Incidental Mutation 'IGL02664:Prl2b1'
ID 302659
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Prl2b1
Ensembl Gene ENSMUSG00000069258
Gene Name prolactin family 2, subfamily b, member 1
Synonyms Prlpk, 2310047B08Rik, PLP-K
Accession Numbers
Essential gene? Probably non essential (E-score: 0.147) question?
Stock # IGL02664
Quality Score
Status
Chromosome 13
Chromosomal Location 27567328-27574829 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) G to T at 27569225 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Asparagine to Lysine at position 124 (N124K)
Ref Sequence ENSEMBL: ENSMUSP00000100019 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000091678] [ENSMUST00000102954]
AlphaFold Q9DAZ2
Predicted Effect possibly damaging
Transcript: ENSMUST00000091678
AA Change: N124K

PolyPhen 2 Score 0.486 (Sensitivity: 0.88; Specificity: 0.90)
SMART Domains Protein: ENSMUSP00000089267
Gene: ENSMUSG00000069258
AA Change: N124K

DomainStartEndE-ValueType
Pfam:Hormone_1 18 235 8.2e-57 PFAM
Predicted Effect possibly damaging
Transcript: ENSMUST00000102954
AA Change: N124K

PolyPhen 2 Score 0.664 (Sensitivity: 0.86; Specificity: 0.91)
SMART Domains Protein: ENSMUSP00000100019
Gene: ENSMUSG00000069258
AA Change: N124K

DomainStartEndE-ValueType
Pfam:Hormone_1 18 228 1.1e-55 PFAM
Coding Region Coverage
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 46 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Ablim2 A T 5: 36,006,860 (GRCm39) D425V probably damaging Het
Afdn G T 17: 14,072,728 (GRCm39) probably benign Het
Afg2a A G 3: 37,490,814 (GRCm39) D453G probably damaging Het
Ap2a2 C T 7: 141,209,136 (GRCm39) T776I probably benign Het
Apcdd1 T C 18: 63,084,891 (GRCm39) probably benign Het
Bdp1 A T 13: 100,188,047 (GRCm39) Y1513N probably benign Het
Btaf1 T C 19: 36,955,828 (GRCm39) probably benign Het
C2cd3 A T 7: 100,068,922 (GRCm39) M917L possibly damaging Het
Cmtm6 T C 9: 114,575,613 (GRCm39) V174A probably benign Het
Cyp2d12 T A 15: 82,443,535 (GRCm39) I448K probably benign Het
Ddb1 A G 19: 10,585,247 (GRCm39) I101V probably benign Het
Dicer1 A G 12: 104,671,388 (GRCm39) Y961H probably damaging Het
Dnaaf1 T G 8: 120,309,260 (GRCm39) I116S probably damaging Het
Ecscr T A 18: 35,854,451 (GRCm39) I5F possibly damaging Het
Eftud2 T C 11: 102,732,538 (GRCm39) E691G probably damaging Het
Fat2 A G 11: 55,201,922 (GRCm39) V384A probably damaging Het
Ftcd T C 10: 76,420,439 (GRCm39) M391T probably damaging Het
Gab2 T G 7: 96,953,389 (GRCm39) S587R probably damaging Het
Gm18856 G A 13: 14,139,809 (GRCm39) probably benign Het
Herc2 A T 7: 55,785,426 (GRCm39) R1559* probably null Het
Inpp5f G A 7: 128,265,738 (GRCm39) R161H probably damaging Het
Iws1 A T 18: 32,203,217 (GRCm39) D31V possibly damaging Het
Klhl2 A T 8: 65,205,801 (GRCm39) Y373* probably null Het
Lce6a A T 3: 92,527,607 (GRCm39) C67S possibly damaging Het
Lrba A G 3: 86,233,038 (GRCm39) I800V possibly damaging Het
Mis18bp1 A C 12: 65,200,654 (GRCm39) Y407* probably null Het
Mllt3 A C 4: 87,949,860 (GRCm39) W29G probably damaging Het
Mon2 A G 10: 122,845,401 (GRCm39) probably benign Het
Mtbp C T 15: 55,483,039 (GRCm39) T372M probably benign Het
Nefm A T 14: 68,357,664 (GRCm39) probably benign Het
Nf1 A T 11: 79,335,424 (GRCm39) probably null Het
Nf1 G A 11: 79,335,425 (GRCm39) probably null Het
Ntn1 T A 11: 68,276,295 (GRCm39) I218F probably benign Het
Numa1 T G 7: 101,648,109 (GRCm39) S613R possibly damaging Het
Or14a259 C T 7: 86,012,811 (GRCm39) V245I possibly damaging Het
Pcsk5 A T 19: 17,434,134 (GRCm39) D1411E probably damaging Het
Rab15 T C 12: 76,851,225 (GRCm39) I30M possibly damaging Het
Rnf215 G T 11: 4,090,307 (GRCm39) V342L probably damaging Het
Saxo4 A T 19: 10,459,655 (GRCm39) S17R probably damaging Het
Togaram2 T A 17: 72,036,234 (GRCm39) I908N probably damaging Het
Trim54 A G 5: 31,293,391 (GRCm39) N205S probably damaging Het
Ttn G A 2: 76,697,795 (GRCm39) T80I possibly damaging Het
Vmn2r106 G A 17: 20,488,344 (GRCm39) T685I possibly damaging Het
Vwa5b2 T C 16: 20,414,063 (GRCm39) probably benign Het
Zfat A T 15: 68,052,570 (GRCm39) I401N probably damaging Het
Zfp40 G A 17: 23,395,960 (GRCm39) S209F probably benign Het
Other mutations in Prl2b1
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL02997:Prl2b1 APN 13 27,569,087 (GRCm39) splice site probably benign
R0600:Prl2b1 UTSW 13 27,574,723 (GRCm39) splice site probably null
R1779:Prl2b1 UTSW 13 27,567,452 (GRCm39) missense probably benign
R1838:Prl2b1 UTSW 13 27,572,549 (GRCm39) missense possibly damaging 0.84
R5936:Prl2b1 UTSW 13 27,572,432 (GRCm39) missense probably damaging 0.99
R6020:Prl2b1 UTSW 13 27,567,491 (GRCm39) missense probably damaging 0.99
R6650:Prl2b1 UTSW 13 27,569,249 (GRCm39) missense probably benign 0.12
R8436:Prl2b1 UTSW 13 27,567,442 (GRCm39) missense possibly damaging 0.90
R9587:Prl2b1 UTSW 13 27,567,601 (GRCm39) missense probably benign 0.00
R9612:Prl2b1 UTSW 13 27,572,479 (GRCm39) missense probably benign 0.00
R9781:Prl2b1 UTSW 13 27,569,129 (GRCm39) missense possibly damaging 0.84
Posted On 2015-04-16