Incidental Mutation 'IGL02669:Eif3e'
ID 302858
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Eif3e
Ensembl Gene ENSMUSG00000022336
Gene Name eukaryotic translation initiation factor 3, subunit E
Synonyms Eif3s6, Int6, eIF3-p48, eIF3-p46, 48kDa
Accession Numbers
Essential gene? Probably essential (E-score: 0.957) question?
Stock # IGL02669
Quality Score
Status
Chromosome 15
Chromosomal Location 43113454-43146115 bp(-) (GRCm39)
Type of Mutation start codon destroyed
DNA Base Change (assembly) T to A at 43146088 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Methionine to Leucine at position 1 (M1L)
Ref Sequence ENSEMBL: ENSMUSP00000022960 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000022960]
AlphaFold P60229
Predicted Effect probably benign
Transcript: ENSMUST00000022960
AA Change: M1L

PolyPhen 2 Score 0.000 (Sensitivity: 1.00; Specificity: 0.00)
SMART Domains Protein: ENSMUSP00000022960
Gene: ENSMUSG00000022336
AA Change: M1L

DomainStartEndE-ValueType
eIF3_N 5 138 4.88e-70 SMART
Blast:eIF3_N 157 193 2e-14 BLAST
Blast:PINT 218 251 7e-9 BLAST
Blast:PINT 284 315 3e-13 BLAST
PINT 327 411 8.17e-19 SMART
Predicted Effect noncoding transcript
Transcript: ENSMUST00000226415
Predicted Effect noncoding transcript
Transcript: ENSMUST00000228892
Coding Region Coverage
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 46 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
A930003A15Rik T A 16: 19,702,505 (GRCm39) noncoding transcript Het
Acap1 G A 11: 69,785,421 (GRCm39) probably benign Het
Adam7 T C 14: 68,745,343 (GRCm39) Y627C probably damaging Het
Agrn C T 4: 156,259,018 (GRCm39) probably benign Het
Aoc1l2 A G 6: 48,908,407 (GRCm39) Y469C probably damaging Het
Bace2 T C 16: 97,238,093 (GRCm39) *515R probably null Het
Baiap3 C T 17: 25,463,322 (GRCm39) V958M probably damaging Het
Brms1l A T 12: 55,888,401 (GRCm39) D63V probably damaging Het
Cnksr1 A T 4: 133,957,774 (GRCm39) I435N probably damaging Het
Col14a1 G A 15: 55,282,178 (GRCm39) G813E unknown Het
Cpne6 A G 14: 55,751,283 (GRCm39) N201S probably benign Het
Dnajc12 A G 10: 63,233,071 (GRCm39) S71G probably damaging Het
Dpp3 A T 19: 4,973,710 (GRCm39) probably null Het
E2f3 A G 13: 30,100,974 (GRCm39) S239P probably benign Het
Erap1 A G 13: 74,823,987 (GRCm39) T867A probably benign Het
Erlin1 G T 19: 44,027,658 (GRCm39) A260E probably damaging Het
Esrp1 A G 4: 11,386,324 (GRCm39) V38A possibly damaging Het
Foxn1 T C 11: 78,261,986 (GRCm39) R128G probably damaging Het
Gnb3 A G 6: 124,814,688 (GRCm39) L70P probably benign Het
Gon4l T C 3: 88,802,806 (GRCm39) V1139A probably damaging Het
Gpt2 G T 8: 86,249,908 (GRCm39) M463I probably benign Het
Gtpbp3 C A 8: 71,943,546 (GRCm39) A201D probably damaging Het
Jaml A C 9: 45,015,489 (GRCm39) K331T possibly damaging Het
Kntc1 G A 5: 123,893,727 (GRCm39) probably benign Het
Ksr2 A G 5: 117,693,446 (GRCm39) K298R probably damaging Het
Mfge8 T C 7: 78,795,429 (GRCm39) D46G probably benign Het
Ncam2 T A 16: 81,314,429 (GRCm39) N468K probably benign Het
Nup88 A G 11: 70,847,110 (GRCm39) M300T probably damaging Het
Or4c118 T A 2: 88,974,564 (GRCm39) K268* probably null Het
Or4k48 A T 2: 111,476,236 (GRCm39) Y35* probably null Het
Or52b4 A G 7: 102,184,868 (GRCm39) M305V probably benign Het
Prdm1 A T 10: 44,315,880 (GRCm39) M752K probably benign Het
Prl3b1 A T 13: 27,429,795 (GRCm39) M78L probably benign Het
Ralgps2 T C 1: 156,660,268 (GRCm39) E268G probably damaging Het
Rgs11 G A 17: 26,426,605 (GRCm39) V279I probably benign Het
Slc4a5 A G 6: 83,240,525 (GRCm39) D279G possibly damaging Het
Tanc1 T A 2: 59,630,330 (GRCm39) I770K probably damaging Het
Tbl2 G A 5: 135,181,852 (GRCm39) R64H probably damaging Het
Tg T A 15: 66,620,575 (GRCm39) probably benign Het
Tmprss13 A T 9: 45,243,824 (GRCm39) I187F probably benign Het
Tubb3 T C 8: 124,147,856 (GRCm39) L263P probably damaging Het
Vmn2r109 T G 17: 20,774,518 (GRCm39) D279A possibly damaging Het
Vps33b A G 7: 79,925,786 (GRCm39) probably benign Het
Yeats2 A G 16: 20,005,033 (GRCm39) S338G probably benign Het
Zfp142 T C 1: 74,610,432 (GRCm39) Q1121R probably benign Het
Zic1 G T 9: 91,246,486 (GRCm39) H195Q possibly damaging Het
Other mutations in Eif3e
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00765:Eif3e APN 15 43,141,745 (GRCm39) missense probably benign 0.17
IGL02333:Eif3e APN 15 43,129,533 (GRCm39) missense probably benign 0.37
IGL03119:Eif3e APN 15 43,129,000 (GRCm39) missense probably benign
IGL03200:Eif3e APN 15 43,115,657 (GRCm39) missense probably damaging 1.00
Verdugo UTSW 15 43,135,685 (GRCm39) missense probably benign 0.29
R0152:Eif3e UTSW 15 43,115,632 (GRCm39) missense possibly damaging 0.83
R1439:Eif3e UTSW 15 43,141,824 (GRCm39) splice site probably benign
R1613:Eif3e UTSW 15 43,113,620 (GRCm39) missense possibly damaging 0.81
R1997:Eif3e UTSW 15 43,129,005 (GRCm39) missense probably damaging 1.00
R2221:Eif3e UTSW 15 43,114,943 (GRCm39) missense possibly damaging 0.95
R3761:Eif3e UTSW 15 43,124,480 (GRCm39) missense probably damaging 0.99
R4241:Eif3e UTSW 15 43,126,086 (GRCm39) missense probably damaging 0.97
R4571:Eif3e UTSW 15 43,129,558 (GRCm39) missense possibly damaging 0.74
R5061:Eif3e UTSW 15 43,115,657 (GRCm39) missense probably damaging 1.00
R5227:Eif3e UTSW 15 43,114,917 (GRCm39) missense probably benign 0.01
R5367:Eif3e UTSW 15 43,115,700 (GRCm39) missense probably damaging 1.00
R5417:Eif3e UTSW 15 43,128,917 (GRCm39) missense probably benign 0.00
R5497:Eif3e UTSW 15 43,134,366 (GRCm39) missense probably damaging 0.98
R5928:Eif3e UTSW 15 43,138,728 (GRCm39) splice site probably null
R6083:Eif3e UTSW 15 43,129,540 (GRCm39) missense probably damaging 1.00
R6337:Eif3e UTSW 15 43,115,692 (GRCm39) missense possibly damaging 0.95
R6964:Eif3e UTSW 15 43,135,685 (GRCm39) missense probably benign 0.29
R7692:Eif3e UTSW 15 43,126,642 (GRCm39) missense probably damaging 0.98
R7825:Eif3e UTSW 15 43,129,667 (GRCm39) splice site probably null
R8034:Eif3e UTSW 15 43,135,703 (GRCm39) missense probably benign 0.02
R9463:Eif3e UTSW 15 43,138,709 (GRCm39) missense probably benign
R9583:Eif3e UTSW 15 43,128,957 (GRCm39) missense probably damaging 0.97
Posted On 2015-04-16