Incidental Mutation 'IGL02667:Atl3'
ID |
302785 |
Institutional Source |
Australian Phenomics Network
(link to record)
|
Gene Symbol |
Atl3
|
Ensembl Gene |
ENSMUSG00000024759 |
Gene Name |
atlastin GTPase 3 |
Synonyms |
5730596K20Rik, 4633402C03Rik |
Accession Numbers |
|
Essential gene? |
Non essential
(E-score: 0.000)
|
Stock # |
IGL02667
|
Quality Score |
|
Status
|
|
Chromosome |
19 |
Chromosomal Location |
7471178-7515974 bp(+) (GRCm39) |
Type of Mutation |
missense |
DNA Base Change (assembly) |
T to C
at 7486781 bp (GRCm39)
|
Zygosity |
Heterozygous |
Amino Acid Change |
Phenylalanine to Leucine
at position 39
(F39L)
|
Ref Sequence |
ENSEMBL: ENSMUSP00000025668
(fasta)
|
Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000025668]
[ENSMUST00000170373]
|
AlphaFold |
Q91YH5 |
Predicted Effect |
possibly damaging
Transcript: ENSMUST00000025668
AA Change: F39L
PolyPhen 2
Score 0.716 (Sensitivity: 0.86; Specificity: 0.92)
|
SMART Domains |
Protein: ENSMUSP00000025668 Gene: ENSMUSG00000024759 AA Change: F39L
Domain | Start | End | E-Value | Type |
Pfam:GBP
|
36 |
310 |
7.2e-99 |
PFAM |
Pfam:GBP_C
|
312 |
438 |
1.7e-9 |
PFAM |
transmembrane domain
|
444 |
466 |
N/A |
INTRINSIC |
transmembrane domain
|
468 |
490 |
N/A |
INTRINSIC |
|
Predicted Effect |
possibly damaging
Transcript: ENSMUST00000170373
AA Change: F34L
PolyPhen 2
Score 0.525 (Sensitivity: 0.88; Specificity: 0.90)
|
SMART Domains |
Protein: ENSMUSP00000132619 Gene: ENSMUSG00000024759 AA Change: F34L
Domain | Start | End | E-Value | Type |
Pfam:GBP
|
31 |
305 |
9.1e-98 |
PFAM |
Pfam:GBP_C
|
307 |
433 |
7.4e-10 |
PFAM |
transmembrane domain
|
439 |
461 |
N/A |
INTRINSIC |
transmembrane domain
|
463 |
485 |
N/A |
INTRINSIC |
|
Coding Region Coverage |
|
Validation Efficiency |
|
MGI Phenotype |
FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a member of a family of dynamin-like, integral membrane GTPases. The encoded protein is required for the proper formation of the network of interconnected tubules of the endoplasmic reticulum. Mutations in this gene may be associated with hereditary sensory neuropathy type IF. Alternatively spliced transcript variants that encode distinct isoforms have been described. [provided by RefSeq, Feb 2014]
|
Allele List at MGI |
|
Other mutations in this stock |
Total: 26 list
Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
6530409C15Rik |
A |
G |
6: 28,217,670 (GRCm39) |
|
noncoding transcript |
Het |
Akr1e1 |
G |
A |
13: 4,645,666 (GRCm39) |
P174L |
possibly damaging |
Het |
Arf5 |
C |
A |
6: 28,425,198 (GRCm39) |
N95K |
probably damaging |
Het |
Atp2a3 |
C |
A |
11: 72,866,165 (GRCm39) |
H262N |
probably benign |
Het |
Cyp2a12 |
T |
C |
7: 26,730,583 (GRCm39) |
S183P |
probably damaging |
Het |
Dicer1 |
T |
A |
12: 104,681,165 (GRCm39) |
R449S |
probably damaging |
Het |
Dlec1 |
T |
C |
9: 118,956,534 (GRCm39) |
I736T |
probably benign |
Het |
Eny2 |
T |
A |
15: 44,292,984 (GRCm39) |
M12K |
possibly damaging |
Het |
Fbxl21 |
C |
T |
13: 56,684,942 (GRCm39) |
R349C |
probably benign |
Het |
Gstm2 |
A |
G |
3: 107,893,424 (GRCm39) |
L13P |
probably damaging |
Het |
Gucy2g |
G |
A |
19: 55,194,609 (GRCm39) |
T936M |
possibly damaging |
Het |
Mbp |
G |
T |
18: 82,572,740 (GRCm39) |
K12N |
probably damaging |
Het |
Mon1b |
G |
T |
8: 114,365,455 (GRCm39) |
R261L |
possibly damaging |
Het |
Myo18a |
A |
G |
11: 77,748,678 (GRCm39) |
|
probably benign |
Het |
Nr2f2 |
T |
C |
7: 70,007,733 (GRCm39) |
S117G |
probably damaging |
Het |
Pi4k2b |
T |
C |
5: 52,907,947 (GRCm39) |
|
probably benign |
Het |
Pi4ka |
A |
G |
16: 17,113,325 (GRCm39) |
F1504L |
possibly damaging |
Het |
Ppm1d |
T |
C |
11: 85,223,111 (GRCm39) |
W239R |
probably damaging |
Het |
Setd1b |
T |
A |
5: 123,295,560 (GRCm39) |
S1043T |
unknown |
Het |
Tgfbrap1 |
T |
C |
1: 43,106,780 (GRCm39) |
I298V |
probably benign |
Het |
Tmem190 |
T |
A |
7: 4,786,157 (GRCm39) |
D20E |
probably benign |
Het |
Tph2 |
A |
T |
10: 114,915,950 (GRCm39) |
C408S |
probably benign |
Het |
Trmt44 |
A |
C |
5: 35,728,396 (GRCm39) |
Y295D |
probably damaging |
Het |
Trpm2 |
C |
T |
10: 77,771,776 (GRCm39) |
R621H |
probably damaging |
Het |
Tut4 |
T |
C |
4: 108,415,905 (GRCm39) |
|
probably benign |
Het |
Ubn1 |
A |
G |
16: 4,880,463 (GRCm39) |
E134G |
probably damaging |
Het |
|
Other mutations in Atl3 |
Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
R0042:Atl3
|
UTSW |
19 |
7,506,388 (GRCm39) |
missense |
probably damaging |
1.00 |
R0607:Atl3
|
UTSW |
19 |
7,507,031 (GRCm39) |
critical splice donor site |
probably null |
|
R0975:Atl3
|
UTSW |
19 |
7,498,500 (GRCm39) |
nonsense |
probably null |
|
R1582:Atl3
|
UTSW |
19 |
7,494,264 (GRCm39) |
missense |
probably damaging |
1.00 |
R4195:Atl3
|
UTSW |
19 |
7,495,911 (GRCm39) |
missense |
possibly damaging |
0.59 |
R4249:Atl3
|
UTSW |
19 |
7,509,703 (GRCm39) |
missense |
probably benign |
0.06 |
R4505:Atl3
|
UTSW |
19 |
7,498,184 (GRCm39) |
missense |
probably benign |
0.00 |
R4836:Atl3
|
UTSW |
19 |
7,486,910 (GRCm39) |
nonsense |
probably null |
|
R5649:Atl3
|
UTSW |
19 |
7,509,592 (GRCm39) |
missense |
possibly damaging |
0.50 |
R5721:Atl3
|
UTSW |
19 |
7,506,376 (GRCm39) |
missense |
probably benign |
0.00 |
R6459:Atl3
|
UTSW |
19 |
7,498,163 (GRCm39) |
missense |
probably benign |
0.07 |
R6530:Atl3
|
UTSW |
19 |
7,499,499 (GRCm39) |
missense |
probably benign |
|
R6543:Atl3
|
UTSW |
19 |
7,487,463 (GRCm39) |
missense |
probably damaging |
1.00 |
R6550:Atl3
|
UTSW |
19 |
7,499,503 (GRCm39) |
missense |
probably benign |
|
R7059:Atl3
|
UTSW |
19 |
7,511,334 (GRCm39) |
missense |
probably benign |
0.08 |
R7059:Atl3
|
UTSW |
19 |
7,511,333 (GRCm39) |
missense |
probably benign |
|
R7220:Atl3
|
UTSW |
19 |
7,506,433 (GRCm39) |
missense |
probably null |
0.02 |
R7666:Atl3
|
UTSW |
19 |
7,487,405 (GRCm39) |
missense |
probably benign |
0.19 |
R9143:Atl3
|
UTSW |
19 |
7,509,408 (GRCm39) |
missense |
probably benign |
0.01 |
R9206:Atl3
|
UTSW |
19 |
7,487,447 (GRCm39) |
missense |
probably benign |
0.09 |
R9208:Atl3
|
UTSW |
19 |
7,487,447 (GRCm39) |
missense |
probably benign |
0.09 |
R9631:Atl3
|
UTSW |
19 |
7,509,553 (GRCm39) |
missense |
probably benign |
0.00 |
R9709:Atl3
|
UTSW |
19 |
7,507,921 (GRCm39) |
missense |
probably benign |
0.00 |
R9733:Atl3
|
UTSW |
19 |
7,509,705 (GRCm39) |
missense |
probably damaging |
0.99 |
X0020:Atl3
|
UTSW |
19 |
7,507,934 (GRCm39) |
missense |
probably benign |
0.00 |
Z1176:Atl3
|
UTSW |
19 |
7,487,402 (GRCm39) |
missense |
probably damaging |
1.00 |
Z1177:Atl3
|
UTSW |
19 |
7,507,918 (GRCm39) |
missense |
probably benign |
0.19 |
|
Posted On |
2015-04-16 |