Incidental Mutation 'IGL02675:Suds3'
ID 303110
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Suds3
Ensembl Gene ENSMUSG00000066900
Gene Name suppressor of defective silencing 3 homolog (S. cerevisiae)
Synonyms 2400003N08Rik, 2410008L21Rik
Accession Numbers
Essential gene? Essential (E-score: 1.000) question?
Stock # IGL02675
Quality Score
Status
Chromosome 5
Chromosomal Location 117229745-117254178 bp(-) (GRCm39)
Type of Mutation splice site (5 bp from exon)
DNA Base Change (assembly) C to T at 117232970 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change
Ref Sequence ENSEMBL: ENSMUSP00000130535 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000086471] [ENSMUST00000166397]
AlphaFold Q8BR65
Predicted Effect probably null
Transcript: ENSMUST00000086471
SMART Domains Protein: ENSMUSP00000083662
Gene: ENSMUSG00000066900

DomainStartEndE-ValueType
low complexity region 2 37 N/A INTRINSIC
Pfam:Sds3 52 223 3.6e-30 PFAM
low complexity region 225 238 N/A INTRINSIC
Predicted Effect probably null
Transcript: ENSMUST00000166397
SMART Domains Protein: ENSMUSP00000130535
Gene: ENSMUSG00000066900

DomainStartEndE-ValueType
low complexity region 2 37 N/A INTRINSIC
low complexity region 44 56 N/A INTRINSIC
Pfam:Sds3 61 296 4.7e-22 PFAM
Predicted Effect noncoding transcript
Transcript: ENSMUST00000202684
Predicted Effect noncoding transcript
Transcript: ENSMUST00000202713
Coding Region Coverage
Validation Efficiency
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] SDS3 is a subunit of the histone deacetylase (see HDAC1; MIM 601241)-dependent SIN3A (MIM 607776) corepressor complex (Fleischer et al., 2003 [PubMed 12724404]).[supplied by OMIM, Mar 2008]
PHENOTYPE: Mice homozygous for a knock-out allele display early embryonic lethality in the peri-implantation period. [provided by MGI curators]
Allele List at MGI
Other mutations in this stock
Total: 44 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Ano8 A G 8: 71,936,184 (GRCm39) I204T probably damaging Het
Anxa8 A G 14: 33,815,371 (GRCm39) D150G probably damaging Het
Arel1 T C 12: 84,977,002 (GRCm39) T438A probably damaging Het
Asphd1 T C 7: 126,546,006 (GRCm39) probably benign Het
Bcl2l12 A T 7: 44,640,824 (GRCm39) probably benign Het
Cand1 A G 10: 119,055,602 (GRCm39) I87T probably damaging Het
Ccdc80 A C 16: 44,936,695 (GRCm39) T707P probably damaging Het
Ccn6 A G 10: 39,027,236 (GRCm39) V332A possibly damaging Het
Cdh9 T A 15: 16,849,162 (GRCm39) probably null Het
Chrd T C 16: 20,558,699 (GRCm39) probably benign Het
Cpn1 T C 19: 43,969,369 (GRCm39) Q98R probably benign Het
D630045J12Rik A G 6: 38,172,420 (GRCm39) S583P possibly damaging Het
Dnah7a A G 1: 53,543,183 (GRCm39) I2329T possibly damaging Het
Egln3 A G 12: 54,249,996 (GRCm39) S118P probably benign Het
Gfra1 G A 19: 58,441,787 (GRCm39) T48I probably damaging Het
Hapln3 C T 7: 78,767,596 (GRCm39) probably null Het
Heatr3 T C 8: 88,871,185 (GRCm39) F180L possibly damaging Het
Herc2 T A 7: 55,813,849 (GRCm39) S2661T probably damaging Het
Hook3 A T 8: 26,551,462 (GRCm39) L126Q possibly damaging Het
Hoxd8 T G 2: 74,536,930 (GRCm39) L214R probably damaging Het
Ifna1 T G 4: 88,768,670 (GRCm39) L116R probably damaging Het
Il31ra T A 13: 112,660,886 (GRCm39) T487S probably benign Het
Kifc2 C T 15: 76,547,179 (GRCm39) R252W probably damaging Het
Meox2 A G 12: 37,228,333 (GRCm39) D290G probably damaging Het
Micu2 A G 14: 58,182,834 (GRCm39) probably benign Het
Myh9 T C 15: 77,673,130 (GRCm39) T406A possibly damaging Het
Naip1 T A 13: 100,545,626 (GRCm39) M1301L probably benign Het
Pbrm1 T C 14: 30,828,244 (GRCm39) L1341P possibly damaging Het
Pcna-ps2 C A 19: 9,261,323 (GRCm39) A194E probably benign Het
Pdcd10 G A 3: 75,434,901 (GRCm39) T130I probably damaging Het
Pprc1 G A 19: 46,051,946 (GRCm39) G491D probably damaging Het
Prss57 A G 10: 79,623,309 (GRCm39) V46A probably benign Het
Ptcd3 A G 6: 71,860,426 (GRCm39) probably null Het
Riok1 C T 13: 38,234,219 (GRCm39) P262S probably damaging Het
Rnf13 A G 3: 57,686,817 (GRCm39) N70S probably benign Het
Skint7 T A 4: 111,839,178 (GRCm39) D157E probably benign Het
Sri T C 5: 8,117,534 (GRCm39) F191S probably damaging Het
Stat5b T C 11: 100,678,200 (GRCm39) R638G probably benign Het
Tmem19 A G 10: 115,178,478 (GRCm39) L281P probably damaging Het
Tmf1 A G 6: 97,141,003 (GRCm39) probably benign Het
Trio A G 15: 27,768,125 (GRCm39) probably benign Het
Usp28 T C 9: 48,950,391 (GRCm39) I940T possibly damaging Het
Zfp280d T A 9: 72,219,504 (GRCm39) I227K probably benign Het
Zfp335 A G 2: 164,752,609 (GRCm39) V45A probably benign Het
Other mutations in Suds3
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL02713:Suds3 APN 5 117,232,970 (GRCm39) splice site probably null
R1779:Suds3 UTSW 5 117,243,309 (GRCm39) missense probably benign 0.02
R1986:Suds3 UTSW 5 117,246,417 (GRCm39) missense probably damaging 0.98
R2519:Suds3 UTSW 5 117,233,018 (GRCm39) missense probably damaging 1.00
R5189:Suds3 UTSW 5 117,238,664 (GRCm39) critical splice donor site probably benign
R6213:Suds3 UTSW 5 117,244,727 (GRCm39) missense probably damaging 0.99
R7756:Suds3 UTSW 5 117,253,802 (GRCm39) missense unknown
R7758:Suds3 UTSW 5 117,253,802 (GRCm39) missense unknown
R7818:Suds3 UTSW 5 117,253,814 (GRCm39) unclassified probably benign
R7879:Suds3 UTSW 5 117,236,335 (GRCm39) critical splice donor site probably null
R8978:Suds3 UTSW 5 117,232,973 (GRCm39) critical splice donor site probably null
R9613:Suds3 UTSW 5 117,243,234 (GRCm39) missense possibly damaging 0.92
Posted On 2015-04-16