Incidental Mutation 'IGL02674:Mrgpra4'
| ID |
303029 |
| Institutional Source |
Australian Phenomics Network
(link to record)
|
| Gene Symbol |
Mrgpra4
|
| Ensembl Gene |
ENSMUSG00000067173 |
| Gene Name |
MAS-related GPR, member A4 |
| Synonyms |
MrgA4 |
| Accession Numbers |
|
| Essential gene? |
Probably non essential
(E-score: 0.051)
|
| Stock # |
IGL02674
|
| Quality Score |
|
|
Status
|
|
| Chromosome |
7 |
| Chromosomal Location |
47630585-47631843 bp(-) (GRCm39) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
C to T
at 47630690 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Valine to Methionine
at position 304
(V304M)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000084327
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000087092]
|
| AlphaFold |
Q91WW2 |
| Predicted Effect |
probably benign
Transcript: ENSMUST00000087092
AA Change: V304M
PolyPhen 2
Score 0.085 (Sensitivity: 0.93; Specificity: 0.85)
|
| SMART Domains |
Protein: ENSMUSP00000084327
Gene: ENSMUSG00000067173
AA Change: V304M
| Domain | Start | End | E-Value | Type |
|---|
|
Pfam:7tm_1
|
38 |
270 |
1.3e-10 |
PFAM |
|
| Coding Region Coverage |
|
| Validation Efficiency |
|
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 38 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| Ago2 |
T |
C |
15: 72,983,643 (GRCm39) |
R689G |
probably damaging |
Het |
| Agrn |
C |
T |
4: 156,259,018 (GRCm39) |
|
probably benign |
Het |
| Akna |
A |
T |
4: 63,289,181 (GRCm39) |
C1247* |
probably null |
Het |
| Appl1 |
T |
G |
14: 26,671,418 (GRCm39) |
T345P |
possibly damaging |
Het |
| Chga |
A |
G |
12: 102,529,160 (GRCm39) |
D379G |
probably damaging |
Het |
| Chrna6 |
C |
T |
8: 27,896,879 (GRCm39) |
A333T |
probably benign |
Het |
| Col14a1 |
G |
A |
15: 55,282,178 (GRCm39) |
G813E |
unknown |
Het |
| Csgalnact1 |
C |
A |
8: 68,854,144 (GRCm39) |
G219V |
probably damaging |
Het |
| Dnhd1 |
A |
G |
7: 105,370,688 (GRCm39) |
Q4656R |
probably benign |
Het |
| Dock9 |
A |
C |
14: 121,833,023 (GRCm39) |
|
probably null |
Het |
| Fat4 |
A |
G |
3: 39,037,486 (GRCm39) |
N3713D |
probably benign |
Het |
| Fsd1 |
A |
T |
17: 56,303,483 (GRCm39) |
T452S |
probably benign |
Het |
| G6pc2 |
A |
G |
2: 69,056,910 (GRCm39) |
|
probably null |
Het |
| Gfus |
T |
C |
15: 75,798,238 (GRCm39) |
D178G |
probably damaging |
Het |
| Itprid1 |
A |
G |
6: 55,874,913 (GRCm39) |
T288A |
probably benign |
Het |
| Kcnh4 |
C |
A |
11: 100,637,720 (GRCm39) |
V646L |
possibly damaging |
Het |
| Kcnk1 |
T |
C |
8: 126,751,753 (GRCm39) |
Y120H |
probably damaging |
Het |
| L3mbtl3 |
C |
T |
10: 26,158,711 (GRCm39) |
E646K |
unknown |
Het |
| Lrrc4c |
T |
C |
2: 97,460,120 (GRCm39) |
W249R |
probably damaging |
Het |
| Meox1 |
A |
T |
11: 101,784,767 (GRCm39) |
L22H |
probably damaging |
Het |
| Ncaph |
T |
C |
2: 126,955,496 (GRCm39) |
Y554C |
probably damaging |
Het |
| Nfx1 |
T |
C |
4: 40,999,717 (GRCm39) |
|
probably null |
Het |
| Or10p1 |
A |
C |
10: 129,443,939 (GRCm39) |
M137R |
possibly damaging |
Het |
| Or8g37 |
A |
G |
9: 39,730,934 (GRCm39) |
|
probably null |
Het |
| Otol1 |
C |
T |
3: 69,926,077 (GRCm39) |
P84L |
probably benign |
Het |
| Pcdhb11 |
T |
C |
18: 37,556,667 (GRCm39) |
S666P |
probably damaging |
Het |
| Pou2f3 |
T |
C |
9: 43,050,628 (GRCm39) |
K244R |
probably damaging |
Het |
| Ppp6r1 |
T |
C |
7: 4,649,812 (GRCm39) |
N51S |
probably damaging |
Het |
| Prdm4 |
A |
T |
10: 85,729,263 (GRCm39) |
L715M |
probably damaging |
Het |
| Rgs11 |
G |
A |
17: 26,426,605 (GRCm39) |
V279I |
probably benign |
Het |
| Rsc1a1 |
G |
T |
4: 141,411,406 (GRCm39) |
P502Q |
probably damaging |
Het |
| Senp1 |
T |
C |
15: 97,954,840 (GRCm39) |
E448G |
probably damaging |
Het |
| Shd |
A |
G |
17: 56,278,554 (GRCm39) |
D39G |
possibly damaging |
Het |
| Skint5 |
A |
C |
4: 113,487,582 (GRCm39) |
|
probably benign |
Het |
| Tmprss15 |
T |
G |
16: 78,798,682 (GRCm39) |
T667P |
possibly damaging |
Het |
| Vps13b |
A |
T |
15: 35,640,104 (GRCm39) |
M1325L |
probably benign |
Het |
| Zfp263 |
T |
C |
16: 3,564,629 (GRCm39) |
|
probably benign |
Het |
| Zfp786 |
A |
G |
6: 47,797,427 (GRCm39) |
F504L |
probably benign |
Het |
|
| Other mutations in Mrgpra4 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL00790:Mrgpra4
|
APN |
7 |
47,631,052 (GRCm39) |
missense |
possibly damaging |
0.54 |
|
IGL02083:Mrgpra4
|
APN |
7 |
47,630,808 (GRCm39) |
nonsense |
probably null |
|
|
IGL02155:Mrgpra4
|
APN |
7 |
47,631,292 (GRCm39) |
missense |
probably damaging |
0.99 |
|
IGL02577:Mrgpra4
|
APN |
7 |
47,630,981 (GRCm39) |
missense |
probably benign |
0.10 |
|
IGL02696:Mrgpra4
|
APN |
7 |
47,631,251 (GRCm39) |
missense |
possibly damaging |
0.96 |
|
R0357:Mrgpra4
|
UTSW |
7 |
47,631,574 (GRCm39) |
missense |
probably benign |
|
|
R0543:Mrgpra4
|
UTSW |
7 |
47,631,058 (GRCm39) |
missense |
probably benign |
0.00 |
|
R0677:Mrgpra4
|
UTSW |
7 |
47,630,728 (GRCm39) |
missense |
probably benign |
0.00 |
|
R1163:Mrgpra4
|
UTSW |
7 |
47,631,224 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1217:Mrgpra4
|
UTSW |
7 |
47,631,085 (GRCm39) |
missense |
probably benign |
0.00 |
|
R2255:Mrgpra4
|
UTSW |
7 |
47,631,523 (GRCm39) |
missense |
possibly damaging |
0.70 |
|
R4191:Mrgpra4
|
UTSW |
7 |
47,630,867 (GRCm39) |
missense |
probably benign |
0.00 |
|
R4303:Mrgpra4
|
UTSW |
7 |
47,630,684 (GRCm39) |
missense |
probably benign |
0.02 |
|
R4472:Mrgpra4
|
UTSW |
7 |
47,631,539 (GRCm39) |
missense |
probably benign |
0.05 |
|
R4757:Mrgpra4
|
UTSW |
7 |
47,630,686 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4976:Mrgpra4
|
UTSW |
7 |
47,631,466 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5004:Mrgpra4
|
UTSW |
7 |
47,631,535 (GRCm39) |
missense |
probably benign |
0.26 |
|
R5034:Mrgpra4
|
UTSW |
7 |
47,631,317 (GRCm39) |
missense |
probably benign |
0.00 |
|
R5119:Mrgpra4
|
UTSW |
7 |
47,631,466 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5722:Mrgpra4
|
UTSW |
7 |
47,630,755 (GRCm39) |
missense |
probably benign |
|
|
R6800:Mrgpra4
|
UTSW |
7 |
47,631,371 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7163:Mrgpra4
|
UTSW |
7 |
47,631,238 (GRCm39) |
missense |
probably benign |
0.42 |
|
R7585:Mrgpra4
|
UTSW |
7 |
47,631,377 (GRCm39) |
missense |
probably benign |
0.24 |
|
R7636:Mrgpra4
|
UTSW |
7 |
47,630,721 (GRCm39) |
missense |
possibly damaging |
0.95 |
|
R8162:Mrgpra4
|
UTSW |
7 |
47,631,221 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8352:Mrgpra4
|
UTSW |
7 |
47,631,425 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8452:Mrgpra4
|
UTSW |
7 |
47,631,425 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8812:Mrgpra4
|
UTSW |
7 |
47,631,481 (GRCm39) |
missense |
probably benign |
|
|
R8996:Mrgpra4
|
UTSW |
7 |
47,630,945 (GRCm39) |
missense |
probably benign |
0.28 |
|
R9026:Mrgpra4
|
UTSW |
7 |
47,631,208 (GRCm39) |
missense |
possibly damaging |
0.73 |
|
X0028:Mrgpra4
|
UTSW |
7 |
47,631,168 (GRCm39) |
nonsense |
probably null |
|
|
| Posted On |
2015-04-16 |
Incidental Mutation