r22
|
UTSW |
6 |
123,614,817 (GRCm39) |
missense |
possibly damaging |
0.47 |
|
R4430:Vmn2r22
|
UTSW |
6 |
123,614,817 (GRCm39) |
missense |
possibly damaging |
0.47 |
|
R4431:Vmn2r22
|
UTSW |
6 |
123,614,817 (GRCm39) |
missense |
possibly damaging |
0.47 |
|
R4701:Vmn2r22
|
UTSW |
6 |
123,627,428 (GRCm39) |
missense |
probably benign |
0.00 |
|
R5274:Vmn2r22
|
UTSW |
6 |
123,627,593 (GRCm39) |
start codon destroyed |
probably null |
0.93 |
|
R5668:Vmn2r22
|
UTSW |
6 |
123,614,873 (GRCm39) |
missense |
probably benign |
0.06 |
|
R5776:Vmn2r22
|
UTSW |
6 |
123,614,673 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6416:Vmn2r22
|
UTSW |
6 |
123,614,697 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7788:Vmn2r22
|
UTSW |
6 |
123,614,559 (GRCm39) |
missense |
not run |
|
|
R8208:Vmn2r22
|
UTSW |
6 |
123,614,444 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8267:Vmn2r22
|
UTSW |
6 |
123,615,000 (GRCm39) |
missense |
possibly damaging |
0.81 |
|
R8400:Vmn2r22
|
UTSW |
6 |
123,614,486 (GRCm39) |
nonsense |
probably null |
|
|
R8814:Vmn2r22
|
UTSW |
6 |
123,614,789 (GRCm39) |
missense |
probably damaging |
0.96 |
|
R8850:Vmn2r22
|
UTSW |
6 |
123,614,454 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9613:Vmn2r22
|
UTSW |
6 |
123,615,075 (GRCm39) |
missense |
probably damaging |
0.99 |
|
| Posted On |
2015-04-16 |
Incidental Mutation