Incidental Mutation 'IGL02670:Vmn1r218'
ID 302882
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Vmn1r218
Ensembl Gene ENSMUSG00000115020
Gene Name vomeronasal 1 receptor 218
Synonyms V1ri5
Accession Numbers
Essential gene? Probably non essential (E-score: 0.140) question?
Stock # IGL02670
Quality Score
Status
Chromosome 13
Chromosomal Location 23320655-23321551 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to G at 23321174 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Isoleucine to Valine at position 94 (I94V)
Ref Sequence ENSEMBL: ENSMUSP00000154769 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000074992] [ENSMUST00000226692] [ENSMUST00000227050] [ENSMUST00000227160] [ENSMUST00000227741]
AlphaFold Q8R261
Predicted Effect probably benign
Transcript: ENSMUST00000074992
AA Change: I174V

PolyPhen 2 Score 0.010 (Sensitivity: 0.96; Specificity: 0.77)
SMART Domains Protein: ENSMUSP00000074519
Gene: ENSMUSG00000115020
AA Change: I174V

DomainStartEndE-ValueType
Pfam:TAS2R 1 288 2e-7 PFAM
Pfam:V1R 33 297 5.4e-41 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000226692
AA Change: I174V

PolyPhen 2 Score 0.010 (Sensitivity: 0.96; Specificity: 0.77)
Predicted Effect probably benign
Transcript: ENSMUST00000227050
AA Change: I174V

PolyPhen 2 Score 0.010 (Sensitivity: 0.96; Specificity: 0.77)
Predicted Effect probably benign
Transcript: ENSMUST00000227160
AA Change: I94V

PolyPhen 2 Score 0.010 (Sensitivity: 0.96; Specificity: 0.77)
Predicted Effect probably benign
Transcript: ENSMUST00000227741
AA Change: I94V

PolyPhen 2 Score 0.002 (Sensitivity: 0.99; Specificity: 0.30)
Predicted Effect noncoding transcript
Transcript: ENSMUST00000228348
Coding Region Coverage
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 27 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Asb1 T C 1: 91,474,640 (GRCm39) probably benign Het
Bltp1 C T 3: 37,021,454 (GRCm39) Q2193* probably null Het
Cnot6 G A 11: 49,575,941 (GRCm39) Q178* probably null Het
Col5a1 C T 2: 27,864,727 (GRCm39) A737V unknown Het
Cyp27b1 T C 10: 126,886,227 (GRCm39) S303P probably benign Het
Dnah5 T C 15: 28,409,442 (GRCm39) L3620P probably damaging Het
Dock7 A T 4: 98,854,523 (GRCm39) probably null Het
Fam161b T C 12: 84,404,368 (GRCm39) D104G probably benign Het
Fam8a1 A G 13: 46,827,080 (GRCm39) M284V possibly damaging Het
Fkbp3 T A 12: 65,115,877 (GRCm39) K65* probably null Het
Gatb A G 3: 85,520,858 (GRCm39) probably null Het
Gm572 A T 4: 148,735,685 (GRCm39) H38L probably benign Het
Gm6576 A C 15: 27,025,598 (GRCm39) noncoding transcript Het
L2hgdh G A 12: 69,739,254 (GRCm39) R406W possibly damaging Het
Lmo7 A T 14: 102,118,416 (GRCm39) T214S probably damaging Het
Map3k12 T C 15: 102,411,981 (GRCm39) H361R probably benign Het
Mios T C 6: 8,235,378 (GRCm39) probably benign Het
Mta1 T C 12: 113,093,741 (GRCm39) L315P probably damaging Het
Pask A C 1: 93,238,540 (GRCm39) V1315G probably damaging Het
Pias4 A T 10: 80,999,904 (GRCm39) C50S probably damaging Het
Rgs11 G A 17: 26,426,605 (GRCm39) V279I probably benign Het
Sgk1 T A 10: 21,804,445 (GRCm39) C92S probably benign Het
Slc2a13 C T 15: 91,381,712 (GRCm39) G259E probably damaging Het
Slc5a4b A G 10: 75,910,934 (GRCm39) C301R probably damaging Het
Sstr4 G T 2: 148,238,453 (GRCm39) G355* probably null Het
Tnrc6a T A 7: 122,770,535 (GRCm39) L775Q possibly damaging Het
Xpa A G 4: 46,185,682 (GRCm39) F99L probably benign Het
Other mutations in Vmn1r218
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL02014:Vmn1r218 APN 13 23,321,001 (GRCm39) missense probably damaging 0.97
IGL03085:Vmn1r218 APN 13 23,321,481 (GRCm39) missense possibly damaging 0.76
IGL03334:Vmn1r218 APN 13 23,320,788 (GRCm39) missense probably damaging 1.00
R0049:Vmn1r218 UTSW 13 23,321,225 (GRCm39) nonsense probably null
R0049:Vmn1r218 UTSW 13 23,321,225 (GRCm39) nonsense probably null
R1387:Vmn1r218 UTSW 13 23,321,478 (GRCm39) missense probably damaging 1.00
R1959:Vmn1r218 UTSW 13 23,320,683 (GRCm39) missense probably damaging 0.96
R3713:Vmn1r218 UTSW 13 23,321,081 (GRCm39) missense probably damaging 1.00
R3714:Vmn1r218 UTSW 13 23,321,081 (GRCm39) missense probably damaging 1.00
R4037:Vmn1r218 UTSW 13 23,320,971 (GRCm39) missense possibly damaging 0.91
R4038:Vmn1r218 UTSW 13 23,320,971 (GRCm39) missense possibly damaging 0.91
R4039:Vmn1r218 UTSW 13 23,320,971 (GRCm39) missense possibly damaging 0.91
R4432:Vmn1r218 UTSW 13 23,321,412 (GRCm39) missense possibly damaging 0.87
R5255:Vmn1r218 UTSW 13 23,320,881 (GRCm39) missense possibly damaging 0.92
R5521:Vmn1r218 UTSW 13 23,320,743 (GRCm39) missense probably benign 0.01
R7384:Vmn1r218 UTSW 13 23,320,895 (GRCm39) missense probably benign 0.00
R7565:Vmn1r218 UTSW 13 23,320,830 (GRCm39) missense probably benign 0.05
R8178:Vmn1r218 UTSW 13 23,321,472 (GRCm39) missense probably benign 0.08
R8536:Vmn1r218 UTSW 13 23,321,535 (GRCm39) missense probably benign 0.00
R9225:Vmn1r218 UTSW 13 23,320,824 (GRCm39) missense probably benign 0.04
R9609:Vmn1r218 UTSW 13 23,320,839 (GRCm39) missense probably benign 0.01
R9734:Vmn1r218 UTSW 13 23,321,034 (GRCm39) missense probably damaging 1.00
Posted On 2015-04-16