Incidental Mutation 'IGL02674:Zfp786'
| ID |
303058 |
| Institutional Source |
Australian Phenomics Network
(link to record)
|
| Gene Symbol |
Zfp786
|
| Ensembl Gene |
ENSMUSG00000051499 |
| Gene Name |
zinc finger protein 786 |
| Synonyms |
A730012O14Rik |
| Accession Numbers |
|
| Essential gene? |
Probably non essential
(E-score: 0.068)
|
| Stock # |
IGL02674
|
| Quality Score |
|
|
Status
|
|
| Chromosome |
6 |
| Chromosomal Location |
47796200-47807801 bp(-) (GRCm39) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
A to G
at 47797427 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Phenylalanine to Leucine
at position 504
(F504L)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000057495
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000058844]
|
| AlphaFold |
Q8BV42 |
| Predicted Effect |
probably benign
Transcript: ENSMUST00000058844
AA Change: F504L
PolyPhen 2
Score 0.221 (Sensitivity: 0.91; Specificity: 0.88)
|
| SMART Domains |
Protein: ENSMUSP00000057495
Gene: ENSMUSG00000051499
AA Change: F504L
| Domain | Start | End | E-Value | Type |
|---|
|
KRAB
|
9 |
69 |
2.6e-22 |
SMART |
|
low complexity region
|
156 |
164 |
N/A |
INTRINSIC |
|
ZnF_C2H2
|
240 |
262 |
5.34e-1 |
SMART |
|
ZnF_C2H2
|
268 |
295 |
1.41e2 |
SMART |
|
ZnF_C2H2
|
420 |
440 |
1.21e2 |
SMART |
|
ZnF_C2H2
|
448 |
470 |
3.52e-1 |
SMART |
|
ZnF_C2H2
|
476 |
498 |
1.89e-1 |
SMART |
|
ZnF_C2H2
|
504 |
526 |
1.69e-3 |
SMART |
|
ZnF_C2H2
|
532 |
554 |
5.59e-4 |
SMART |
|
ZnF_C2H2
|
560 |
582 |
4.79e-3 |
SMART |
|
ZnF_C2H2
|
588 |
610 |
3.69e-4 |
SMART |
|
ZnF_C2H2
|
616 |
638 |
3.63e-3 |
SMART |
|
ZnF_C2H2
|
644 |
665 |
5.92e0 |
SMART |
|
ZnF_C2H2
|
671 |
693 |
2.57e-3 |
SMART |
|
ZnF_C2H2
|
699 |
721 |
1.38e-3 |
SMART |
|
ZnF_C2H2
|
727 |
749 |
1.45e-2 |
SMART |
|
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000080603
|
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000143979
|
| Coding Region Coverage |
|
| Validation Efficiency |
|
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 38 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| Ago2 |
T |
C |
15: 72,983,643 (GRCm39) |
R689G |
probably damaging |
Het |
| Agrn |
C |
T |
4: 156,259,018 (GRCm39) |
|
probably benign |
Het |
| Akna |
A |
T |
4: 63,289,181 (GRCm39) |
C1247* |
probably null |
Het |
| Appl1 |
T |
G |
14: 26,671,418 (GRCm39) |
T345P |
possibly damaging |
Het |
| Chga |
A |
G |
12: 102,529,160 (GRCm39) |
D379G |
probably damaging |
Het |
| Chrna6 |
C |
T |
8: 27,896,879 (GRCm39) |
A333T |
probably benign |
Het |
| Col14a1 |
G |
A |
15: 55,282,178 (GRCm39) |
G813E |
unknown |
Het |
| Csgalnact1 |
C |
A |
8: 68,854,144 (GRCm39) |
G219V |
probably damaging |
Het |
| Dnhd1 |
A |
G |
7: 105,370,688 (GRCm39) |
Q4656R |
probably benign |
Het |
| Dock9 |
A |
C |
14: 121,833,023 (GRCm39) |
|
probably null |
Het |
| Fat4 |
A |
G |
3: 39,037,486 (GRCm39) |
N3713D |
probably benign |
Het |
| Fsd1 |
A |
T |
17: 56,303,483 (GRCm39) |
T452S |
probably benign |
Het |
| G6pc2 |
A |
G |
2: 69,056,910 (GRCm39) |
|
probably null |
Het |
| Gfus |
T |
C |
15: 75,798,238 (GRCm39) |
D178G |
probably damaging |
Het |
| Itprid1 |
A |
G |
6: 55,874,913 (GRCm39) |
T288A |
probably benign |
Het |
| Kcnh4 |
C |
A |
11: 100,637,720 (GRCm39) |
V646L |
possibly damaging |
Het |
| Kcnk1 |
T |
C |
8: 126,751,753 (GRCm39) |
Y120H |
probably damaging |
Het |
| L3mbtl3 |
C |
T |
10: 26,158,711 (GRCm39) |
E646K |
unknown |
Het |
| Lrrc4c |
T |
C |
2: 97,460,120 (GRCm39) |
W249R |
probably damaging |
Het |
| Meox1 |
A |
T |
11: 101,784,767 (GRCm39) |
L22H |
probably damaging |
Het |
| Mrgpra4 |
C |
T |
7: 47,630,690 (GRCm39) |
V304M |
probably benign |
Het |
| Ncaph |
T |
C |
2: 126,955,496 (GRCm39) |
Y554C |
probably damaging |
Het |
| Nfx1 |
T |
C |
4: 40,999,717 (GRCm39) |
|
probably null |
Het |
| Or10p1 |
A |
C |
10: 129,443,939 (GRCm39) |
M137R |
possibly damaging |
Het |
| Or8g37 |
A |
G |
9: 39,730,934 (GRCm39) |
|
probably null |
Het |
| Otol1 |
C |
T |
3: 69,926,077 (GRCm39) |
P84L |
probably benign |
Het |
| Pcdhb11 |
T |
C |
18: 37,556,667 (GRCm39) |
S666P |
probably damaging |
Het |
| Pou2f3 |
T |
C |
9: 43,050,628 (GRCm39) |
K244R |
probably damaging |
Het |
| Ppp6r1 |
T |
C |
7: 4,649,812 (GRCm39) |
N51S |
probably damaging |
Het |
| Prdm4 |
A |
T |
10: 85,729,263 (GRCm39) |
L715M |
probably damaging |
Het |
| Rgs11 |
G |
A |
17: 26,426,605 (GRCm39) |
V279I |
probably benign |
Het |
| Rsc1a1 |
G |
T |
4: 141,411,406 (GRCm39) |
P502Q |
probably damaging |
Het |
| Senp1 |
T |
C |
15: 97,954,840 (GRCm39) |
E448G |
probably damaging |
Het |
| Shd |
A |
G |
17: 56,278,554 (GRCm39) |
D39G |
possibly damaging |
Het |
| Skint5 |
A |
C |
4: 113,487,582 (GRCm39) |
|
probably benign |
Het |
| Tmprss15 |
T |
G |
16: 78,798,682 (GRCm39) |
T667P |
possibly damaging |
Het |
| Vps13b |
A |
T |
15: 35,640,104 (GRCm39) |
M1325L |
probably benign |
Het |
| Zfp263 |
T |
C |
16: 3,564,629 (GRCm39) |
|
probably benign |
Het |
|
| Other mutations in Zfp786 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL00593:Zfp786
|
APN |
6 |
47,796,605 (GRCm39) |
makesense |
probably null |
|
|
IGL02442:Zfp786
|
APN |
6 |
47,798,301 (GRCm39) |
missense |
probably benign |
0.00 |
|
IGL02814:Zfp786
|
APN |
6 |
47,796,775 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL03072:Zfp786
|
APN |
6 |
47,798,177 (GRCm39) |
missense |
probably benign |
0.01 |
|
IGL03294:Zfp786
|
APN |
6 |
47,798,258 (GRCm39) |
nonsense |
probably null |
|
|
IGL03393:Zfp786
|
APN |
6 |
47,798,458 (GRCm39) |
missense |
possibly damaging |
0.88 |
|
3-1:Zfp786
|
UTSW |
6 |
47,797,379 (GRCm39) |
missense |
probably damaging |
1.00 |
|
PIT4581001:Zfp786
|
UTSW |
6 |
47,796,756 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1071:Zfp786
|
UTSW |
6 |
47,798,239 (GRCm39) |
missense |
possibly damaging |
0.91 |
|
R1426:Zfp786
|
UTSW |
6 |
47,802,013 (GRCm39) |
missense |
probably benign |
0.17 |
|
R1976:Zfp786
|
UTSW |
6 |
47,796,691 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2114:Zfp786
|
UTSW |
6 |
47,803,931 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2115:Zfp786
|
UTSW |
6 |
47,803,931 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2117:Zfp786
|
UTSW |
6 |
47,803,931 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2176:Zfp786
|
UTSW |
6 |
47,797,905 (GRCm39) |
missense |
possibly damaging |
0.65 |
|
R2304:Zfp786
|
UTSW |
6 |
47,797,633 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R3110:Zfp786
|
UTSW |
6 |
47,797,160 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R3112:Zfp786
|
UTSW |
6 |
47,797,160 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R3623:Zfp786
|
UTSW |
6 |
47,798,357 (GRCm39) |
missense |
probably benign |
0.00 |
|
R4654:Zfp786
|
UTSW |
6 |
47,797,868 (GRCm39) |
missense |
probably benign |
0.01 |
|
R4741:Zfp786
|
UTSW |
6 |
47,797,625 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4927:Zfp786
|
UTSW |
6 |
47,797,087 (GRCm39) |
missense |
probably benign |
0.43 |
|
R4936:Zfp786
|
UTSW |
6 |
47,798,202 (GRCm39) |
nonsense |
probably null |
|
|
R5084:Zfp786
|
UTSW |
6 |
47,796,953 (GRCm39) |
missense |
probably benign |
0.00 |
|
R5445:Zfp786
|
UTSW |
6 |
47,796,619 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6662:Zfp786
|
UTSW |
6 |
47,803,920 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7290:Zfp786
|
UTSW |
6 |
47,796,929 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7561:Zfp786
|
UTSW |
6 |
47,796,667 (GRCm39) |
missense |
probably benign |
0.02 |
|
R8038:Zfp786
|
UTSW |
6 |
47,798,188 (GRCm39) |
missense |
probably benign |
0.01 |
|
R8090:Zfp786
|
UTSW |
6 |
47,796,943 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8250:Zfp786
|
UTSW |
6 |
47,797,729 (GRCm39) |
missense |
possibly damaging |
0.85 |
|
R8438:Zfp786
|
UTSW |
6 |
47,796,934 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8516:Zfp786
|
UTSW |
6 |
47,797,477 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8868:Zfp786
|
UTSW |
6 |
47,802,015 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R9596:Zfp786
|
UTSW |
6 |
47,797,406 (GRCm39) |
nonsense |
probably null |
|
|
R9788:Zfp786
|
UTSW |
6 |
47,797,816 (GRCm39) |
missense |
probably benign |
0.00 |
|
| Posted On |
2015-04-16 |
Incidental Mutation