Mutagenetix > Incidental Mutation

Incidental Mutation 'IGL02669:Or4c118'

302865

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Or4c118

Ensembl Gene

ENSMUSG00000075100

Gene Name

olfactory receptor family 4 subfamily C member 118

Synonyms

MOR233-10, Olfr1223, GA_x6K02T2Q125-50623664-50622729

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.049) question?

Stock #

IGL02669

Quality Score

Status

Chromosome

Chromosomal Location

88974430-88981680 bp(-) (GRCm39)

Type of Mutation

nonsense

DNA Base Change (assembly)

T to A at 88974564 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Lysine to Stop codon at position 268 (K268*)

Ref Sequence

ENSEMBL: ENSMUSP00000150550 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000099793] [ENSMUST00000217342]

AlphaFold

A0A1L1SU13

Predicted Effect

probably null
Transcript: ENSMUST00000099793
AA Change: K268*

SMART Domains

Protein: ENSMUSP00000097381
Gene: ENSMUSG00000075099
AA Change: K268*

Domain	Start	End	E-Value	Type
Pfam:7tm_1	39	286	2e-26	PFAM
Pfam:7tm_4	138	283	5.6e-37	PFAM

Predicted Effect

probably null
Transcript: ENSMUST00000217342
AA Change: K268*

Coding Region Coverage

Validation Efficiency

MGI Phenotype

FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]

Allele List at MGI

Other mutations in this stock

Total: 46 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
A930003A15Rik	T	A	16: 19,702,505 (GRCm39)		noncoding transcript	Het
Acap1	G	A	11: 69,785,421 (GRCm39)		probably benign	Het
Adam7	T	C	14: 68,745,343 (GRCm39)	Y627C	probably damaging	Het
Agrn	C	T	4: 156,259,018 (GRCm39)		probably benign	Het
Aoc1l2	A	G	6: 48,908,407 (GRCm39)	Y469C	probably damaging	Het
Bace2	T	C	16: 97,238,093 (GRCm39)	*515R	probably null	Het
Baiap3	C	T	17: 25,463,322 (GRCm39)	V958M	probably damaging	Het
Brms1l	A	T	12: 55,888,401 (GRCm39)	D63V	probably damaging	Het
Cnksr1	A	T	4: 133,957,774 (GRCm39)	I435N	probably damaging	Het
Col14a1	G	A	15: 55,282,178 (GRCm39)	G813E	unknown	Het
Cpne6	A	G	14: 55,751,283 (GRCm39)	N201S	probably benign	Het
Dnajc12	A	G	10: 63,233,071 (GRCm39)	S71G	probably damaging	Het
Dpp3	A	T	19: 4,973,710 (GRCm39)		probably null	Het
E2f3	A	G	13: 30,100,974 (GRCm39)	S239P	probably benign	Het
Eif3e	T	A	15: 43,146,088 (GRCm39)	M1L	probably benign	Het
Erap1	A	G	13: 74,823,987 (GRCm39)	T867A	probably benign	Het
Erlin1	G	T	19: 44,027,658 (GRCm39)	A260E	probably damaging	Het
Esrp1	A	G	4: 11,386,324 (GRCm39)	V38A	possibly damaging	Het
Foxn1	T	C	11: 78,261,986 (GRCm39)	R128G	probably damaging	Het
Gnb3	A	G	6: 124,814,688 (GRCm39)	L70P	probably benign	Het
Gon4l	T	C	3: 88,802,806 (GRCm39)	V1139A	probably damaging	Het
Gpt2	G	T	8: 86,249,908 (GRCm39)	M463I	probably benign	Het
Gtpbp3	C	A	8: 71,943,546 (GRCm39)	A201D	probably damaging	Het
Jaml	A	C	9: 45,015,489 (GRCm39)	K331T	possibly damaging	Het
Kntc1	G	A	5: 123,893,727 (GRCm39)		probably benign	Het
Ksr2	A	G	5: 117,693,446 (GRCm39)	K298R	probably damaging	Het
Mfge8	T	C	7: 78,795,429 (GRCm39)	D46G	probably benign	Het
Ncam2	T	A	16: 81,314,429 (GRCm39)	N468K	probably benign	Het
Nup88	A	G	11: 70,847,110 (GRCm39)	M300T	probably damaging	Het
Or4k48	A	T	2: 111,476,236 (GRCm39)	Y35*	probably null	Het
Or52b4	A	G	7: 102,184,868 (GRCm39)	M305V	probably benign	Het
Prdm1	A	T	10: 44,315,880 (GRCm39)	M752K	probably benign	Het
Prl3b1	A	T	13: 27,429,795 (GRCm39)	M78L	probably benign	Het
Ralgps2	T	C	1: 156,660,268 (GRCm39)	E268G	probably damaging	Het
Rgs11	G	A	17: 26,426,605 (GRCm39)	V279I	probably benign	Het
Slc4a5	A	G	6: 83,240,525 (GRCm39)	D279G	possibly damaging	Het
Tanc1	T	A	2: 59,630,330 (GRCm39)	I770K	probably damaging	Het
Tbl2	G	A	5: 135,181,852 (GRCm39)	R64H	probably damaging	Het
Tg	T	A	15: 66,620,575 (GRCm39)		probably benign	Het
Tmprss13	A	T	9: 45,243,824 (GRCm39)	I187F	probably benign	Het
Tubb3	T	C	8: 124,147,856 (GRCm39)	L263P	probably damaging	Het
Vmn2r109	T	G	17: 20,774,518 (GRCm39)	D279A	possibly damaging	Het
Vps33b	A	G	7: 79,925,786 (GRCm39)		probably benign	Het
Yeats2	A	G	16: 20,005,033 (GRCm39)	S338G	probably benign	Het
Zfp142	T	C	1: 74,610,432 (GRCm39)	Q1121R	probably benign	Het
Zic1	G	T	9: 91,246,486 (GRCm39)	H195Q	possibly damaging	Het

Other mutations in Or4c118

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL01346:Or4c118	APN	2	88,974,575 (GRCm39)	missense	possibly damaging	0.55
IGL01560:Or4c118	APN	2	88,974,947 (GRCm39)	missense	probably damaging	1.00
IGL01817:Or4c118	APN	2	88,974,702 (GRCm39)	missense	probably benign	0.01
IGL03270:Or4c118	APN	2	88,975,089 (GRCm39)	missense	probably damaging	0.98
R0062:Or4c118	UTSW	2	88,974,966 (GRCm39)	missense	possibly damaging	0.95
R0062:Or4c118	UTSW	2	88,974,966 (GRCm39)	missense	possibly damaging	0.95
R0304:Or4c118	UTSW	2	88,975,108 (GRCm39)	nonsense	probably null
R1651:Or4c118	UTSW	2	88,975,346 (GRCm39)	missense	probably damaging	1.00
R1971:Or4c118	UTSW	2	88,975,078 (GRCm39)	nonsense	probably null
R2006:Or4c118	UTSW	2	88,975,241 (GRCm39)	missense	probably benign	0.21
R2101:Or4c118	UTSW	2	88,975,301 (GRCm39)	missense	probably benign	0.03
R2410:Or4c118	UTSW	2	88,974,899 (GRCm39)	missense	possibly damaging	0.88
R3683:Or4c118	UTSW	2	88,975,364 (GRCm39)	start codon destroyed	probably null	1.00
R3685:Or4c118	UTSW	2	88,975,364 (GRCm39)	start codon destroyed	probably null	1.00
R3939:Or4c118	UTSW	2	88,974,474 (GRCm39)	nonsense	probably null
R6162:Or4c118	UTSW	2	88,975,114 (GRCm39)	missense	probably benign	0.00
R8431:Or4c118	UTSW	2	88,974,723 (GRCm39)	missense	probably benign	0.06
R8842:Or4c118	UTSW	2	88,975,074 (GRCm39)	missense	probably benign
R9631:Or4c118	UTSW	2	88,975,522 (GRCm39)	start gained	probably benign

Posted On

2015-04-16