Mutagenetix > Incidental Mutation

Incidental Mutation 'IGL02672:Vmn2r96'

302943

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Vmn2r96

Ensembl Gene

ENSMUSG00000091679

Gene Name

vomeronasal 2, receptor 96

Synonyms

EG433070

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.157) question?

Stock #

IGL02672

Quality Score

Status

Chromosome

Chromosomal Location

18793282-18818419 bp(+) (GRCm39)

Type of Mutation

missense

DNA Base Change (assembly)

T to A at 18818376 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Isoleucine to Asparagine at position 651 (I651N)

Ref Sequence

ENSEMBL: ENSMUSP00000131564 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000165692] [ENSMUST00000177244] [ENSMUST00000231261] [ENSMUST00000231286]

AlphaFold

E9PZU5

Predicted Effect

probably benign
Transcript: ENSMUST00000165692
AA Change: I651N

PolyPhen 2 Score 0.019 (Sensitivity: 0.95; Specificity: 0.80)

SMART Domains

Protein: ENSMUSP00000131564
Gene: ENSMUSG00000091679
AA Change: I651N

Domain	Start	End	E-Value	Type
Pfam:ANF_receptor	1	257	8.6e-20	PFAM
Pfam:NCD3G	317	370	3.7e-22	PFAM
Pfam:7tm_3	402	638	3.9e-53	PFAM

Predicted Effect

probably benign
Transcript: ENSMUST00000177244
AA Change: I843N

PolyPhen 2 Score 0.013 (Sensitivity: 0.96; Specificity: 0.78)

SMART Domains

Protein: ENSMUSP00000135095
Gene: ENSMUSG00000091679
AA Change: I843N

Domain	Start	End	E-Value	Type
Pfam:ANF_receptor	1	245	4.2e-19	PFAM
Pfam:NCD3G	317	370	6.9e-21	PFAM
Pfam:7tm_3	400	639	3.4e-75	PFAM

Predicted Effect

probably benign
Transcript: ENSMUST00000231261

Predicted Effect

probably benign
Transcript: ENSMUST00000231286
AA Change: I843N

PolyPhen 2 Score 0.013 (Sensitivity: 0.96; Specificity: 0.78)

Coding Region Coverage

Validation Efficiency

Allele List at MGI

Other mutations in this stock

Total: 41 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Agrn	C	T	4: 156,259,018 (GRCm39)		probably benign	Het
Alpi	A	G	1: 87,028,994 (GRCm39)	L60P	probably damaging	Het
Arpc1a	A	C	5: 145,041,697 (GRCm39)	I327L	probably damaging	Het
Col5a1	C	T	2: 27,864,727 (GRCm39)	A737V	unknown	Het
Dcaf7	T	C	11: 105,945,684 (GRCm39)		probably benign	Het
Dnah9	T	G	11: 65,818,427 (GRCm39)	I3304L	probably benign	Het
Dpp10	T	A	1: 123,304,376 (GRCm39)	H508L	probably benign	Het
Dync1i1	A	G	6: 5,767,034 (GRCm39)	D86G	probably benign	Het
Enpp7	T	C	11: 118,883,166 (GRCm39)		probably null	Het
Fbxw9	C	A	8: 85,792,682 (GRCm39)		probably null	Het
Foxred2	A	G	15: 77,829,777 (GRCm39)		probably null	Het
Gas2l2	C	T	11: 83,315,957 (GRCm39)	R254H	probably damaging	Het
Gatad2b	C	T	3: 90,249,198 (GRCm39)	L79F	possibly damaging	Het
Igf1r	A	T	7: 67,839,781 (GRCm39)	D696V	probably benign	Het
Kcnk5	A	G	14: 20,196,580 (GRCm39)	I96T	probably damaging	Het
Lrrc8c	C	T	5: 105,755,224 (GRCm39)	T333M	possibly damaging	Het
Mcm10	T	C	2: 5,006,092 (GRCm39)	T417A	probably benign	Het
Mesp2	T	C	7: 79,461,145 (GRCm39)	S157P	probably benign	Het
Naca	A	G	10: 127,876,152 (GRCm39)		probably benign	Het
Or5t17	A	T	2: 86,832,417 (GRCm39)	M35L	probably benign	Het
Osgepl1	A	G	1: 53,359,270 (GRCm39)	T260A	probably benign	Het
Otop1	T	C	5: 38,435,170 (GRCm39)		probably null	Het
Pdk1	T	C	2: 71,726,096 (GRCm39)	S335P	probably damaging	Het
Phkb	A	G	8: 86,668,987 (GRCm39)	N338S	probably benign	Het
Pogz	G	A	3: 94,763,410 (GRCm39)	V61I	probably benign	Het
Ppp4r1	A	G	17: 66,147,942 (GRCm39)	Y928C	probably damaging	Het
Rab17	T	C	1: 90,886,940 (GRCm39)	E160G	probably damaging	Het
Rasgrp3	T	A	17: 75,803,412 (GRCm39)	F70Y	probably benign	Het
Rere	T	A	4: 150,594,483 (GRCm39)	N364K	unknown	Het
Ryr1	A	T	7: 28,703,944 (GRCm39)		probably benign	Het
Sae1	A	G	7: 16,104,273 (GRCm39)	V112A	probably damaging	Het
Serpinb6d	C	T	13: 33,855,372 (GRCm39)	H349Y	probably benign	Het
Slc12a1	T	C	2: 125,012,596 (GRCm39)	V286A	probably damaging	Het
Smad3	A	T	9: 63,575,009 (GRCm39)		probably null	Het
Sox8	T	A	17: 25,787,963 (GRCm39)	D162V	probably damaging	Het
Sptbn1	A	G	11: 30,087,239 (GRCm39)	F1067L	probably damaging	Het
Tmprss3	T	C	17: 31,409,981 (GRCm39)	Y211C	probably damaging	Het
Top2b	T	C	14: 16,409,166 (GRCm38)		probably benign	Het
Tpp1	A	T	7: 105,396,168 (GRCm39)	H510Q	probably benign	Het
Ugcg	T	A	4: 59,218,587 (GRCm39)		probably benign	Het
Wdr25	A	T	12: 108,864,007 (GRCm39)	K51*	probably null	Het

Other mutations in Vmn2r96

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00562:Vmn2r96	APN	17	18,804,077 (GRCm39)	missense	probably benign	0.00
IGL00563:Vmn2r96	APN	17	18,804,077 (GRCm39)	missense	probably benign	0.00
IGL00769:Vmn2r96	APN	17	18,804,081 (GRCm39)	missense	probably benign	0.00
IGL01314:Vmn2r96	APN	17	18,803,226 (GRCm39)	missense	probably benign	0.00
IGL01983:Vmn2r96	APN	17	18,817,527 (GRCm39)	missense	probably damaging	0.99
IGL02314:Vmn2r96	APN	17	18,804,221 (GRCm39)	missense	probably benign	0.01
IGL02600:Vmn2r96	APN	17	18,817,829 (GRCm39)	missense	probably benign
IGL02750:Vmn2r96	APN	17	18,802,851 (GRCm39)	missense	probably benign	0.01
IGL03068:Vmn2r96	APN	17	18,803,137 (GRCm39)	missense	probably benign	0.00
IGL03411:Vmn2r96	APN	17	18,806,634 (GRCm39)	missense	possibly damaging	0.88
R0316:Vmn2r96	UTSW	17	18,802,827 (GRCm39)	missense	probably damaging	1.00
R0502:Vmn2r96	UTSW	17	18,804,262 (GRCm39)	missense	probably benign
R0580:Vmn2r96	UTSW	17	18,802,900 (GRCm39)	missense	probably damaging	1.00
R0652:Vmn2r96	UTSW	17	18,817,830 (GRCm39)	missense	probably benign	0.05
R0789:Vmn2r96	UTSW	17	18,802,738 (GRCm39)	missense	possibly damaging	0.81
R1462:Vmn2r96	UTSW	17	18,817,660 (GRCm39)	missense	possibly damaging	0.94
R1462:Vmn2r96	UTSW	17	18,817,660 (GRCm39)	missense	possibly damaging	0.94
R1660:Vmn2r96	UTSW	17	18,817,988 (GRCm39)	missense	probably benign	0.00
R1755:Vmn2r96	UTSW	17	18,802,915 (GRCm39)	missense	possibly damaging	0.50
R1843:Vmn2r96	UTSW	17	18,818,183 (GRCm39)	missense	probably benign	0.14
R1943:Vmn2r96	UTSW	17	18,806,664 (GRCm39)	missense	probably benign	0.09
R1993:Vmn2r96	UTSW	17	18,804,138 (GRCm39)	missense	probably damaging	1.00
R2018:Vmn2r96	UTSW	17	18,804,263 (GRCm39)	missense	probably benign
R2405:Vmn2r96	UTSW	17	18,818,102 (GRCm39)	missense	probably damaging	0.96
R3977:Vmn2r96	UTSW	17	18,817,941 (GRCm39)	missense	probably damaging	1.00
R3979:Vmn2r96	UTSW	17	18,817,941 (GRCm39)	missense	probably damaging	1.00
R4059:Vmn2r96	UTSW	17	18,818,339 (GRCm39)	missense	probably benign	0.20
R4693:Vmn2r96	UTSW	17	18,803,270 (GRCm39)	missense	probably benign	0.03
R4709:Vmn2r96	UTSW	17	18,803,088 (GRCm39)	missense	probably benign	0.36
R4776:Vmn2r96	UTSW	17	18,817,770 (GRCm39)	missense	probably damaging	1.00
R4882:Vmn2r96	UTSW	17	18,817,866 (GRCm39)	missense	probably damaging	1.00
R4920:Vmn2r96	UTSW	17	18,802,918 (GRCm39)	missense	probably benign	0.07
R5143:Vmn2r96	UTSW	17	18,804,120 (GRCm39)	missense	possibly damaging	0.65
R5301:Vmn2r96	UTSW	17	18,817,950 (GRCm39)	missense	probably damaging	0.98
R5507:Vmn2r96	UTSW	17	18,818,091 (GRCm39)	missense	probably damaging	1.00
R6151:Vmn2r96	UTSW	17	18,804,221 (GRCm39)	missense	probably benign	0.01
R6181:Vmn2r96	UTSW	17	18,804,126 (GRCm39)	missense	probably benign
R6339:Vmn2r96	UTSW	17	18,804,124 (GRCm39)	missense	possibly damaging	0.84
R6404:Vmn2r96	UTSW	17	18,817,793 (GRCm39)	missense	probably damaging	1.00
R6452:Vmn2r96	UTSW	17	18,804,117 (GRCm39)	missense	probably benign	0.07
R6749:Vmn2r96	UTSW	17	18,818,352 (GRCm39)	missense	probably damaging	0.99
R6813:Vmn2r96	UTSW	17	18,802,116 (GRCm39)	missense	probably benign	0.04
R6851:Vmn2r96	UTSW	17	18,802,800 (GRCm39)	missense	possibly damaging	0.95
R6944:Vmn2r96	UTSW	17	18,817,891 (GRCm39)	missense	probably benign	0.16
R6949:Vmn2r96	UTSW	17	18,818,100 (GRCm39)	missense	probably damaging	1.00
R6962:Vmn2r96	UTSW	17	18,818,283 (GRCm39)	missense	probably damaging	0.99
R6990:Vmn2r96	UTSW	17	18,804,082 (GRCm39)	missense	probably benign
R7149:Vmn2r96	UTSW	17	18,817,989 (GRCm39)	missense	possibly damaging	0.89
R7346:Vmn2r96	UTSW	17	18,803,029 (GRCm39)	missense	probably benign	0.15
R7385:Vmn2r96	UTSW	17	18,803,302 (GRCm39)	missense	probably damaging	1.00
R7442:Vmn2r96	UTSW	17	18,793,662 (GRCm39)	missense	probably benign	0.02
R7509:Vmn2r96	UTSW	17	18,802,995 (GRCm39)	missense	probably benign	0.02
R7652:Vmn2r96	UTSW	17	18,793,832 (GRCm39)	missense	probably benign
R7659:Vmn2r96	UTSW	17	18,793,749 (GRCm39)	missense	probably benign	0.00
R7753:Vmn2r96	UTSW	17	18,806,663 (GRCm39)	missense	possibly damaging	0.46
R7855:Vmn2r96	UTSW	17	18,818,130 (GRCm39)	missense	possibly damaging	0.59
R8166:Vmn2r96	UTSW	17	18,802,744 (GRCm39)	missense	probably damaging	1.00
R8260:Vmn2r96	UTSW	17	18,804,243 (GRCm39)	missense	probably benign	0.04
R8323:Vmn2r96	UTSW	17	18,803,023 (GRCm39)	missense	probably damaging	0.99
R8787:Vmn2r96	UTSW	17	18,818,250 (GRCm39)	missense	probably damaging	1.00
R8837:Vmn2r96	UTSW	17	18,802,888 (GRCm39)	missense	probably benign
R8933:Vmn2r96	UTSW	17	18,804,241 (GRCm39)	missense	probably benign	0.11
R9306:Vmn2r96	UTSW	17	18,803,226 (GRCm39)	missense	probably benign	0.00
R9481:Vmn2r96	UTSW	17	18,793,621 (GRCm39)	start gained	probably benign
R9626:Vmn2r96	UTSW	17	18,793,758 (GRCm39)	missense	probably benign	0.14
R9629:Vmn2r96	UTSW	17	18,803,257 (GRCm39)	missense	probably benign	0.15
Z1088:Vmn2r96	UTSW	17	18,817,628 (GRCm39)	missense	possibly damaging	0.86
Z1177:Vmn2r96	UTSW	17	18,818,376 (GRCm39)	missense	probably benign	0.02

Posted On

2015-04-16