Mutagenetix > Incidental Mutation

Incidental Mutation 'IGL02664:Vmn2r106'

302643

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Vmn2r106

Ensembl Gene

ENSMUSG00000091656

Gene Name

vomeronasal 2, receptor 106

Synonyms

EG224576

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.166) question?

Stock #

IGL02664

Quality Score

Status

Chromosome

Chromosomal Location

20487809-20505692 bp(-) (GRCm39)

Type of Mutation

missense

DNA Base Change (assembly)

G to A at 20488344 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Threonine to Isoleucine at position 685 (T685I)

Ref Sequence

ENSEMBL: ENSMUSP00000126534 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000167464]

AlphaFold

E9PY92

Predicted Effect

possibly damaging
Transcript: ENSMUST00000167464
AA Change: T685I

PolyPhen 2 Score 0.881 (Sensitivity: 0.82; Specificity: 0.94)

SMART Domains

Protein: ENSMUSP00000126534
Gene: ENSMUSG00000091656
AA Change: T685I

Domain	Start	End	E-Value	Type
signal peptide	1	19	N/A	INTRINSIC
Pfam:ANF_receptor	83	471	3.8e-37	PFAM
Pfam:NCD3G	514	567	5.7e-22	PFAM
Pfam:7tm_3	596	835	1.3e-49	PFAM

Coding Region Coverage

Validation Efficiency

Allele List at MGI

Other mutations in this stock

Total: 46 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Ablim2	A	T	5: 36,006,860 (GRCm39)	D425V	probably damaging	Het
Afdn	G	T	17: 14,072,728 (GRCm39)		probably benign	Het
Afg2a	A	G	3: 37,490,814 (GRCm39)	D453G	probably damaging	Het
Ap2a2	C	T	7: 141,209,136 (GRCm39)	T776I	probably benign	Het
Apcdd1	T	C	18: 63,084,891 (GRCm39)		probably benign	Het
Bdp1	A	T	13: 100,188,047 (GRCm39)	Y1513N	probably benign	Het
Btaf1	T	C	19: 36,955,828 (GRCm39)		probably benign	Het
C2cd3	A	T	7: 100,068,922 (GRCm39)	M917L	possibly damaging	Het
Cmtm6	T	C	9: 114,575,613 (GRCm39)	V174A	probably benign	Het
Cyp2d12	T	A	15: 82,443,535 (GRCm39)	I448K	probably benign	Het
Ddb1	A	G	19: 10,585,247 (GRCm39)	I101V	probably benign	Het
Dicer1	A	G	12: 104,671,388 (GRCm39)	Y961H	probably damaging	Het
Dnaaf1	T	G	8: 120,309,260 (GRCm39)	I116S	probably damaging	Het
Ecscr	T	A	18: 35,854,451 (GRCm39)	I5F	possibly damaging	Het
Eftud2	T	C	11: 102,732,538 (GRCm39)	E691G	probably damaging	Het
Fat2	A	G	11: 55,201,922 (GRCm39)	V384A	probably damaging	Het
Ftcd	T	C	10: 76,420,439 (GRCm39)	M391T	probably damaging	Het
Gab2	T	G	7: 96,953,389 (GRCm39)	S587R	probably damaging	Het
Gm18856	G	A	13: 14,139,809 (GRCm39)		probably benign	Het
Herc2	A	T	7: 55,785,426 (GRCm39)	R1559*	probably null	Het
Inpp5f	G	A	7: 128,265,738 (GRCm39)	R161H	probably damaging	Het
Iws1	A	T	18: 32,203,217 (GRCm39)	D31V	possibly damaging	Het
Klhl2	A	T	8: 65,205,801 (GRCm39)	Y373*	probably null	Het
Lce6a	A	T	3: 92,527,607 (GRCm39)	C67S	possibly damaging	Het
Lrba	A	G	3: 86,233,038 (GRCm39)	I800V	possibly damaging	Het
Mis18bp1	A	C	12: 65,200,654 (GRCm39)	Y407*	probably null	Het
Mllt3	A	C	4: 87,949,860 (GRCm39)	W29G	probably damaging	Het
Mon2	A	G	10: 122,845,401 (GRCm39)		probably benign	Het
Mtbp	C	T	15: 55,483,039 (GRCm39)	T372M	probably benign	Het
Nefm	A	T	14: 68,357,664 (GRCm39)		probably benign	Het
Nf1	A	T	11: 79,335,424 (GRCm39)		probably null	Het
Nf1	G	A	11: 79,335,425 (GRCm39)		probably null	Het
Ntn1	T	A	11: 68,276,295 (GRCm39)	I218F	probably benign	Het
Numa1	T	G	7: 101,648,109 (GRCm39)	S613R	possibly damaging	Het
Or14a259	C	T	7: 86,012,811 (GRCm39)	V245I	possibly damaging	Het
Pcsk5	A	T	19: 17,434,134 (GRCm39)	D1411E	probably damaging	Het
Prl2b1	G	T	13: 27,569,225 (GRCm39)	N124K	possibly damaging	Het
Rab15	T	C	12: 76,851,225 (GRCm39)	I30M	possibly damaging	Het
Rnf215	G	T	11: 4,090,307 (GRCm39)	V342L	probably damaging	Het
Saxo4	A	T	19: 10,459,655 (GRCm39)	S17R	probably damaging	Het
Togaram2	T	A	17: 72,036,234 (GRCm39)	I908N	probably damaging	Het
Trim54	A	G	5: 31,293,391 (GRCm39)	N205S	probably damaging	Het
Ttn	G	A	2: 76,697,795 (GRCm39)	T80I	possibly damaging	Het
Vwa5b2	T	C	16: 20,414,063 (GRCm39)		probably benign	Het
Zfat	A	T	15: 68,052,570 (GRCm39)	I401N	probably damaging	Het
Zfp40	G	A	17: 23,395,960 (GRCm39)	S209F	probably benign	Het

Other mutations in Vmn2r106

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00979:Vmn2r106	APN	17	20,497,837 (GRCm39)	missense	possibly damaging	0.90
IGL01313:Vmn2r106	APN	17	20,498,651 (GRCm39)	missense	probably damaging	0.99
IGL01419:Vmn2r106	APN	17	20,499,807 (GRCm39)	missense	probably benign	0.06
IGL01574:Vmn2r106	APN	17	20,488,572 (GRCm39)	missense	possibly damaging	0.94
IGL01796:Vmn2r106	APN	17	20,488,314 (GRCm39)	missense	possibly damaging	0.79
IGL01893:Vmn2r106	APN	17	20,497,730 (GRCm39)	missense	probably benign	0.06
IGL01895:Vmn2r106	APN	17	20,499,227 (GRCm39)	missense	probably benign	0.02
IGL02378:Vmn2r106	APN	17	20,497,791 (GRCm39)	missense	probably damaging	1.00
IGL02430:Vmn2r106	APN	17	20,499,158 (GRCm39)	missense	probably benign	0.38
IGL03308:Vmn2r106	APN	17	20,498,785 (GRCm39)	nonsense	probably null
IGL03384:Vmn2r106	APN	17	20,488,405 (GRCm39)	missense	probably damaging	0.99
R0401:Vmn2r106	UTSW	17	20,499,281 (GRCm39)	missense	possibly damaging	0.86
R0842:Vmn2r106	UTSW	17	20,488,465 (GRCm39)	missense	probably damaging	1.00
R0964:Vmn2r106	UTSW	17	20,487,859 (GRCm39)	missense	probably benign	0.00
R1235:Vmn2r106	UTSW	17	20,499,741 (GRCm39)	missense	probably benign	0.00
R1709:Vmn2r106	UTSW	17	20,499,373 (GRCm39)	missense	probably benign	0.12
R1712:Vmn2r106	UTSW	17	20,498,997 (GRCm39)	missense	probably benign	0.01
R1770:Vmn2r106	UTSW	17	20,488,560 (GRCm39)	missense	probably damaging	0.99
R2049:Vmn2r106	UTSW	17	20,488,566 (GRCm39)	missense	possibly damaging	0.90
R2245:Vmn2r106	UTSW	17	20,488,423 (GRCm39)	missense	probably benign	0.13
R2336:Vmn2r106	UTSW	17	20,488,470 (GRCm39)	missense	probably benign	0.18
R2910:Vmn2r106	UTSW	17	20,498,946 (GRCm39)	missense	probably damaging	1.00
R3025:Vmn2r106	UTSW	17	20,499,147 (GRCm39)	missense	probably benign	0.00
R3944:Vmn2r106	UTSW	17	20,487,913 (GRCm39)	missense	probably damaging	1.00
R4081:Vmn2r106	UTSW	17	20,487,818 (GRCm39)	nonsense	probably null
R4153:Vmn2r106	UTSW	17	20,488,080 (GRCm39)	missense	probably damaging	1.00
R4356:Vmn2r106	UTSW	17	20,499,910 (GRCm39)	missense	probably benign	0.06
R4426:Vmn2r106	UTSW	17	20,505,641 (GRCm39)	missense	probably benign	0.00
R4590:Vmn2r106	UTSW	17	20,497,728 (GRCm39)	missense	probably damaging	0.99
R4661:Vmn2r106	UTSW	17	20,487,885 (GRCm39)	missense	probably benign	0.10
R5106:Vmn2r106	UTSW	17	20,499,395 (GRCm39)	critical splice acceptor site	probably null
R5341:Vmn2r106	UTSW	17	20,497,788 (GRCm39)	missense	probably benign	0.00
R5509:Vmn2r106	UTSW	17	20,498,684 (GRCm39)	missense	probably damaging	0.99
R5826:Vmn2r106	UTSW	17	20,499,133 (GRCm39)	missense	probably benign
R5859:Vmn2r106	UTSW	17	20,505,583 (GRCm39)	missense	possibly damaging	0.72
R5937:Vmn2r106	UTSW	17	20,505,667 (GRCm39)	nonsense	probably null
R5972:Vmn2r106	UTSW	17	20,498,738 (GRCm39)	missense	probably benign
R6056:Vmn2r106	UTSW	17	20,487,806 (GRCm39)	splice site	probably null
R6108:Vmn2r106	UTSW	17	20,488,638 (GRCm39)	missense	probably benign	0.11
R6114:Vmn2r106	UTSW	17	20,488,638 (GRCm39)	missense	probably benign	0.11
R6115:Vmn2r106	UTSW	17	20,488,638 (GRCm39)	missense	probably benign	0.11
R6132:Vmn2r106	UTSW	17	20,488,666 (GRCm39)	missense	probably benign
R6208:Vmn2r106	UTSW	17	20,488,591 (GRCm39)	missense	probably damaging	0.99
R6217:Vmn2r106	UTSW	17	20,488,501 (GRCm39)	missense	probably benign	0.10
R6289:Vmn2r106	UTSW	17	20,488,725 (GRCm39)	missense	probably damaging	1.00
R6378:Vmn2r106	UTSW	17	20,498,667 (GRCm39)	missense	probably benign	0.19
R6390:Vmn2r106	UTSW	17	20,488,725 (GRCm39)	missense	probably damaging	1.00
R6391:Vmn2r106	UTSW	17	20,488,725 (GRCm39)	missense	probably damaging	1.00
R6392:Vmn2r106	UTSW	17	20,488,725 (GRCm39)	missense	probably damaging	1.00
R6405:Vmn2r106	UTSW	17	20,499,361 (GRCm39)	missense	probably benign	0.22
R6427:Vmn2r106	UTSW	17	20,488,725 (GRCm39)	missense	probably damaging	1.00
R6428:Vmn2r106	UTSW	17	20,488,725 (GRCm39)	missense	probably damaging	1.00
R6435:Vmn2r106	UTSW	17	20,488,725 (GRCm39)	missense	probably damaging	1.00
R6436:Vmn2r106	UTSW	17	20,488,725 (GRCm39)	missense	probably damaging	1.00
R6437:Vmn2r106	UTSW	17	20,488,725 (GRCm39)	missense	probably damaging	1.00
R6511:Vmn2r106	UTSW	17	20,488,725 (GRCm39)	missense	probably damaging	1.00
R6512:Vmn2r106	UTSW	17	20,488,725 (GRCm39)	missense	probably damaging	1.00
R6587:Vmn2r106	UTSW	17	20,488,725 (GRCm39)	missense	probably damaging	1.00
R6703:Vmn2r106	UTSW	17	20,488,725 (GRCm39)	missense	probably damaging	1.00
R6730:Vmn2r106	UTSW	17	20,499,096 (GRCm39)	missense	possibly damaging	0.64
R6961:Vmn2r106	UTSW	17	20,488,646 (GRCm39)	nonsense	probably null
R7054:Vmn2r106	UTSW	17	20,499,182 (GRCm39)	missense	probably damaging	0.96
R7379:Vmn2r106	UTSW	17	20,488,037 (GRCm39)	missense	possibly damaging	0.75
R7402:Vmn2r106	UTSW	17	20,487,883 (GRCm39)	missense	probably damaging	0.99
R7497:Vmn2r106	UTSW	17	20,488,201 (GRCm39)	missense	probably damaging	1.00
R7692:Vmn2r106	UTSW	17	20,505,490 (GRCm39)	missense	possibly damaging	0.96
R8539:Vmn2r106	UTSW	17	20,499,271 (GRCm39)	missense	probably benign	0.00
R8827:Vmn2r106	UTSW	17	20,487,868 (GRCm39)	missense	probably benign	0.05
R8872:Vmn2r106	UTSW	17	20,488,401 (GRCm39)	missense	probably benign	0.19
R9118:Vmn2r106	UTSW	17	20,505,667 (GRCm39)	missense	probably benign	0.00
R9254:Vmn2r106	UTSW	17	20,496,066 (GRCm39)	missense	probably damaging	1.00
R9379:Vmn2r106	UTSW	17	20,496,066 (GRCm39)	missense	probably damaging	1.00
R9571:Vmn2r106	UTSW	17	20,505,641 (GRCm39)	missense	probably benign	0.17

Posted On

2015-04-16