Mutagenetix > Incidental Mutation

Incidental Mutation 'IGL02676:Vmn2r14'

303113

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Vmn2r14

Ensembl Gene

ENSMUSG00000091059

Gene Name

vomeronasal 2, receptor 14

Synonyms

EG231591

Accession Numbers

Essential gene?

Possibly essential (E-score: 0.526) question?

Stock #

IGL02676

Quality Score

Status

Chromosome

Chromosomal Location

109362822-109372488 bp(-) (GRCm39)

Type of Mutation

missense

DNA Base Change (assembly)

G to A at 109367882 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Threonine to Isoleucine at position 370 (T370I)

Ref Sequence

ENSEMBL: ENSMUSP00000128015 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000170341]

AlphaFold

E9Q759

Predicted Effect

probably benign
Transcript: ENSMUST00000170341
AA Change: T370I

PolyPhen 2 Score 0.032 (Sensitivity: 0.95; Specificity: 0.82)

SMART Domains

Protein: ENSMUSP00000128015
Gene: ENSMUSG00000091059
AA Change: T370I

Domain	Start	End	E-Value	Type
signal peptide	1	26	N/A	INTRINSIC
Pfam:ANF_receptor	76	466	8.3e-31	PFAM
Pfam:NCD3G	507	561	1.1e-17	PFAM
Pfam:7tm_3	594	829	1.2e-55	PFAM

Coding Region Coverage

Validation Efficiency

Allele List at MGI

Other mutations in this stock

Total: 48 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Apc	G	A	18: 34,448,687 (GRCm39)	S1827N	probably damaging	Het
Atrnl1	T	A	19: 57,680,316 (GRCm39)	C739S	probably damaging	Het
Cep350	T	C	1: 155,737,977 (GRCm39)	E2622G	possibly damaging	Het
Chd5	C	T	4: 152,440,530 (GRCm39)		probably benign	Het
Chst11	T	A	10: 83,027,563 (GRCm39)	L330Q	probably damaging	Het
Clcnka	A	T	4: 141,120,094 (GRCm39)	V275E	probably damaging	Het
Clip4	G	A	17: 72,135,616 (GRCm39)	S456N	probably damaging	Het
Cmya5	A	T	13: 93,229,361 (GRCm39)	I1909N	probably damaging	Het
Cyp26b1	A	G	6: 84,553,626 (GRCm39)	I176T	probably damaging	Het
Dst	A	G	1: 34,346,668 (GRCm39)	R7717G	probably damaging	Het
Eml2	C	T	7: 18,918,846 (GRCm39)	R99*	probably null	Het
Fibin	T	C	2: 110,192,929 (GRCm39)	Q71R	probably benign	Het
Fsip2	T	G	2: 82,812,501 (GRCm39)	I2940S	possibly damaging	Het
Gabrb3	G	T	7: 57,241,112 (GRCm39)		probably benign	Het
Gfra1	G	A	19: 58,441,787 (GRCm39)	T48I	probably damaging	Het
Gm6483	C	T	8: 19,743,675 (GRCm39)		noncoding transcript	Het
Hdgfl1	G	A	13: 26,953,348 (GRCm39)	R242C	possibly damaging	Het
Hmcn1	T	C	1: 150,494,760 (GRCm39)	T4110A	probably benign	Het
Lama2	T	G	10: 26,994,489 (GRCm39)	M1807L	probably benign	Het
Larp4	T	C	15: 99,888,302 (GRCm39)	V113A	possibly damaging	Het
Mkx	T	C	18: 7,000,640 (GRCm39)	T101A	probably benign	Het
Nfe2l1	A	G	11: 96,718,491 (GRCm39)	F15L	probably damaging	Het
Nherf2	A	T	17: 24,860,930 (GRCm39)	V204E	probably damaging	Het
Nif3l1	G	A	1: 58,494,895 (GRCm39)		probably null	Het
Nop14	A	G	5: 34,796,565 (GRCm39)	V764A	probably damaging	Het
Nosip	C	A	7: 44,726,752 (GRCm39)	A259E	probably damaging	Het
Ntn5	T	C	7: 45,341,300 (GRCm39)		probably benign	Het
Or9g20	T	C	2: 85,629,934 (GRCm39)	I227V	possibly damaging	Het
Phospho1	G	A	11: 95,721,714 (GRCm39)	G128D	probably damaging	Het
Ppp4r3a	G	A	12: 101,008,770 (GRCm39)	T703M	probably benign	Het
Pramel21	T	C	4: 143,342,667 (GRCm39)	F258S	possibly damaging	Het
Pramel58	A	G	5: 94,831,730 (GRCm39)	T246A	possibly damaging	Het
Prdm8	G	A	5: 98,334,418 (GRCm39)	E662K	probably damaging	Het
Ralgapa1	A	G	12: 55,723,202 (GRCm39)	S1775P	probably damaging	Het
Rapgef6	T	C	11: 54,540,172 (GRCm39)		probably benign	Het
Rasef	T	C	4: 73,677,966 (GRCm39)	T87A	possibly damaging	Het
Scrn3	A	G	2: 73,160,215 (GRCm39)	Q286R	probably benign	Het
Sema3d	A	T	5: 12,620,945 (GRCm39)	Q517L	probably benign	Het
Taf6l	T	C	19: 8,752,413 (GRCm39)	Y425C	probably damaging	Het
Tbk1	T	C	10: 121,403,985 (GRCm39)	N254S	possibly damaging	Het
Tcf3	C	T	10: 80,256,925 (GRCm39)	G64R	probably damaging	Het
Tmco4	T	C	4: 138,750,380 (GRCm39)		probably null	Het
Trappc11	A	G	8: 47,946,448 (GRCm39)		probably benign	Het
Vmn1r19	A	T	6: 57,382,025 (GRCm39)	I193F	possibly damaging	Het
Vmn2r65	T	A	7: 84,589,381 (GRCm39)	H845L	possibly damaging	Het
Vmn2r98	A	T	17: 19,285,521 (GRCm39)	T114S	probably benign	Het
Zfp280d	A	T	9: 72,242,356 (GRCm39)	R661S	probably damaging	Het
Zranb1	T	C	7: 132,568,410 (GRCm39)	I356T	probably benign	Het

Other mutations in Vmn2r14

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL01472:Vmn2r14	APN	5	109,364,180 (GRCm39)	nonsense	probably null
IGL01504:Vmn2r14	APN	5	109,369,285 (GRCm39)	missense	probably benign	0.01
IGL01828:Vmn2r14	APN	5	109,372,443 (GRCm39)	missense	possibly damaging	0.71
IGL02093:Vmn2r14	APN	5	109,368,275 (GRCm39)	missense	possibly damaging	0.94
IGL02103:Vmn2r14	APN	5	109,372,349 (GRCm39)	missense	probably damaging	0.96
IGL02123:Vmn2r14	APN	5	109,367,933 (GRCm39)	missense	probably damaging	1.00
IGL02145:Vmn2r14	APN	5	109,368,454 (GRCm39)	nonsense	probably null
IGL02720:Vmn2r14	APN	5	109,369,305 (GRCm39)	missense	probably damaging	1.00
IGL02877:Vmn2r14	APN	5	109,368,054 (GRCm39)	missense	probably damaging	0.99
IGL02974:Vmn2r14	APN	5	109,369,292 (GRCm39)	missense	possibly damaging	0.55
IGL03151:Vmn2r14	APN	5	109,364,260 (GRCm39)	missense	probably damaging	1.00
IGL03297:Vmn2r14	APN	5	109,363,973 (GRCm39)	missense	probably damaging	1.00
IGL03386:Vmn2r14	APN	5	109,368,350 (GRCm39)	missense	possibly damaging	0.90
IGL03394:Vmn2r14	APN	5	109,367,702 (GRCm39)	missense	probably null	0.83
ANU74:Vmn2r14	UTSW	5	109,366,910 (GRCm39)	missense	probably benign	0.00
R0316:Vmn2r14	UTSW	5	109,366,762 (GRCm39)	missense	probably benign	0.07
R0755:Vmn2r14	UTSW	5	109,364,226 (GRCm39)	missense	possibly damaging	0.81
R1219:Vmn2r14	UTSW	5	109,372,440 (GRCm39)	missense	probably benign	0.17
R1321:Vmn2r14	UTSW	5	109,364,117 (GRCm39)	missense	probably benign	0.08
R1465:Vmn2r14	UTSW	5	109,368,195 (GRCm39)	missense	possibly damaging	0.47
R1465:Vmn2r14	UTSW	5	109,368,195 (GRCm39)	missense	possibly damaging	0.47
R1509:Vmn2r14	UTSW	5	109,363,862 (GRCm39)	missense	probably benign	0.00
R1551:Vmn2r14	UTSW	5	109,369,283 (GRCm39)	missense	probably damaging	1.00
R1628:Vmn2r14	UTSW	5	109,367,838 (GRCm39)	missense	probably benign	0.00
R1668:Vmn2r14	UTSW	5	109,366,913 (GRCm39)	nonsense	probably null
R2013:Vmn2r14	UTSW	5	109,369,109 (GRCm39)	missense	probably benign	0.00
R2201:Vmn2r14	UTSW	5	109,366,698 (GRCm39)	splice site	probably null
R2417:Vmn2r14	UTSW	5	109,372,329 (GRCm39)	missense	probably benign	0.00
R3029:Vmn2r14	UTSW	5	109,363,776 (GRCm39)	missense	probably damaging	1.00
R3120:Vmn2r14	UTSW	5	109,372,431 (GRCm39)	missense	probably null	0.00
R3729:Vmn2r14	UTSW	5	109,364,095 (GRCm39)	missense	probably damaging	1.00
R3762:Vmn2r14	UTSW	5	109,368,033 (GRCm39)	missense	probably benign	0.02
R3943:Vmn2r14	UTSW	5	109,363,930 (GRCm39)	missense	probably damaging	1.00
R3944:Vmn2r14	UTSW	5	109,363,930 (GRCm39)	missense	probably damaging	1.00
R4222:Vmn2r14	UTSW	5	109,364,149 (GRCm39)	missense	probably benign	0.00
R4224:Vmn2r14	UTSW	5	109,364,149 (GRCm39)	missense	probably benign	0.00
R4239:Vmn2r14	UTSW	5	109,364,277 (GRCm39)	critical splice acceptor site	probably null
R4240:Vmn2r14	UTSW	5	109,364,277 (GRCm39)	critical splice acceptor site	probably null
R4782:Vmn2r14	UTSW	5	109,369,370 (GRCm39)	missense	probably benign	0.01
R4832:Vmn2r14	UTSW	5	109,363,976 (GRCm39)	missense	probably damaging	1.00
R4884:Vmn2r14	UTSW	5	109,369,384 (GRCm39)	splice site	probably null
R4896:Vmn2r14	UTSW	5	109,368,246 (GRCm39)	missense	probably benign	0.19
R5004:Vmn2r14	UTSW	5	109,368,246 (GRCm39)	missense	probably benign	0.19
R5117:Vmn2r14	UTSW	5	109,363,961 (GRCm39)	missense	probably benign	0.16
R5285:Vmn2r14	UTSW	5	109,365,442 (GRCm39)	missense	probably damaging	0.98
R5413:Vmn2r14	UTSW	5	109,369,154 (GRCm39)	missense	probably benign	0.29
R5569:Vmn2r14	UTSW	5	109,368,261 (GRCm39)	missense	probably benign	0.44
R5701:Vmn2r14	UTSW	5	109,367,816 (GRCm39)	missense	probably damaging	1.00
R5726:Vmn2r14	UTSW	5	109,365,486 (GRCm39)	missense	possibly damaging	0.95
R5763:Vmn2r14	UTSW	5	109,363,724 (GRCm39)	missense	possibly damaging	0.49
R5872:Vmn2r14	UTSW	5	109,369,222 (GRCm39)	missense	probably benign
R5985:Vmn2r14	UTSW	5	109,368,082 (GRCm39)	missense	possibly damaging	0.89
R6268:Vmn2r14	UTSW	5	109,369,283 (GRCm39)	missense	possibly damaging	0.87
R6273:Vmn2r14	UTSW	5	109,369,133 (GRCm39)	missense	probably benign	0.44
R6409:Vmn2r14	UTSW	5	109,364,096 (GRCm39)	missense	probably benign	0.09
R6944:Vmn2r14	UTSW	5	109,364,140 (GRCm39)	missense	probably benign	0.06
R6944:Vmn2r14	UTSW	5	109,363,925 (GRCm39)	missense	probably benign	0.22
R7608:Vmn2r14	UTSW	5	109,369,276 (GRCm39)	missense	probably benign	0.03
R7740:Vmn2r14	UTSW	5	109,368,324 (GRCm39)	missense	probably benign	0.41
R7768:Vmn2r14	UTSW	5	109,368,086 (GRCm39)	missense	probably benign	0.01
R7804:Vmn2r14	UTSW	5	109,368,324 (GRCm39)	missense	probably benign	0.41
R7872:Vmn2r14	UTSW	5	109,369,219 (GRCm39)	missense	probably benign	0.02
R7993:Vmn2r14	UTSW	5	109,363,862 (GRCm39)	missense	probably benign	0.00
R8006:Vmn2r14	UTSW	5	109,368,324 (GRCm39)	missense	probably benign	0.41
R8007:Vmn2r14	UTSW	5	109,368,324 (GRCm39)	missense	probably benign	0.41
R8187:Vmn2r14	UTSW	5	109,368,420 (GRCm39)	missense	probably benign	0.03
R8369:Vmn2r14	UTSW	5	109,369,342 (GRCm39)	missense	probably damaging	1.00
R8463:Vmn2r14	UTSW	5	109,369,340 (GRCm39)	missense	probably benign	0.30
R8968:Vmn2r14	UTSW	5	109,365,533 (GRCm39)	missense	probably benign	0.01
R9008:Vmn2r14	UTSW	5	109,367,893 (GRCm39)	missense	probably benign	0.00
R9030:Vmn2r14	UTSW	5	109,368,054 (GRCm39)	missense	probably damaging	0.99
R9039:Vmn2r14	UTSW	5	109,367,902 (GRCm39)	nonsense	probably null
R9150:Vmn2r14	UTSW	5	109,367,783 (GRCm39)	missense	probably damaging	1.00
R9164:Vmn2r14	UTSW	5	109,364,087 (GRCm39)	missense	probably damaging	1.00
R9216:Vmn2r14	UTSW	5	109,369,112 (GRCm39)	missense	probably benign	0.01
R9225:Vmn2r14	UTSW	5	109,369,288 (GRCm39)	missense	probably damaging	1.00
R9245:Vmn2r14	UTSW	5	109,368,176 (GRCm39)	missense	possibly damaging	0.89
R9342:Vmn2r14	UTSW	5	109,368,428 (GRCm39)	missense	probably damaging	1.00
R9472:Vmn2r14	UTSW	5	109,367,962 (GRCm39)	missense	probably benign	0.00
R9678:Vmn2r14	UTSW	5	109,364,041 (GRCm39)	missense	probably damaging	1.00
R9774:Vmn2r14	UTSW	5	109,369,126 (GRCm39)	missense	probably benign	0.07
Z1177:Vmn2r14	UTSW	5	109,367,741 (GRCm39)	missense	probably benign	0.33

Posted On

2015-04-16