Incidental Mutation 'IGL02663:Or5b111'
ID 302615
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Or5b111
Ensembl Gene ENSMUSG00000062199
Gene Name olfactory receptor family 5 subfamily B member 111
Synonyms MOR202-28, GA_x6K02T2RE5P-3645346-3644423, Olfr1465
Accession Numbers
Essential gene? Probably non essential (E-score: 0.089) question?
Stock # IGL02663
Quality Score
Status
Chromosome 19
Chromosomal Location 13290724-13291647 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to G at 13290743 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Valine to Alanine at position 302 (V302A)
Ref Sequence ENSEMBL: ENSMUSP00000146645 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000080142] [ENSMUST00000207340]
AlphaFold Q7TQR2
Predicted Effect probably benign
Transcript: ENSMUST00000080142
AA Change: V302A

PolyPhen 2 Score 0.008 (Sensitivity: 0.96; Specificity: 0.76)
SMART Domains Protein: ENSMUSP00000079039
Gene: ENSMUSG00000062199
AA Change: V302A

DomainStartEndE-ValueType
Pfam:7tm_4 29 306 7.4e-47 PFAM
Pfam:7tm_1 39 288 3.7e-20 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000207340
AA Change: V302A

PolyPhen 2 Score 0.008 (Sensitivity: 0.96; Specificity: 0.76)
Coding Region Coverage
Validation Efficiency
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 32 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Bcl9 A C 3: 97,112,648 (GRCm39) F1269C probably damaging Het
Cdc20b T A 13: 113,192,665 (GRCm39) probably null Het
Chrna1 A G 2: 73,404,660 (GRCm39) probably benign Het
Creb5 A G 6: 53,657,946 (GRCm39) H236R probably damaging Het
Cyp17a1 A G 19: 46,661,005 (GRCm39) F93S probably damaging Het
Cyp4a32 T A 4: 115,467,787 (GRCm39) L257H probably damaging Het
Dnai3 A T 3: 145,760,312 (GRCm39) M692K possibly damaging Het
Fahd1 C T 17: 25,068,478 (GRCm39) G200R probably damaging Het
Ifit1 A G 19: 34,618,380 (GRCm39) probably benign Het
Mfhas1 G T 8: 36,057,060 (GRCm39) V512L probably damaging Het
Myh13 C T 11: 67,245,753 (GRCm39) Q1095* probably null Het
Nfia A G 4: 97,929,856 (GRCm39) T339A probably benign Het
Npas3 T C 12: 54,115,691 (GRCm39) L840P probably damaging Het
Nsf T C 11: 103,821,641 (GRCm39) T2A probably benign Het
Or11g7 A G 14: 50,691,309 (GRCm39) T267A probably benign Het
Or14j10 A T 17: 37,934,935 (GRCm39) I197K probably benign Het
P2rx2 C T 5: 110,488,115 (GRCm39) E480K possibly damaging Het
P2rx2 G T 5: 110,488,052 (GRCm39) probably null Het
Ppp1r8 G A 4: 132,560,419 (GRCm39) T94I probably damaging Het
S100a11 A T 3: 93,431,464 (GRCm39) E33D probably damaging Het
Sec31b C A 19: 44,522,717 (GRCm39) A92S probably damaging Het
Serpina3g C T 12: 104,205,399 (GRCm39) T46I possibly damaging Het
Sgo2b A T 8: 64,396,148 (GRCm39) I36N probably damaging Het
Slc35e1 A G 8: 73,242,053 (GRCm39) L223P probably damaging Het
St14 T C 9: 31,011,678 (GRCm39) probably null Het
Sult2a8 A G 7: 14,159,368 (GRCm39) Y84H possibly damaging Het
Tas1r2 T C 4: 139,387,593 (GRCm39) Y322H probably benign Het
Tmem59 T C 4: 107,054,738 (GRCm39) L181P probably damaging Het
Trp73 A G 4: 154,146,963 (GRCm39) probably null Het
Ube2h A G 6: 30,241,412 (GRCm39) V86A probably damaging Het
Vmn2r22 A T 6: 123,626,117 (GRCm39) H106Q probably benign Het
Xirp2 T C 2: 67,339,802 (GRCm39) V681A possibly damaging Het
Other mutations in Or5b111
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01296:Or5b111 APN 19 13,291,490 (GRCm39) missense probably damaging 1.00
IGL01548:Or5b111 APN 19 13,291,350 (GRCm39) missense possibly damaging 0.95
IGL02548:Or5b111 APN 19 13,291,302 (GRCm39) missense probably damaging 0.98
BB010:Or5b111 UTSW 19 13,291,569 (GRCm39) missense probably benign
BB020:Or5b111 UTSW 19 13,291,569 (GRCm39) missense probably benign
PIT4651001:Or5b111 UTSW 19 13,291,556 (GRCm39) missense probably benign 0.12
R0563:Or5b111 UTSW 19 13,291,112 (GRCm39) missense probably benign 0.28
R1803:Or5b111 UTSW 19 13,291,535 (GRCm39) missense possibly damaging 0.90
R2146:Or5b111 UTSW 19 13,291,485 (GRCm39) missense probably benign 0.23
R4674:Or5b111 UTSW 19 13,291,178 (GRCm39) missense probably benign 0.17
R4697:Or5b111 UTSW 19 13,291,081 (GRCm39) missense probably benign 0.39
R4825:Or5b111 UTSW 19 13,291,684 (GRCm39) splice site probably null
R4884:Or5b111 UTSW 19 13,291,034 (GRCm39) missense probably benign 0.28
R5647:Or5b111 UTSW 19 13,291,553 (GRCm39) missense probably damaging 1.00
R6401:Or5b111 UTSW 19 13,290,878 (GRCm39) missense probably damaging 1.00
R6913:Or5b111 UTSW 19 13,290,998 (GRCm39) missense probably benign 0.01
R6996:Or5b111 UTSW 19 13,291,036 (GRCm39) missense probably benign 0.15
R7933:Or5b111 UTSW 19 13,291,569 (GRCm39) missense probably benign
R8946:Or5b111 UTSW 19 13,291,502 (GRCm39) missense probably damaging 0.97
R8966:Or5b111 UTSW 19 13,291,196 (GRCm39) missense probably damaging 1.00
R9641:Or5b111 UTSW 19 13,291,100 (GRCm39) missense probably damaging 0.98
Posted On 2015-04-16